Advicor Information

What's inside Advicor

Advicor in the News

FDA OKs Abbott cholesterol drug Simcor - Forbes
Abbott has targeted this market with drug Advicor, which includes Niaspan and the lower-strength statin Lovastatin. An estimated 80 million Americans have ...
Fri Feb 15 18:33:13 -0500 2008

Trans World Entertainment Q2 Loss Widens; Sales Down 10% - Quick ... - RTT News
As Director of Marketing, Glickman was responsible for the launch of ADVICOR, the second commercial product for Kos. Prior to Kos, he was at Bristol-Myers ...
Thu Aug 23 04:28:43 -0400 2007

Abbott Reviews 2006 Accomplishments at Annual Shareholders' Meeting - PR Newswire (press release)
... position in the $20 billion lipid management market by expanding the company's cholesterol franchise with medications Niaspan(R) and Advicor(R); ...
Fri Apr 27 21:16:33 -0400 2007

Advicor Chemical Information

lovastatin - A lactone metabolite isolated from the fungus Aspergillus terreus with cholesterol-lowering activity and potential antineoplastic activity. Lovastatin is hydrolyszed to the active beta-hydroxyacid form, which competitively inhibits 3-hydroxyl-3-methylgutarylcoenzyme A (HMG-CoA) reductase, an enzyme involved in the cholesterol biosynthesis. In addition, this agent may inhibit tumor cell proliferation and reduce tumor cell invasiveness, thereby decreasing tumor metastatic potential; induce tumor cell apoptosis, possibly by inhibiting protein geranylgeranylation and; arrest cells in the G1 phase of the cell cycle, an effect that sensitizes tumor cells to the cytotoxic effects of ionizing radiation. (NCI04)

niacin - A water-soluble vitamin belonging to the vitamin B family, which occurs in many animal and plant tissues, with antihyperlipidemic activity. Niacin is converted to its active form niacinamide, which is a component of the coenzymes nicotinamide adenine dinucleotide (NAD) and its phosphate form, NADP. These coenzymes play an important role in tissue respiration and in glycogen, lipid, amino acid, protein, and purine metabolism. Although the exact mechanism of action by which niacin lowers cholesterol is not fully understood, it may act by inhibiting the synthesis of very low density lipoproteins (VLDL), inhibiting the release of free fatty acids from adipose tissue, increasing lipoprotein lipase activity, and reducing the hepatic synthesis of VLDL-C and LDL-C.