Altocor Information

What's inside Altocor

Altocor in the News

Australia Opens Doors to World's Largest Exotic ''Nature Bank ... - PharmaLive.com (press release)
The cholesterol-lowering drug lovastatin (Altocor(TM)) was derived from a fungus. The next generation drug atorvastatin (Lipitor(TM)) is the world's largest ...
Mon May 07 05:11:56 -0400 2007

Australia Opens Doors to World’s Largest Exotic “Nature Bank” -- a ... - Business Wire (press release)
The cholesterol-lowering drug lovastatin (Altocor TM ) was derived from a fungus. The next generation drug atorvastatin (Lipitor TM ) is the world’s largest ...
Mon May 07 04:52:19 -0400 2007

Australia Opens Doors to World's Largest Exotic ''Nature Bank ... - Genetic Engineering News (press release)
The cholesterol-lowering drug lovastatin (Altocor(TM)) was derived from a fungus. The next generation drug atorvastatin (Lipitor(TM)) is the world's largest ...
Mon May 07 05:07:42 -0400 2007

Altocor Chemical Information

lovastatin - A lactone metabolite isolated from the fungus Aspergillus terreus with cholesterol-lowering activity and potential antineoplastic activity. Lovastatin is hydrolyszed to the active beta-hydroxyacid form, which competitively inhibits 3-hydroxyl-3-methylgutarylcoenzyme A (HMG-CoA) reductase, an enzyme involved in the cholesterol biosynthesis. In addition, this agent may inhibit tumor cell proliferation and reduce tumor cell invasiveness, thereby decreasing tumor metastatic potential; induce tumor cell apoptosis, possibly by inhibiting protein geranylgeranylation and; arrest cells in the G1 phase of the cell cycle, an effect that sensitizes tumor cells to the cytotoxic effects of ionizing radiation. (NCI04)