Climara Pro Information

What's inside Climara Pro

Climara Pro in the News

Dr. JoAnn Manson Answered Your Questions About Hormone Replacement ... - ABC News
Cecilia from Utica, NY, asked: "I am now taking Climara Pro patch. Does it have the same risks as traditional hormone replacement therapy? ...
Wed Mar 05 22:56:49 -0500 2008

Climara Pro Chemical Information

estradiol - The most potent form of the naturally occurring steroid sex hormone in humans, produced by ovary, placenta, testis, and in small amount by adrenal cortex. Estradiol binds to a specific intracellular estrogen receptor located in female organs, breasts, hypothalamus and pituitary. The receptor-ligand complex promotes gene expression necessary for the maintenance of fertility and secondary sexual characteristics in females. In addition, estradiol exhibits mild anabolic and metabolic properties, and increases blood coagulability. Estradiol, the principal intracellular human estrogen, is substantially more active at the cellular level than its metabolites, estrone and estriol.

levonorgestrel - The levorotatory form of norgestrel and synthetic progestogen with progestational and androgenic activity. Levonorgestrel binds to the progesterone receptor in the nucleus of target cells, thereby stimulating the resulting hormone-receptor complex, initiating transcription, and increasing the synthesis of certain proteins. This results in a suppression of luteinizing hormone (LH) activity and an inhibition of ovulation, as well as an alteration in the cervical mucus and endometrium.