Desonate Information
What's inside Desonate
Desonate Active Ingredients: desonide, details.| Desonate Dosages & Strengths | ||||
|---|---|---|---|---|
| Strength | Format | Route | Strength | Class |
| Desonate 0.05% | gel | topical | 100.0 gram(s) | OTC |
Desonate in the News
New TNS Serum From SkinMedica Exclusively Applied Through ... - PharmaLive.com (press release)
SkinMedica's Desonate(TM) (desonide) Gel 0.05% is indicated for the treatment of mild-to-moderate atopic dermatitis; EpiQuin(R) Micro (4% hydroquinone) ...
Tue Apr 24 08:21:22 -0400 2007
Desonate Chemical Information
desonide - A synthetic glucocorticosteroid for topical use, with anti-inflammatory activity. Desonide binds to glucocorticoid receptors in the cytoplasm, and the ligand-receptor complex is translocated as a homodimer into the nucleus, where transcription activation via glucocorticoid response elements within glucocorticoid-responsive genes occur. This agent induces transcription of genes coding for anti-inflammatory proteins, including lipocortin-1, interleukin-10, interleukin-1 receptor antagonist and neutral endopeptidase. Increased synthesis of lipocortin-1 has an inhibitory effect on phospholipase A2, which in turn inhibits the release arachidonic acid, thereby controlling the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes.
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