Eloxatin Information
What's inside Eloxatin
Eloxatin Active Ingredients: oxaliplatin, details.| Eloxatin Dosages & Strengths | ||||
|---|---|---|---|---|
| Strength | Format | Route | Strength | Class |
| Eloxatin 100 mg | powder for injection | intravenous | 1.0 each | OTC |
| Eloxatin 50 mg | powder for injection | intravenous | 1.0 each | OTC |
| Eloxatin 5 mg/mL | solution | intravenous | 1.0 milliliter(s) | OTC |
Eloxatin in the News
Sanofi-Aventis: FDA grants priority review to Eloxatin prescribing ... - CNNMoney.com
The primary endpoint evaluated how the addition of Eloxatin affected disease-free survival at three years. Secondary endpoints included overall survival and ...
Wed Feb 20 12:51:31 +0000 2008
Inclusion of Six-Year Overall Survival Data in the Eloxatin(R ... - FOXBusiness
In the MOSAIC trial, Stage III colon cancer patients treated after complete surgical resection of the tumor with Eloxatin in combination with infusional ...
Thu Feb 21 08:55:56 +0000 2008
Sanofi-Aventis’ Eloxatin Gets FDA Priority Review - FDA news (subscription)
Sanofi-aventis said the FDA has assigned priority review status to its supplemental new drug application (sNDA) for its colorectal cancer drug Eloxatin. ...
Thu Feb 28 17:37:52 +0000 2008
Eloxatin Chemical Information
oxaliplatin - An organoplatinum complex in which the platinum atom is complexed with 1,2-diaminocyclohexane (DACH) and with an oxalate ligand as a 'leaving group.' A 'leaving group' is an atom or a group of atoms that is displaced as a stable species taking with it the bonding electrons. After displacement of the labile oxalate ligand leaving group, active oxaliplatin derivatives, such as monoaquo and diaquo DACH platinum, alkylate macromolecules, forming both inter- and intra-strand platinum-DNA crosslinks, which result in inhibition of DNA replication and transcription and cell-cycle nonspecific cytotoxicity. The DACH side chain appears to inhibit alkylating-agent resistance. (NCI04)
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