Excedrin Migraine Information

What's inside Excedrin Migraine

Recent Excedrin Migraine Side Effects

Posted by joeylabiche 6 months ago
I am well acquainted with migraines, I went from bayer Aspirin to Tylenol to Motrin and finally to Excedrin and have been u...

Posted by tampagirl 8 months ago
I only took Excedrin occasionally, when I got really severe migraines because it was the only thing that worked. However, on...

Posted by cebloom 11 months ago
I get migraines all the time and Excedrin Migraine really helped for a long time. It's the only thing that gets rid of my mig...

Excedrin Migraine in the News

Leaving the Rabbit Hole - New York Times
Their doctors have marginalized them telling them, ‘Get rid of your husband, quit your job and get off the Excedrin, and your headaches will be fine. ...
Tue Feb 19 23:25:35 -0500 2008

Leaving the Rabbit Hole - New York Times
Their doctors have marginalized them telling them, ‘Get rid of your husband, quit your job and get off the Excedrin, and your headaches will be fine. ...
Tue Feb 19 23:25:35 -0500 2008

Sex: It does a body good - The Spectator
Over-the-counter pain relievers like Tylenol, Advil and Excedrin help cure the body's common aches and pains. The hormones released from a sexual orgasm ...
Mon Feb 11 01:21:08 -0500 2008

Excedrin Migraine Chemical Information

acetaminophen - An acetanilide with analgesic and antipyretic activity. Although the exact mechanism through which acetaminophen exert its effects has yet to be fully determined, this agent probably acts by inhibiting prostaglandin synthesis in the central nervous system (CNS). Inhibition of prostaglandin synthesis in the CNS results in elevation of the pain threshold and lowering of the thermal set point in the hypothalamus.

aspirin

caffeine - A naturally occurring xanthine derivative with central nervous system (CNS) stimulating activity. Due to the structural similarity to adenosine, caffeine binds to and blocks adenosine receptors, thereby preventing the inhibitory effects of adenosine on nerve cells. This leads to stimulation of medullary, vagal, vasomotor, and respiratory centers in the brain; and the release of epinephrine. Physiologic responses can include bradycardia, tachycardia, vasoconstriction, CNS excitablility, increased respiratory rate, increased blood pressure, increased blood flow to muscles, decreased blood flow to skin and inner organs, and release of glucose by the liver. Due to the interaction between adenosine A2A and dopamine D2 receptors, caffeine can also indirectly increase the levels of dopamine in the brain.