Fluex Information

What's inside Fluex

Fluex in the News

Illinois RNs Remain at Forefront of Disaster Preparedness - Nurse.com
These have included FLUEX 2006, a three-day exercise that simulated a major health crisis occurring simultaneously with a terrorist attack, ...
Mon Feb 25 06:29:39 -0500 2008

Governor Blagojevich appoints new director of Public Health - IGNN (press release)
... Program and shepherding IDPH through two statewide emergency preparedness drills – TOPOFF 2 and FLUEX 2006 – more than any other state in the country. ...
Fri Sep 14 14:14:03 -0400 2007

Governor Blagojevich appoints new director of Public Health - IGNN (press release)
... Program and shepherding IDPH through two statewide emergency preparedness drills – TOPOFF 2 and FLUEX 2006 – more than any other state in the country. ...
Fri Sep 14 14:14:03 -0400 2007

Fluex Chemical Information

fluocinonide - A synthetic glucocorticoid and derivative of fluocinolone acetonide with anti-inflammatory and antipruritic activity. Fluocinonide binds the glucocorticoid receptor, followed by translocation of the ligand-receptor complex to the nucleus and transcription activation of genes containing glucocorticoid-responsive elements. Lipocortin-1 is one factor induced by fluocinonide that interacts and inhibits cytosolic phospholipase 2 alpha, thereby preventing phospholipase translocation to the perinuclear membrane and subsequent release and conversion of arachidonic acid to inflammatory prostaglandins. In addition, MAPK phosphatase 1 is induced, thereby preventing the triggering of the MAPK cascade resulting in pro-inflammatory effects via Jun N-terminal kinase and c-Jun. Finally, fluocinonide binds to and inhibits nuclear factor kappa-B directly, resulting in inhibition of cyclooxygenase 2 transcription and subsequent prostaglandin synthesis.