GlipiZIDE-Metformin Information

What's inside GlipiZIDE-Metformin

GlipiZIDE-Metformin in the News

Market Report -- In Play (CPD) - MSN Money
According to IMS Data, for the twelve months ended September 2007, Glipizide/Metformin HCl generic and brand products combined had annual sales of approx ...
Mon Jan 14 12:10:19 -0500 2008

The Maybach Journal: Has added Caraco Pharma Labs to their watch list. - Trading Markets (press release)
... Abbreviated New Drug Application (ANDA) for Glipizide/Metformin Hydrochloride Tablets, 2.5/250 mg, 2.5/500 mg and 5/500 mg (Glipizide/Metformin HCl). ...
Tue Jan 15 15:31:02 -0500 2008

GlipiZIDE-Metformin Chemical Information

glipizide - A member of the second generation of the sulfonylurea hypoglycemic agents. Glipizide inhibits the ATP-sensitive potassium channels on the beta-cell membrane, thereby preventing potassium efflux leading to membrane depolarization and subsequent calcium influx. The increased intracellular calcium levels induce insulin secretion from functioning beta-cells of the pancreatic islet tissue and reduces blood glucose levels.

metformin hydrochloride - The hydrochloride salt form of metformin, a biguanide with antihyperglycemic activity. Metformin hydrochloride exerts its action by improving hepatic sensitivity to insulin, thereby suppressing hepatic glucose production and increasing hepatic glycogen stores. In addition, metformin hydrochloride increases the number and/or affinity of insulin receptors on cell surface membranes in muscle and adipose tissue, thereby increasing the sensitivity to insulin at receptor and post-receptor binding sites and increasing glucose uptake peripherally.