Hydrochlorothiazide-Lisinopril Information

What's inside Hydrochlorothiazide-Lisinopril

Recent Hydrochlorothiazide-Lisinopril Side Effects

Posted by wait2sea 13 days ago
Me too... I've had a nagging cough ever since an upper resp tract infection (treated & improved w Z-pak). This has been ov...

Posted by gigg 26 days ago
I have been taking Hydrocholorthizide and I love it... I have had untreated high blood pressure for 7 years and could not wak...

Posted by fauxmy 3 months ago
Within one hour after my first dose of Lisinopril I was having severe sinus congestion and mild dizziness. Since this seemed...

Hydrochlorothiazide-Lisinopril Chemical Information

hydrochlorothiazide - The hydrogenated derivative of chlorothiazide, a thiazide diuretic with antihypertensive and anti-urolithic effects. This agent binds to the electroneutral Na-K-Cl cotransporter (NKCC) and thereby impairs Na+, K+ and Cl- reabsorption on the luminal membrane of the early segment in the distal convoluted tubule in the kidney. This leads to an increase in urinary excretion of sodium, chloride, potassium, bicarbonate and water subsequently reducing plasma and extracellular fluid volume leading to a reduction in blood pressure. Hydrochlorothiazide also decreases urinary calcium and uric acid excretion by direct action on the distal tubule.

lisinopril - A synthetic peptide derivate and long-acting angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. Lisinopril specifically and competitively inhibits angiotensin-converting enzyme thereby decreasing the formation of the potent vasoconstrictor angiotensin II. This leads to a diminished vasopressor activity. In addition, angiotensin II-stimulated aldosterone secretion by adrenal cortex is decreased which results in a decrease of sodium and water retention and an increase of serum potassium.