Isosorbide Mononitrate Information

What's inside Isosorbide Mononitrate

Isosorbide Mononitrate in the News

WuXi PharmaTech: Poster Child for China’s CRO Industry - Seeking Alpha
In a 1350-patient clinical trial, the isosorbide mononitrate sustained release tablet produced a therapeutic effect, though Lotus is holding specific data ...
Sun Feb 10 09:47:53 -0500 2008

Balancing Efficacy and Safety of Drug-Eluting Stents in Patients ... - Annals of Internal Medicine
Also, all patients should receive optimal medical therapy, including anti-ischemic therapy (such as long-acting metoprolol or isosorbide mononitrate) and ...
Mon Feb 04 18:01:00 -0500 2008

AMRI Acquires Pilot Plant Facilities in India; Manufacture of ... - Business Wire (press release)
Additionally, the purchase ensures the addition of another compound, ISMN (Isosorbide Mononitrate), to AMRI’s generics portfolio. AMRI intends to implement ...
Mon Feb 04 08:37:18 -0500 2008

Isosorbide Mononitrate Chemical Information

isosorbide mononitrate - The mononitrate salt form of isosorbide, an organic nitrate with vasodilator activity. Isosorbide mononitrate relaxes vascular smooth muscle by formation of the free radical nitric oxide (NO), which is identical to the endothelium-derived relaxing factor (EDRF). NO activates guanylyl cyclase, thereby increasing the synthesis of cGMP within smooth muscle, resulting in dephosphorylation of light chain myosin and relaxation of peripheral arteries and veins. In addition, isosorbide mononitrate relaxes coronary arteries, thereby increasing the blood circulation through the ischemic area. (NCI05)