Megace ES Information

What's inside Megace ES

Megace ES in the News

Alfacell Deals US Rights for Onconase to Strativa - BioWorld Online
Inc. So far, Strativa markets just one product: Megace ES for anorexia, cachexia and unexplained weight loss in HIV patients. Although the company has deals ...
Tue Jan 15 20:54:58 -0500 2008

Par Pharmaceutical Files Form 10-Qs for First and Second Quarters ... - Earthtimes
Sales of Megace(R) ES (megestrol acetate) oral suspension increased 124 percent to $19.1 million in the second quarter. Par's second-quarter gross margin ...
Wed Nov 21 06:03:16 -0500 2007

Par Pharmaceutical Provides Summary of Analyst/Investor Day - PR Newswire (press release)
... 8 potential first-to-file ANDA submissions -- Terminated certain non-core assets -- 9 generic product launches -- Megace ES(R) sales annualizing at over ...
Fri Sep 28 06:31:57 -0400 2007

Megace ES Chemical Information

megestrol acetate - The acetate salt form of megestrol, a synthetic derivative of the naturally occurring female sex hormone progesterone with anti-estrogenic activity and used in breast cancer treatment. Mimicking the action of progesterone, megestrol acetate binds to and activates nuclear progesterone receptors in the reproductive system, and causes the ligand-receptor complex to be translocated to the nucleus where it binds to and promotes expression of target genes. This leads to an alteration in protein synthesis, which modulates cell growth of reproductive tissues. Due to the negative feedback mechanism seen with progesterone, megestrol also blocks luteinizing hormone (LH) release from the pituitary gland, thereby leading to an inhibition of ovulation and an alteration in the cervical mucus and endometrium. Furthermore, without stimulation of LH, estrogen release from the ovaries is stopped, hence impedes the growth of estrogen-sensitive tumor cells.