Methotrexate Information

What's inside Methotrexate

Recent Methotrexate Side Effects

Posted by mjstuck about 1 month ago
I have been on Methotrexate for about 1 year to treat RA. It has worked great for pain BUT I have noticed a lot of things go...

Posted by sheilab about 1 year ago
Has anyone experienced mood instability or anxiety while on Methotrexate? I am on week two and am taking 10 mg to start....

Posted by huffmanrebecca over 2 years ago
I am 28 and have lupus, I was put on 10 mg of methotrexate last week weekly. Im expierencing some really weird side effects,...

Methotrexate in the News

Arthritis drugs also reduce heart attack, stroke risks - Bihar Times
However, previous studies have shown that treating the condition with disease-modifying anti-rheumatic drugs (DMARDs), such as methotrexate, may reduce this ...
Fri Mar 07 09:09:03 -0500 2008

Arthritis Medications Reduce Risk Of Heart Attacks And Strokes ... - Science Daily (press release)
Taking methotrexate -- the most widely used DMARD -- for just one year for example was found to be associated with an 18% reduction in risk of heart attack ...
Fri Mar 07 10:40:56 -0500 2008

Pre-Open Movers 3/10: Keryx Biopharma (KERX) Sinks on Drug Failure ... - StreetInsider.com (subscription)
It is indicated after high-dose methotrexate therapy in patients with osteosarcoma, and to diminish the toxicity and counteract the effects of impaired ...
Mon Mar 10 10:35:22 -0400 2008

Methotrexate Chemical Information

methotrexate - An antimetabolite with antineoplastic and immunomodulating properties. Methotrexate binds to and inhibits the enzyme dihydrofolate reductase, resulting in inhibition of purine nucleotide and thymidylate synthesis and, subsequently, inhibition of DNA and RNA syntheses. Methotrexate also exhibits potent immunosuppressant properties. (NCI04)