Ocuhist Information
What's inside Ocuhist
Ocuhist Active Ingredients: naphazoline hydrochloride, pheniramine maleate, details.| Ocuhist Dosages & Strengths | ||||
|---|---|---|---|---|
| Strength | Format | Route | Strength | Class |
| Ocuhist 0.025%-0.3% | solution | ophthalmic | 100.0 milliliter(s) | OTC |
Ocuhist in the News
What types of OTC eye-care products are there? - TamilStar.com
... in patients at risk for developing angle-closure glaucoma. Examples of products that combine an antihistamine and decongestant are Naphcon A and Ocuhist.
Wed Feb 06 06:48:53 -0500 2008
Ocuhist Chemical Information
naphazoline hydrochloride - The hydrochloride salt form of naphazoline, an imidazole derivative and a direct-acting sympathomimetic amine with vasoconstrictive properties. Upon ocular administration, naphazoline hydrochloride exerts its effect by acting on alpha-adrenergic receptors in the arterioles of the conjunctiva to produce vasoconstriction, resulting in decreased conjunctival congestion and diminished itching, irritation and redness.
pheniramine maleate - The maleate salt form of pheniramine, an alkylamine derivative with antihistaminic and vasodilatory properties. Pheniramine maleate binds to histamine H1 receptors, thereby inhibiting phospholipase A2 and production of endothelium-derived relaxing factor, nitric oxide. Subsequent lack of activation of guanylyl cyclase through nitric oxide results in decreased cyclic GMP (cGMP) levels, thereby inhibiting constriction of smooth muscle tissue, and decreased capillary permeability and histamine-activated allergic reactions.
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