PredniSONE Information

PredniSONE

Prednisone is a synthetic corticosteroid drug that is particularly effective as an immunosuppressant, and affects virtually all of the immune system. It is used to treat certain inflammatory diseases and (at higher doses) cancers, but has significant adverse effects. It is usually taken orally but can be delivered by intramuscular injection or intravenous injection. It has a mainly glucocorticoid effect. Prednisone is a prodrug that is converted by the liver into prednisolone, which is the active drug and also a steroid.

Prednisone can, therefore, be used in autoimmune diseases, inflammatory diseases (such as severe asthma, severe allergies, Juvenile dermatomyositis, angioedema episodes, severe urushiol-induced contact dermatitis, systemic lupus erythematosus, ulcerative colitis, rheumatoid arthritis, Still's disease, Bell's palsy, Crohn's disease, pemphigus and sarcoidosis), uveitis, various kidney diseases including nephrotic syndrome, mononucleosis Epstein-Barr virus, and to prevent and treat rejection in organ transplantation. Prednisone has also been used in the treatment of migraine headaches and cluster headaches and for severe aphthous ulcer ("Cankersore") outbreaks. It can also be used to treat autoimmune pancreatitis.

What's inside PredniSONE

Recent PredniSONE Side Effects

Posted by knee_coley 1 day ago
I am 18, and used to be sooo healthy. In August 2009, I left home to go to school, I met new friends, and felt like I was starting my own life and becoming independent. Sometime in October 2009 I started to feel weird symptoms, mostly just being really tired all the time. The week of Thankgiving 2009, I was hospitalized and diagnosed with having Auto Immune Hemolytic Anemia (the warm kind, I can't find the difference between the cold and the warm kind). I had a blood transfusion, and the doctors started me on 80mg of the prednisone a day. Now I am coming off the predisone, and currently taking 5mg a day. Tapering off of this drug has been hell not just for me, but for my family as well. My whole life I have always been a happy easy going kid, and in December 2009 the side effects started to take over. I didn't have any energy to do things, sometimes all I could do in a day was shower. I had trouble sleeping, developed a very pale moon face with the darkest circles, couldn't concentrate (I couldn't return to school this semester or drive for two months), my mind felt like it was going at a million miles an hour, felt anxious all the time, I had the worse mood swings, swelling in my ankels, a sort of "dry rash" began to develop on my legs, the "peach fuzz" on my cheeks got darker, I had shakes in my hands for a while, I lost my sense of humor and started to feel depressed, which really scared my family. They thought I might become suicidal and wanted me to take anit-depressents. I found an alternative. When my side effects were really bad, caffeine calmed me down when I was having mood swings, but that made my shakes worse, so sometimes I took anti-anxiety pills, which really mellowed me out. I would reccomend taking anit-anxiety meds to help calm yourself, but those did tire me out a lot. Recently (and I know this will sound cheesy), I have found that playing video games has helped me a lot, it gives me something to concentrate on, and I have noticed an incredible decrease in my mood swings. These side effects are still somewhat present, but have become much more mild. I am starting to feel a little bit normal, but I have started to loose more hair than I usually do. I have always seemed to "shed" but now it is getting rediculous. I was wondering if that goes away after getting off the prednisone. I cannot wait to get off of this drug and back to living like a young adult. Before reading the other posts, I felt like I was alone, going crazy and never thought I would ever be the same person I was before I became sick. Now, I know that I will be alright, and I would like to thank everyone who has shared their story on this site. As far as the prednisone goes, I would NEVER ever recommend it to anyone unless their life depended on it!! The side effects are terrible and not worth the trouble. And anyone that is taking it and is stuck at home for months at a time, I feel for you. It is going to be rough, but you will get through it!

Posted by dukedeck 3 days ago
i am a 63 yo male and was given dexamesone {i am told 5 times stronger than pred. for severe arititis have been on it for 2 years and my life is gone i gained 100lbs and cant pass up sweets.my legs are exreemely weak and i have shortness of breath.for breathing priblem was prescribed albuterol of course with steroids.

Posted by mark72 4 days ago
took it for a week to reduce sinus swelling...felt like i wanted to go on a killing spree,argue with everyone,get into physical altercations.....this stuff is dangerous!!!

PredniSONE in the News

Celgene Plans To Seek Approval Of Revlimid As An Initial Treatment For ... - The Myeloma Beacon
Celgene Plans To Seek Approval Of Revlimid As An Initial Treatment For ...The Myeloma BeaconIn the study, researchers compared the combination of melphalan (Alkeran) and prednisone followed by a placebo (MP-Pl) with the combination of melphalan, ...and more »
Wed Jan 13 17:28:19 +0000 2010

Illuminating Uveitis; Lux Seeks Luveniq Approval in US, Europe - BioWorld Online
Illuminating Uveitis; Lux Seeks Luveniq Approval in US, EuropeBioWorld Online... and the addition of Luveniq also allowed for the withdrawal of immunosuppressive therapy and lessened the use of daily prednisone treatment. ...Lux Biosciences Files for LUVENIQ™ Approval in US and Europe for Noninfectious ...Earthtimes (press release)all 28 news articles »
Fri Feb 05 01:35:27 +0000 2010

PEOPLE v. TRIBBLE - Leagle.com
PEOPLE v. TRIBBLELeagle.comHe claims that he was in a state of prednisone-induced delirium. In response, the prosecution introduced psychiatric testimony and statements Tribble made ...and more »
Thu Jan 28 12:32:10 +0000 2010

PredniSONE Chemical Information

prednisone - A synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. After cell surface receptor attachment and cell entry, prednisone enters the nucleus where it binds to and activates specific nuclear receptors, resulting in an altered gene expression and inhibition of proinflammatory cytokine production. This agent also decreases the number of circulating lymphocytes, induces cell differentiation, and stimulates apoptosis in sensitive tumor cells populations. (NCI04)