Promethazine with Codeine Information

What's inside Promethazine with Codeine

Promethazine with Codeine in the News

Gym Class Hero Admits To Drug Addiction - HipHopDX
... rapper Pimp C's untimely death was partially due to mixing medications including 'syrup' , Promethazine w/Codeine syrup abused by people to get high. ...
Mon Mar 10 15:59:43 -0400 2008

Bun B Plans First Album After Pimp C’s Death - Vibe
... David Banner, Rick, and the late Pimp C, UGK’s second-half, who died December 4, of an accidental overdose of Promethazine and Codeine, known as “syrup. ...
Fri Feb 29 16:22:32 -0500 2008

Bun B Comments on Lil Wayne's Syrup Addiction - HipHopDX
The above is a quote from Bun B, commenting on the New Orleans rapper’s addiction to promethazine codeine cough syrup. Pimp C, Bun B’s partner in the duo ...
Thu Mar 06 21:36:17 -0500 2008

Promethazine with Codeine Chemical Information

codeine - The phosphate salt form of codeine, a naturally occurring phenanthrene alkaloid and opioid agonist with analgesic, antidiarrheal and antitussive activity. Codeine phosphate mimics the actions of opioids by binding to the opioid receptors at many sites within the central nervous system (CNS). Stimulation of the mu-subtype opioid receptor stimulates the exchange of GTP for GDP on the G-protein complex and subsequently inhibits adenylate cyclase. This results in a decrease in intracellular cAMP and leads to a reduction in the release of neurotransmitters such as substance P, GABA, dopamine, acetylcholine and noradrenaline. The analgesic effect of codeine phosphate is likely due to its metabolite morphine, which induces opening of G-protein-coupled inwardly rectifying potassium (GIRK) channels and blocks the opening of N-type voltage-gated calcium channels, thereby resulting in hyperpolarization and reduced neuronal excitability.

promethazine hydrochloride - The hydrochloride salt form of promethazine, a phenothiazine derivative with antihistaminic, sedative and antiemetic properties. Promethazine hydrochloride selectively blocks peripheral H1 receptors thereby diminishing the effects of histamine on effector cells. Promethazine hydrochloride also blocks the central histaminergic receptors, thereby depressing the reticular system causing sedative and hypnotic effects. In addition, promethazine hydrochloride also has centrally acting anticholinergic properties and probably mediates nausea and vomiting by acting on the medullary chemoreceptive trigger zone.