Pyrazinamide Information

What's inside Pyrazinamide

Pyrazinamide in the News

Guidelines Updated on Managing Drug Interactions When Treating HIV ... - Medscape (subscription)
When used with isoniazid, rifampin, and pyrazinamide, there is some concern about hepatotoxicity. Antiviral activity when used with rifampin is favorable. ...
Wed Feb 06 15:28:52 -0500 2008

Animal to human TB transmission largely ‘forgotten’, experts say - Africa Science News Service
She said it was important for the role of zoonotic TB be investigated since bovine TB was resistant to pyrazinamide – one of the most accessible and ...
Tue Nov 20 04:39:20 -0500 2007

The Exterminators - Esquire
A single course of the antibiotics needed to cure TB -- isoniazid, rifampin, pyrazinamide, and ethambutol -- takes six to nine months. The "short course. ...
Tue Nov 20 00:20:13 -0500 2007

Pyrazinamide Chemical Information

pyrazinamide - A synthetic pyrazinoic acid amide derivative, bactericidal tuberculostatic Pyrazinamide is particularly active against slowly multiplying intracellular bacilli (unaffected by other drugs) by an unknown mechanism of action. Its bactericidal action is dependent upon the presence of bacterial pyrazinamidase, which removes the amide group to produce active pyrazinoic acid. Pyrazinamide is an important component of multidrug therapy for tuberculosis. (NCI04)