Sinemet CR Information

What's inside Sinemet CR

Sinemet CR in the News

XenoPort Reveals Initiation Of Clinical Trials On XP19986 And ... - RTT News
The company attributed the sales growth to increased CR-V, Civic, Fit and all-new Accord sales. Total car sales rose 4.2% to 882215 from 843950 in the same ...
Thu Jan 03 14:59:48 -0500 2008

Forex kitty - Calcutta Telegraph
... carbidopa and levodopa, used in the treatment of parkinson’s disease. Carbidopa and levodopa are generic equivalents of Bristol Myers Squibbs’ Sinemet CR.
Sat Aug 25 13:59:56 -0400 2007

Sinemet CR Chemical Information

carbidopa - A hydrazine derivative of dopa. Carbidopa is a peripheral dopa decarboxylase inhibitor that is used as an adjunct to levodopa administration to prevent peripheral biosynthesis of levodopa to dopamine, thereby reducing peripheral side effects. Carbidopa does not penetrate the blood brain barrier so that levodopa, after it reaches the brain, can be metabolized to dopamine by dopa decarboxylase where it exerts its effect on dopamine receptors.

levodopa - An amino acid precursor of dopamine with antiparkinsonian properties. Levodopa is a prodrug that is converted to dopamine by DOPA decarboxylase and can cross the blood-brain barrier. When in the brain, levodopa is decarboxylated to dopamine and stimulates the dopaminergic receptors, thereby compensating for the depleted supply of endogenous dopamine seen in Parkinson's disease. To assure that adequate concentrations of levodopa reach the central nervous system, it is administered with carbidopa, a decarboxylase inhibitor that does not cross the blood-brain barrier, thereby diminishing the decarboxylation and inactivation of levodopa in peripheral tissues and increasing the delivery of dopamine to the CNS.