Spironolactone Plus Information

What's inside Spironolactone Plus

Spironolactone Plus in the News

Inhibitors of the Renin–Angiotensin System: Proven Benefits ... - Annals of Internal Medicine
... admissions and death, as occurred after physicians began to use spironolactone plus ACE inhibitors in routine care of severe heart failure (7). ...
Mon Nov 05 19:11:22 -0500 2007

Spironolactone Use Requires Monitoring for Potassium Levels in ... - DG News
Their rate of spironolactone withdrawals was 25.0%, with the reasons being given as hyperkalaemia plus renal failure (10.5%); hyperkalaemia alone (6.6%); ...
Thu Jun 14 11:04:25 -0400 2007

Spironolactone Plus Chemical Information

hydrochlorothiazide - The hydrogenated derivative of chlorothiazide, a thiazide diuretic with antihypertensive and anti-urolithic effects. This agent binds to the electroneutral Na-K-Cl cotransporter (NKCC) and thereby impairs Na+, K+ and Cl- reabsorption on the luminal membrane of the early segment in the distal convoluted tubule in the kidney. This leads to an increase in urinary excretion of sodium, chloride, potassium, bicarbonate and water subsequently reducing plasma and extracellular fluid volume leading to a reduction in blood pressure. Hydrochlorothiazide also decreases urinary calcium and uric acid excretion by direct action on the distal tubule.

spironolactone - A synthetic 17-spironolactone corticosteroid with potassium-sparing diuretic, antihypertensive, and antiandrogen activities. Spironolactone competitively inhibits adrenocortical hormone aldosterone activity in the distal renal tubules, myocardium, and vasculature. This agent may inhibit the pathophysiologic effects of aldosterone produced in excess by various types of malignant and benign tumors. (NCI04)