Tri-Luma Information

What's inside Tri-Luma

Tri-Luma in the News

CollaGenex Being Acquired by Galderma for $420M Cash - BioWorld Online
Its leading dermatology brands include Differin, Rozex/Metro, Clobex, Tri-Luma, Loceryl and Cetaphil. Products recently launched by Galderma include ...
Tue Feb 26 21:27:45 -0500 2008

Erasing brown patches - MiamiHerald.com
Prescription topical products like Tri-Luma and Claripel are highly effective in lightening dark patches. Retinoids also improve melasma by speeding cell ...
Tue Nov 13 03:08:12 -0500 2007

Erasing brown patches - MiamiHerald.com
Prescription topical products like Tri-Luma and Claripel are highly effective in lightening dark patches. Retinoids also improve melasma by speeding cell ...
Tue Nov 13 03:08:12 -0500 2007

Tri-Luma Chemical Information

fluocinolone acetonide - The acetonide salt form of fluocinolone, a synthetic fluorinated corticosteroid with antiinflammatory, antipruritic and vasoconstrictive properties. Fluocinolone is a glucocorticoid receptor agonist that binds to cytoplasmic glucocorticoid receptors and subsequently translocates to the nucleus where it initiates the transcription of glucocorticoid-responsive genes such as lipocortins. Lipocortins inhibit phospholipase A2, thereby blocking the release of arachidonic acid from membrane phospholipids and preventing the synthesis of prostaglandins and leukotrienes, both are potent mediators of inflammation. Fluocinolone exerts its vasoconstrictive effect through inhibition of nitric oxide synthase, thereby blocking nitric oxide production and effectively diminishing the effect of nitric oxide on vascular smooth muscles leading to reduced blood flow.

hydroquinone - Produced as an inhibitor, an antioxidant, and an intermediate in the synthesis of dyes, motor fuels, and oils; in photographic processing; and naturally in certain plant species, Hydroquinone is a phenol derivative with antioxidant properties that can cause toxicity in several organs, notably the kidney. Used as a topical treatment for skin hyperpigmentation and in various cosmetic products, it is metabolized mainly to glutathione conjugates and forms mutagenic DNA adducts in in-vitro systems. (NCI04)

tretinoin