Trizivir Information

What's inside Trizivir

Trizivir in the News

Test Detects Sensitivity to HIV Drug - Forbes
At issue is the AIDS drug abacavir, also known by the brand name Ziagen, which is found in compound drugs known as Trizivir and Epzicom. ...
Wed Feb 06 17:28:03 -0500 2008

Gilead Fights Deadly Diseases - CNNMoney.com
Despite competition from GlaxoSmithKline's (NYSE:GSK) GSK Trizivir and Abbott Laboratories (NYSE:ABT) ' ABT Lopinavir, Gilead's HIV treatments continued to ...
Fri Jan 18 20:11:30 -0500 2008

GlaxoSmithKline Withdraws Patent Applications For Antiretrovirals ... - Medical News Today (press release)
GlaxoSmithKline recently withdrew the patent applications for its antiretroviral drugs Abacavir and Trizivir in India, the Economic Times reports. ...
Tue Dec 11 10:12:11 -0500 2007

Trizivir Chemical Information

lamivudine - A synthetic nucleoside analogue with activity against hepatitis B virus (HBV) and HIV. Intracellularly, lamivudine is phosphorylated to its active metabolites, lamiduvine triphosphate (L-TP) and lamiduvine monophosphate (L-MP). In HIV, L-TP inhibits HIV-1 reverse transcriptase (RT) via DNA chain termination after incorporation of the nucleoside analogue into viral DNA. In HBV, incorporation of L-MP into viral DNA by HBV polymerase results in DNA chain termination. L-TP is a weak inhibitor of mammalian DNA polymerases alpha and beta, and mitochondrial DNA polymerase. (NCI04)

zidovudine - A synthetic dideoxynucleoside. After intracellular phosphorylation to its active metabolite, zidovudine inhibits DNA polymerase, resulting in the inhibition of DNA replication and cell death. This agent also decreases levels of available pyrimidines. (NCI04)

abacavir sulfate