Adrenal gland symptoms and conditions

Hi I am dumb struck by coming across this site i never dream it could be my mirena causing my unexplained symptoms but the more an more i read it i am fighting with my hospital to get it removed A.S.A.P. i have suffered severe dizzy spells,heavy legs,fatigue,sweats,headaches,loss of concentration,mood swings,bloating,thinning of hair,weight gain, depression,dont want to communicate,just fallen apart in the last 17 months,had number of tests all come back normal,i been back to hospital today to fight this corner an they need to see how many women this really affects as every doctor i have seen says no way can it be the mirena but reading all these this needs looking into.i am worried about the dizzy spells they are my most concern along with panic attacks that come out of the blue..makes me think it may be my mirena after all :( just want to be back to my old self again..i have been to A& E at least 9 times with same symptoms only to be put on diazepam which i don't like to take,i am so upset that i still got to wait 6 weeks+ to have it removed as i got to go under to have it done as they cant reach the threads they are up instead of down...i am hoping after my long wait that i have now found an answer to all my symptoms an the mirena needs to be looked into more.an after it is removed i hope i get better as i have also read it can have after affects.nightmare wish i never had it put in.....

lower back pain, hair loss,joint pain, complicated migraines, vertigo, palpitation, hormonal imbalances (lowered DHEA, increased aldosterone-it affected my adrenal glands and kidneys), epigastric pain, bleeding, extreme fatigue, anxiety,pulmonary failure etc. I had to go through ER, 2 CT scans ( abdominal and brain), 2 MRIs, neurologist, endocrinologist, GI, gyno etc. I threw my Yaz pills in the trash after the first CT scan that revealed multiple tumors in my liver and left adrenal gland ( i took the pills for about 3 and 1/2 years)... the past 6 months have been a hell, but there are no more migraines, anxiety or other neurological symptoms at this point. By the way, one of my best friends who just started on Yaz recently ended up in the ER last week with a blood cloth in her left lung. Please stay away from that drug!

I have been on Synthroid .2 for 31 years. Recently I had to add 3 half doses to what I already take. About 10 years ago I experienced rapid weight gain, 40 pounds, in two months. The doctor's reply, "I highly doubt that!" I literally got up one day and could not fit into my clothes. I don't know why doctors discount the drug for this symptom and for anxiety. It seems to me the adrenal gland would be affected by these hormones in some way which could cause stress symptoms. I called the manufacturer and they said they have no knowledge of Synthroid causing weight gain. Perhaps we should all contact the company and REPORT our side effects.

I'm sitting here in tears reading all of your posts because I've also been on prednisone and have horrible side effects. I was diagnosed with metastatic breast cancer in my lungs in June of 2002 and, after starting at 60 mg/day then, I have been on 20 mg/day for years now. The very first posting that I read mentioned problems with the femur bone. Besides all of the other problems associated with this devastating drug, in December, 2007, I broke a bone in my left foot with no known cause for it. Then I started experiencing pain standing or walking in my left leg and was diagnosed with a fractured femur bone and after several months of trying to get it to heal (including an ultrasonic bone healing system), it just kept getting worse until an orthopedic surgeon recommended that I have a 16 inch rod put into my leg which I did and it ended up to be one of the worst decisions that I have ever made. After experiencing all of the prednisone side effects for almost seven years including depression, severe fatigue, weight gain, moon face, thin skin, cataract surgery on both eyes, hump on my back, mood swings, etc., the pain and suffering that were caused by that operation brought me to seriously consider suicide. I was also diagnosed with chemical neuropathy in both of my legs also which makes my legs so weak that I have to crawl up any steps and have trouble just standing. I actually have an appointment for this evening to have an x-ray done to see what is wrong with my knees and did not realize that this also is yet another side effect. I never make it through the night without waking up in pain and getting a pain pill and then getting up in the morning is almost unbearable with that "burning" pain. I am now on Cymbalta for depression, Xanax for anxiety, Percocet for pain, and of course 20 mg of Prednisone. I was told that I would have to remain on Prednisone for the rest of my life because of the lung scarring and COPD. After reading all of your comments, I have decided that I would rather put up with any breathing problems (and I don't even know how slight they may be at this point) than to remain on the Prednisone. I have tried weaning off several times but get so fatigued that I can't move and that's dropping one mg every week. I'm affected by the decrease but it gets out of hand when I get to 14 mg and I get so frustrated and depressed at not being able to do anything that I just go back up to the 20 mg/day. If you have been able to wean off of it, would you please let me know how you did it and what you had to go through? I'm 65 years old now but I have two wonderful granddaughters (ages 4 and 6) who I can't do any normal "Grammy" things with anymore at this point and I have to change this condition for them and for me. Obviously, the doctors don't recognize the severity of the drug because they just keep prescribing it and out of a regular doctor, an oncologist, an orthopedic surgeon and a neurologist, they can't seem to get together to come up with a solution. I have to say that I haven't considered suicide lately but I do wish that I would just die and be out of this pain. My family and definitely my granddaughters and wanting to see them grow up are the only things that keep me going. There are probably things that I'm forgetting but I'm sure that one of you have covered it in our posting. Although my family is so supportive, no one and I really mean not one of them, realizes knows what we all go through because of this drug. How could they know that something that is supposed to help you could cause these problems? My life is a living hell, all because a pulmonary doctor prescribed prednisone seven years ago and I trusted him to only do what was right without informing me of what was to come. I more than sympathasize with all of you. I sincerely appreciate the time that you took to post to this site and so thankful to know now that this knee pain is not something new that I have but another side effect of the prednisone. I wouldn't have known that if it wasn't for this site because I'd be willing to bet that after I would have had this x-ray done, one of my doctors would have just prescribed another medication to take. Please feel free to contact me directly with any comments or especially any help that you can give me. I know that all of you are going through the same thing so if I can do anything for you, even just listen and understand, please contact me also. Sometimes that's the only thing that people can do is to listen and someone who is in the same situation can always understand. I'm here for anyone who needs a hug for the day.

Wow! Let me tell you my story: I was first diagnosed with HBP (170/140) during a high school sports physical in the beginning of 8th grade (I was about 14 years old). I was in top shape and a very healthy eater. I had probably (from what I remember) every test done to see what was the cause of this hypertension - and the only thing found was that my kidney's produce too much renin (the hormone that increases BP). I was then put on Lisinopril 10mg. Everything continued good for about 6 years - I also stayed in shape and ate healthy. However, throughout those 6 years, I did notice my curly hair turing straight and my incredibly (can't do nothing with) thick hair started to thin and become stylable. Now...I do know this is my fault, but in the past 2 years my healthy eating habits have slipped, I've gained weight and started smoking - plus have a sit down, don't move kinda job. However, about 1 year ago, I had a slight spike in my pressure and my doctor added a diuretic (HCTZ 12.5mg) to my lisinopril. Ok, that brought the pressure down and all seemed well. Then..... in December 2008, not long ago, I started not feeling well. Thinking I was sick, I went to the doctor's to find my blood pressure to be 190/140. Immediately, my does was increased to 30-12.5mg. That brought a quick drop in my BP down to 110/66 - I was so darn dizzy I could barely function. I was also but on short-term disability because all this caused me to be off work for so long. Unfortunately, when my dose was adjusted to 20-12.5mg and the dizziness stopped I went back to work. Now, I can't go back on S.T.D. for many, many weeks. And....... The past month has been complete HELL!! My hands (mainly fingers) and toes are almost always cold, I've been dieting for over a month and am struggling to lose weight, my hands and feet go numb more often than usual - I never used to find myself waking up in the middle of the night because of pins/needles feeling, my hair is thinner than ever and stick straight - I'm afraid I'm not gonna have any left, I have UNBEARABLE headaches (sometimes all I want to do is sleep and sometimes, like tonight -it's 4:12am- I can't sleep), I have acne like a teenager - mind you, I never had more than 1 to 2 pimples at a time growing up, and that was rare (I was lucky)... Thank god for FMLA, or I would of lost my job since I've spent so much time home since I thought all was good and went back to work. Only wish I could make a dollar again. Now to top it off...I was referred to a nephrologist (kidney specialist) who after seeing me only once for about 30min and reviewing bloodwork from the end of January (I had a high calcium level as well as some others that deal with the kidneys) wants to take away the diuretic (HCTZ) part of my medication (hopefully to reduce the calcium level) BUT DOUBLE MY MG OF LISINOPRIL. HE WANTS ME TO TAKE 20MG TWO TIMES A DAY. I was starting to think all these new symptoms that came on so quick were a result from the increase of lisinopril - now I think I'm sure. I'm not changing my medications until I can talk this over with my PCP - I'm going to ask we try a medication change. Does anyone have any suggestions? Or any suggestions why a 20-year-old has blood pressure as high as 190/140 with no family history of HBP or really any health problems? Any suggestions why the kidneys are producing too much renin? Any meds that drop the pressure and we don't get headaches - I can live with cold limbs and numbness - it's the headaches that are rendering this 24-year-old helpless :(

58-year-old female who received five 40 mg. Kenalog shots within a two-month period. I now have full blown Cushings Syndrome and my adrenal gland (I only have one kidney) has stopped functioning. Moon face, barrel belly, weak muscles in hips and legs, weakness, hump on my neck, hairy face. Does anyone know of an attorney in Central California that can help me. This doctor needs to be stopped before he harms anyone else!

I'm 48, wm, very healthy>
Thirty five days ago, I went to a doctor
for anxiety. I told him I felt as though I had
an over-active adrenal gland, and too much
adrenaline was surging through my body
causing me to be really nervous, especially
in public places.
I said I took Inderal 20 years ago for two days, and it made me feel weird.
He said the new generation Beta Blockers
are far better, and that most golfers take them so they won't shake during an important putt.
He said he'd put me on the lowest dosage (25mg/day) and said the side effects were minimal. (HA!)
After one week, all went pretty well, except I noticed my previously strong sex drive had diminished. I used to masturbate 3 times per day, and then it was maybe once per week.
I thought the trade off to be calm vs. constant erections due to the adrenaline levels would be fine.
Then the nightmares...
I was in Africa and being shot by Ninja warriors with their AK 47's and feeling the bullets tear into my liver, and abdomen- or falling off cliffs to my impending death, only to wake up at 1am and not being able to go back to sleep for hours.
Then, at the two week mark, I noticed also
I couldn't recall things as quickly as I used to.
At the three week mark, it was becoming clear that the Toprol was making me slow, tired, flacid, fuzzy in my thinking, and giving me constant nightly dreams that were
terrifying.
Finally, I drove to LA from SF, and a song came on the radio. I knew who it was, but just couldn't grasp in my mind who it really was! (Stevie Wonder)
I started to feel really bizarre, kinda like LSD, or mushrooms, and was worried I was going to go insane!
I knew it was the Toprol, but didn't know if I stopped taking it if I would recover.
I just wanted to be like I was before I started this taking this truly awful compound!
Three days ago I stopped (cold turkey) and
flushed my body out with water, and a lot of soup.
Only this morning- after three days without
taking those terrible pills do I feel normal again. I'm not 100% yet, but I know I will be soon.
The lesson here, is I should have read more about this drug before taking it.
I have never taken pharmaceutical drugs before- not even aspirin. This is one more reason to stay clear from quack doctors
who think taking heart drugs/BP drugs are an easy cure for anxiety.
I really feel sorry for all those people out there taking dangerous medications like Toprol.
This drug should have never been approved by the FDA, and the only reason anyone should take this drug, is to understand how it feels to lose your mind, have your sex drive removed, and have dreams every night where all you do is end up dead!
TOPROL should be schedule I, and be banned- or only used by our military on known terrorists...

I took one Caltrate Plus and I got flushed and BP went from 130 to 180...Had to take a fast acting med to lower my BP...I have taken Rolaids with calcium, so I know I am not sensitive to calcium..Do any of the added minerals affect kidney function or adrenal gland??

I was admitted through the ER in sept. i had previously taken Bactrim for a bug bite on my foot three months prior. I had been severely bruising and had some lab work done. I got a call from my Dr. around midnight to go to ER immediately. My platelet count was at 11,000 a normal being 100,000-400,000. I went to ER and was admitted for 5 days. After running test after test there was no conclusion to what had caused this low platelet count but I was diagnosed with ITP. From here they put me on 50 mg/day of Prednisone for 1 month. I have now started to taper 40/ 2 weeks. 30/2 weeks. But then the side- effects started to come so fast. At first it was just sweating, minor anxiety, mood swings, and slight increase of appetite. Now that I had tapered my adrenal gland is suppressed much more and I am going through withdrawal. I am 21 years old I am 5'7" and I weighed 118 two weeks ago, since I have gained 12lbs of water weight. I am working out daily and eating healthy, although it is more than I used to eat. I have some family friends that work at Stanford University and they are ITP specialists. They told me their regimen for Prednisone is a 5mg/wk taper instead of 10/ 2 weeks. So the past two weeks I have been going down by 5. Today was my second day at 20 mg. I have gone through all of the mentioned side- effects except the back hump. I am hoping and praying that these symptoms will clear asap. And to everyone else out there your not alone.

As a fairly healthy 34 year old male, I went to my doctor for help getting over poison ivy mid-July 2008. I received the Kenalog 40 injection without being advised on any potential side effects. Within 36 hours I started having severe anxiety attacks with spikes in my blood pressure and vision problems (spotty, increased sensitivity to light). These attacks continued for 4-8 weeks during which time I underwent an MRI (head), stress test, and blood work to make sure nothing else was causing my symptoms.....conclusion: everything normal. My doctor prescribed me Xanax to help with the out of control anxiety. Started feeling more normal 60-90 days later. I started trying to run on my treadmill to get back in shape at the 90 day mark, and once again....symptoms returned. It's been a couple of weeks and I'm getting closer to being back to "normal", but I have no idea how long it will be before the Kenalog has completely metabolized out of my system, and I can get on with life. This has been a horrible experience and I would caution anyone from receiving this drug!

My name is M. and I recently and FINALLY got off of prednisone. I was on it for 7 years and came to believe that I could never get off it, until I was finally referred to an endocrinologist, who helped me to get off of it. Unfortunately, my adrenal gland has stopped working so.... I now take a medication with virtually no side effects called hydrocortisone. I will probably have to take it for the rest of my life, but its a BILLION TIMES BETTER than the horrifying prednisone.
-TO L. IN AUSTRALIA- I hope this tid bit of info can be helpful to you. I don't know if you've seen an endocrinologist or know that if you're disease can be managed by another med you can probably go from the pred to the hydrocortisone. I truly hope the best for you, You are only the second person I've ever found who's been on the pred for longer then I was. I hope I've been of some help to you truly, my heart goes out to you.

Has anyone seen concerned citizen lately. I'm wondering what Singulair does to cortisol levels. This is the natural hormone produced by the adrenal gland that allows you to deal with stress. I'm wondering what happens to a human being who's physical ability to deal with stress has been compromised.

Hi everyone,

i need to tell you about what just happened to me, because it seems most people are definitely not informed of all the possible side effects of prednisone - not only just relating to the dose of prednisone you take but also for how long.

I have been using prednisone for almost 14 years now, the doctors all tell me i'm unlikely to ever get off prednisone now because i've been on it too long. I know all about it's usual side effects (water retention, mood swings, thinning of all tissues including blood, acne, anemia, etc etc).

One side effect i was not advised of, not even in any educational material about prednisone either, was that long-term dependence can lead to Acute Adrenal Crisis. Which is deadly if not diagnosed and treated promptly. Thus i nearly died two weeks ago. I became rapidly ill with vague symptoms that i now know are symptoms of acute adrenal crisis. *THE ONLY REASON THE ACUTE ADRENAL CRISIS OCCURRED WAS BECAUSE OF LONG-TERM USE OF PREDNISONE*. Not many doctors will warn patients in advance of this. It is however, very very important that people are aware that long-term use of prednisone needs to be very carefully weighed with the benefits of using prednisone (i was started on prednisone in 1995 to treat severe Crohn's Disease).

Acute adrenal crisis can happen over weeks, months or years - in other words, it can come on so slowly that by the time you know there's something wrong you're already very very ill and in great danger.

I am very glad to have found this website and i hope you will all refer anyone who has any experience with prednisone to this site - education and knowledge is power - the power to stay alive.

(by the way, the treatment for acute adrenal crisis is to load up on prednisone - seems i'll probably never be free of this drug unless i can get my adrenal glands to begin working again (as prednisone "takes over" for the adrenal glands and they effectively go to sleep, and this is especially true for long-term use)).

My sympathies to everyone who has to go through the many nasty experiences with prednisone, especially the young children (I had to start it when i was 16). It really does mess with your body and mind, and in my case, became lethal.

Please pass on all your information relating to use of prednisone to everyone you can - it really is that important and seems to be the only way to avoid most of the disasters related to prednisone use.

take care everyone,
Linda
(Australia)

Does montelukast affect growth in children? Remember the report of identical twins, one took Singulair and one didn't. If I remember correctly, the one who took Singulair was at least two inches shorter in a short period of time.

If anyone would like a reason to look into that, then I refer you to this study. It could suggest that leukotrienes act on the pituitary to release pituitary hormones. We don't know what happens when the production of leukotrienes are blocked by montelukast.

"Finally, leukotrienes have also been found to act on the pituitary to modulate the release of the pituitary hormones."

"The distribution data of HPN321 suggests major role(s) for this receptor in endocrine and cardiovascular systems. CysLTs are well known for their modulatory effects in cardiovascular functions, where they reduce myocardial contractility and coronary blood flow (Letts and Piper, 1982) and have vasoactive effects (Drazen et al., 1980). They are thus considered to be important players in cardiovascular diseases (for review, see Folco et al., 2000). The strong expression of HPN321 in adrenal gland points at a new tissue where to study the influence of CysLTs on endocrine circuits. Finally, leukotrienes have also been found to act on the pituitary to modulate the release of the pituitary hormones (Hulting et al., 1984; Saadi et al., 1990). Our discovery of the existence of the HPN321 message in pituitary adds a molecular credence to this concept. The HPN321 receptor may thus modulate a variety of different physiological functions, which can now be tested using BAY u9773."

Vol. 58, Issue 6, 1601-1608, December 2000

ACCELERATED COMMUNICATION

Molecular Cloning and Characterization of a Second Human Cysteinyl Leukotriene Receptor: Discovery of a Subtype Selective Agonist
Hans-Peter Nothacker, Zhiwei Wang, Yuhong Zhu, Rainer K. Reinscheid, Steven H. S. Lin, and Olivier Civelli

Departments of Pharmacology (H.P.N., Z.W., Y.Z., R.K.R., S.H.S.L., O.C.) and Developmental and Cell Biology (O.C.), University of California at Irvine, Irvine, California; and NeoGene Technologies, Inc., Irvine, CA (H.P.N., Z.W., R.K.R., O.C.)

http://molpharm.aspetjournals.org/cgi/content/full/58/6/1601

you can't seriously think you got PCOS from taking Yasmin. PCOS is a syndrome, and taking the pill is used as one of the treatments for it.
One of the possibilities is the it is genetic, and it can be caused by insulin resistance or problems in your adrenal gland. You can't possibly get PCOS from taking yasmin. And PCOS does in fact increase the risk for cervical cancer, cardiovascular disease, and Diabetes, but has nothing to do with taking the pill or not.

As I read through these posts, I had mixed feelings between thinking they were a little too whiny (please, no offense) to too many memories sweeping back in.
Here is my story... I was on Yasmin for a few years, a few years ago, from ages 18-21. I am now 26. I'd always been active and in shape, no major health problems. At 19, I started to get weird leg pains, tingling and numbness. It got much much worse. Long story short, I had two herniated discs in my lower back which was causing pinched nerves. I had steroid injections localized to my herniations. At this point my adrenal gland stopped working, my face swelled up like a balloon and I lost a ton of weight. Eventually, I had surgery on my back, but went to specialist after specialist to figure out what was going on with my non functioning adrenal gland. We figured that somehow the steroids had gotten into my bloodstream, which doctor after doctor told me was next to impossible. They were ready to do a write up in a medical research journal about my case. Eventually my 3rd Endocronologist (sp?) FINALLY told me to get off Yasmin. Somehow, this small bit of information was missed. My adrenal gland eventually kicked back into shape, my bloating went away and I finally and slow got healthy again.
So... coming back to Yasmin. After reading this site and continuing research on the effects of an influx of potassium, all of my symptoms lead straight to this source. The potassium increase caused the face swelling, muscle spasms, possibly even the nerve weakness (Only speculating, could have caused the herniation.) , from what multiple web sites state.
I must say that this is all speculation; however, light bulbs have just gone off in my head.
I was considering getting back on Yasmin because I now live in Thailand and they offer this pill. I have been on the NuvaRing and I love it, but I cannot find it here. If Yasmin was the cause of what happened to my body or not, I will not take my chances. Most of the symptoms listed by other women are effects of increased potassium. Please research this fact to become more informed about what is happening with your body. It helped me. I hope my story will in effect, help someone else.
And, I'd love to hear if anyone else had something similarly severe...

I started taking Yasmin 2 years ago, and after about the first 2-3 months of taking Yasmin, I started experiencing horrendous pains after sex. Once my doctor figured out what was going on, I was diagnosed with Endometriosis. Not long after that, I was diagnosed with Polycystic Ovarian Syndrome. Now I am more than likely unable to have children, and am at risk for cervical cancer, cardiovascular disease, and Diabetes.
If anyone else has recently been diagnosed with Endometriosis, or PCOS after taking Yasmin....PLEASE reply or contact me!!!!!!!!!!!

I had a kidney removed due to cancer and was told that it was removed in time before spreading. Now, after experiencing fatigue, it turns out I have some type of Addison's disease (low aldosterone). The doctor told me it may have been caused by the trauma of the surgery when they removed the adrenal gland from the top of the diseased kidney. I am now on Prednisone 180 mg for three days and then weaning off by day nine. I have a pounding heartbeat and can't seem to contain my tears. Has anyone else heard of this type of reaction following nephrectomy? Is this a high dose of Prednisone? I weigh 160lbs.
P

Anti Androgen and Anti-Mineralocortoid Properties of Yasmin's Ingredients:

While I continue learning about Yasmin and its "unique" properties and ingredients, wanted to share some other information that I thought could be helpful for other women here. It really is a bit of a puzzle learning about all these things, what they mean to our bodies and why we experienced some of the many side effects that we did while taking it or in the healing coming off of it.

Two acting effects in Yasmin are anti-mineralocortoid (diasperonone) and anti-androgenic effects (Spironolactone). While this is something most of us don't read about or understand about one of the many ways Yasmin works, I think it is really important in the larger picture-putting together the many ways in which the ingredients may act upon our bodies:

MINERALOCORTOID
(Yasmin has ANTI-mineralocortoid function/effects):

Mineralocorticoids are a class of steroid hormones characterised by their similarity to aldosterone and their influence on salt and water balance. (note Yasmin has diasperonone as an acting ingredient which acts as a potassium sparing diuretic.)

The primary endogenous mineralocorticoid is aldosterone. Yasmin has anti-aldosterone properties. Aldosterone acts on the kidneys to provide active reabsorption of sodium and an an associated passive reabsorption of water, as well as the active secretion of potassium. Note: Yasmin has diasperonone that is a potassium sparing diuretic. This in turn results in an increase of BLOOD PRESSURE and BLOOD VOLUME.

Aldosterone is produced in the cortex of the adrenal gland its secretion is mediated principally by angiotensin II, but also by ACTH (adrenocoritotrophic hormone) and local potassium levels.

Hyperaldosteronism (the symtpom caused by elevated aldosterone) often shows up as:

1. Hypertension-high blood pressure. High blood pressure that is arterial in nature gives a higher risk of heart attack or stroke than any other disease. Persistent hypertension/high blood pressure is one of the risk factors for strokes, heart attacks, heart failure and arterial aneurysm, and is a leading cause of chronic renal failure (which means chronic kidney failure)

2. Accelerated excretion oif potassium ions. With extreme K+ loss (note Yasmin has potassium sparing diuretic), ther is muscle weakness and eventually paralysis

Underproduction, or hypoaldosteronism, leads to the salt wasting state associated with Addison's disease (also known as chronic adrenal insufficiency or hypocortisolism) is a rare endocrine disorder in the body produces insufficient amounts of adrenal steroid hormones (glucocorticoids and mineralocorticoids) (note Yasmin has anti-mineralocorticoid effect)-it is essentially the inability of the Adrenal Gland to produce adquate amounts of CORTISOL in response to stress. This is an Endocrine discorder caused by high levels of cortisol in the blood. Cortisol is released from the adrenal gland in response to ACTH being released from the pituitary gland in the brain. Or..

HYPOADRENIA/ADRENAL FATIGUE:
The adrenal glands are part of the body's mechanism for short term stress response and management. (Note Yasmin's effect on adrenal glands). They are involved in the production of the hormone adrenaline (also known as EPINEPHRINE **-the famous fight or flight chemical released in stressful situations which increases the body's metabolic energy regulation and control system-and thus control to an extent the energy available to body systems.

Theorized by alternative medical practictionerS that under conditions of long term stress, the adrenal glands can become less responsive to circumstance and cease to function optimally leading to a wide* but slightly vauge range of FATIGUE AND STRESS RELATED CONDITIONS including a greater likelihood of psychological conditions such as depression and possibly certain other mood disorders.

SYMPTOMS OF ADRENAL FATIGUE:
1) DEPLETION OF ENERGY
2) LOSS OF RESILIENCE
3) FATIGUE
4) NERVOUSNESS
5) ANXIETY
6) EXACERBATED PMS
7) DEPRESSION
BRAIN FOG
9) CARBOHYDRATE CRAVINGS
10) ALLERGIES
11) MUSCULAR PAIN
12) JOINT PAIN
13) IRRITABLE BOWEL SYNDROME

Does this set off any bells or what ladies ? Very likely makes taking an Adrenal Function test as well as seeing an Endocrinologist.

CORTICOSTEROIDS:
Additionally, the corticosteroids functions, prodcued in the adrenal cortex include that of stress response, immune response, regulation of inflammation*, carbohydrate metabolism, protein catabolism, blood electrolyte levels and behavior. Interesting is the fact that Yasmin's side effects include trouble with colds and flu, "nervousness", insulin resistance (which is carbohydrate/sugar intolerance), -good likelihood for creating an imbalance in our electrolytes-which are minerals due to the potassium sparing diuretic. If you were like me, reading through this was unbelievable to me.

Yasmin's ANTI-ANDROGEN is Spironolactone
Synthetic steroid which is commonly used as a diuretic or as an Anti-androgen. -Potassium sparing diuretic. This on its own is a weak diuretic. Due to its anti-androgenic effect, it is common component in hormone therapy for male-to-female Transsexual and transgendered people and is also used for treating hair loss and acne in women....hmmm. Why then I wonder some women report the hair loss. It is marketed as a drug to treat acne.

Spironolactone inhibits the effects of aldosterone by competing for intracelluar aldosterone receptor. This increases the secretion of water and sodium, while decreasing the excretion of potassium. Spironolactone has a fairly slow onset of action, taking several days to develop and similarly the effect diminishes slowly.

ADVERSE REACTIONS TO SPIRONOLACTONE:
include menstrual irregularities and testicular atrophy, ataxia, erectile dysfunction , drowsiness and rashes*. A carcinogenic effect has been demonstrated in rats. Carcinogen is a term that refers to any substance or radiation which is an agent directly involved in the promotion of cancer or in faciliation of its propagation.

ATAXIA:
Steady and clumsy motion of the limbs or torso due to failure of the gross coordination of muscle movements. This often occurs when parts of the nervous system that control movement are damaged. People with ataxia experience a failure of muscle control in their arms and legs.

There is loads to consider on this front and lots of information available. I hope that this is helpful as you make your way through both understanding what some of your symptoms may be as well as informing/sharing your knowledge with a chosen medical practictioner.

Recommended for Adrenal Support:
Panthonene, B6, Zinc, magnesium and Vitamin C as they play a critical role in the optimal functioning of the adrenal gland and in the manufacture of adrenal hormones (which are suppressed taking Yasmin).

Take a look at:
Siberian and Panax Ginsengs

panthothenic acid

Ashwagandha
provides adrenal and immune support

Astralagus
in New Chapter Organic's multi and many other vitamins-used historically for strenghtening and regulating the immune system-as a tonic

Shisandra
improves immune function, increasing physical performance and endurance and for increasing resistance to disease and distress. Also possibly effective for increasing concentration due to the variety of lignans found in the fruit.

Maca-Peruvian Ginseng-
used for chronic fatigue syndrome, enhancing energy and stamina. In the female reproductive system, its use for enhancing fertility, regulating the menstrual cycle, treating common menopause symptoms and to increase libido. Its benefits have been known to the people of Peru for many generations.

Androgens are the precursor of all estrogens (the female sex hormones). the primary and most well known androgen is testosterone.

A subset of androgens, called adrenal androgens, includes any of 19-carbon steroids synthesized by the adrenal cortex, the outer portion of the adrenal gland that function as weak steroids or steroid precursors, including DHEA (dehydroepiandrosterone), DHEA-S (dehydroepiandrosterone), and androstenedione. Because Yasmin's ingredients have an anti-androgen effect that effect our adrenal glands-women with adrenal problems are advised not to take it.

Besides testesterone (which is responsible for sexual libido/function), other androgens include:

1) DHEA
(dehydroepiandrosterone: -a steroid hormone produced from cholesterol in the adrenal cortex which is the primary precursor of natural estrogens.

2) Androstenedione (Andro)-
an androgenic steroid, which is produced in the testes, adrenal cortex and ovaries*. While androstenediones are converted metabolically to testosterone and other androgens, they are also the parent structure of estrone. Estrone is an estrogenic hormone secreted by our ovaries. It is one of three estrogens which also include estriol and estradiol. Estrone is the least prevalent of the three hormones, estradiol being prevalent almost always in the female body, estriol being prevalent primarily during pregnancy.

3) Androstenediol:
the steroid metabolite that is thought to act as the main regulator of gonadotropin secretion-protein hormones secreted by gonadotrope cells of the pituitary gland. The two principle gonadotropins are LUTENIZING HORMONE (LH) and FOLLICLE STIMULATING HORMONE (FSH)-both of these are what are naturally release by our bodies on a monthly cycle are part of natural menstruation. The third human gonadotropin is human chorionic gonadotropin (hCG) produced by our placentas during pregnancy.

4) Androsterone:
a chemical by-product created during the breakdown of of androgens-or derived from progesterone -that also exerts minor masculnizsing effects, but with one seventh the intensity of testesterone.

5) DHT Dihydrotestosterone-
a metabolite of testosterone that is actually a more potent androgen in that it binds more strongly to androgen receptors.

FUNCTIONS OF ANDROGENS:
(keep in mind Yasmin has anti-androgenic properties):

Muscle mass:
Androgens promote the enlargement of skeletal muscle cells and probably act in a coordinated manner to enhance muscle function. (note: how many of us have experienced muscle fatigue and that Asthenia-was experienced by women in the Clinical Trials.

BRAIN:
Circulating levels of androgens can influence human behavior because some neurons are sensitive to steroid hormones. Androgen levels have been implicated in the regulation of human AGGRESSION and LIBIDO. Note, Yasmin's ingredients have anti-androgenic effects. That means essentially translates as suppressing the effects that androgen has in our bodies to regulate aggression and sexual libido...

I have been taking Yaz for almost one month now and I am noticing hundreds of changes. Originally this was prescribed to me for my extreme mood swings and sadness and a tendency towards ovarian cysts.
I have to start by describing my medical situation as after reading these posts I am growing extremely concerned about whether I should be taking this at all. About 4 years ago I had acne so bad that nothing would help. My Gyno put me on Orthotricyclin and a steroid, which I can't recall the name of now. I took that for almost 3 years, until I noticed my life was becoming full of depression and weight issues. I consulted the doctor about this, and since I had clear skin, I was ready to get off both pills. I said that no matter how much I tried to lose weight, I couldn't. He basically said that I was depressed because I was too fat and that I needed to keep trying to lose weight. Well, out of frustration, I quit the pill and the steroid. With the steroid you should come off slowly and taper, but I just took one month to come off and that was it. Of course, I got really sick, with all kinds of muscle problems and weakness, and had my first problems with ovarian cysts. The muscle weakness was from the adrenal gland having to all of a sudden work on its own, my new doctor said. Eventually, after visits to an endocrinologist and a cardiologist and a possible hole in my heart, I started to get better. This all finally was over about a year ago. In July of last year I moved in with my fiance (to Germany from Texas...a big change) and it was my first time to live with a guy. My body started to go crazy, as if it was working overtime to get pregnant or something. My hormones went crazy, I was an emotional wild woman. I had never ending cramps and finally saw a doctor in Germany about it. He confirmed my ovarian cysts were back in action. When I got to go back to the US for a visit, my doctor said that I should try Yaz, and gave me packs for free since I wouldn't get it without prescription in Germany. As soon as I started, my nipples became so sensitive they couldn't be touched. My emotions started to level out, but almost to the point of not caring about anything. I have had a few cramps, and spotting since last week although I am not due for another 5 days. My back pain is worse, and I have zero desire to have sex. I have a lot of itching, not only around my vagina but on my legs and arms as well. I do have a sense of sadness, and when I try and think about why, it always comes back to having taken the steroid and being in this position in the first place. And that I cannot get myself in the mood to have sex with my (now) husband. The doc basically said that I should take this only for 6 months to do what she referred to as a hormone flush. And that directly after that I could even try to have a baby. I am at a loss of what to do. I realize that this is kind of a complaining letter rather than a post of symptoms, but I have to talk somewhere.

SIDE EFFECTS OF YASMIN AS NOTED ON THE INISERT THAT COMES WITH THE PRESCRIPTION:
Nausea
vomiting
headache
diarrhea
bleeding between menstrual periods (spotting)
weight gain
acne
stomach cramps
rash
swelling or bloating
skin spots
breast tenderness
or difficulty wearing contact lenses may occur.

If any of these effects persist or worsen, notify your doctor promptly. Tell your doctor immediately if any of these serious side effects occur:
dizziness
flu-like symptoms (e.g., fever, cough, unusual weakness/fatigue, sore throat, muscle aches)
mental/mood changes
trouble sleeping
hair loss
vaginal infections.

Tell your doctor immediately if any of these unlikely but serious side effects occur:
severe headache
pain in the lower legs or groin
trouble breathing
chest pain
vision changes
severe stomach pain
one-sided weakness
yellowing eyes or skin
lumps in the breast.

If you notice any other effects not listed above, contact your doctor or pharmacist.

PRECAUTIONS: Tell your doctor your medical history, especially of:
heart problems
stroke
gallbladder disease
diabetes
high cholesterol or triglyceride levels
high blood pressure
migraines
seizures
irregular vaginal bleeding
depression
any allergies.

This medication is not recommended for use if you have the following medical conditions:
liver problems
kidney or adrenal gland problems
history of blood clots (thrombophlebitis)
blood vessel problems (e.g., cerebral vascular disease, coronary artery disease)
history of certain cancers (especially endometrial or breast cancer)
heavy smoking (especially if older than 35 years of age).
If you are near-sighted or wear contact lenses you may develop vision problems or have trouble wearing your contact lenses.

Contact your eye doctor if this occurs. If you stop taking this birth control medicine and want to become pregnant, it may take a longer time than is usually seen with women not taking birth control medicine. Consult your doctor.

Do not smoke cigarettes. Birth control pills combined with smoking cigarettes, especially in women older than 35 years of age, puts you at a much higher risk of developing serious health problems than with birth control pills alone. Consult your doctor or pharmacist for more information.

If you will be having surgery, be confined to a chair or bed for a long period of time (e.g., a long plane flight), or have recently delivered a baby, notify your doctor beforehand. Special precautions may need to be taken in these circumstances while you are taking this drug. This medication must not be used during pregnancy. If you become pregnant or think you may be pregnant, inform your doctor immediately. This medication passes into breast milk and has had undesirable effects on nursing infants. Consult your doctor before breast- feeding.

Okay, so I think I may have stumbled on something more.....for all of you out there who have expeirenced the irregular heart rhythms....here's more on what I found in research about potassium. I learned that this was one of the greatest risks of Yasmin...but had no idea I was at 5.7 in blood tests just confirmed this morning after 3 months of being off of Yasmin and just last Dec. 2005-it was 4.7? So now, I am starting to wonder if my Adrenal Glands may not be doing their job as noted below to the release of adolsterone?

Why is the Test Performed?

Potassium (K+) is the major positive ion within cells and is particularly important for maintaining the electric charge on the cell membrane. This charge allows nerves and muscles to communicate and is necessary for transporting nutrients into cells and waste products out of the cell. The concentration of potassium inside cells is about 30 times that in the blood and other fluids outside of cells.

Potassium levels are mainly controlled by the steroid hormone aldosterone. (For more information see the aldosterone test.) Aldosterone is secreted from the adrenal gland when levels of potassium increase. Aldosterone, in turn, causes the body to rid itself of the excess potassium.

Metabolic acidosis (for example, caused by uncontrolled diabetes) or alkalosis (for example, caused by excess vomiting) can affect blood potassium.

Small changes in the potassium concentration outside cells can have substantial effects on the activity of nerves and muscles. This is particularly true of heart muscle. Low levels of potassium cause increased activity (which can lead to an irregular heartbeat), whereas high levels cause decreased activity. Either situation can lead to cardiac arrest in some circumstances.

In normal people, taking potassium supplements or potassium-containing drugs is of no consequences, because the kidneys efficiently dispose of excess potassium.

I was on Yasmin 2 different times. After 6 months of being on the pill, I ended up in ICU with acute Gastrointestenal bleeding with no known cause. I went off Yasmin-no more problems. I went back on it 4 years later (not knowing the connection) 6 months after taking it ended up in the hospital with acute GI bleeding. This time I stayed on the pill, still not putting it together. Then my real nightmare began. I almost died from Anemia, I kept having boughts of bleeding, anxiety depression, hypoglycemia, you name it. I wanted help from the DR.'s no help. I wanted help getting off the pill because I was scared. I finally took the plunge, and it was like going to HELL. I would not wish this on any living thing. I became so overtaken with either deep depression, or anxiety, it is only by the grace of God and a few friends and family I am here today. I spent thousands on tests 4x in the hospital, couldn't work, or work out for the pat 3 years. I use to run 3-5 miles a day, and work physically about 6-8 hours everyday. They say the fact I was so healthy saved my life. I have since gained 25 lbs, had Fibromyalgia symptoms, chronic Fatigue symptoms, adrenal gland problems, and never have had another normal period, and now it is gone. No sex drive, vaginal irregularities, lost my hair (it grew back thank God), still have issues with unknown causes. It has been 3.5years since I started the pill, and 2 since I went off it, This pill is straight from Hell. I believe it is ruining women. We need to unite to get it off the market. Has anyone else had their life severily damaged from taking this pill. Words can not express enough the horror I have experienced and the continued pain emotionally, physically and mentally I must go through as I believe and hold faith for full recovery. Let your Doctors know what is happening so they will stop pushing this evil drug. PB

Guest 34613,
Yasmin is a pill that causes tons of side effects when going off of it. If you go through this whole forum like I did when I first found it you will be amazed. I was on Yaz the sister pill for only 2mths and it practically took my sanity. I did get swollen glands and felt achey. The feeling and down and depressed well you can definetly see from here that is from the pill. I had to go on a A/D because of such bad depression and anxiety. Yes it does affect the adrenal gland, I had a friend that was on Yasmin and it messed up hers. I also have seen it in some post on here. Have you lost any weight? I am so tired since going off of it. I think it just drained our body so much.

ok i have done weeks of research online this pill seems to have an effect on our adrenal glands that produce our hormones if you research adrenal gland you will get answers to all of your questions this pill is dangerous and i cant believe how we all put ourselves in such medical ruin. its almost similar to addisons disease im not sure because i am not a doctor but this pill and our side effects are real and none of us know for sure how dangerous because 9 out of 10 doctors wont diagnose us properly, this is very scary because if you read on this site even women who have been off of this a year or more arent 100% so what will our future bring? we have to take a stand and do something. lets not just be victims!!!!!!!!!!!!!!!1