Adult symptoms and conditions

The best drug out there !! No I am not ignorant enough to make these cart blanche statements like some of these posts---Millions of people have used this drug successfully like I have. Just because it works for one individual they should not recommend it to the world nor if it causes you personally some harm YOU SHOULD NOT POST A STATEMENT THAT INFERS IT WILL HARM EVERYONE--IN-OTHER-WORDS GET A LIFE!

SINGULAIR'S LABEL HAS BEEN UPDATED:

The following has been added to the "Precautions" section of Singulair's label:

"Neuropsychiatric Events
Neuropsychiatric events have been reported in adult, adolescent, and pediatric patients taking SINGULAIR. Post-marketing reports with SINGULAIR use include agitation, aggressive behavior or hostility, anxiousness, depression, dream abnormalities, hallucinations, insomnia, irritability, restlessness, somnambulism, suicidal thinking and behavior (including suicide), and tremor. The clinical details of some post-marketing reports involving SINGULAIR appear consistent with a drug-induced effect.

Patients and prescribes should be alert for neuropsychiatric events. Patients should be instructed to notify their prescribe if these changes occur. Prescribes should carefully evaluate the risks and benefits of continuing treatment with SINGULAIR if such events occur (see ADVERSE REACTIONS, Post- Marketing Experience)."

Just started my six year old son on Zyrtec again. The dr. said he could take the adult pill now 10mg. The last few nights he has wakened with terrible nightmares/night terrors. And after reading these posts i remember taking him off for the winter (he was on the liquid 5mg) and i remember him always itching his arms and legs. i remember giving him oatmeal baths. Now i know it is from stopping the Zyrtec. I am calling the doc tomorrow about these nightmares. He was also on Singulair 4mg for 1 1/2 years then one year ago was upped to 5mg. Within one dose we noticed he was very depressed and cried easily. After a week called the doc about it, stopped it then had our son back in a few days. Will Never give Singulair again and now stopping Zyrtec. All these meds are so scary. A part of me feels these meds are created because it is a HUGE business. They have side effects then you have to take other meds for those side effects and it is a never ending circle i feel purposely created by pharmaceutical companys to make money. And we are all suffering because of their greed. Shame on them

I started taking zyrtec a few days ago for seasonal allergies. I had tried the claritin (loratidine) before and it didn't seem to really help me much. I was avoiding the zyrtec because I knew it could potentially make me drowsy and I didn't want to be tired if I was working. I'm a pharmacist so I decicded to try it knowing the potential side effects. It works really well for me - but I started having really vivid strange - and disturbing - dreams. It has only been a week and they havent been too bad so far - but I am going to monitor it and if they get worse I will stop and try something else. The reason this is so strange is I don't normally dream much at all. I maybe remember bits and pieces of a dream - these are wierd and strange and make absolutely no sense. These dreams seem so real and are so clear - I can remember every detail of what was done and said.

I'm 15 and take Yaz but I feel the opposite of most of all. I have an increased sexual drive even though I shouldn't and I'm not depressed at all. As for emotional... Well I feel very emotional with many mood swings... hmm.

Mirena...WOW who would have known, that trying to prevent pregnancy would hurt so bad. I have had Mirena for 2 years now after the birth of my second child. Started out okay, within 3 months, I would only spot during my cycle, and before long no spotting. I thought it was great. Then I noticed myself becoming tired, no energy, just thought i needed more sleep. It didn't matter if i slept 12 hours I was still tired throughout the day. Then I noticed my patience going out the window. Every little thing irritated me, I would get so upset over nothing. Before long I was yelling at my kids, getting mad at them like I would an adult over something. Everything would be okay one minute and the next minute I would want to rip someone's head off. There's been a couple of times after an episode where i'm sitting there thinking what the hell is happening to me. This isn't me.

Then I got online to start doing some research and low and behold I find websites that are covered up with comments just like mine. My husband had just about been at the end of his rope with me just thinking I was being a b**** for no reason. Now that he has seen everyone elses reviews he believes that this thing has something to do with it. I have been depressed, I have basically lost all weight from my second birth except for my stomach. I look like I am 3 - 4 months pregnant and it will not go down.
I've been to the doctor's office asking what's going on and having test run and it all comes back normal. Nurses see my stomach and look at me saying "are you sure your not pregnant, because that's not because you are fat".

I am finally taking the plung and having this removed. The only thing I will miss about this thing is not having a period at all and no cramping. My kids and my life is more important to me than having to go buy tampons and deal with a monthly period. I've done it before and survived, and I'm so ready to have my mind back. Your gut lets you know when your not yourself and mine has been telling me for a while that I'm not myself. If you have been ingnoring your gut feeling start acknowledging it, it's trying to tell you something.

Will post later and let you all know step by step what happened after having it removed and whether or not my stomach went down and if I have a better mood about life.

Just wondering....has anyone started a civil suit towards Mirena? There's enough testimonies here that someone needs to listen.

My first post was yesterday. Today I called my doctor and got an appt for 2:15. I went to work for a 1/2 day...Cried most of the time in my office. Barely got through the 1/2 day. Cried most of the way to the Dr.'s. She finally saw me at about 4:00ish. I was crying hysterically... I think I scared her. Her first question was...are you suicidal...I said NO! But what was going on was UNCONTROLLABLE and NOT ME!!!! She didn't think it could be the Mirena but I insisted it had to be! She agreed to take The Beast Mirena out! Thank you God! It hurt a little bit but was over quickly. She gave me an anti-anxiety prescription because it will take awhile for my body to even back out she said. I was so relieved! I had two crying episodes on the way to the pharmacy. I have not taken the meds as I am alone with my three children and I don't want to chance any more problems without another adult with me. It's is about 2 hours after the removal....and guess what ladies....I am already feeling an improvement. Knock on wood...We'll see what the rest of the night brings. I do have some cramping and area pain. Gonna go pop a Motrin! I am so happy...you'll never know! Too bad for Valentine's Day though! I was hoping this year would be a nice one since I haven't had one since my Husband passed away in 1997...OH WELL...

I just started taking Celexa (generic) a little less than a week ago. My life had slowed down and suddenly I was have huge amounts of anxiety. I remember having anxiety attacks as a child but I think I kept myself overly busy as an adult to deal with it. I got really sacred because it was getting hard to function.

I am finding similar affects. I feel like the anxiety is worse and I am going crazy. I am getting hot flashes or anxiety surges and am having a really hard time sleeping. I start therapy next week and I am hoping everyone is right.. That it takes time for the drug to kick in. I feel at least a little relieved that others are having similar experiences.

Took two adult doses 4 days ago for vomiting and diarrhea in a two hour period and have had constant tinnitus in both ears since.

I am 34 years old. I am a pharmacy tech. I have asthma and allergies. I have taken singulair pretty much every day since it came out on the market. I've had asthma since i was about 10 years old. I took theophylline as a kid. Steriods on and off especially during times when my allergies are bad. I still use Advair during the fall and spring. Every drug has a side effect. However breathing is pretty good damn thing. Do I have days when I feel low? Yeah. Do I sometimes have nightmares? Yup. Are "natural" products the answer. Not always. The fish oil that some of the posters are touting can also cause GI problems. Some of the natural products contain herbs and other plant derivatives that can be harmful for a child that suffers from allergies. Not proactively treating asthma can be deadly. Some of the parents are suggesting steriods as the answer - those can cause weight gain, growth suppression and can lead to a worsening of asthma.

Singulair has never made me feel like I've wanted to kill myself. I was more depressed and angry as kid when my asthma did not allow me to partipate in normal childhood things. I was sad and hated life when I couldn't keep up with friends at recces because I was having trouble breathing. You have to outweigh the costs with the benefits. I am more irritable when I have asthma flareup then I am on a normal day. For me, I choose to breathe. And singulair has been helping me for almost a decade.

I'm not saying the medication isn't causing these symptoms but maybe there is an underlying cause to your child's depression.

Any drug has a side effect. But without medical research and the medications that come with them - people would still be dying of simple diseases and we wouldn't have vaccinations. As a society, as a whole, we are a culture that looks to someone else to fix things and then blames the people who try to fix it. We need to stop being the "hot McDonald's coffee'" society.

I am shocked and outraged at the "NEW" list of side effects that were attached to my newly refilled Singulair prescription. I am an adult and have been taking this medication for 3 years. I also know that I have not been happy in three years and every day I feel more and more hopeless and withdrawn. I have little interest in leaving my house, being with other people or anything else. Everything in life seems like an overwhelming task for me. I am filled with ideas about how to 'get away-far away'. I am a decent person, a wife and a mother of 3, but lately I would have done anything to be able to get a divorce and run. I have hated myself for these thoughts, which makes it all worse. I'm always reminding myself that these are people that I'm supposed to love! I ran out of my Singulair right before Thanksgiving and kept putting off refilling it, quite frankly, because I just didn't have the 'energy' to go to the store and pick it up. I did pick it up 2 days ago and that's when I noticed the new labels all over the bottle and was shocked when I read the description of the side effects. It was if they had been written about me. I have not taken any more of it and have now been off for more than a week and I feel like a human being again.

So, after my boyfriend and i used condoms and it ruptured due to the fact we used a warming lubracant that wasn't water soluble.
I got pregnant and we aborted. this was 2 weeks ago
I started the nuvaring that planned parenthood gave me.

well, i've been feeling tired, depressed and not hungry.
i barely eat any food these days
and i fear my weight is slipping, i used to be 112 lbs, and i;ve been exercising for lean muscle gain (since i had very little) and now i'm up to 118.
I'm scared i'm going to lose all that lean muscle i worked hard to put on.
i haven't been working out for 2 weeks since the abortion and all.

but anyway, ive been feeling very depressed lately.
i feel ugly and unworthy and i know that neither of those are true.
i feel like i'm a terrible person, i feel sad all them, i cry so easily (like i'm doing right now)
the other night i had a breakdown when felt horribly down on my self, i felt like i'm worthless and i felt ashamed because i feel like i always want sex from my boyfriend and i feared that i i don't love him, i feared that my sex drive is out of control, and then i felt like because he doesn't want to have sex with me everyday, i felt like i must not be worthy or that i'm ugly, stupid, a pain, and that he doesn't love me and then i thought things like 'well would you want to have sex with you? who could blame him?"

today i started feeling those feelings for no reason again, this time i started feeling like i hate my life and wondering why i'm alive

when i had thought perhaps i was suffering from early adult bipolar (im 24 btw)
i had an epiphany and realized, WAIT, it probably ISN'T bipolar, if all this just happened RECENTLY
and before the ring i was really happy. AND my boyfriend never does anything to make me feel unloved or unworthy.
he always takes his time and he's very sweet to me all the time.
he treats me to almost everything and he's so patient and loving.

I realized that my sudden mood changes MUST be because of the damn Nuvaring!

i have a follow up from planned parenthood tomorrow, so i'm going to tell them everything i've felt and i'm only going to continue this damn ring until nov 24th.
i get my prenup for my tubes to be tied.

my boyfriend and i don't want kids ever, (if the recent abortion is ANY proof to that one)

anyway, i would NOT recommend this ring to ANYONE
i know everyone is different, but still.

and i do realize that i COULD be having early adult bipolar or some other sort of depression/anxiety issues that i might just THINK are ring related.
I will continue to monitor my health and if i ever feel like this again i will seek help

I was put on Singulair about three weeks ago, and noticed immediately that my mood had changed. I am an adult ,and felt this sense of sadness, anxiety, solitude, not wanting to be around anyone. I took myself off the drug and have tics all over my body and eyelids ,which is driving me crazy! I even had heart palpitations ,which are very distressing. Today it seems to be better, and this is day three off the med. The only way I can explain how I felt on this drug is doom and gloom.

Now that I have had mine removed and can think clearly again, I just realized that I had anxiety at work all year long and felt so overwhelmed with everything coming at me all the time, feeling like I had developed Adult ADD and scared I would lose my job because I couldn't keep up or kept screwing up little things with my foggy brain. WOW - it was this IUD messing up my body and my mind the whole time. Why won't doctors listen to us and hear our cry for help???

I am re-posting this from June. I believe that we have many reasons to suspect that Singulair does indeed penetrate the blood brain barrier. I personally believe that under certain unusual conditions that Singulair can cause neurological damage. I tried before to put together a scenario of brain biochemistry that could explain how this can happen. Of course, I am just hypothesizing and all of my ideas will not prove to be totally correct. From the number of postings here regarding neurological symptoms, I believe that there is an answer out there somewhere. Why the FDA is not searching for this answer is a complete mystery to me.

I believe that it is possible that Singulair causes the same biochemical response in the brain that is cited in this study -- thus causing neurological damage.

"Thus, elevated NO production leading to mitochondrial dysfunction, glutamate release, and excitotoxicity may contribute to neuronal death in neurological diseases."

IS SINGULAIR CAUSING THE DEATH OF NERVE CELLS IN SOME PATIENTS? DOES THIS HAPPEN - ALTHOUGH INFREQUENTLY- BECAUSE OF GENETIC OR BIOCHEMICAL FACTORS OR BOTH?

June 12th
2008
2:56 AM
I have stated many times that I am not an expert. I just post what I find. This has been a mind boggling journey for me. This is way over my head but I struggle to read and understand. Finding answers to why children are suffering from neuro-psychiatric side effects is worth the effort.

I have made the following observations.

1. Some quinolines are known to be able to cross the blood brain barrier.
2. Molecules that ionize are known to be more likely to be able to cross cell membranes. So if montelukast ionizes as a result of change in blood pH to sufficient acid conditions, then it could be possible that it does in fact cross the blood brain barrier.
3. We know that there are cysLT1 receptors in the brain.
4. We know that researchers believe that montelukast may bind at the arginine of the cysLT1 receptor.
5. We know that arginine contains four nitrogens. And montelukast contains one.
6. We don't know what happens to those nitrogens. Are those nitrogens converted to nitric oxide?
7. We do know what macrophages create nitric oxide as I posted.
8. We do know that if something cause excessive nitric oxide to build in the brain that there would be damage to the neurons.

Some people may remember when I got stuck at the astrocytes, the cysLT1 receptors and glutamate. I keep looking for research reports that may shed more light on this.

Titre du document / Document title
Nitric oxide causes glutamate release from brain synaptosomes
Auteur(s) / Author(s)
MCNAUGHT K. S. P. (1) ; BROWN G. C. (1) ;
Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
(1) Department of Biochemistry, University of Cambridge, Cambridge, ROYAUME-UNI
Résumé / Abstract
We determined the ability of pathological levels of nitric oxide (NO) to cause glutamate release from isolated rat brain nerve terminals using a fluorometric assay. It was found that NO (0.7 and 2 μM) produced (4 and 10 nmol/mg of synaptosomal protein) Ca2+-independent glutamate release from synaptosomes (after 1 min of exposure). Spermine/NO complex (spermine NONOate; a slow NO donor) and potassium cyanide (an inhibitor of cytochrome oxidase) also caused Ca2+-independent glutamate release. Preincubation of synaptosomes with 5 μM 1H- oxadiazole quinoxalin-1-one (an inhibitor of soluble guanylyl cyclase) had no effect on NO-induced Ca2+-independent glutamate release. Ca2+-independent glutamate release produced by NO was greater in a low-oxygen medium. NO, spermine NONOate, and potassium cyanide inhibited synaptosomal respiration with a similar order of potency with respect to their ability to cause glutamate release. Because NO has been shown previously to inhibit reversibly cytochrome oxidase in competition with oxygen, our findings in this study suggest that NO (and cyanide) causes glutamate release following inhibition of mitochondrial respiration at the level of cytochrome oxidase. Thus, elevated NO production leading to mitochondrial dysfunction, glutamate release, and excitotoxicty may contribute to neuronal death in neurological diseases.
Revue / Journal Title
Journal of neurochemistry ISSN 0022-3042 CODEN JONRA9
Source / Source
1998, vol. 70, no4, pp. 1541-1546 (29 ref.)

INIST-CNRS, Cote INIST : 4037, 35400007527188.0230

Singulair caused terrible nightmares, vivid, evil dreams and tremors. After a while change of personality and aggression, irritability and anxiety. As soon as it was stopped the nightmares stopped and back to being normal. Very dangerous medication. (Adult)

My dog was prescribed Cepro on 10/8/2008
500 mg 2 capsules am
1 capsule pm

Stopped giving him the drug after he started to vomit three days later
Symptoms:
Vomiting, heavy breath, exhaustion.

13 Oct --
Refuses to eat.
Sudden drop in quantity of urine.
Refuses to drink.
Bloating of stomach.
A bit of seizures.
Death.

I am a loving mother of a 5 1/2 year old boy. He has been on Singulair for over 3 years. In this past 3 years my son has suffered in an unspeakable amount. He came down with Rota Virus and was hospitalized at 2. He then came in contact with Pneumonia in the hospital while he was there. They automatically put him on Singulair, Zyrtec, Prednisone, and antibiotics to treat the pneumonia. Since that day, my son has gone though more tests than I have in my entire life. He has had asthma, sinusitis, leg cramping ( to the point he cannot walk for 2 years), IBS, Acid reflux,(they gave him laxatives for a year that made things worse and addicted to them also), stomach pain, constipation and diarrhea back and forth. He also got Erythema Mulitforme TWICE, while on this drug. All of which the doctors said could NOT be caused by Singulair. He has had several Upper GI's and CT scans. Along with Barium enemas, several hundreds of blood tests, and many many pokes and prodded that were not necessary. All since he has been on Singulair. He now has frequent bathroom trips, depression, confusion, and anger outbursts. He also has to go to the restroom every 5 minutes. He has had genital swelling, and many other aches and pains. None of which his "doctor" ever said could be a result of Singulair. I am 100% sure it was!!!! He currently has anxiety and emotional sporadic issues causing problems in school The teachers and counselors say that it is so strange because there is no TRIGGER and the outbursts are completely inconsistent. His preschool teacher and director are sure he has ADHD. Well, we had him tested and he does not have any part of it. He has no learning disability what-so-ever. So that brought me back to square one. He is in a positive loving enviroment. How could he be depressed and want to hurt everyone around him? He cannot sit still. He cries and says he is 'stupid" and "can't think" like the other boys. He has nightmares and cannot sleep alone. He is scared of everyone and everything. So, as I sit here crying, I realized that this has all been a reaction of his "medicine" Singulair. He never should have gone through all of those painful tests, only to prove they couldn't find anything. So many treatments and sound full advice speeches from his doctors. How could they be so naive and selfish in the life of my son?

When I called my pediatrician of 5 years, she told me that " parents that have children with behavioral problems will LOOK for something to blame their problems on." She also said "drug companies only put side effects on their labels to PROTECT the drug companies. (as she laughed at me) They are not always valid". Then she said "if you take you child off of Singulair you will be playing Russian Roulette in his life." Then she said that all children around 5 or 6 go though this emotional time in their lives." She told me that if I take my child off of Singulair that she would no longer be a part of his health regimen for his asthma. She told me to see a Pulmonologist for further treatment.
Who is paying who? This is my son's life???????? I decided to go with my mother-gut instinct and get him off of this medicine. No matter what. He has been a different person since. He is currently going though a lot of side effects and withdrawals (leg pain, insomnia, hic-ups, emotional distress) but every day is getting better. How can the drug companies say that this is a "wonder drug?" There are more reported side effected patients then clinical studied patients! How can a "medication" that stimulates the brain not be connected to other problems? This "medication" interferes with the bio synthesis and action of LTs and has been marketed as NOVEL medication against asthma and allergic rhinitis. Who the hell is playing God here??? The pocket books of Merck or our over PAID "doctors?" Who pays the price? Our children? Or us. Thank god I found this before it was too late. I would not be able to withstand the pain of losing my son due to their lack of scientific evidence. They are lucky I am one of the smart ones. I will not settle for less than Justice for the drug companies and their paid "doctors?" You all end up in the same place. HELL

There are 18 million people on this drug. Most of them are children. Please save a life if not your own child's life. Thank You

My daughter is 12 and just started taking Prednisone 5 days ago (40mg - she weighs 105lbs) .. I've been watching her salt intake - tonight she looks a little pale to me - is that a side effect? has anyone else experienced that? She has Ulcerative colitis (2 years this month) - started w/asacol, colazol, 6mp (gave her pancreatits) now is on methotrexate since Nov '07 - was put on prednisone because of a recent flare - to me none of these medications have put her into remisson - always goes 3-5 times a day - sometimes blood - sometimes not - don't know if prednisone will help - so afraid of the side effects -
Dr. said if it doesn't - Remicade will be the next option - after that surgery - only thing - my daughter has never complained of pain - except when she was on 6mp -
sorry for babbling - just so scared...

I have asthma that was not controlled. I coughed and wheezed constantly. I had trouble eating, because even the food passing through the esophagus was enough to cause an attack. I was in and out of the emergency room for years, and the Ambulance folks knew to arrive with epinephrine when I'd call.

I started taking Singulair sometime around 1998. I haven't had any serious problems since then with asthma, and have had ZERO side effects.

Every drug has side effects for some people. For me, Claritin causes my heart to race. I can take that or that purple circurlar inhaler thing. I had a terrible reaction to that.

For ME, Singulair works. I am not sure it should be given to children if they are having severe problems. But it certainly should NOT be removed from the market...because people like me needed it to control their asthma.

My son has been taking Singular as well as Advair and Zyrtec and Nasonix for the past 6 months. He is doing so well. He has not had to go to emergency, he has not been sick, and he has not had mood swings. If you look at the prescription information that comes with Singular, you can see what the side effects can be. My recommendation is to take your child off of them if they have a side effect. I contacted my Dr. and Merck is studying only 1 case with a child that had side effects, but they did not say if this child was on other Psych medicine at the same time. The 2 psych meds that have shown a bad interaction with Singular are Phenobarbital and Rifanpin (spelling may be wrong). With all the posts I have read, very few people indicate if they are taking other medications at the same time as Singular. My suggestion is that you consult your Dr. and then send your case to Merck for more studies. If all you are doing is posting on the web, you are not solving this issue with the makers of the medication.

I took Zoloft a few years ago, and as an adult over 40, I must say the side effects were awful. I developed very dry skin with patches of dryness on my face, arms and legs. I was always thirsty, drinking 24 or more ounces of water a day. Another side effect was constipation. I didn't stay on it very long.

I am sure that all kinds of people told Kate Miller that Concernedcitizen was a cuckoo or a Merck competitor. I haven't been employed by a pharma company in many years. Everybody ever employed by a pharma company higher than a certain level (practically the mailroom) knows this stuff and what to look for.

I think that I am about ready to say my opinion on how montelukast works and why these problems develop. It will just be my opinion. I need to try to find actual proof but I may forego that and just say it soon.

i am 14, and i have never use a nuvaring before but wanting to look for an easy to use contraceptive method, i had been doing it with the withdrawal method for 5 months now and wanting to consider using some sort of contraception... but i also want to know what food i can eat to reduce the risk of getting pregnant?

My Grandson is one of the children who has experienced these horrible side effects. In the two months that he has been taking singulair, I have watched my daughter and her husband become increasingly terrified at the changes in our happy loving little boy. I am urging each and everyone of you to contact Merck and the FDA and file a complaint in order to stop this drug from being used in children. It is one thing as an informed adult to take a medication with potential side effects, it is a totally different thing for a parent to give a medication that they have been led to "Believe" to be safe to their child. There is strength in numbers and if we all contact the news, Merck, FDA, any one we can think of and inform them about what is happening to our children on this drug, we will be able to stop other potential victims from experiencing what our families are going thru....Please I urge you to continue to spread the word about this drug - tell everyone you know. Remember, Merck doesn't really care about our kids. They only care about the bottom line - PROFITS.