Adverse reaction symptoms and conditions

This site may have saved my life! My blood pressure & cholesterol meds were changed last Sept., and like Virge, 3 months later I had a severe vertigo attack (while driving). Long story short, I have been a wreck ever since...feeling dizzy & faint, anxiety attacks, spiking BP, acute insomnia, soreness in the back of my neck, overly sensitive to bright lights and loud sounds, and several reactions to anti-anxiety meds & vitamin B pills (some of which placed me in ER!).

I've seen over 20 different doctors & specialists, and NOT ONE has ever questioned the Simvastatin. A couple weeks ago, I Googled Simvastatin & vertigo and saw that vertigo was listed as a side-effect...then I saw the notes on this site. This prompted another visit to my doctor.

I've been off it ever since, and have noticed a substantial change for the better (I can sleep well again!) - although I'm still always dizzy and my BP has risen. I'm hoping that by taking it for so long, I haven't incurred any substantial long-term side-effects! I'm also wondering why some of us react so negatively to the drug - if there is another underlying medical condition that would cause such an adverse reaction?

I went to my primary doctor last Wednesday. He gave me samples for a 5 day regime of Avelox to treat a head/chest cold. Well, the cold does seem a little better, but, I would have never traded that to the side effects I am experiencing now! I took my first daily dose of Avelox last Wednesday. On Friday I thought I had dry skin. By Sunday I was itching so bad that it was almost unbearable. My eyelids are itching, burning and swollen, my forehead looks sunburned from the itching and scratching, my chest, stomach, back and thighs feel tingly and are itching NONSTOP. I am taking an antihistamine, but it doesn't seem to be helping much. I hope this goes away. I cannot imagine what this drug does to people that have allergies and sensitivities to medications. I have never experienced an adverse reaction to medications before this. I would never recommend this drug to anyone.

This is just amazing to me. My son was prescribed singulair for asthma when he was 8, he is 19 now. I only kept my son on this medication for about 4 weeks. I noticed a HUGE change in his personality, defiant and very fired up. I took him off, because there was just no talking to him. It made a difference, he was back to normal. I said something to his doctor, and he didn't know what to think, he said that the drug shouldn't alter his personality, it's an asthma medicine. I'm glad i listened to my gut instinct and took him off. My doctor just prescribed singulair to me for severe allergies and i wanted to see what the side effects where. I had NO idea i would see the side effect, that i knew my son was having 10 years ago, when this medicine first came out. I am speechless...

I have founded an advocacy group called Parents United for Pharmaceutical Safety and Accountability. The activities of this group will include supporting Kate and Dave Miller's efforts to initiate change in the adverse event reporting system and failed system of updated drug info notification to physicians and pharmacies, and to educate the public and motivate them to demand change too. Another activity will be to educate the public about the dangers of Singulair and how to spot adverse reactions. And finally, the biggie: putting pressure on the FDA to AT LEAST "black box" Singulair.

I personally wonder how many people out there have experienced adverse reactions to Singulair. At some point, if the FDA lets us down, I want the group to conduct its own study to determine this and maybe identify new adverse reaction?

Hopefully the website will go live next week. Anyone who wants to volunteer or give input is invited to sign up via a private message to me at this site. If you provide your email address I will contact you when the site goes live. If you would like to speak to me directly, send me your phone number and I will call you.

I have already contacted some of you directly, and if I have not yet gotten back to you, forgive me, I will.

Thanks in advance for any support you can give!

Jenna M.

Besides hair loss, vision problems, pain all the time, dry mouth, diarrhea, sleeplessness, pounding heart, I also had a problem with mucus filling my stomach and my food would get stuck. So I had to vomit to get the mucus up so I can continue eating. The first time I quite taking this poison pill, I got to feeling much better and my stomach got much better too. But never connected Lipitor with my problems. When I started taking this poison pill again, all my problems returned. But only worse, because I was in so much pain that it was hard for me to climb stairs and I had to hold on to everything just to go to the bathroom at night. Than I quit taking this poison pill again and haven't taken anymore since. All my problems disappeared again. I told my new doctor what this poison pill was doing and he told me to stop taking it, which I had already done.

So how many more people is this poison pill going to hurt and kill before Lipitor is taken off the market? I'm once again seeing Lipitor advertised on TV claiming this poison pill is FDA approved. Wasn't Baycol approved by the FDA as well and was taken off the market because it was too dangerous?Scary!

I'm 62

To anyone new to this site whose child is on Singulair and having problems consistent with the adverse reactions to Singulair documented on this site: take your child to the doctor as soon as possible and tell them you believe that your child is having an adverse reaction to the drug. Do not let yourself be talked into believing that Singulair does not have these side effects. Too many of us right here can confirm that it does. Even though the prescribing information for this drug has been updated to include a warning about these adverse effects, and the FDA is conducting an investigation into the safety of this drug, not all doctors are aware and some are simply unwilling to believe. If you hear "anecdotal evidence", "highly unlikely," or "I've never seen it happen" uttered during your visit, know that your doctor is making excuses for not knowing accurate information about this drug.

Doctors may attribute your child's behavior to their personality or developmental stages. But any child on Singulair should be removed from the drug if a consistent pattern of different or abnormal behavior is present. Most children do not fly off the handle for no reason, have night terrors, prolonged, violent temper tantrums, and act anxious, angry, sad, hateful, disconnected, or withdrawn most of the time. Most children do not have behavior problems that consistently leave you feeling like the worst parent in the world and completely mentally exhausted at the end of each and every day.

Tell your doctor that you want them to prescribe another asthma maintanence medication with a documented low risk of side effects. If your doctor trivializes your concerns or refuses to honor your request, FIND A NEW DOCTOR! YOU are the expert on your child, not someone who sees them a few times a year for a few minutes at a time.

After Singulair has been stopped, watch for a positive change in behavior over the course of several weeks. Make sure you have rescue medications on hand in case needed.

Most importantly, GO WITH YOUR GUT. "If something doesn't feel right, then something ain't right!"

Welcome a board singulairsurvivor. I received back an email from the woman at the lung association,she was of course sorry for our experiancr,and went on to say the scientist that reviewed the data were some of the best,and the association has no ties to any product.then as i am watching the updates on the hurricanes,i am inendated with singulair commercials as once again it is allergy season,so what a windfall for Merck that this article came out this month and not next....Coincidense i think not shame shame shame on you.To all those unsuspecting people about to get their prescription .i am sorry

I apologize that the summary is not ready yet. At this time, I am inclined to believe that the FDA will "black box" Singulair. Maybe, I am just hoping but we will see. I also believe that the FDA will also investigate the entire category of drugs with genetic components and warn doctors that these drugs do NOT behave AS EXPECTED when the patient has a genetic variant.

I am posting this again.

I just wanted everyone to know that I am still here and concerned about everyone who is having side effects from Singulair. Sometime within the next few weeks I am going to post a summary and conclusion about all of the research that I have posted. I hope to come up with a well organized concise statement about why everyone who experiences side effects from Singulair should stop using the drug immediately. Not everyone has an adverse reaction to this drug. For those who do, it is very dangerous to continue this medication even for one more day. STOP IMMEDIATELY IF YOU SUFFER SIDE EFFECTS FROM SINGULAR. WHEN YOU SUFFER SIDE EFFECTS FROM SINGULAIR, THE REASON IS THAT YOU ARE NOT COMPATIBLE WITH THE DRUG'S GENETIC BASED MODEL. Singulair targets the CysLT1 receptor, which is a gene. This gene is not the same for everyone. If your doctor does not understand that the mode of action of Singulair has a genetic component, then tell him/her.

Please add me to the list of people with an extremely adverse reaction to Singulair. I had been taking 10 mg Singulair since 2005 after sinus surgery In June 2008 after returning from vacation I didn't get my prescription refilled in a timely manner and went without it for ~one week. In July I got a new prescription filled for Singulair and also began taking Advair Diskus 250/50 and AllegraD after an increase in asthma symptoms. I first thought the anxiety attacks were from the AllegraD as the "D" is for decongestant and contains psuedo-epinipherine. But the anxiousness continued and got worse after stopping the AllegraD. I then stopped taking the Advair (and also a nasal spray that I use called Flonase also since 2005) but was still in a major depressive episode with daily thoughts of suicide. It wasn't until I stopped taking the Singulair on August 23 that I started to return to normal. My normal does include a history of depression for which I take 10mg Paxil daily. Like the post from the psychiatrists wife noted, I am not sure if there is a direct scientific connection between these events. I do know that I never want to go back to that place I was in. I am shocked at the speed with witch I started to feel good after stopping the Singulair. I still have low grade sad feelings but I have stopped planning my own death. I always took my dose of Singulair in the morning and ~one hour later would begin to feel anxious. My evenings were tolerable with emotions slightly better. I simply stopped taking the medication without tapering and I am beginning to deal with what happened to me. Thank you all for sharing. Thank you.

I have had trouble with eczema/psoriasis for several years and it has spread to most of my body. Hands, arms, elbows, back, chest and stomach, hips, back-side of my thighs, knees, bottoms of my feet, scalp, inside my ears, forehead, what haven't I mentioned? So far, Prednisone is the only medication I can take that clears it up. Trouble is, the doc won't let me take it long enough to completely clear the rash before I'm tapered off. After reading some of the other posts, I've got to say that I've never noticed any adverse reaction. My appetite is up a little, but my energy level is also up and I burn off any extra calories. I sleep better (no itching) and for longer periods, wake feeling better, have a better outlook for the day and am ready to go. I'm a salesman, so my mental attitude is important, and my wife and family all agree that I'm less moody and in a generally better frame of mind while taking Prednisone. I've noticed no stomach or bowel distress except for being a little less regular than normal. But no constipation and no diarrhea. I'm 61 so a few muscular aches and pains and joint stiffness are to be expected, but I've noticed no unusual incidents. While I don't advocate taking large doses (define large doses???) for long periods, I've read that taking Prednisone on an every-other-day basis can be effective while greatly reducing the risk of side-effects. I think Prednisone has been a real "miracle drug" for me and just wish there was something as effective without the side-effects.

My 6th time for Botox and ten days after the injections, I ended up in the ER with flu like symptoms, nausea, tingling in hands and feet, dry mouth, and extreme anxiety. After multiple, and expensive tests, the physician said that I was experiencing an adverse reaction to Botox. I cannot get the Dermatologist to call me back and my Family Practitioner isn't familiar with this condition. I am reaching out in the hopes of finding someone who can relate to this and welcome any feedback or referrals to help me.

I just wanted everyone to know that I am still here and concerned about everyone who is having side effects from Singulair. Sometime within the next few weeks I am going to post a summary and conclusion about all of the research that I have posted. I hope to come up with a well organized concise statement about why everyone who experiences side effects from Singulair should stop using the drug immediately. Not everyone has an adverse reaction to this drug. For those who do, it is very dangerous to continue this medication even for one more day.

STOP IMMEDIATELY IF YOU SUFFER SIDE EFFECTS FROM SINGULAR. WHEN YOU SUFFER SIDE EFFECTS FROM SINGULAIR, THE REASON IS THAT YOU ARE NOT COMPATIBLE WITH THE DRUG'S GENETIC BASED MODEL.

Singulair targets the CysLT1 receptor, which is a gene. This gene is not the same for everyone. If your doctor does not understand that the mode of action of Singulair has a genetic component, then tell him/her.

After having the third shot I noticed my hair began falling out (July 2007). It is now over a year later and after having numerous blood tests, visiting a dermatologist and doing tons of research, I have concluded that gardasil must be causing this. My hair continues to fall out, I have bald areas around the crown of my head and my mood is very depressed by this. I also experienced soreness in my legs and joints but these are not constant. My periods also are out of whack. They can be between 28-50 days apart. I would not recommend anyone getting this vaccine. I wish my OBGYN had not sold me on it. I was 31 when I got it but she said age didn't matter, she said one day insurance companies would cover this vaccine for all women no matter what age they are. I paid $190.00 a shot and now I have a thin head of hair that may one day soon be bald if it doesn’t stop falling out. I think they should take this vaccine off the market. If anyone else has had severe hair loss, has it stopped falling out after a certain point?

I had 95% occlusion of the major artery in my heart July 2007 with no symptoms except slight shoulder pain on 3 occasions. They did a cath and inserted 2 stents. Started with Lipitor 10 mg. and my LDL dropped from 75 to 112. The MD wanted to double the dose, but I refused because of intermittent nocturnal nausea. MD switched me to another statin and I had immediate muscle involvement and severe nausea at night. She wanted me to try another statin drug and I refused. After a 2 month period of no statins, she put me back on Lipitor 10 mg. daily. I decided to cut the pill in half and take it twice a week, then move to every other day and gradually go to 10 mg. daily. Immediately, the nocturnal nausea started again. Last night I awoke at 2 a.m. with nausea, sweating, sore muscles around my rib cage. Still no sleep at 4:30 a.m., so I got up and tried to eat something. This has been the pattern every night since I went on Lipitor.

I don't know if I can take this any more.

CK

I have had a mirena in for 2 1/2 months. Within one week I had developed a rash on my hands which after two consultations with specialists is excema. I have used steroid creams but it gets worse. I have never had any thing like this before. This rash is also on my feet. I have had the mirena removed today as the link seems too much of a coincidence.

The mirena has been helpful in stopping heavy bleeding etc but I cannot live with my burning peeling hands and need to know whether it is the mirena.

I have been taking Simvastatin 20 mg. for about two and 1/2 months now. It really lowered my Cholesterol but I have been extremely fatigued and now I am getting really dizzy when standing up and having some nausea.

I have been prescribed Prednisone after I had an adverse reaction to an antibiotic which i was taking after an insect bite became infected. I am covered in a sore extremely itchy rash of weels all over my body.

I took 6x5 mg of Presnisone with breakfast and as I was feeling ill because of the rash I took it easy and lay on the sofa suddenly about 60 to 90 minutes after taking the pills I had an overwhelming feel of wanting to be sick and diarrhea, my head was spinning and I came out in a cold sweat. I become very anxious and felt like I would die, so quickly and severely did this come upon me.

All I could do was lie down and let it pass. fortunately my husband was at home and I felt reassured that if needed he would ring for emergency treatment. after a while this feeling passed but did return about an hour later. It took about six hours before I could move my head without feeling sick.

I spoke to my GP on the phone and he said I shouldn't have had a reaction like that, it was not the usually side effect! Reading the post on this forum I think it most definitely a side effect of Prednisone.

Now I have to decide whether to take it again tomorrow I am still very itchy and the rash hasn't got any better but no worse. My GP suggested taking 3x 5mg for breakfast and 3x 5mg with lunch.

I only have to hopefully take it for one more day after that. I do feel for those of you who have no choice but to take.

My 17 yr old daughter received her first Gardasil on April 17,08 with only pain at the injection site on June 16th 08 she received the 2nd within days she started complaining of severe headaches and eye pain so I scheduled a routine eye exam thinking that her glasses may need to be updated. After her exam her optomatrist called me intot he room telling me that she had severe swelling of her optic nerve and scheduled her for an MRI before we could get that done she went to the ER for severe pain in the eye and headaches there they did the MRI and it was normal no tumors or anything that would cause such headaches. On July 3 she called me from work asking to be picked up because the pain was so bad she could not function at all she was weak, dizzy and overall just not feeling good. I took her to the ER again where they performed a spinal tap and tons of bloodwork and admitted her for pain control on July 5th she had a 2nd spinal tap and every day more bloodwork was performed so far ALL tests ran have come back normal. She was in the hospital 5 days. She seen her ophthalmologist a week after being released and we talked to her about the Gardasil and she felt there was enough "coincidence" to have my daughters pediatrician file a adverse reaction form. That has been done and my daughter has learned to live with the pain since nothing seems to help it anymore. Also the last 6 weeks she has had bad insomnia and nose bleeds.

As a retired Healthcare Professional, like you I almost died from a statin overdose. If you’re a U.S. resident or Canadian resident, I would encourage patients/consumers to send their complaint/statin adverse reaction report to the web sites listed below. Also, if your physician is unresponsive to your negative experience from any statin, inform him/her that you refuse to continue with this drug, and have sent an adverse reaction complaint to the FDA/Canadian equivalent. Provide both your doctor and pharmacy with a copy of the completed FDA Form 3500, if you’re a U.S. resident, so they (medical community) know you're serious (see my recent postings of July 20 and July 25, 2008). In addition, I would bring to the attention of your physician the following clinical experience of Dr Peter H. Langsjoen, MD, FAAC, a Blue Ribbon Cardiologist: “Over the past five years, statins have become more potent, are being prescribed in higher doses, and are being used with reckless abandon in the elderly and in patients with "normal" cholesterol levels. We are in the midst of a CHF (Congestive Heart Failure) epidemic in the US with a dramatic increase over the past decade. Are we causing this epidemic through our zealous use of statins? In large part I think the answer is yes. We are now in a position to witness the unfolding of the greatest medical tragedy of all time - never before in history has the medical establishment knowingly (Merck & Co., Inc. has two 1990 patents combining CoQ10 with statins to prevent CoQ10 depletion and attendant side effects) created a life threatening nutrient deficiency in millions of otherwise healthy people, only to then sit back with arrogance and horrific irresponsibility and watch to see what happens - as I see two to three new statin cardiomyopathies per week in my practice, I cannot help but view my once great profession with a mixture of sorrow and contempt.” Finally, I hope you find, as I did the following newsletters/medical information helpful:
http://www.vitacost.com/newsletter/newsletter.cfm?nl=189

http://www.vitacost.com/newsletter/newsletter.cfm?nl=234

http://www.vitacost.com/newsletter/newsletter.cfm?nl=370
-------------------------------------------------------------------------------------
U.S.A.
http://www.fda.gov/opacom/backgrounders/problem.html
CANADA
http://www.hc-sc.gc.ca/dhp-mps/alt_formats/hpfb-dgpsa/pdf/compli-conform/gui-44_consumer_complaint-plainte_consommateur-eng.pdf
Contact Name: Drug Compliance Verification and Investigation Unit
Tel: (613) 952-9906
Fax: (613) 954-0941
E-Mail: DCVIU_UVCEM@hc-sc.gc.ca

As a retired Healthcare Professional, like you I almost died from a statin overdose. If you’re a U.S. resident (FDA Form 3500) or Canadian resident, I would encourage patients/consumers to send their complaint/statin adverse reaction report to the web sites listed below. Also, if your physician is unresponsive to your negative experience from any statin, inform him/her that you refuse to continue with this drug, and have sent an adverse reaction complaint to the FDA/Canadian equivalent. Provide both your doctor and pharmacy with a copy of the FDA Form 3500, if you’re a U.S. resident, so they (medical community) know you're serious (see my recent postings of July 20 and July 25, 2008). In addition, I would bring to the attention of your physician the following clinical experience in quotes of Dr Peter H. Langsjoen, MD, FAAC, a Blue Ribbon Cardiologist: “Over the past five years, statins have become more potent, are being prescribed in higher doses, and are being used with reckless abandon in the elderly and in patients with "normal" cholesterol levels. We are in the midst of a CHF epidemic in the US with a dramatic increase over the past decade. Are we causing this epidemic through our zealous use of statins? In large part I think the answer is yes. We are now in a position to witness the unfolding of the greatest medical tragedy of all time - never before in history has the medical establishment knowingly (Merck & Co., Inc. has two 1990 patents combining CoQ10 with statins to prevent CoQ10 depletion and attendant side effects) created a life threatening nutrient deficiency in millions of otherwise healthy people, only to then sit back with arrogance and horrific irresponsibility and watch to see what happens - as I see two to three new statin cardiomyopathies per week in my practice, I cannot help but view my once great profession with a mixture of sorrow and contempt.” Finally, I hope you find, as I did the following newsletters/medical information helpful:
http://www.vitacost.com/newsletter/newsletter.cfm?nl=189

http://www.vitacost.com/newsletter/newsletter.cfm?nl=234

http://www.vitacost.com/newsletter/newsletter.cfm?nl=370
-------------------------------------------------------------------------------------
U.S.A.
http://www.fda.gov/opacom/backgrounders/problem.html
CANADA
http://www.hc-sc.gc.ca/dhp-mps/alt_formats/hpfb-dgpsa/pdf/compli-conform/gui-44_consumer_complaint-plainte_consommateur-eng.pdf
Contact Name: Drug Compliance Verification and Investigation Unit
Tel: (613) 952-9906
Fax: (613) 954-0941
E-Mail: DCVIU_UVCEM@hc-sc.gc.ca

The first time I heard the word prednisone was late Dec 07 when I was hospitalized for severe pneumonia. I started off with a bad sinus infection that quickly advanced into pneumonia in a matter of a couple weeks. I tried 3 courses of antibiotics but I continued to get worse and got to the point where I was unable to breath on my own. Within a day of being at the hospital I felt like I was living in a dream world and from there I continued to get more stoned by the minute. I had no idea I was being pumped full of prednisone intravenously, along with my antibiotics. I was given a dose of 250 mgs daily, and obviously it was way too much for me. As I progressed into my dream world, I had a couple of “episodes” where I acted completely out of character, and got really paranoid and highly emotional. I pulled my IV out of my arm the one night and sat and watched the blood dripping from my hand, not really understanding where I was or what was going on. Later on I got really paranoid that the nursing staff was conspiring against me and talking about me behind my back (lol) , which I normally would not care about, but for some reason it made me really upset and I sobbed uncontrollably at times. I also tried to leave my room in intensive care a few times, as I was convinced that I was not supposed to be there and wanted to go home. My doctors were really freaked out so they gradually lowed my dose over the last few days I was in the hospital, even sent me for a CT scan of my brain in case I was going crazy. Prednisone is an extremely strong and evil drug – that is why I had the adverse reaction!! Not because I’m crazy! And one should never be given a drug like prednisone without their knowledge!! A few weeks after leaving the hospital I started going down hill again and the doctors realized that what I had was an immune disorder and not just pneumonia per se. After a few months of on again off again prednisone (never longer than a week at a time), I was put on a daily regiment (50 mgs) of it starting in May. Since then I have experienced all of the same side effects noted by everyone on here, weight gain, sleeplessness, anxiety, hair growth (the worst is on my face and fingers!!) dizziness, confusion, trembling hands, tooth aches, and the worst of all , big time MOON FACE! I feel like a complete freak most days. I am now tapering and am down to 10 mgs. So far I have seen no improvement in the side effects, accept now I have withdrawal side effects on top of everything - nausea, headaches, flu like symptoms and trouble breathing. I HATE this drug, even though I know it ultimately saved my life in the hospital and my kidneys – as I had complications caused by the autoimmune disorder. I see my doctor next week and I want off this drug completely. I am not sure the benefits out weigh the side effects to be honest. I want to feel normal again and be able to recognize my own face in the mirror  People should use extreme caution when using this drug and it should only be used to save people’s lives, not used for minor things like poison ivy. That is unconscionable!!!! Good luck to all who are on this drug.

Wow, that's all I can say. I started suffering with allergies pretty bad this March. Terrible headaches and ended up with two sinus infections. My doctor, after doing a sinus x-ray, sent me to an allergist who did a scratch test and a needle prick test with 28 shots. I am allergic to dust, dust mites, some trees and cats. He said that I should just do Mucinex and Nasonex. I've been noticing that my pulse rate is up and flutters. I wasn't sure what would cause that. I monitor my bp pretty regularly since having to get off of bp medicine due to a severe adverse reaction from that. I just assumed I was going to have to go back on bp med to control rapid pulse even thought the bp was in the normal range. This whole medicine thing is maddening. I am going to try and not take it tomorrow and see what happens. The weird thing is I use the Nasonex in the morning but the rapid pulse doesn't show up until the evening. Could Nasonex still be the cause??