Adverse reactions symptoms and conditions

Please be sure to read the article and contact or email the following individual: Heather Grzelka
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I have invited her to review the Medications.com site and contact any parent to discuss the negative side effects that their children have suffered. The word needs to get out about the living nightmare that some families have endured all due to the pediatricians that are not aware of the adverse reactions to Singulair and continue to prescribe this drug.

My wife has been ill and was recently diagnosed with a sinus infection, upper respiratory infection, and middle ear infection. She was prescribed Avelox, along with a combination of corticosteroids, a NSAID, and another medication.

Today was her third day, and LAST day of taking Avelox. The adverse reactions began yesterday when she began complaining of body aches and dry mouth. After waking this morning, she found that her entire neck was swollen, stiff, and sore to touch. We believed that this problem was probably glandular, caused by the sinus drainage, and we expected it to subside through the day.

As the day went on, she began to feel fatigued and the soreness continued to increase, escalating to tenderness and a physical pain response to touching her neck.

She took her third dose of Avelox at 9 p.m. and the reactions escalated from that point. Within an hour she felt her lips began to tingle with a numbing sensation, and believed that her tongue was swelling. She also began to feel the soreness and pain spread across her body, extending to her abdomen, arms, and legs.

Luckily, I have a significant amount of medical and emergency response training based on my career, and was previously a pharmacy technician. On top of that, I'm blessed with a father who is a DoctorPh. and has spent over 20 years in hospital pharmacy. I recognized the signs of these reactions and called my dad. We agreed that the Avelox was the problem and gave my wife 50mg of Benadryl.

It is now 1:40 a.m., and the effects are still ongoing, however they appear to be subsiding. In total, my wife experienced: muscle and joint pain, stiffness, numbness and tingling of the entire body, swelling of the tongue and neck, gastrointestinal pain, nausea, body chills including uncontrollable chattering of the teeth, an epidermal pain response to any physical stimulus (even the slightest touch), and also another reaction that I have not seen listed anywhere else -- her entire lyphatic system seems swollen and tender. You can actually feel the swollen nodes across her body (neck, arms, legs, etc.).

I am very thankful to have found this sight. I am sorry that so many people have experienced similar effects, however their stories have assisted me and my wife extremely. Our physicians office will definitely be receiving a complete and detailed account of the experience with this drug. Thank you again!

I've been taking Fosamax once a week for about 4 months. During that time what began-before taking Fosamax-as mild pain in my lower back-has gotten progressively worse. This is the only negative possible symptom I’ve experienced, but of late it has increased and spread to my hips. I decided to stop taking it today, and see if it makes any difference. If it does, I will post another reply here with details.

I think all reading these personal accounts should consider this: obviously many medical professionals see far more benefit than loss in the majority of users. My osteoporosis was only diagnosed via a bone scan 6 months ago. -2.5 The increased pain and worsening conditions in my back might in fact be much worse if I hadn’t started taking the Fosamax. One must beware of apophenia setting in with self diagnosis.

Most posting here already had serious medical needs to have Fosamax prescribed in the first place, given a small percentage of diagnostic errors. Most of the conditions I’ve seen described vary greatly, and without a serious study are purely antidotal. I suspect there are legitimate adverse reactions, but for now the percentage and severity remains a big unknown. There seem to be some activists here, so get a campaign going for publicly funded analysis of the now considerable amount of data on file.

If my back gets better, I’ll still be unsure as it might have been a delayed benefit from the drug. Likely I will take Fosamax again either way. If it doesn’t improve in several months I’ll assume F-max wasn’t the cause and begin taking it again. If it gets better, I will take F-max again to see if the problems return when I do. If they don’t I’ll keep taking it. If they do, that will red-line my ‘coincidence meter’ and I’ll never touch the stuff again.

I hope some will find my approach to our common dilemma helpful. We all have to be our own advocates within the modern health care cabal. I worry about the old adage that when we do so, we have a fool for a client. Feel free to criticize my reasoning, and thanks to all the others that took the time to share your experience. It helped me make my decision, and I’ll share the results in about 6 months.

I have had trouble with eczema/psoriasis for several years and it has spread to most of my body. Hands, arms, elbows, back, chest and stomach, hips, back-side of my thighs, knees, bottoms of my feet, scalp, inside my ears, forehead, what haven't I mentioned? So far, Prednisone is the only medication I can take that clears it up. Trouble is, the doc won't let me take it long enough to completely clear the rash before I'm tapered off. After reading some of the other posts, I've got to say that I've never noticed any adverse reaction. My appetite is up a little, but my energy level is also up and I burn off any extra calories. I sleep better (no itching) and for longer periods, wake feeling better, have a better outlook for the day and am ready to go. I'm a salesman, so my mental attitude is important, and my wife and family all agree that I'm less moody and in a generally better frame of mind while taking Prednisone. I've noticed no stomach or bowel distress except for being a little less regular than normal. But no constipation and no diarrhea. I'm 61 so a few muscular aches and pains and joint stiffness are to be expected, but I've noticed no unusual incidents. While I don't advocate taking large doses (define large doses???) for long periods, I've read that taking Prednisone on an every-other-day basis can be effective while greatly reducing the risk of side-effects. I think Prednisone has been a real "miracle drug" for me and just wish there was something as effective without the side-effects.

My mother is on Bactrim for a UTI. She has Alzheimer's disease, but can normally function pretty well. Two days after starting the three day treatment she got more confused and couldn't even figure out how to take her medication. Now she has leg pain, muscle weakness, and joint pain although I think it has helped the UTI.

I'm not a person that necessarily thinks the drug should be removed from the market because of what I've read here. We aren't reading posts from the thousands of people that it has helped without ill effects. All drugs potentially have side effects. There is always the potential for adverse reactions or allergic reactions. As a matter of fact, many people on this forum continued to take the medication when they were clearly having allergic reactions making themselves sicker in the process. We must be diligent and educate ourselves about medications and not just rely on someone else to tell us that it is fine. That being said, I feel for those on this board who have endured such suffering and hope that they recovered without incident.

I have had three kenalog shots: once when i was 15 to combat severe allergies, sinusitis, rhinitis, nasal polyps, and everything else that can go wrong in the nose. I also have moderate to severe persistent asthma. Yet after this shot i was cheerleading, running the mile and 800m in track, and running the 3mile in cross country. I had another shot almost 2 years ago after a severe asthma attack made me go to the hospital and yesterday i had another shot.
I have never had any adverse reactions to Kenalog (besides weight gain, same with prednisone) and i am sorry to hear that so many people have experienced terrible side effects. I have never had any mood swings, period problems, dissolving of my butt cheeks, joint pain, etc.
Kenalog keeps me alive and breathing.

i have been on warfarin since April 2008 when i had a clot in my left leg. since, i haven`t really had much going on until last week. i was rushed to the hospital by ambulance. i got dizzy and had a very cold wave rush up my body twice. when it was over, i couldn`t hear anything and my temples were tingling and my heart rate was elevated along with my bp. the er drs didn`t seem concerned with any thing that had to do with the dvt or the warfarin. their response???????? you drink too much coffee. WELL. i haven`t had a cup of coffee for almost a week, and have also quit smoking. i am still dizzy. my head feels heavy. i get little cool rushes that almost take my breath away, i don`t feel like ME. i feel like someone has taken over the me i knew. my family doctor has done liver, mono, hepatitis, b12, folic acid profiles, all negative. had a ct scan yesterday, normal. having an echocardiogram next week and having a holter monitor put on for 24 hrs to monitor my heart. i have done nothing but sleep since this episode. my husband is scared to death i`m gonna die during the night, he wakes up just to check on me. i haven`t been sleeping very well, as i`m afraid i`m not gonna wake up. i am only 40. i am not ready to let my life go to pot because of a drug that all the doctors insist is "safe". well i don`t know. call me stupid, but if its so safe, why do they kill rats with it????????????

I just wanted to be sure you all read the directions in the pamphlet that they give you when you get the IUD....here they are in case you forgot to read the fine print.

ADVERSE REACTIONS
The most serious adverse reactions associated with the use of
MIRENA are discussed above in the Warnings section. Others are
presented in the Precautions section. Other adverse events reported
by 5% or more subjects include:
Abdominal pain Upper respiratory infection
Leukorrhea Nausea
Headache Nervousness
Vaginitis Dysmenorrhea
Back pain Weight increase
Breast pain Skin disorder
Acne Decreased libido
Depression Abnormal Pap smear
Hypertension Sinusitis
Other reported adverse reactions occurring in less than 3% of
patients include: failed insertion, migraine, vomiting, anemia,
cervicitis, dyspareunia, hair loss, eczema.

I was diagnosed in April 2006 with congestive heart failure and End Stage renal Failure. Out of the blue! One month before I was diagnosed I began bruising severely, and just not feeling well overall. I have maintained uncontrollable hypertension for about 3-4 years now.

I have been on at least 15-20 different medications, not all at the same time, but in different combination. I have adverse reactions to everyone I have been on in some form or fashion. ie rashes,, sometimes in the form of blisters from my hands up to my elbows, severe deep itching, headache, nausea, vomiting or they simply do not work. The only medication that I have been on for the entire time without stopping, only changing the dosage is Clonidine.

I am very sensitive to a lot of chemical drugs, even the chemical form of folic acid!

I recently had a biopsy done on my kidney. I came back positive to chronic and acute inflammation, causing scarring of the kidney. Therefor causing my kidneys to shut down to about 7% activity. There is still some active inflammation. Could this be from the clonidine? Since it is the only thing that has been a constant for the past 4 years?

It has certainly raised a question in my mind.

I would encourage every patient on statins to read the recent article (Feb. 2008) by Dr. Peter Langsjoen, MD/Cardiologist: http://www.lef.org/magazine/mag2008/feb2008_Alleviating-Congestive-Heart-Failure-With-Coenzyme-Q10_01.htm

The following information from this article is pertinent to complaints of muscle pain/weakness and fatigue:

"All statin drugs block the biosynthesis of both cholesterol and CoQ10, which explains statins’ common side effects of fatigue, muscle pain and muscle weakness, and a worsening of heart failure. When CoQ10 levels are lowered by statin drug therapy, one of the first changes to occur is a weakening of heart muscle function, known as diastolic dysfunction. This has nothing to do with diastolic blood pressure, but rather represents impairment in the relaxing or filling phase of the cardiac cycle. After heart muscle contracts, it takes a great deal of cellular energy, or ATP, to re-establish the calcium gradients such that muscle fibers may relax. Thus, if diastolic dysfunction is severe, it can result in congestive heart failure. In 2004, a study published in the American Journal of Cardiology showed that diastolic dysfunction (heart muscle weakness) occurred in 70% of previously normal patients treated with 20 mg a day of Lipitor® for six months. This heart muscle dysfunction was reversible with supplemental CoQ10."

I hope this information will be of help to patients suffering adverse reactions from statins..

UNTIL READING DIFFERENT REACTIONS TO BACTRIM, I THOUGHT THAT I MAY POSSIBLY HAVE A BRAIN TUMOR. I STARTED BACTRIM FOR POSSIBLE STAPH INFECTION AFTER HAVING POISON IVY AND SOME SPIDER BITES. AFTER TWO DAYS ON BACTRIM, I DEVELOPED A LOW FEVER AND HAD DIFFICULTY SLEEPING ALSO HEADACHE. I STOPPED TAKING IT ABOUT HALFWAY THROUGH MY PRESCRIPTION AND DEVELOPED DOUBLE VISION FOR THE NEXT SIX DAYS OFF AND ON. THE WORST TWO DAYS FOR ABOUT FOUR HOURS STRAIGHT. I SAW A OPHTHALMOLOGIST WHO COULD FIND NOTHING WRONG WITH MY EYES AND SUGGESTED THAT MANY THINGS COULD CAUSE IT FROM MEDS TO A BRAIN TUMOR. I FEEL BETTER AFTER READING OTHER ADVERSE REACTIONS. I ALSO DEVELOPED HIVES ON BOTH THIGHS. NASTY MED.

My wife had Mirena inserted last year around May. Side effects were similar to those detailed here. Non-existent libido. Acne. Consistent with other's reports of joint pain, my wife experienced symptoms that were diagnosed and treated as Lyme disease. At the time we wondered how it could be Lyme disease when the doctor reported that several tests for Lyme disease came back negative. Now we wonder if the joint pain was actually the Mirena.

After reading the comments on this site, we had the Mirena removed in late May, despite a skeptical doctor. A week of uncomfortable heavy period, but not to bad. My wife's libido has returned, her face has cleared up, and I've gotten a vasectomy.

best wishes, Jim in VA

The following article in the WSJ may explain the reason for the significant number of Adverse Reactions to statin drugs.

Why You Can't Tell Where
Your Medication Was Made
April 8, 2008; Page D1- Wall Street Journal
Bananas come with those little stickers listing their country of origin. Why not pharmaceuticals?
That's what some consumers -- and even some physicians -- are asking since the Food and Drug Administration linked the deaths of 19 people to contaminated batches of the blood thinner heparin from China.
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I encourage every patient with a bad experience taking statins to contact the FDA (see, July 1, 2008 posting for FDA contact info).

The following article in the WSJ may explain the reason for the significant number of Adverse Reactions to statin drugs.

Why You Can't Tell Where
Your Medication Was Made
April 8, 2008; Page D1- Wall Street Journal
Bananas come with those little stickers listing their country of origin. Why not pharmaceuticals?
That's what some consumers -- and even some physicians -- are asking since the Food and Drug Administration linked the deaths of 19 people to contaminated batches of the blood thinner heparin from China.
******

I encourage every patient with a bad experience taking statins to contact the FDA (see, June 29, 2008 posting for FDA contact info).

Just had a bowl of cereal, took two lactaid chewables just before and about two spoonfuls into my cereal I was running to the bathroom with violent vomiting. I had been using lactaid for about a year and lately I had been feeling kinda nauseas when I used it but had not pinpointed to the reason. Until today I can now surely say it was the two lactaid tablets I took. The reaction was almost immediately and violent to say the least. Does any one know whats going on with this type of reaction after you have been taking it just fine for some months and then this reaction to the product?

I have read over a lot of the comments and I must say I am one of the few people who does not have many complaints. No acne, no difference is my sex drive, no headaches, no depression. I don't have much of a period anymore. But this is where my complaints start. Before Mirena, my period would come and go without much pain but since insertion, I have noticed more cramping during and two weeks prior. The cramping does include back pain. I have also noticed the first two days of my period I am exhausted. But other than, I have been pleased with Mirena. Just like any medicine, there are side effects and it varies from person to person.

Because of a “Global economy” - I suspect ingredients (even for Brand names) are coming from China or being manufactured in India with poor to non-existent quality control standards, and is the primary reason for the majority of Adverse Reactions to the Statins in general. Please take time to submit your complaint directly to the FDA, and hope they investigate and take action (see bottom of page for web sites to submit complaint).

My own recent experience with statins: After 3-weeks of being on generic Simvastatin 80mg for elevated LDL, I experienced significant fatigue, shortness of breath with tightness around my chest and a bout of Gout in my left foot. I would encourage patients/consumers to directly send their complaint to the web sites listed at the very bottom, if you are either a U.S. (FDA Form 3500) or Canadian resident. Also, if your physician is unresponsive to your negative experience with Statins (generic or Brand Name), inform him/her that you refuse to continue with this drug, and that you have sent an adverse reaction complaint to the FDA/Canadian equivalent. Provide both your doctor and pharmacy with a copy of the FDA Form 3500 if you’re a U.S. resident, so they know you're serious. Lastly, I'm back to feeling normal, after I "demanded" my physician switch me to generic Pravastatin 40mg (2 tabs a day - 80mg), manufactured by Teva Pharmaceutical - corporate HQ Israel with manufacturing facility in Pennsylvania. By the way, a 90-day supply of this quality-controlled drug is available at Walmart Pharmacy for $10. I hope this helps, especially seniors on a fixed income.

U.S.A.
http://www.fda.gov/opacom/backgrounders/problem.html

CANADA
http://www.hc-sc.gc.ca/dhp-mps/alt_formats/hpfb-dgpsa/pdf/compli-conform/gui-44_consumer_complaint-plainte_consommateur-eng.pdf
Contact Name: Drug Compliance Verification and Investigation Unit Tel: (613) 952-9906 Fax: (613) 954-0941 E-Mail: DCVIU_UVCEM@hc-sc.gc.ca

I agree Kenalog has a lot of adverse reactions, being a nurse myself, I suffer from pollen, ragweed, mold, dust mites I can go on and on, and have swollen eyes and wheeze/sob almost on a daily basis from asthma and allergies all yr around, am tired all the time ... I have a heart murmur so I cant take the fast acting inhalers, I also suffer from panic disorder, have 2 benign lung nodules on my left upper lung as of today, still in my 2 yr for the sit back and see if it grows follow up with cat scans every 6 month's, my 19 yr old son passed away from a brain bleed in 06, and am still working in nursing where I want to help out other's, it has changed my thought process to live life to the fullest , try not to dwell on the petty things in life, and yeah every single drug that helps us in one way or another has a side-effect, don't pitty me , just think about this , or at least this is how I get by, I sit and weigh my options, would i rather have sweaty palms, rapid heart rate, tired a lot of the time, mod joint pain, period irr and pit in my butt leg and foot cramps day and night a few, h/a's rather than to, sneeze 24/7, have nasty swollen eyes that burn and hurt to the point I cant see, or not be able to take in one deep breathe and feel like im breathing through a straw, yeah you may not like this post, but to all the people who do not have a whole lot of medical knowledge, I ask you to do your research, don't beg the lawyers to take it off the market, thats what I call petty in my case Kenalog is a godsend!.. have the smarts before you go in, after all they are just Dr's not GOD..we should all re-evaluate what is a priority in our lives, since the death of my son in 06 I have, but please note people , its not the Dr's faults , we need to know what we are taking and have all the info before we take it whether it be the internet, a PDR, they are free to read in the library as well in every doctor office just ask to see one (that might through them into shock making them think your having a part in your health as well), a local pharmacist, because lets face it this world is becoming a fast paced, whirlwind circus and in the end, we all just cant sit back and blame the busy Dr's. I will say one thing though, Kudos to all the Nurses in this world, if it were not for us, now where would the Dr's be :P ..so make the best out of life, we never know whats around the corner, but most of all remember EVERY single drug has a side-effect every one of them, we must realize that we have to take the good with the bad..been there still doing it... take chare of your life, be informed, or get the info, you can do everyone of you! Just food for thought.

I just started using Singulair a few days ago. I am 54 years old and just started coughing at night only. I would be fine during the day and then never failed, at night I started to cough keeping me awake. I was given antibiotics, narcotic cough syrups but it only helped temporarily and then I went back to coughing nights only again. So as I mentioned, I started taking Singulair a few days ago because my physician thinks I have developed allergies and Singulair is noted to help night coughs. It is helping my night coughs but I still cough a few times at night and now I cough quite a few times in the day when I never use to cough in the daytime. Wondering if Singulair is worth taking as the symptoms are becoming opposite? I hate taking drugs and don't know if I should find a safer alternative? Help, anyone? Thank you

I wrote the message below on March 9th, 2008, but I think it might be useful if I repeat it.

Please educate yourself.

Are you really sure that it`s high cholesterol that is causing heart disease?

All statins have similar side effects!!
_________________________

It`s very disturbing to read all these stories. I really feel for you.

My experience comes from seeing what happened to people close to me.

They all took statins.

I started to look for information on statins, and other medications in 2004 and it continues to this day although two of my relatives are dead.

I have nothing to do with the health or pharmaceutical industry.

I saw the suffering and it made me very angry.

I am an ordinary lady in her sixties who live in Sweden.

The situation is almost the same here as in the U.S.

There is very little discussion about risks/benefits with this kind of medicatications - or others.

I think it`s a good idea to turn to the Internet and books to get other views about the cholesterol issue.

Is it really true that it`s the cholesterol that is causing heart disease?

Are you sure?

Please visit:

*******

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Also search articles etc on "Stopped our statins" and on the names of the different authors below.

Also read:

The Cholesterol Myths (Uffe Ravnskov)

The Great Cholesterol Con (Antony Colpo)

Book with the same title (Malcolm Kendrick)

Overdosed America (John Abramson)

The Truth about the Drug Companies (Marcia Agnell)

Malignant Medical Myths (Joel M. Kauffman)

There are many more.

Please look on the Internet for more information about each book.

It´s good to have some other information than the one given by doctors because most of them have been "educated" by the pharmaceutical companies themselves - and why should they talk about risks, side effects etc. They are interested in profits.

Finally - here are some side effects that I have seen:

pains in legs, hands, elbows, shoulders, knees, hips, cracking noise in ribs, muscle weakness, loss of hair, head ache, burning, tingling sensations in hands and feet, numbness, difficulties to swallow, loss of taste, ringing noise in ears, cramps, insomnia, irritation, depression, difficulty with short-term memory and then advancing into more serious problems.

These side effects - for 3 different people - all over 65 - did not come at once.

All of them had taken statins for years (Zocor)

It doesn´t matter which product -all statins have similar side effects.

Search for "Stopped our statins" on Google. It´s a very informative site and under "print articles" there are som articles that you can take along to your doctor for discussion.

I particularly like the one from Weston Price Foundation
and explains the different statin studies and side effects. .

My relatives also had some other medications which makes it even easier for doctors (and patients) to say that it`s just old age.

I am happy for those who get problems right away because then there maybe a chance for the patient and the doctor to see that there is a connection.

You really have to look out for yourself and the people around you!

Good Luck.

My husband was hospitalized at Fl Hospital April 11 – 16, 2008. He had severe stomach pain to the point he became suicidal. We asked for a psychiatrist in the hospital. The doctor prescribed Mirtazapine along with Lexipro. After 6 days of being on this medicine and 2 days after he was released from the hospital he committed suicide by shooting himself with a 357 Magnum in the head. His 18 year old son found him in the bathroom almost dead. He never exhibited signs of suicide or depression in the past 26 years we were married. This medication can give you serious adverse reactions. Please do not take it! I will do everything I can to get it off the market! Two weeks before my husband was hospitalized he was racing his motorcycle at Jennings raceway with his son. This medication will alter your mind and impair your judgment! My husband passed away on April 19, 2008

Hello everyone. I have had my mirena in for 2 years now and have absolutely no desire for sex at all. I decided to google the Mirena side effects to see what I could find and this site came up. Let me tell you all your story sound just like mine, but the one symptom that I haven't seen is having symptoms similar to Lactose intolerance or Gluten intolerance. I did find this ****** website and it specifically states "Glucose Tolerance
Levonorgestrel may affect glucose tolerance, and the blood glucose concentration should be monitored in diabetic users of Mirena ." Now I am not a diabetic, but my family Dr. said that I had all the symptoms of being Glucose intolerant. I was tested and came out negative. Also all my symptoms increase the longer I go with out a period. I usually go 2 months without, as soon as I have it it is like my body come back to normal for a week.
Now my husband is all about permanent solutions, so I told him that I was ready for a more permanent birth control. snip snip. I am planning on having mine taken out this year. I just want my body back.

Oh this website that I have attached is the actual Official FDA information sheet that we don't get to see, but the doctor does. Make sure you read the adverse reactions. Here they are so if you don't get to the website.

Adverse Reactions
The most serious adverse reactions associated with the use of Mirena are discussed above in the Warnings section. Others are presented in the Precautions section. Other adverse events reported by 5% or more subjects include:

Abdominal pain Upper respiratory infection
Leukorrhea Nausea
Headache Nervousness
Vaginitis Dysmenorrhea
Back pain Weight increase
Breast pain Skin disorder
Acne Decreased libido
Depression Abnormal Pap smear
Hypertension Sinusitis

Other reported adverse reactions occurring in less than 3% of patients include: failed insertion, migraine, vomiting, anemia, cervicitis, dyspareunia, hair loss, eczema.

******

We have all been saying that our issues regard not being informed about all of the possible side effects. And, we know that Singulair works well for some people. Nobody wants to take a good drug away from those for which it probably performs miracles. People who have toxic side effects have a right to know up front.

My observations about montelukast's chemical structure are either general or not quite 100% correct or could be quite vague - so forgive me. I do not claim to be good at organic chemistry. But from doing a little work, I have come up with some observations.

1. It would seem to me that montelukast might work quite well for people who have developed mold category related asthma. I observed that chloroquinolin, a component of montelukast, is a good fungicide effective against Aspergillus, Alternaria, Cladosporium, Penicillium and Candida. Dust mites can only digest if helped by aspergillus so they go into the mold category. Molds produce millions of spores so anyone who lives in contact with mold would be chronically sick from their presence. Then people get hypersensitized to that.

I am probably wrong but I could imagine that montelukast is: 1) a ligand that binds to an empty cysLT1 receptor for a period of time 2) 7-chloroquinolin-2-yl which either acts intact or breaks down into a quinoline fungicide so that it kills the chronic mold/fungus infection and 3) a sulphur/methyl anti-inflammatory component that tells the t-cells that they are not needed so they will die. Wow, that would be great for mold asthma if it was completely non-toxic. It would be also great under controlled circumstances for many people who are mold-miserable. If I am wrong, I better go out into my garage and start inventing such a drug.

This is my visualization to try to explain the side effects of neurotoxicity. So adverse reactions could be to the quinoline component as an allergic reaction or dose related so that it just built up to a toxic level over time. There are many signs that t-cell populations are significantly reduced by montelukast. The fact that the Italians can do it in the test tube might be that it's a chemical component of montelukast designed to cause the t-cells to die.

Montelukast is a large molecule so Artie says it cannot penetrate the blood brain barrier. That would be an argument if nobody was complaining about neuro-psychiatric side effects. The neuro-psychiatric side effects are identical to quinoline and quinolones. When I read about Lariam, it just sounds like a more extreme version of Singulair side effects. Chloroquinolins were used before they invented Lariam, which is stronger. The malaria Plasmodiums became immune. Hallucinations, anxiety, depression, suicidal thoughts are completely consistent in all of the quinoline/quinolones. If montelukast breaks into sub-molecules then quinolines easily penetrate the blood brain barrier.

I find clinical evidence that montelukast may act as more than more molecule. And, that there is a rational for the existence of the chloroquinolin and evidence that it may be the source of toxicity.

I am glad to risk being called crazy. That is what the internet is for. We can present our ideas and discuss. So, just take this with a grain of salt. If I am close to the truth, this post will find it's proper home.

I believe that objective sources of information should be posted periodically so that they are not missed.

Adverse Reactions
(As reported in adults)
>10%: Central nervous system: Headache (18%)

1% to 10%:

Central nervous system: Dizziness (2%), fatigue (2%), fever (2%)

Dermatologic: Rash (2%)

Gastrointestinal: Dyspepsia (2%), dental pain (2%), gastroenteritis (2%), abdominal pain (3%)

Neuromuscular & skeletal: Weakness (2%)

Respiratory: Cough (3%), nasal congestion (2%), upper respiratory infection (2%)

Miscellaneous: Flu-like symptoms (4%), trauma (1%)

Postmarketing and/or case reports: Agitation, anaphylaxis, angioedema, arthralgia, bleeding tendency, bruising, cholestasis (rare), diarrhea, dream abnormalities, drowsiness, edema, eosinophilia, hallucinations, hepatic eosinophilic infiltration (rare), hepatitis, hypoesthesia, insomnia, irritability, muscle cramps, myalgia, nausea, palpitation, pancreatitis, paresthesia, pruritus, restlessness, seizure, urticaria, vasculitis, vomiting

http://www.umm.edu/altmed/drugs/montelukast-088375.htm