June 20th
2008
10:51 AM
This testimony should help strengthen our case for warnings for Singulair.
Neurologist Sought Warning for Pfizer Drug
By JEREMY SINGER-VINE
June 20, 2008; Page B10
A British neurologist who analyzed effects of the drug Neurontin told a court hearing Thursday that he advised its maker -- now a unit of Pfizer Inc. -- to include a warning on the drug's label for potential side effects of depression and aggression, but his advice wasn't followed.
The University of London neurologist, Michael R. Trimble, was testifying at a hearing to decide whether civil cases brought against Pfizer alleging suicides linked to Neurontin can proceed. The hearing was jointly held by judges for U.S. District Court in Boston and a New York state court who are hearing similar cases. In various lawsuits consolidated in the federal court, plaintiffs allege more than 100 suicides were connected to Neurontin usage.
Dr. Trimble described what he said was a "plausible biological pathway" that could lead from the compound gabapentin -- the chemical name for Neurontin -- to suicidal behavior, hostility, and aggression. Dr. Trimble said that in 1995 and 1996, he was hired to write two confidential reports for Parke-Davis -- now a unit of Pfizer -- because the company "was concerned about psychosis in relation to their drug." Dr. Trimble said he was unable to find a link to psychosis, but noted effects of depression and aggression.
Lawyers for Pfizer argued at the hearing that the evidence linking the drug to suicidal side effects wasn't scientifically sound. Under cross-examination, they challenged his description of a pathway as a patchwork of studies that didn't prove a biological connection. Neurontin and generic forms of gabapentin are approved for treating epileptic convulsions, but have also been prescribed widely "off label" for other conditions.
In five of nine patient cases he analyzed in 1996, Dr. Trimble said he saw depression and aggression in patients who had no previous symptoms of the side effects, so he said he recommended to the company that the drug "should carry some kind of warning" for susceptible patients.
Thursday's proceedings were the initial phase of a hearing requested by Pfizer to challenge the opinions of the plaintiffs' experts. Under cross-examination and a subsequent examination by the plaintiffs' attorney, Dr. Trimble said the biological pathway between Pfizer's Neurontin and suicidal events were plausible and supported by a series of peer-reviewed neurology research.
-- By concernedcitizen | Reply | (3) replies | Private Message me
July 26th
2004
8:49 AM
I have been taking 10 mg Paxil at night and 150 mg Wellbutrin daily for the past 6 months. I was still feeling a bit low energy wise and decided to ask my doctor to ratchet up the Wellbutrin to 300mg. He prescribed the XL formulation.
First day was fine. On the second day, I had a strong cappuccino for breakfast and two diet cokes (at lunch). Also had 3 shots of scotch at a dinner party. I woke up with severe diarrhea and nausea. For the next 3 days, I stopped all caffeine and alcohol intake but my digestive upset has not gone.
The symptoms are very similar to the Irritable Bowel Disorder I suffered for years before Paxil. Alternating diarrhea and Constipation with concommitant dyspepsia.
I am now seeing my doctor today to see what he thinks. I have a suspicion that Wellbutrin and Caffeine do not mix well. Almost a year ago when I first started Wellbutrin (300 mg) and drank 2 diet cokes, I felt very weird. I immediately cut the dose down to 150 mg. Maybe that is all my body can tolerate.
On the plus side, when I started Wellbutrin, I was feeling extremely low energy-wise and was sleeping a lot. At that time I was on 20 mg of Paxil. I have felt much better after adding 150 mg Wellbutrin and cutting the Paxil down to 10 mg.
My original problem was essentially chronic anxiety throughout childhood (a family condition) accompanied by a variety of psychosomatic illnesses like mild Psoriasis, back pain and IBD. I also had a mild stuttering problem that has now almost disappeared. Paxil has been responsible for alleviating all these conditions.
Unfortunately, as is well known Paxil is no panacea and it makes me very drowsy.
-- By sandy_gupte | Reply | Private Message me
July 3th
2008
10:17 PM
I am a 56 y/o female who started on Fosamax last Sunday. I have a dx of osteopenia. I followed the directions of taking pill with full glass of water and remained upright for 30 minutes before having anything to eat. I was fine on Sunday but on Monday I woke with SEVERE bone pain! My whole rib cage, back, knees and heels were hurting so bad. It felt like I had pain in every bone in my body. I could not take in a full deap breath as my rib cage was hurting so bad. I could not bend or turn without terrible pain. My energy level was zero. I immediately called my doctor who told me to hold the Fosamax (ya think?) and ordered Vit D lab levels. Apparently when you Vit D levels are off (don't know if too high or too low) you can suffer this bone pain. I am awaiting the results. The pain is better today and I was told it takes 5 days to get out of your system. I only wish I had done my homework and found this site before taking this poison. I have to say I'm a registered nurse and know that ALL medications have side effects and everyone responds to meds differently. Some side effects subside as your body gets use to it and some can experience severe allergic reactions. But it's important to weigh the risk vs the benefit. I would rather deal with osteopenia in another way. So my search begins for alternatives to Fosamax for good bone health. Has anyone had good results with other supplements/meds?
-- By ldyjanern | Reply | (2) replies | Private Message me