Allergic rhinitis symptoms and conditions

From the FDA's "Updated Information on Leukotriene Inhibitors: Montelukast (marketed as Singulair), Zafirlukast (marketed as Accolate), and Zileuton (marketed as Zyflo and Zyflo CR)"

6/12/2009

Neuropsychiatric events have been reported in some patients taking montelukast (Singulair), zafirlukast (Accolate), and zileuton (Zyflo and Zyflo CR). FDA has requested that manufacturers include a precaution in the drug prescribing information (drug labeling).

Montelukast is used to treat asthma, and the symptoms of allergic rhinitis (sneezing, stuffy nose, runny nose, itching of the nose), and to prevent exercise-induced asthma. Zafirlukast and zileuton are used to treat asthma.

The reported neuropsychiatric events include postmarket cases of agitation, aggression, anxiousness, dream abnormalities and hallucinations, depression, insomnia, irritability, restlessness, suicidal thinking and behavior (including suicide), and tremor.

This information reflects FDA’s current analysis of available data concerning this drug.

Advice to patients and healthcare professionals:

Patients and healthcare professionals should be aware of the potential for neuropsychiatric events with these medications.

Patients should talk with their healthcare providers if these events occur.

Healthcare professionals should consider discontinuing these medications if patients develop neuropsychiatric symptoms.

Background

In April 2009, FDA completed its review of neuropsychiatric events, (mood and behavioral changes) possibly related to drugs that act through the leukotriene pathway (montelukast, zafirlukast, zileuton). As part of its review, FDA reviewed post-marketing reports and also requested that manufacturers submit all available clinical trial data for these products.

The post-market reports of patients on these medications included cases of neuropsychiatric events. Some reports included clinical details consistent with a drug-induced effect. In the clinical trial data submitted by manufacturers, neuropsychiatric events were not commonly observed. However, the available data were limited because the trials were not designed to look for neuropsychiatric events. Sleep disorders (primarily insomnia) were reported more frequently with all three products compared to placebo.

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The studies published to date demonstrate that leukotriene receptor antagonists are sometimes more effective than placebo, are no more effective than nonsedating antihistamines, and are less effective than intranasal corticosteroids in the treatment of allergic rhinitis. The combination of a leukotriene receptor antagonist and an antihistamine has not been proven to be more effective than either agent alone. This review reveals several inconsistencies that require resolution. First, whereas leukotriene receptor antagonists are predicted on the basis of their mechanism of action to improve nasal congestion significantly, clinical studies reveal leukotriene receptor antagonists to be no better than antihistamines at improving congestion. Second, leukotriene receptor antagonists would not be expected on the basis of their putative mechanism of action or nasal challenge data to improve significantly sneezing, nasal itching, or drainage. However, some studies show improvement in these symptoms during treatment with leukotriene receptor antagonists. Considered in aggregate, the data available to date do not clearly support a unique role of leukotriene receptor antagonists in the treatment of allergic rhinitis whether or not it is accompanied by asthma.

I'd like to hear more clarification from the FDA and Merck on the following media statements:
"Merck believes that the data support the continued use of Singulair in appropriate patients with asthma and allergic rhinitis.”
But, the agency also noted that the trials were not designed to examine such behavior, and that the safety review will continue, probably for several more months."
If the trials were not designed to examine psychiatric events what good is the data and why would it take 9 months to rehash submitted data that does not contain appropriate information?
Another statement that needs clarification is, "Merck believes that the data support the continued use of Singulair in appropriate patients with asthma and allergic rhinitis.”
Why such careful wording as "appropriate patients"? That is to suggest that Singulair is "inappropriate" for some, perhaps many people.
Lastly, "We have finished our analyses of all the data the companies submitted," FDA spokeswoman Karen Riley told the Associated Press. "But that doesn't mean we have closed the book on suicidality."
My questions are were there any unsubmitted data and why would they leave the book open unless there were a legitimate reason to?
This is definitely not over and as well it should not be.

I am 34 years old. I am a pharmacy tech. I have asthma and allergies. I have taken singulair pretty much every day since it came out on the market. I've had asthma since i was about 10 years old. I took theophylline as a kid. Steriods on and off especially during times when my allergies are bad. I still use Advair during the fall and spring. Every drug has a side effect. However breathing is pretty good damn thing. Do I have days when I feel low? Yeah. Do I sometimes have nightmares? Yup. Are "natural" products the answer. Not always. The fish oil that some of the posters are touting can also cause GI problems. Some of the natural products contain herbs and other plant derivatives that can be harmful for a child that suffers from allergies. Not proactively treating asthma can be deadly. Some of the parents are suggesting steriods as the answer - those can cause weight gain, growth suppression and can lead to a worsening of asthma.

Singulair has never made me feel like I've wanted to kill myself. I was more depressed and angry as kid when my asthma did not allow me to partipate in normal childhood things. I was sad and hated life when I couldn't keep up with friends at recces because I was having trouble breathing. You have to outweigh the costs with the benefits. I am more irritable when I have asthma flareup then I am on a normal day. For me, I choose to breathe. And singulair has been helping me for almost a decade.

I'm not saying the medication isn't causing these symptoms but maybe there is an underlying cause to your child's depression.

Any drug has a side effect. But without medical research and the medications that come with them - people would still be dying of simple diseases and we wouldn't have vaccinations. As a society, as a whole, we are a culture that looks to someone else to fix things and then blames the people who try to fix it. We need to stop being the "hot McDonald's coffee'" society.

I have an 8y.o. daughter that has been on Singulair for about 3 years now. Since she started taking singulair she has been absolutely miserable! She cries at everything, is very moody, has leg pains, wont leave my side and is tired ALL the time. She has circle under her eyes, she looks like she hasn't slept a wink in days! She has been off her Singulair for about 5 days now and she is a totally different person. She has been "happy-go-lucky" and full of herself, she has even woke up happy (which hasn't happened in I dont know how long). She was put on Singulair by our Doctor b/c she had Pnemonia two times in a row. She has Allergies and Asthma and for the past 3 years has been on: Singulair (4mg), albuterol, flovent, Zyrtec, and Flonase. That is just too much for a little girl to be on. She hardly eats at all, gets headaches. I just see such a difference when she is not on it but, what will she take in place of this? My husband also takes Singulair (he is miserable all the time), he doesnt sleep at night and is always tired. Anyone have alternative to this drug?

I am a pediatrician and my and I take care of my one year granddaughter is with allergic rhinitis and bronchial asthma. In her past history other than her usual problems she developed an episode of ketotic hypoglycemia after a viral syndrome.
I started her in Singular as she was having nocturnal episodes of cough in spite of having Pulmicort twice daily. As soon as she was started in Singulair she developed restless episodes of irritability. She never behaved that way before. She is now sleeping well all night after she had discontinued Singular.

What you will not hear elsewhere: Though Singulair is likely safe, it is ridiculously over prescribed. Singulair is indicated for the treatment of allergies and asthma. For allergies, It has not been shown to be more effective than Claritin (which is now generic and over-the-counter). In fact, when Merck-Schering were trying to add Singulair to Claritin, they found it no more effective than Claritin alone (sound familiar?). In this case, they decided not to manufacture this new pill. The most effective agents for allergic rhinitis are inhaled nasal corticosteroids. Flonase is now available as generic fluticasone, and is much more effective then Singulair (which is not generic), Claritin or the combination of the two. Regarding asthma, the updated 2007 NIH guidelines recommend inhaled corticosteroids for asthmatics of all ages. The data is overwhelming, clear and convincing. Singulair, which has much less of an effect is considered alternative therapy by the NIH. Yet, Singulair remains one of the most commonly prescribed drugs for asthma.

PRAISE GOD for all of the stories shared on this site. And I've only read page one. My husband called me back today to say that he "googled" Singulair and found some interesting things (to say the least). While we were on the phone, my three-year-old was in the throes of another meltdown, kicking me, hitting me, throwing whatever he could get his hands on. My older two boys, 8 and 12, were ordered, once again, to lock themselves in their rooms to avoid being hurt by him. He will throw stuff, bite, hit, kick, and, at times, spit on us. This disturbing behavior is rather constant lately. He is like a mad man. Very scary.

Caleb has been on Singulair since about age 1, when he was diagnosed with chronic sinusitis and allergic rhinitis. Unfortunately, we initially equated his rages with the onset of "terrible two's" and dismissed his behavior to a chorus of "oh, he's just a boy!" My husband felt, at times, that I was just not disciplining him properly. I intuitively knew, having raised two other boys, that this behavior was abnormal, even for severe tantrums. We received a variety of suggestions from his pediatrician, caregivers, and grandparents, all to no avail. We have several calm days but things always deteriorate back to insanity. He is VERY unpredictable.

Last Thanksgiving, Caleb (age 3) was kicked out of his daycare setting for biting and hitting. Once I witnessed him run as fast as he could into a group of playing children, falling on them, kicking them. He would walk up to sweet little girls half his size and push them down as hard as he could. It was a nightmare. My husband had to take 3 weeks of leave to stay home with him while we prayed and searched for new care. We had him evaluated and he was staffed into the "developmentally delayed" program in our school district (for poor adaptive skills and personal/social behaviors). We recently had his tonsils removed, hoping that some of the sinusitis symptoms and behaviors would improve. They really haven't. This past week we have been looking into the Feingold diet. We have been PRAYING for answers. The last time we spoke with his developmental neurologist, he recommended a trial of Risperdol (sp?). We feel like more meds would be like a band-aid, not a solution. But his rage is becoming unbearable.

So, that brings us to today. I was so moved by your accounts. Unlike so many of you, we don't have much of a "before" to go by. But his "after" sounds VERY much like what you have all described. It's probably the pure rage that I see on his face that is the scariest part. And at the same time he seems desperate and vulnerable. He truly seems to snap. If we had pool chairs, I can just picture him throwing them (citing another post :).

We are going to throw the Singulair away. He will never, ever have it again. Even if this isn't the cause of his problems, I certainly don't want to exacerbate any behaviors with this toxic medicine. I will post again just to let anyone who's interested know if this changes his behavior. I am praying that my entry will help someone else, just as all the other postings have helped me. I have renewed hope.

I have copied many of your comments to a Word document. I will be sharing it with a high ranking officer at the medical clinic/hospital on Keesler Air Force Base. I hope that he will discuss this with his staff and that perhaps we can at least make a difference here. I, too, will be filing a report with the FDA. I can only pray that this medicine has not permanently altered his developing brain.

Here is the best example of what is wrong with our medical system. Look what the Italian doctors do when a patient developed a skin rash after taking Singulair. It seems like they have a procedure to follow. If the case then meets the standards for a drug reaction, they write about it so that others will know. If you look at examples on this board, if somebody gets a skin rash from Singulair the doctor gives them prednisone because they never heard of adverse reactions to Singulair.

1: Ann Pharmacother. 2004 Jun;38(6):999-1001. Epub 2004 Apr 27. Links
Montelukast-induced generalized urticaria.Minciullo PL, Saija A, Bonanno D, Ferlazzo E, Gangemi S.
Department of Human Pathology, Division and School of Allergy and Clinical Immunology, University of Messina, 98123 Messina, Italy.

OBJECTIVE: To report a case of generalized urticaria induced by montelukast treatment. CASE SUMMARY: A 28-year-old man with allergic rhinitis and moderate persistent asthma developed generalized urticaria 5 days after the initiation of montelukast and inhaled fluticasone. Symptoms disappeared within one day after suspension of both drugs. Two months later, after the resumption of montelukast and fluticasone, the patient developed generalized urticaria and eyelid angioedema, which were successfully treated with intravenous betamethasone, achieving complete remission within hours. After 2 days, the patient resumed inhaled fluticasone only and continued this therapy for several months without any adverse reaction. DISCUSSION: We attributed the adverse reaction to montelukast because of the temporal relationship between use of montelukast and urticaria, the absence of other identified causative factors and other explanations for allergic reactions, and the positive dechallenge and rechallenge. The Naranjo probability scale showed a probable relationship between skin manifestations and montelukast treatment. CONCLUSIONS: The use of antileukotrienes is increasing in asthma therapy. In cases of generalized urticaria in asthmatic patients undergoing montelukast therapy, physicians should be aware of a potential adverse reaction to this drug.

PMID: 15113985

FYI: Go to

http://www.drugs.com/fda/singulair-montelukast-12368.html

Singulair (montelukast)
March 27, 2008
Audience: Pulmonologists, respiratory therapists, other healthcare professionals, patients
FDA informed healthcare professionals and patients of the Agency's investigation of the possible association between the use of Singulair and behavior/mood changes, suicidality (suicidal thinking and behavior) and suicide. Singulair is a leukotriene receptor antagonist used to treat asthma and the symptoms of allergic rhinitis, and to prevent exercise-induced asthma. Patients should not stop taking Singulair before talking to their doctor if they have questions about the new information. Healthcare professionals and caregivers should monitor patients taking Singulair for suicidality (suicidal thinking and behavior) and changes in behavior and mood.

This early communication is in keeping with FDA’s commitment to inform the public about its ongoing safety reviews of drugs. Due to the complexity of the analyzes, FDA anticipates that it may take up to 9 months to complete the ongoing evaluations. As soon as this review is complete, FDA will communicate the conclusions and recommendations to the public.

Latest FDA MedWatch Alerts...

Our son started taking Singulair when he was 2 for severe allergic rhinitis and cough variant asthma (in addition to Zyrtec, which didn’t control all of his symptoms). He is 5 now. For the last three years, he has been an increasingly violent, difficult, defiant, argumentative, volatile child who has intense mood swings--one minute he’s laughing uncontrollably, the next he’s weeping over nothing. His doctor and therapist recommended that we see a psychiatrist to have him evaluated for bipolar disorder, which used to be unknown in children. Because he has such chronic sleep problems, the doctor also suggested we take him off Singulair (and increase his Zyrtec dose) to see if it improved his sleep issues. Within a week, he was sleeping much better and was a calmer, happier, gentler boy. He suddenly could take “no” for an answer without flipping out and trying to hurt me. We thought that we were just in an unusual, calm window that would shift either to mania or intense sadness or both, any minute. We also thought that his behavior change might be due to sleeping better. We were enjoying the rare reprieve. Over the last weekend, his springtime allergies really flared up. We gave him Singulair on Monday and by noon, he was completely out of control. I had to strap him into his car seat at one point to keep him from hurting either me or himself. It finally occurred to me that Singulair might be causing his “bipolar” disorder. Of course, we stopped the Singulair. After two days he was a new boy. Yesterday, I Googled “Singulair bipolar children” and got a few hits. I am stunned to read how similar other families’ experiences have been to ours and I feel sick that we gave this drug to our child for three years.

I just visited Merck's Singulair website and spent a long time really, really thinking about everything that they had for physicians. After thinking about the pathways for myself from the standpoint of chemical interactions, I wanted to know what was explained to the physician. I approached the site from the standpoint of -- if one of my patients was overdosing, how could I recognize that. What would happen? Merck's site has diagrams and movies on the nasal passages and the lungs. You get a picture of a mast cell producing-- doing it's thing. That was it. And on every page, this...

SINGULAIR is indicated for relief of symptoms of allergic rhinitis (seasonal allergic rhinitis in adults and children aged 2 years and older and perennial allergic rhinitis in adults and children aged 6 months and older).

In clinical trials, SINGULAIR was generally well tolerated, with a safety profile similar to that of placebo. Adverse events varied by age. The most commonly reported adverse events, occurring at a frequency of ≥1% and at an incidence greater than placebo, regardless of causality assessment, were sinusitis, upper respiratory infection, sinus headache, cough, epistaxis, headache, otitis media, pharyngitis, and increased ALT.

SINGULAIR is contraindicated in patients with hypersensitivity to any component of this product.

Okay, let's talk about headache at greater than 1%. Headache is 18-19%. How do I know that from what they put on their website?

It might be a very good question to ask your doctor if they could go to the Singulair website and be able to know what would happen if they had a group of children or adults that liked to take pills. Yum, one of good, more is better. I had no clue from that website if there was a risk of overdose or not.

This is not my area. I am trying to help. I am essentially as in the dark as you are.

New FDA Warning:

FDA informed health care professionals and patients of the Agency's investigation of the possible association between the use of Singulair and behavior/mood changes, suicidally (suicidal thinking and behavior) and suicide. Singulair is a leukotriene receptor antagonist used to treat asthma and the symptoms of allergic rhinitis, and to prevent exercise-induced asthma. Patients should not stop taking Singulair before talking to their doctor if they have questions about the new information. Healthcare professionals and caregivers should monitor patients taking Singulair for suicidally (suicidal thinking and behavior) and changes in behavior and mood.
This early communication is in keeping with FDA’s commitment to inform the public about its ongoing safety reviews of drugs. Due to the complexity of the analyzes, FDA anticipates that it may take up to 9 months to complete the ongoing evaluations. As soon as this review is complete, FDA will communicate the conclusions and recommendations to the public.

Read the complete 2008 MedWatch Safety Summary, including a link to the FDA Early Communication About An Ongoing Safety Review regarding this issue at: http://www.fda.gov/medwatch/safety/2008/safety08.htm#Singulair

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My daughter was put on Nasonex last year for mild fall allergies, which had just been diagnosed. She ended up with heart palpitations, shortness of breath, anxiousness and night terrors. Once I finally made the connection with Nasonex , after three weeks, we had her stop using it and she was fine. During that time she hardly slept was afraid to play soccer because of the heart palps and ended up having a heart ultrasound because our doctor was so concerned. We since use an over the counter med on bad allergy days and she uses an over the counter menthol inhaler during soccer games. For us these alternatives help enough to make up for the bad side effects of Nasonex. By the way, our doctor doesn't agree, we came up with alternatives by talking to other parents. My doctor still keeps asking if we need a refill even though I've insisted she will never take it again.

My six year old daughter started taking Singulair for winter allergies about 1 year ago. After a couple of months she woke up seeing floating bubbles. These were very real hallucinations. We were back and forth with specialists for about 6 months. After she was taken off of the Singulair in the spring, the hallucinations gradually went away. We did not notice the connection. She has been back on the Singulair for one week, and last night she woke up seeing ants crawling on the bed and on her. I am stopping the medication and contacting the doctor. I would really like to know if anyone else has had similar problems.

My son is six years old and been on Singulair for 2 weeks, on the 3rd day he started complaining of stomach pain. That night he had a horrible nightmare and everyday since it has been something else it seems to get worse everyday. Sleepwalking uncontrollable rage that we have never seen before. He gets out of breath very easy and his comprehention is very bad since he has takin this drug. He is on day two of no Singulair and is still having trouble sleeping but the other effects are slowly ending thank god any parents thinking of this treatment for their child needs to do more research my doctor did not think it was the meds that it is just a normal child stage he is going through. (bull-h--t).

I read the email from the woman who had taken Allegra for 5 years and her doctor put her on Singulair. To her I am addressing this, and to anyone else interested. Also to the woman who started kicking stuff out of her way, and tried to move away from herself.

I am Ginger, and I am 58, a retired babysitting granny, and love it. I have allergic rhinitis, and have had frequent sinus infections the last 5 months, even using Nasonex and Astelin and Allegra. My doctor, whom I love and respect, suggested he put me on Singulair and it did help, I was having a drainage so salty it was choking me and at night when I lay down, I would wake up all night with thick mucus choking me. The Singulair did thin the music and I got over the sinus thing with a Z-pack.

I took the Singulair for about 4 weeks, and I ran out and called my doctor last week, and got samples for a few weeks. I am super sensitive to medications, and Vytorin gave me chemically induced hepatitis, which went away when I stopped taking it, and I can't take Calcium, strong antibiotics, anything hardly at all. So I was glad I could take the Singulair.

Okay, I began to notice I had no patience with my husband who is a bad diabetic and in stage 3 of kidney failure. I realized I had known for several years that my husband has anemia from kidney failure, and his blood sugar bottoms out and I call 9-1-1 several times a year when he goes out on me. He is my best friend and my husband of nearly 22 years. When he forgot something and was talking, I would just clam up and make him ask me to tell him, or not tell him. If he got a little short, I used to walk away and not say anything. BUT lately, like the last month, it has gotten worse, to the point we argue over stuff that should never be argued over. It is because I will not let it go, like I used to, because I have no patience.

Okay, I went to internet side effects, and yes, I have been having trouble sleeping, trouble waking up at night and laying there, been on WW and in 4 weeks only lost 6 pounds. I noticed I had some of most of the side effects. I also have had fibromyalgia diagnosed in 1988, so I don't need any more muscle aches.

Okay, I thought the Allegra did not help, so my brother gets the generic CLaratin 300 for $16 at Sam's Wholesale, and I had him get me a bottle, and GOODBYE TO SINGULAIR AND ALLEGRA.

The side effects slipped up on me so subtly it took a while to realize I really did not hate the person driving slow in front of me, and I did not really hate to answer the phone, etc. No More Singulair for me!!! Ginger

I have received kenalog injections (only one) per year during allergy season for severe allergic rhinitis. I was recently out of town and was miserable and tha local ER would not give me the injection. The reason was beacause it can cause avascular necrosis especially involving the head of the femur. Which means it can slow down the blood supply to
the top of the femur and cause the bone to die. I had never heard of this before and I will probably still take this injection as planned when I get back to town.

I was on Advair for almost three weeks. Within the first few days, I thought it was helping. Then I started having really bad problems with acid reflux, throat irritation/hoarseness, a dry cough, need for nearly constant throat clearing, and tightness in the throat. It also seemed like the Advair was getting less effective in helping my breathing. I ended up going to a asthma specialist. In addition to asthma, I found out I may also have this other condition called Vocal Cord Dysfunction (VCD). VCD is commonly mistaken for asthma as the symptoms and triggers are very similar. Also, there is a fairly high rate of co-occurance with asthma and some literature even suggests having asthma predisposes one for developing VCD (having GERD and allergic rhinitis also appear to be triggers). In one study, 56% of individuals with "severe" asthma were found to also have this condition. Another 10% were found to not even have asthma. The point in talking about all this is that I think in my case taking Advair significantly exacerbated my symptoms of VCD. M y doctor's response was to put me on prednisone when the Advair didn't work. It seems like lots of people posted concerns about similar side effects to mine and some even noted they were having more trouble breathing. They might want to look into this condition. Here's a link: www.cantbreathesuspectvcd.com

I have used flonase for several years now. It is apparent to me that I have lost my sense of smell. I know that Zicam is being sued for a side effect that causes the loss of sense of smell. Has anyone else experienced this with Flonase?

I started taking Singulair in January for Allergic Rhinitis and asthma - 3/4 weeks after taking this medication I started getting severe pins and needles and cramp in both arms during the night, spent 4 weeks sat up in bed trying to sleep, most nights only getting about 4 hours. Couldn't understand what was happening to me never had these problems before. Looked at side effects of this medication, spoke to GP and stopped taking Singulair and amazing good nights sleep returned.

I have had a 60mg Kenalog shot in the hip every 5-6 months for ~10 years for allergic rhinitis and bad polyps. I had had 2 painful surgeries for the polyps (and in any case they came back within months). The Kenalog is the ONLY thing that restores breathing and sense of smell. The effect lasts ~ 3-4 months so I always have an uncomfortable period before my next shot. I am taking Rhinocort 1x day to try to extend this time but I'm not sure it helps.Kenalog side effects? I have one large divot in my butt at injection site from 5 years ago (fat necrosis they called it) so I will not be a thong suit model any time soon. None other that I can identify. My vision has deteriorated but the opthamologist says it is normal aging. I'd LOVE to have a more benign remedy. Xolair?

I have been on Advair 100/50 for over 2-1/2 years and it's the best thing I've ever taken. It increased my lung capacity 33.5% and I do not wake up at night with asthma attacks. I don't have to depend on my Albuterol for rescue all the time either. I took Azmacourt 4 times a day prior and constantly had shortness of breath and asthma issues. I've been very fortunate on Advair! I have not had insomnia, difficulty sleeping, no musle weakness, no heartburn, and no rashes. I have had slight weight gain, and managed to get it off. I have constant allergies and allergic rhinitis so I do get occasional headaches. I can actually take a deep breath and not cough my head off. I can actually run and workout now! I do get dry mouth but that's easy enough to deal overcome. I may be an exception but it's a blessing for me! I take Allegra too and it is the best thing I've taken too. Seldane is better but they took it off the market. So I guess it works for some! Thanks.

I have been taking Singulair for about 2 weeks for severe allergies. Right away all of my symtoms completely disappeared and I thought I discovered a miracle drug. I have chronic allergic rhinitis along with some drug allergies-so since Singulair was taking care of all my symtoms, I decided not to take any antihistimines or decongestants. I am still using the cortisone nasal spray.

I can truthfully say I feel somewhat depressed. I even asked the doctors assistant about it, and she was going to look into it. I feel like I don't want to do anything which is totally unlike me. Everything is a chore and I have to force myself to do my daily work. I have not had any nightmares but I can also attest to the crabbiness. It's strange - I snap at the littlest things. Also I have the tightness in my chest (daily) and wondered if it was related. Just yesterday I noticed a very strange twinge in the muscle in my thigh. It hurts everytime I walk which I have never experienced before.

After reading all of your posts - I think I'm ditching the Singulair and going back to my Chlortrimeton and deal with my headaches. I feel like I can deal with the headaches better than this other nonsense....since the allergies have been a chronic problem most of my adult life. I have never felt like this before and have no reason to.