Amino acids symptoms and conditions

I will be on prednisone for the rest of my life so my Pulmonologist says. I have an auto-immune disorder called allergic broncho pulmonary aspergillosis. I thought I was alone until I read all your messages when it comes to leg, and joint pain. My doctor acts as if I am crazy, and that it is not a side effect of the medication I am taking. It has gotten worse the longer I have been on the drug. I rarely sleep, and I have an appointment with him tomorrow. If anyone can suggest something that helped them I would love to hear it. I have tried everything, and the only relief is when I take pain medicine which I do not want to be on forever.

Just read posts. Will think how to make experience better.

I have taken my three doses within two days, as prescribed so far.
(100mg twice a day).
I may just take one dose today to give my system a reprieve and then think I will stock up on things to help, and go again and try to do the week prescribed.
I AM NOT A DR. so don't take what I Say, as Your authority...but remember that doctors are "practicing" experts at their work" and drug companies like money. Some prescriptions save lives, and others, well...one needs to research and work with or change the method or part of the method. I go herbal whenever possible and hardly take any medications.

My adverse symptoms during this prescription are: Feeling a bit depressed anxious, and withdrawn, almost toward paranoid, Almost. But still ok,"riding the rim" so to speak.
1. "I have heard"... alpha lipoic acid crosses blood brain barrier so that ought to help with brain talking to itself re:
low heavy mood.
Also amino acids, thanks for that too!
2. WATER.
3. Exercise.
4. I think nettle tea as general tonic:
(must boil first for 25 minutes for fresh nettles)
5. I'll get some dandelion root if I don't have milk thistle on hand, or maybe even if I do!
6. I know Omega 3's help with mood
and more so I hope that won't interfere
(does it have minerals???),
I will likely take it anyway between pills.
7. Stay out of sun for now.
8. Vitamin D3.
9. Eat good size meal first.
10. Some Vit. C seems good and also B Vit for stress.
11. Rescue Remedy is a Bach flower remedy for stress. Take as directed, but AGAIN, go slowly if you are listening here, as EVERYONE is different.I take no responsibility for how these things
may effect YOU...but i hope it helps.
One needs to think and trust...
"How do I really feel?" and do the research and look for YOUR options. What works for one doesn't always work for another. I am going to think: what is an immune booster and what is a mood stabilizer, with foods and vitamins, and see if I can keep the prescription going for the week. Coffee~caffeine causes me anxiety. But Turkey has tryptophan in it, that calms.
This is how I NEED,
to THINK...very carefully.
Will call Dr. NOW and let him know what's up for me, and meanwhile, I will try to manage it from info I can muster.
Will see...I don't know outcomes yet, but I do feel, depressed right now.
Stay alert, be gentle and pampering where possible, with my day, calming music, meditate on PEACE...call a friend for temporary support, and do my best.
Here I go....water, big meal, pay attn. to what I need.
CHANGE prescription if too hard!
But...try this way first.
Some people generally absorb meds well and some don't.

I had been treated with Depakote, Lamictal, Lithium, Fluoxetine and more (I do not even remember all of them...).
I have been depressed most of my adult life I guess.
My depression caused me to destroy many relationships, loose friends, making me unable to build a carrier and ruining my marriage too. Wasting years of my life feeling always an unworthy mistake. I have had many suicidal thoughts too.
Then this past August I started to loose A LOT of weight, suddenly and for no apparent reason... I would also be so terribly tired and unreasonably nervous (but you know...being a dark depressed looser... that was usual and "normal"), feeling week and exhausted. Being summer and having always had low blood pressure I did not pay too much attention to all that until I did by chance some blood tests...
I AM HAVING BIG TIME THYROID PROBLEMS!
...I am not crazy! My depression had an actual physiological problem and I have been always treated with medicines that would actually make the thyroid gland worse!
I hated Depakote, it made me sick even while I was sleeping, waking up dizzy and nauseous! And I hated all the rest!! These medicines poisoned my liver, my memory and intelligence!
Check this out... to any of you that my have a thyroid problem instead:
*******
That's my experience and I hope it might help you. If it doesn't... good luck. I do understand the pain of being ALWAYS "under the weather"....
(PS. You'd might like to look at this too if you do not already know M. T.... IT DOES HELP! ****** )

I have been on Depakote 1000mg x2 daily for 2 months now. I am experiencing really itchy skin so bad i can break the skin.Also my appetite has increases loads and i'm tired a lot of the time.
I take it for personality disorder and i think i have noticed a slight change in my moods, i'm more stable and not so impulsive and don't feel the need to self harm so much.

I recently lost about 25 lbs and decided after about 8 years of 10 mg of lipitor, to go off of it, cold turkey. I consulted both my MD and my pharmacist about whether or not I should wean, and both declined.

I now feel that my sweats, hot flashes are out of control. I am so hot and tired. I feel as though I cannot do the daily functions that I am responsible for.

I truly had NO side effects that I know of ON the drug. I just figured I'd see how I do now that I lost some weight. I wonder if going OFF lipitor is dangerous?

If anyone knows, please reply!

Thank you!

I was on Lipitor for less than a week 2 years ago and the muscle pains were so bad that moving my head was painful. I called the doctor's office and was instructed to stop taking the medication; which I did and felt 'back to normal' within a few days. I haven't had my cholesterol checked since that time, or if I did before surgery, no one mentioned anything negative about it. However 6 weeks ago I had a heart attack. Apparently my cholesterol was twice what it should it have been, and my potassium was incredibly low. So I'm now on Lipitor (standard procedure after having a heart attack and high cholesterol seen as the cause of it) to ensure that another blockage does not occur.

The only problem is I'm now bloated even though I've changed my diet drastically (no more junk food or soft drinks, no 'white' flour products, no dairy products with more than 5% M.F and lots of veggies and fruits). I've lost 3 or 4 pounds but my pants are too tight around my waist, and now I have a my upper abdomen bulges over the waistline. Besides that, I get muscle 'kinks' in very places and after sitting for more than 10 minutes I limp when I take the first few steps.

People have told me to 'keep taking Lipitor and Plavix' but exercise more. The only problem with that is that I have a brain aneurysm and the neurosurgeons don't think it can be operated on 'without it being a very high risk procedure'. The first one ruptured 10 years ago and since then I've managed to control my blood pressure. However the meds I took for that was what lead to my potassium being so low that my electrolytes were imbalanced. That combination of low potassium and high cholesterol is what lead to the heart attack.

I'm 54 and feel as though I'm losing control of 'how' I feel. Between Lipitor, Plavix and diuretics and medication for hypertension I'm not sure if it's one drug in particular that's making me 'ache, limp and look like a blimp' or if it's because of the interaction of all of them. How do I decide 'what' to stop? What's more important to look after first - my heart or my brain?

Didn't have bad side effect but kept a constant look out for what they listed on the paperwork. But I was in so much shoulder pain that I needed this too bad. (I've used it before (5 yrs) so I knew people had bad experiences).

Hunger pains were the worse but I kept food in the house and with me so that I could eat (protein) when the SHARP hunger pains happened.

I have only been taking singulair for about a month. I have noticed that I have become more irritable, grouchy, hateful and just numb, not really wanting to be around anyone, not caring about anyone else's feelings much. I also noticed I have become extremely lethargic, to the point of falling asleep at work as well as heart palpitations and stomach pains. I just started new birth control pills so at first assumed they were causing these side effects, that is until I looked up the side effects of this drug! I have over half of the side effects so I stopped it immediately and can already tell a difference in my mood. I have to sons age 11 and 14, both who have asthma and allergies. The took this medication for a few years with no side effects but have not taken it for about a year now. My youngest son however, has been diagnosed with ADHA and ODD and possibly BiPolar disorder. As I read the other posts, I realize the description of how their children act while on this drug is exactly how my son acts. I wonder if there can be irreversible permanent damage from taking this medicine? He has been on a number of ADHD drugs, none have helped except to make him stop eating and lose weight and he is small for his age, so I have taken him off everything. Has anyone else out there experienced what could be permanent damage from this drug in their children? Even after being off the drug for a year or so? If it could make me miserable within a month, what can it do when one takes it for years? Its sometimes hard to tell the effects of medicine on small children. My son prob starting taking it around 4 yrs old and took it til he was about 8 or 9. Just wondering if anyone else out there has had this happen to them or their children.

My son began taking singulair when he was 6. About that time we were hading into the school years. He was labeled as a "special" child from that time on. Impulsive, aggressive, angry, anti-social, etc. He had a hard time focusing at school and every day was a battle. About 5th grade, after 3 schools, he was diagnosed with ADHD. I never, ever thought that it could be this medication. He was on it for about 4 years off and on during allergy season. I transferred him to a private school for children with behavioral issues and as time went on through therapy and special schooling it seemed to get better. I look back now and see that our "good" times were when he finally went off it for good. The beginning of his Freshman year was great! He had a 3.58 GPA, making friends and finally happy. The unfortunate thing is now that puberty has really kicked in, we are back to the old behaviors but much worse. Impulsive, angry, anxious, afraid of the dark, afraid of death. Violent thoughts, impulsive and very unhappy. I can see now that my son never had ADHD. He was misdiagnosed because thier were no warnings at that time. I don't think it ever "goes away". Even after years of being off of it. Something with the puberty hormones is re-triggering this behavior. IT IS LONG TERM!!!!! Even after discontinued use. Please, please keep an eye on your children. I AM SO ANGRY FOR HIM!! Also, for me. Special school $400 month, psychologist appointments, $300 month, my poor Son in a dark place I can't get him out, PRICELESS. . .I want my Son just to be happy. Thank you all for sharing your stories, it gives me strength that I need for him.

decomposition of lisinopril in acidic medium so narrow absorption window.

My four old son has been on singulair for about two weeks. The change from wheezing/coughing attacks at night and terrible allergies during the day has been amazing. They are almost non-existent to this point a great plus. However, a i stress however his behavior and speech has been VERY INAPPROPRIATE and quite frankly it concerns me. He now states "im a bad boy" and "i dont listen" and his mornings are very testy to say the least. Granted these sound like normal 4 yr. old sayings that he would pick up from other children on the playground but how do you explain them happening almost simultaneously with his taking singulair. I find it very hard to believe that it is a coincidence and that these are normal things for a 4 yr old to say/do when all other things have remained the same. My advice is to diligently watch your child for these warning signs and find other remedies if you have reservations. Im not promoting natural cures but i am leaning toward a diet change for the whole family and consulting my doctor for food allergen testing. I hope this helps. Be Well.

I spent the weekend reading about the development of Singulair. The early studies recognized that the first phase of the acute asthma response bronco-constriction was probably not caused by leukotrienes. They identified histamines and prostaglandins as the probable sources. I don't think that changed because the Singulair literature states that it should not be considered as a treatment for that. Leukotrienes were a source of inflammation caused by eosinophils and mast cells present in greater numbers (than normal) in airway tissue. So, it was beneficial to find a way to decrease that.

The cysLT1 receptor was identified as source of the signals that tell the cells to produce leukotriene. The receptor, a gene, consist of 337 (they think) amino acids. They modified a compound that would bind to that receptor thus blocking the cells ability to produce leukotrienes. This compound is very specific. It was formulated to bind to the "model" receptor. This compound will not even bind to cysLT receptor sub-types. (That is the good thing.) There is an enormous amount of research that discusses the genetic variability of the chemical reactions that occur in the leukotriene (calling it this for simplicity) pathway. We are also seeing that a number of researchers would like to use gene profiles to predict whether patients will respond favorably to different asthma/allergy drugs. ALL PATIENTS HAVE A RIGHT TO KNOW IF IT IS INHERENT THAT SOME PEOPLE WILL NOT RESPOND TO SINGULAIR OR RESPOND ADVERSELY.

There are many studies from the 1998 era that conclude that montelukast is not effective for everyone. Those researchers stated that it can be predicted that those people who are going to respond favorably will do that within the first 14 days or so. That conclusion would be consistent with a genetic component for efficacy and safety of Singulair. Those doctors concluded that those who did not respond within that time frame should not take Singulair for fear of harming them. That makes good sense.

The Italian researchers wanted to know if there was more going on than blocking leukotrienes in the action of montelukast. They set up a "test tube" study regarding montelukast, the cysLT1 receptor, and some t-cells that they selected. Why? Researchers always have something on their minds. They observed the death of these particular t-cells.

Montelukast is a quinoline. We basically know of quinilines and quinolones as compounds that were invented as broad spectrum antibiotics. They work because they interference with bacterial DNA so they cannot replicate themselves. Montelukast is a quinoline modified to bind with the cysLT1 receptor (a gene) and prevent that gene from activating. That's consistent with what a quinoline/quinolone does.

So what does montelukast do in blood plasma if it does not bind to the receptor because of genetic mis-match? (If montelukast does bind, then a chemical reaction has occurred and the liver will break down the by-products. Montelukast metabolized in 10-12 hours.) What happens if it doesn't bind? How long before it breaks down? Does it produce toxic by-products?

I want to know what happens to lymphocytes such as t-cells just because montelukast is a quinoline. Maybe nothing but what's up with the Italians researchers? I want to know if montelukast has the capability to interfere with lymphocytes who can clone themselves. That could be a good thing under circumstances when these lymphocytes are causing inflammation. But it could be a bad thing in the case of normal individuals with no problems.

I want to know if the bad side effects are due to the fact that the body has to break down and metabolize a quinoline that did not bind to the receptor for which it was created. The side effects of Singulair are strangely similar to what is observed in the quinolones such as levaquin. I have not as yet been able to compare montelukast as a quinoline to levaquin as a quinolone. I am hoping to find something on these categories. There may be no reason to worry that they cause similar damage. But frankly, I think that there is. There is some terrible chit happening to some people. The scariest is the neurological damage.

All of these questions would be in the everybody pharma knows to ask category. I don't know where the answers are. I haven't found them as of yet. Maybe there are no answers. We have to remember that Singulair and Vioxx were released in the same year. They have continued to be drugs under the current executive management of Merck. If the Vioxx marketing promoters had their ghost writers, why not the Singulair marketing promoters. The genetic component appears to be widely accepted but we haven't heard one thing about even that.

I think that it is sad that maybe the marketing of Singulair as one stop shopping for asthma/allergies may have destroyed the original concept. I really think from reading the original work that they knew that they couldn't engineer a drug for one size fits all. Everybody gets harmed when information is withheld.

Shame on the allergist who yelled at the mother who wanted to discuss issues. Does he know exactly who is allergic to Singulair and who isn't? Get him a dunce hat. Just because Singulair is marketed for allergies does not mean that you cannot be allergic to it. See the power of Madison Avenue? The ad agencies focus group these drugs to death. The ad agencies cleverly craft the product information. A good piece of legislation would be to prohibit consumer drugs ads.

I had severe stomach pains for 2 weeks when I switched to ER. However, I was able to regain control of the epilepsy when the depakote stopped working so well after 15 years.???
I have gained 80 pounds on depakote and ER over the past 20 years but I cannot fairly blame the drug for that. I have also had bouts with depression-like symptoms (never sought help) but again, who is to say that can be blamed on the drug? While I have lost hair, I still have more than many 40-year old men.
When first going on Depakote 20 years ago I slept for days it seemed. I have never felt as though I had the same energy level as before starting the medication but it has been so long and I am so thankful that I can lead a normal life without seizures by using the med.

I live in Israel, and here in this country not only do the police do their duty incorrectly, but so do psychiatric officials.
I was in a bad state emotional, and that did not result in any obscene or out-of-the-order matter, but me having chosen to move on with my life was a bad idea since moving on meant letting go and kicking out of my life a she-devil that posed as a girlfriend.
she had connections and accused me wrongfully of stuff i didn't do, and since she had friends in the police force, I ended up being admitted to a psychiatric hospital, there I was forced to take 10 mg of ZYPREXA, every day, for a little more than a month and a half, after a couple of weeks i developed a rash on my head, and vibrations with palpitations.
when i stopped taking ZYPREXA, the rash continued, the vibrations when i go to sleep with the palpitations continue but are even worse,
I cant sleep, and when i do fall asleep I wake up every hour, if lucky i sometimes manage to sleep for 2 hours and then only wake up, and i keep waking up until i give up on sleeping, i get headaches, nausea, dizziness, i eat, and after 30 minutes to 1 hour i go the the toilet and diarrhea..
my left eye sees blurry, i hear much less in my left ear, and not to mention that i have no tinnitus, - all day long i hear an electric pulse in my ears, i am disconnected from emotions, cant concentrate, my memory is impaired, i cant seem to make myself do anything, i cant even figure out what i am feeling, my teethes health has gone bad, get mood swings which are not extreme at all, resulting in me not knowing what it is I'm going through, i think this Zyprexa ordeal as resulted in multiple sclerosis which hasn't been diagnosed yet, and i don't know what more else there is, since i am quite handicapped mentally emotional and physically i can do stuff, but for some reason i don't do anything.
bad dreams (when i do manage to get several minutes of sleep), and i feel stoned all the time. and this is not all, but seriously, here in Israel or overseas, who really gives a damn? and who can help these things go away??..Ive been told to wait (I've been waiting a little more that 3 months) for all this to go away, and nothing as gone away, instead more things slowly gather.
too bad there is no death sentence here in Israel, if there was I might try to get it, to end this suffering, though, what can i say, even dying is not something I can manage to get myself to do, I cant seem to actually decide to do anything, I just think of it, and in the meanwhile, my whole life is passing in front of my eyes, making me realize, this might be the ending of my life as I know it, and all i have to do about it is just sit and wait, either for things to change (cause i cant change them), or to die.

MY GOD PEOPLE WAKE UP ! HAVE YOU EVER THOUGHT ABOUT LOOKING OUTSIDE OF THE BOX AND SEEING WHAT THE REST OF THE WORLD IS DOING ! THEY ARE GETTING RID OF THERE MERCURY FILLINGS AND CURING THEMSELVES ! 50% OF SILVER FILLINGS ARE MERCURY> HENCE THE SAYING MAD AS A HATTER ! FLUSH YOUR BODY WITH A GLASS OF GREEN JUICE EVERY DAY. YOU CAN BE LAZY AND TAKE A PILL AND AND JUMP OFF A CLIFF WITH EVERYONE ELSE OR YOU CAN LOOK AROUND AND SEE PEOPLE ARE WAKING UP AND CURING THEMSELVES ! IF YOUR CHILD IS YOUNG AND SPASTIC MAYBE IT WAS THE MERCURY SHOTS THEY GAVE THEM OR YOU CHILD JUST CANT HANDLE THE FLUORIDE ! LOOK OPEN SEE THE TRUTH OF ALL THE THOUSANDS OF PEOPLE SAVED FROM THESE DRUGS THAT KILL YOU !

My little boy who is now 4 has been off the Reglan for two years. I really thought my husband and I were doing the right thing by putting him on the Reglan at 8 months because he was vomitting blood. The gastric doctor said he had to be on it plus prevacid .Well I WISH WE HAD KNOWN THE SIDE EFFECTS. Now my son is in the process of going to a Neurologist next week because they think he might have Tardive Dyskinesia . He has the symptoms of it on and off for a year now and the doctors have said it is from stress not possible because all of the stress therapist we have taken him to say he is not stressed. I would like to say one thing do not put your child on this drug because it could be the biggest mistake of your life . This is a disease that can not be curred.

hi, guest 4248 in response to, just to comment on beta-sisterol.

I took it along with some amino acids---l-glutamine acid, glycine l-lysine, l-arginne, and bete-sterol, and i noticed a slower stream while urinating,

have not taken since i noticed the side-effects with the
wellb.

wellbutrin alone is fine.

thanks