Anal fissure symptoms and conditions

Has anyone experienced anal fissures? Since Advair has mucus forming as one of it's side effects my husband and I were curious to see if anyone else was reporting weeping around the anus which is causing very painful skin irritation and a fissure. He also has terrible leg cramps while sleeping at night, hair loss, mouth sores, thrush in his throat. He has been on advair for over two years and we are now reading of all the same side effects that have been plaguing him for some time now. The anal fissure is difficult to discuss, but I did read of a mother below that wondered if her son's soiled underwear could be related. Does anyone else have this symptom?

Taking low dose of Lipitor 20mg for about 6 months. Genital peritoneal edema gradual but kept getting worse. I had so much swelling that it felt like when I was 9 months pregnant with my son. Labia area of skin was dry and splitting. I had a hemmrhoidectomy (unrelated) 4 months after the hemmroidectomy, I suddenly had an anal fissure that the surgeon said he usually only sees in older male gay patients. I am a 44 year old female. I stopped lipitor. The swelling went down within 3 days and two week later the anal fissure is healing. My doctor that put me on Lipitor says it can't be the Lipitor. He can't exlpain it either. I don't think he plans on reporting my side effects to anyone. Now I have horrible kidney pain. No bladder pain. Doc says some blood in urine. Put me on CIPRO. 36 hours later, pain is worse. Can't bend over to put on my socks. Trying to figure out what to do.