Anecdotal reports symptoms and conditions

I am currently 58 years old and lead a very active, healthy lifestyle. I began taking 10mg of Zocor, along with 1000mg of niacin in the summer of 2004 to reduce cholesterol (251) and triglycerides (571). The therapy dramatically improved my blood tests, however, within 6 weeks, I began to experience minor chronic skin infections, both fungal and bacterial. They were easily controlled with topical over the counter type medications, but they were annoying. At no time was this new condition linked to the statin/niacin therapy by my doctor(s). The infections became progressively worse over the next 3 years, and evolved into chronic folliculitis in my scalp, neck, and face, cystic acne, and persistent fungal infections that were becoming more difficult to control. In addition, I began to get chronic eye infections. It was as if my immune system was becoming ineffective. I stopped taking niacin in December of 2007 and the symptoms immediately lessened. I stopped taking Zocor in March of 2008 and within 2 weeks, all the skin problems and eye infections completely ended. My health was restored completely and I am glad to have put that whole mess behind me! I have been taking Omega 3 supplements to control my cholesterol and triglycerides and have had results that equaled the Zocor and Niacin therapy, with cholesterol at 160, triglycerides at 91, and a favorable HDL/LDL ratio. My physician is skeptical, but I know that my body was not functioning correctly with the statin/niacin treatment. I have found anecdotal reports from others who seem to have experienced a change in their immune system, but no mention of this as a side effect by the medical establishment.

I am a 37 year old female ~185lbs already under treatment for clinical depression with two medications. I used to take Alavert (loratidine) for seasonal allergies but found it had "stopped working" well for me. Since Zyrtec (certirizine) went over-the-counter, I decided to try it.

I took it sporadically at 10mg daily for a period of 2-3 weeks, and then, during a particularly bad allergic exacerbation, began to take it consistently at 10mg daily. My depression, which was previous well-controlled on medication, worsened to the point of severity. Extreme despair, emotional detachment, and loss of interest in pleasurable activities--well, in ANY activity beyond sleep.

I am a pharmacist, and on a whim, I decided to do some research into interactions with my other medications, and found several anecdotal reports of depression onset and worsening in Zyrtec users. This particular side effect of Zyrtec was unknown to me, nor have I received any educational materials or reports in my trade literature listing depression as a possible adverse effect.

I have discontinued the medication in both myself and my three year old daughter (5mg daily). I can already see a difference in her disposition, and I am starting to crawl out of my pit of gloom. I'm using Alavert again, as I never had one issue with it, and I'm supplementing with Benadryl (diphenhydramine) at night as needed for exacerbations.