Array symptoms and conditions

I have been on prednisone for 8 weeks, the first two at 40 mg., then 30. I have sarcoidosis and had a cough for several years, then shortness of breath, a fever for three weeks, very low energy, headaches every day, vision problems, mental fuzziness, fatigue, leg cramps, weight loss, a host of symptoms that were impacting my life. With the prednisone, I have had some jitteriness and occasional insomnia, though not bad. I have had increased energy, clearer mind, no cough, the sarcoid symptoms have almost disappeared. I do have increased appetite and have gained maybe 5 pounds. I occasionally have a day when I have low energy and am depressed, but most often, my energy is a lot better since taking the prednisone. So, for me, prednisone is most definitely NOT a devil drug. In fact, I believe that thinking of it this way is very harmful both to the person thinking that way and to others who come to this site looking for help. It is helpful to know that there are other people having similar problems to yours. But focusing on all the negatives without acknowleging the vast array of positives can only hurt. When I take the pills, I remind myself to be grateful that there is something that can help me fight the sarcoid. When I start being fearful of the side effects (from reading these internet sites), I remind myself of all the many people who have taken prednisone and gotten better and lived a long, good life as a result. My sister-in-law took it years ago for Crohns and loved it. My friend's daughter took it and had a few side effects, primarily the moon face, but it helped her and she now is as thin as ever and doing well. Focus on the positives, people! Where your mind goes, your body will follow. Be aware of the possible effects and work to offset them. Exercise, eat less, find reasons to laugh and be with people. It sucks to have any disease that would cause you to have to be on prednisone, but we are lucky to have medicine and people to help us. Be thankful for what is good in your lives.

I started taking YAZ in May 2008, after I told my doctor that I wanted to regulate my period (basically because I was going on scuba diving trip and didn't want to have my period) - I also told him that I was kind of b*tchy lately and maybe there was a pill that could help that as well. He prescribed YAZ - I went on my trip, no period (very light periods also)... In September 2008, I went to a cardiologist for heart palpitations, chest pains, shortness of breath (never thinking that YAZ had anything to do with it). After a huge array of tests (cat scans, blood clot scans, blood work, stress tests, etc...), he didn't find anything, but advised me to take 1 baby aspirin per day. About a month later, I started getting dizzy spells. I stopped taking the aspirin, figuring that's what was causing that (still never thinking about the YAZ - basically, because I had never had a problem with any other birth control pills). I took my last YAZ in January 2009. It seemed that my ill conditions slowly stopped.... Then, last week, in June 2009, I bought a pack from my almost expired prescription because I was going on another scuba trip and my period was scheduled to come when I would be away... I took a pill on Wednesday, Thursday, Friday, Saturday, Sunday (got my period, but it was very light), but by Sunday, I was so dizzy again, I could barely stand up. That was 3 days ago; still dizzy, but I'm writing off YAZ for good - it seems like that was cause of my health problems and it really isn't worth it just so I can plan a vacation around my period. I will be looking into alternatives to YAZ - I would advise if you have any of these symptoms, to do so as well.... Good luck! L....

I'm a 38 y/o woman. For 7 yrs I knew my cholesterol has been high. I refused to take cholesterol medication and decided to diet and exercise but that didn't work. I've had 2 children in the past 3 yrs. In May of this year I started having chest pains and palpitations. I had blood tests done. I was given Inderal and also prescribed Zocor 20mg for my cholesterol. It was 243 with and LDL of 178. I took Zocor for a week. I felt so awful. I was weak, I lost my appetite. I was constantly tired. I couldn't even carry my 10 month old son, yet alone care for him. I informed my physician and she changed it to Lipitor 20mg. I thought I was doing fine. I checked my levels again after a month. My cholesterol was 113 and LDL 58. I trusted the doctor knew what she was doing. At the same time I also was taking Omega 3's. I asked my doc to lower the dosage to 10mg. From the time I was taking Zocor and the start of Lipitor. I was feeling tingling and numbness in my arms, hands, fingers, toes, feet and legs. I also was having muscle pain. I asked my doctor about that. She mentioned because of my heart palpitations, it could be symptoms of anxiety and panic. I had feeling of pins and needles throughout my body, not knowing when it would occur. I had muscle pain in my arms and legs and neck pain. I went online to see the side effects of Lipitor and came across this website. I decided to do an experiment. I stopped taking Lipitor 9 days ago. I was on statins for almost 4 months. I don't have the feeling of tingling and numbness, but I still have pins and needles and muscle pain. I have to say, I feel so much better. I hope to get better. I 'd really like to know, how long does the medication stay in your system? What are the effects of getting off it so suddenly. I'd love to feel myself again.

Hopefully this will prove to the doubters that there are genetic reasons for the variation of efficacy and adverse side effective when taking Montelukast.

I have several areas of concern (concerned citizen is concerned). One of the main areas is the reliability of Montelukast due to differences in genetics among populations. The cysLT1 (Singulair) receptor is a GENE. As I said before, it would be possible to predict those patients for which Montelukast would and would not be effective and those patients whose gene expression profile would cause them to have unwanted side effectives.

I have been looking for a way to give reasonable proof of that which could be used to convince your doctors that Montelukast is not for everybody. I happened to locate a researcher who had invented and patented methods for predicting drug sensitivity and efficacy in inflammatory disease. I have quoted below from his patent application. He intended to provide a method for determining efficacy and drug sensitivity for pharmaceuticals which include leukotriene antagonists - Montelukast.

Quoted from:

Methods for predicting drug sensitivity in patients afflicted with an inflammatory disease
US Patent Issued on December 12, 2006

Methods are disclosed for predicting the efficacy of a drug for treating an inflammatory disease in a human patient, including: obtaining a sample of cells from the patient; obtaining a gene expression profile of the sample in the absence and presence of in vitro modulation of the cells with specific cytokines and/or mediators; and comparing the gene expression profile of the sample with a reference gene expression profile, wherein similarities between the sample expression profile and the reference expression profile predicts the efficacy of the drug for treating the inflammatory disease in the patient.

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The field of pharmacogenomics measures differences in the effect of medications that are caused by genetic variations. Such differences are manifested by differences in the therapeutic effects or adverse events of drugs. For most drugs, the genetic variations that potentially characterize drug-responsive patients from non-responders remain unknown.
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In another embodiment, the invention is directed to a method for predicting the efficacy in a human asthma patient of leukotriene antagonists including, but not limited to, montelukast (a.k.a., SINGULAIR™; Merck, Whitehouse Station, N.J.), zafirlukast (a.k.a., ACCOLATE™, AstraZeneca, Wilmington, Del.), and zileuton (a.k.a., ZYFLO™; Abbott Laboratories, Chicago, Ill.), comprising: obtaining a sample of cells from the patient; obtaining a gene expression profile from the sample in the absence and presence of in vitro modulation of the cells with specific mediators; and comparing the gene expression profile of the sample with a reference gene expression profile, wherein similarity in expression profiles between the sample and reference profiles predicts the efficacy in the human asthmatic patient of leukotriene antagonists.

Many of the cells involved in causing airway inflammation are known to produce signaling molecules within the body called "leukotrienes." Leukotrienes are responsible for causing the contraction of the airway smooth muscle, increasing leakage of fluid from blood vessels in the lung, and further promoting inflammation by attracting other inflammatory cells into the airways. Oral anti-leukotriene medications have been introduced to fight the inflammatory response typical of allergic disease. These drugs are used in the treatment of chronic asthma. Recent data demonstrates that prescribed anti-leukotriene medications can be beneficial for many patients with asthma, however, a significant number of patients do not respond to anti-leukotriene drugs.

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The genes selected are those that have been determined to be differentially expressed in either a disease, drug-responsiveness, or drug-sensitive cell relative to a normal cell and confer power to predict the response to the drug. By comparing tissue samples from patients with these reference expression profiles, the patient's susceptibility to a particular disease, drug-responsiveness, or drug-resistance can be determined.

http://www.patentstorm.us/patents/7148008-description.html

The inventor's website: Hakon Hakonarson M.D. The Children's Hospital of Philadelphia

http://stokes.chop.edu/research/profiles/?ID=251

Wow. Thank god for this Bulletin! I was diagnosed with hypertension at age 28
and tried a variety of drugs with no control over the BP. So, about 2 1/2 - 3 years ago, I was prescribed 100MG of Toprol XL which seemed to control it well, but with debilitating long term illness. I had no idea until today that Toprol XL was causing similar grief to others. The horrible symptoms that I have been experiencing now for several years are Extreme Chronic Fatigue, Profuse Cold Clammy Sweating, Dizzy spells, weight gain, seeing specs of light and thousands of eye floaters, severe depression, muscle aches, headaches.

After reading about others with similar side effects, I am confident that it's from this medication. I have had all kinds of testing done including T3 & T4 Throid levels and a full array of blood work with NO LUCK! Regardless of the consequences, I am going to quit this damn medicine today because it appears to take 5 weeks or so to get it out of the body to notice a difference. I am so desperate for change. It is ruining my life because I can
't wake up, I'm always tired even though I get 10-14 hours of sleep. My wife and kids are bummed because I have no energy to do anything, EVER!

If you have any other suggestions or would like to comment about this.

Sincerely,

Sean

I started Yasmin about 5 months ago and thought I had no side effects. Did not gain a single pound and didnt really think my mood changed. The only weird side effect i did have is gas and bloating. Now at first I didnt think it was due to Yasmin so I went through an array of tests for gastro-intestinal problems and finally made the connection because I took yasmin at night and only had those problems at night. Never ever during the day. Oh yeah and the migraines. I would get them for about 5 days straight. It was really annoying to have to deal with. Now I will definitely switch to Alesse although I am questioning that alternative as it may be just better for me to not be on any birth control. And I do want to say that not everyone will have these random side effects. A few of my friends are using Yasmin and are absolutely satisfied. (their side effects: no weight gain and breast enlargement...what more could you want!! :) )

I have read a ton of the posts in this category. I have been taking Lisinopril as an addition to my regular blood pressure medication for approximately 3 years, with absolutely no problems. My 10mg was increased to 20mg a week ago. Still no problems. It has only helped me. If there are any changes, I will definitely post it. I believe that symptoms can arise from reading an article. I actually know a couple people who read things, and suddenly they are convinced they have the problem or disease referenced. I call it an Epidemic of Diagnoses. Always seek a doctors advice before stopping medications. Stopping suddenly on certain drugs, can be more dangerous than taking them.

i have been takin this drug for about amonth the dr gave it to me for aearthat i couldnt hear out of myhearing problem just happened iassume that it was from aalergies this year since it was so dry here in tex it has not helped but i have had an array of side effects iam going to stop taking it today even though i still have about four days leftthanks for the postings

I have been taking Avelox for five days after being diagnossed with pneumonia. I was prescribed other drugs as well and has since stopped taking those because of adverse side affect.Since the Avelox has been my only medication, and I have experienced an array of side affects. I have been having trouble sleeping, vomitting, stomach pains, dry mouth,headaches, muscle fatigue, and other abnormalities that have been a nuisance throughout. I understand medications affect people in a variety of ways, but to cure one problem and create numerous more is ludicrous. Has To Be A Better Way!!!!!!