Arthralgia symptoms and conditions

I had this thing placed in April of 2008. I was fine had minor cramping and went back for check up. everything was okay until January 2009 I got a yeast infection. I did an otc med and it went away for about 3 days. It came back with Avengeance not only did I have a yeast infection but it was accompanied with migrated arthralgia. I could hardly walk at one point on my right foot then it moved from my right hand to my left and has settled in to my right foot. I called my PCP and she gave me meds to treat and it went away for a month. I was told that if it came back with the arthralgia she was going to test me for lupus!!!! LUPUS I thought I was in a lot of trouble the next month because it came back. I have had 8 yeast infections in 6 months. Every time my husband and I have sex it feels like a rug burn and I get the infection back. I was told (when I finally thought to call) by my GYN that if you get yeast infection and it doesn't fully go away it can live on the strings and keep coming back. I was treated this last time with a vag cream insert and an oral med. I thought I was free and clear but two months later here I am again. I am going in to see my GYN/PCP to have this removed tomorrow she agrees that the mirena is the issue. I have had all these other symptoms thought mostly the weight issue I can't lose weight not matter how hard I work at it. I have facial swelling and have been very fatigued. Also be warned that you should not have this placed if you have history of endometriosis. I consulted as to why with one of the doc that i am a nurse for and she said that this can cause bleeding to be worse since endometrial tissue can attach anywhere in the body. I have endometriosis removed twice and I am not willing to take the risk of abn bleeding elsewhere I already have enough CRAP to deal with. I am sure that some women have had this and it hasn't been an issue. More power to you!! but for those of you who are suffering form this. You can file a formal complaint with the FDA I think if enough of us file complaints maybe will step back and take a closer look at the TRUE SE of this horrible device!!

If you are having musculo-skeletal symptoms such as soreness, arthritis, tendons, etc., they have known about those side effects for eleven years.

Toxicol Pathol. 1997 Nov-Dec;25(6):635-43.

Links Toxic effects of quinolone antibacterial agents on the musculoskeletal system in juvenile rats.Kashida Y, Kato M. Drug Safety Research Laboratory, Daiichi Pharmaceutical Co., Ltd., Tokyo, Japan. JDN07402@niftyserve.or.jp

Quinolone antibacterial agents have adverse effects on the musculoskeletal system in humans, consisting mainly of myalgia and arthralgia, and additionally of tendon disorders and rhabdomyolysis. The present study was conducted to examine the toxic effects of quinolones on the musculoskeletal system in juvenile rats using light microscopy, 5-bromo-2'-deoxyuridine (BrdU) immunohistochemistry and electron microscopy. Single oral administration of 900 mg/kg pefloxacin (PFLX) or levofloxacin (LVFX) was found to induce lesions in the muscle + fascia, tendon + sheath, and synovial membrane, in addition to articular cartilage in the fore- and hindlimbs. Articular cartilage lesions were not necessarily associated with changes in the muscle, tendon, and synovial membrane, or the reverse. Among all lesions, the ankle and elbow showed the highest incidence and severity. Changes were more severe in the PFLX than in the LVFX group. Lesions in the muscle + fascia, tendon + sheath, and synovial membrane were similar and characterized by edema and increased number of mononuclear cells, many of which were positively stained with BrdU, as well as vascular endothelial cells in the Achilles tendon sheath and synovial membrane in the ankle. Electron microscopic examination revealed an increased number of fibroblasts and macrophages and collagen deposition in the matrix of the synovial membrane and tendon sheath. Capillary endothelial cells were hypertrophied, increased in number, and stratified. These results suggest that quinolones have toxic potentials in the muscle, tendon, and synovial membrane in addition to articular cartilage, and that local vascular hyperpermeability may contribute to the development of these lesions. PMID: 9437810

An element of the side effects of Singulair that are listed here are musculo-skeletal symptoms. Quinolones such as levaquin are known to cause those issues. Singulair is a quinoline, while not the exact same category, their roots are similar. It makes the possibility that the symptoms have a common cause worth pursuing.

Here is an example of some poor rats in Tokyo that were selected to prove that the symptoms in humans were real. Maybe we should tell the levaquin board that at least some of their problems have been known since 1997.

1: Toxicol Pathol. 1997 Nov-Dec;25(6):635-43.Links
Toxic effects of quinolone antibacterial agents on the musculoskeletal system in juvenile rats.Kashida Y, Kato M.
Drug Safety Research Laboratory, Daiichi Pharmaceutical Co., Ltd., Tokyo, Japan. JDN07402@niftyserve.or.jp

Quinolone antibacterial agents have adverse effects on the musculoskeletal system in humans, consisting mainly of myalgia and arthralgia, and additionally of tendon disorders and rhabdomyolysis. The present study was conducted to examine the toxic effects of quinolones on the musculoskeletal system in juvenile rats using light microscopy, 5-bromo-2'-deoxyuridine (BrdU) immunohistochemistry and electron microscopy. Single oral administration of 900 mg/kg pefloxacin (PFLX) or levofloxacin (LVFX) was found to induce lesions in the muscle + fascia, tendon + sheath, and synovial membrane, in addition to articular cartilage in the fore- and hindlimbs. Articular cartilage lesions were not necessarily associated with changes in the muscle, tendon, and synovial membrane, or the reverse. Among all lesions, the ankle and elbow showed the highest incidence and severity. Changes were more severe in the PFLX than in the LVFX group. Lesions in the muscle + fascia, tendon + sheath, and synovial membrane were similar and characterized by edema and increased number of mononuclear cells, many of which were positively stained with BrdU, as well as vascular endothelial cells in the Achilles tendon sheath and synovial membrane in the ankle. Electron microscopic examination revealed an increased number of fibroblasts and macrophages and collagen deposition in the matrix of the synovial membrane and tendon sheath. Capillary endothelial cells were hypertrophied, increased in number, and stratified. These results suggest that quinolones have toxic potentials in the muscle, tendon, and synovial membrane in addition to articular cartilage, and that local vascular hyperpermeability may contribute to the development of these lesions.

PMID: 9437810

From a UK Yellow Card Report.

Montelukast

The product information for montelukast has been amended to include the following ADRs: Reaction No. of UK Yellow Card reports

Nausea 63 Diarrhoea 54 Rashes 52 Insomnia 44 Dizziness 42 Fatigue 37 Vomiting 24 Pruritus 24 Arthralgia 20 Urticaria 19 Malaise 18 Dyspepsia 13 Myalgia 12 Dry mouth 9 Anaphylaxis 4 Angioedema3

In addition, the following suspected ADRs have been reported and are still being evaluated: psychiatric disorders (63) ; also nightmares (13), sedation (13), palpitations (12), tremor (10) and increased sweating (10).
--------------------------------------------------------------------------------

Zafirlukast The most frequently reported ADRs under the Yellow Card Scheme for zafirlukast have been rashes (7), headache (7), abdominal pain (6), nausea (6) and pruritus (5). All of these are included in the product information which has also been updated to include the following ADRs that have been identified from data other than UK Yellow Card reports: urticaria, angioedema, blistering, bruising, bleeding disorders, including menorrhagia (rare), thrombocytopenia and agranulocytosis (both very rare). Churg-Strauss syndrome Churg-Strauss syndrome (CSS) is a rare syndrome characterised by a history of asthma, and often rhinitis and sinusitis, with systemic vasculitis and eosinophilia. There has been a recent increase in the number of reports of CSS associated with the use of anti-asthma drugs, particularly the leukotriene receptor antagonists. The MHRA/CSM have received 63 reports of CSS through the Yellow Card Scheme since 1963, 59 since the beginning of 1998; Of these, 90% were associated with drugs used to treat asthma (mainly leukotriene receptor antagonists). In many, but not all cases there was documented evidence of a reduction or withdrawal of oral corticosteroid therapy prior to the onset of the reaction. There are clear warnings regarding the possible association with CSS in the product information for montelukast and zafirlukast. Prescribers should be aware of the possibility that, although rare, CSS may be the underlying cause of asthma in their patients. In patients prescribed a leukotriene receptor antagonist prescribers should be alert to the development of eosinophilia, vasculitic rash, worsening pulmonary symptoms, cardiac complications and/or peripheral neuropathy. The identification of new and suspected ADRs emphasises the important role of the Yellow Card Scheme in helping to ensure the safe use of medicines. The safety profile of leukotriene receptor antagonists remains under close review. Please continue to report all suspected ADRs to montelukast (Singulairt) and zafirlukast (Accolatet) through the Yellow Card Scheme.1. MHRA/CSM Current Problems in Pharmacovigilance 1998; 24:14.
-----------------------------------------------------------------------------

http://64.233.169.104/search?q=cache:3fU602hhlG8J:www.mhra.gov.uk/home/groups/pl-p/documents/publication/con2023236.pdf+montelukast+ADR&hl=en&ct=clnk&cd=10&gl=us

From England 1998:

Montelukast

Montelukast (Singulair) is a leukotriene antagonist for use as an add-on therapy in patients with mild to moderate asthma who are inadequately controlled by inhaled corticosteroids and short acting beta2-agonists. Since it was marketed in January 1998, CSM Mersey has received 31 yellow cards detailing 47 suspected reactions to montelukast including:
• 15 (32%) CNS disorders including headache and drowsiness
• 14 (30%) GI disorders including abdominal pain and indigestion
• 5 (11%) skin disorders including sweating
• 7 (15%) musculoskeletal disorders including arthralgia and cramps
• 2 (4%) psychiatric disorders.
26 of these reactions were not listed in the Summary of Product Characteristics at the time of reporting.

http://www.liv.ac.uk/~druginfo/csm/ADR_bulletin14.pdf

I started on Advair 250/50 6/28/07 for continued wheezing, bronchitis problems even though I quit smoking 12/25/06. In mid July I began to have Lt knee pain, the dx from the Dr was "arthritis--you are getting older you know" I was 46 yrs old. I got a cortisone shot 7/24 since the pain was so terrible, the shot gave we 1 week pain free, then 8/10 I had #2 shot, same knee, again this shot only lasted 1 week, then pain returned with a vengenance. End of August I had an MRI done on Lt knee due to continued knee pain---this showed a menescal tear. So we are in the 1st week of Sept and the pain continues to worsen, now I have pain in Rt knee also. Grasping at various straws I re-read the Side Effects and Adverse Reactions to Advair. Imagine my surprise/shock to read under Musculoskeletal: arthralgia (Severe arthritic joint pain), bone and cartilaage disorders, muscle pain, muscle stiffness. Also wt gain.
Needless to say I quit the Advair..Even tho I had been on Advair for less than 1 month before my knee problems started . Next week I go in for surgical repair on torn menesci Lt knee, and so far so good with my breathing, but tomarrow I tell my Dr that "I quit the Advair, and the reason why I quit."

After taking it for 6 days, Omeprazole caused me to suffer arthralgia. That translates to joint pain (knees, elbows, wrists, shoulders, neck, back), swelling (hands and feet), stiffness (all over), weakness (especially in the hands), and fatigue. I am having problems driving because it hurts to hold the steering wheel and exert enough pressure to turn the wheel, and overall I can barely move. I found a case study on the net that examined five other people who also got arthralgia, and the symptoms went away 10-18 days after stopping the drug. This is only my first day off Omeprazole, so I hope things will clear up for me quickly.

I have had 80% of the symptoms posted here all within 3 weeks of first taking Lisinopril.
I found this online...the manufacturers know what it cn do, but they make a lot of money from our suffering.

It read:
Lisinopril --In clinical trials adverse reactions which occurred with lisinopril were also seen with PRINZIDE. In addition, and since lisinopril has been marketed, the following adverse reactions have been reported with lisinopril and should be considered potential adverse reactions for PRINZIDE: Body as a Whole: Anaphylactoid reactions (see WARNINGS , Anaphylactoid and Possibly Related Reactions ), malaise, edema, facial edema, pain, pelvic pain, flank pain, chills; Cardiovascular: Cardiac arrest, myocardial infarction or cerebrovascular accident, possibly secondary to excessive hypotension in high risk patients (see WARNINGS , Hypotension), pulmonary embolism and infarction, worsening of heart failure, arrhythmias (including tachycardia, ventricular tachycardia, atrial tachycardia, atrial fibrillation, bradycardia, and premature ventricular contractions), angina pectoris, transient ischemic attacks, paroxysmal nocturnal dyspnea, decreased blood pressure, peripheral edema, vasculitis; Digestive: Pancreatitis, hepatitis (hepatocellular or cholestatic jaundice) (see WARNINGS , Hepatic Failure ), gastritis, anorexia, flatulence, increased salivation; Endocrine: Diabetes mellitus; Hematologic: Rare cases of neutropenia, thrombocytopenia, and bone marrow depression have been reported. Hemolytic anemia has been reported; a causal relationship to lisinopril cannot be excluded; Metabolic: Gout, weight loss, dehydration, fluid overload, weight gain; Musculoskeletal: Arthritis, arthralgia, neck pain, hip pain, joint pain, leg pain, arm pain, lumbago; Nervous System/Psychiatric: Ataxia, memory impairment, tremor, insomnia, stroke, nervousness, confusion, peripheral neuropathy (e.g., paresthesia, dysesthesia), spasm, hypersomnia, irritability; Respiratory: Malignant lung neoplasms, hemoptysis, pulmonary edema, pulmonary infiltrates, eosinophilic pneumonitis, bronchospasm, asthma, pleural effusion, pneumonia, wheezing, orthopnea, painful respiration, epistaxis, laryngitis, sinusitis, pharyngitis, rhinitis, rhinorrhea, chest sound abnormalities; Skin: Urticaria, alopecia, herpes zoster, photosensitivity, skin lesions, skin infections, pemphigus, erythema. Other severe skin reactions (including toxic epidermal necrolysis and Stevens-Johnson syndrome) have been reported rarely; causal relationship has not been established; Speical Senses: Visual loss, diplopia, photophobia, taste disturbances; Urogenital: Acute renal failure, oliguria, anuria, uremia, progressive azotemia, renal dysfunction (see PRECAUTIONS and DOSAGE AND ADMINISTRATION ), pyelonephritis, dysuria, breast pain.

I am on my 10th day on Neurontin at 300mg OD for a severe cervical muscle pain, the pain did go away but... at first the only noticeable side effects were drowsiness especially in the AM, loss of coordination. But a few days later, the numbness on my lower extremities was noticed as well as moderate to severe headache more on the frontal area and arthralgia (joint pains). I also had episodes of irregular heart beats so I had to be put on Betablocker. The dosage was not that big, but anyway, patient's response varies individually. This will be my last day of Neurontin. I hope my body will eliminate all the traces of this drug.

Deep bone pain, shoulder ache. Arthralgia listed as occassinal side effect at drug manufacturer's site. Any help with this symptom? Thanks.
James age 58

The following are the known, listed and published adverse drug events associated with fluoroquinolone therapy. Levaquin is a chemotherapuetic antibiotic belonging to this clas:

Adverse effects related to fluoroquinolones
Asthenia

Edema

Fever

Malaise

Rigors

Substernal Chest Pain

Syncope

Cardiovascular Disorders

Cardiac Failure

Circulatory Failure

Hypertension

Central and Peripheral Nervous System Disorders

Abnormal Coordination

Coma

Convulsions

Seizures

Hyperkinesia

Hypertonia

Hypoaesthesia

Involuntary Muscle Contractions

Paresthesia

Paralysis

Speech Disorders

Stupor

Tremor

Vertigo

Gastrointestinal System Disorders

Dry Mouth

Dysphagia

Gastroenteritis

G.I.Hemorrhage

Pancreatitis

Pseudomembranous Colitis

Tongue Edema

Hearing and Vestibular Disorders

Ear Disorders

Tinnitus

Heart Rate and Rhythm Disorders

Arrhythmia

Atrial Fibrillation

Bradycardia

Cardiac Arrest

Heart Block

Palpitation

Supraventricular Tachycardia

Tachycardia

Ventricular Fibrillation

Hematology

Decreased Lymphocytes

Liver and Biliary System Disorders

Abnormal Hepatic Function

Cholelithiasis

Hepatic Coma

Jaundice

Metabolic and Nutritional Disorders

Aggravated Diabetes

Mellitus

Decreased Glucose

Decreased Magnesium

Increased Calcium

Dehydration

Hyperglycemia

Hyperkalemia

Hypoglycemia

Hypokalemia

Increased LDH

Weight Loss

Musculo-Skeletal System Disorders

Arthralgia

Arthritis

Arthrosis

Muscle Weakness

Myalgia

Osteromyelitis

Rhabdomyolysis

Synovitis

Tendinitis

Myo, Endo, Pericardial and Valve Disorders

Angina

Pectoris

Coronary Thrombosis

Myocardial Infarction

Neoplasms

Carcinoma

Parosmia

Platelet, Bleeding and Clotting Disorders

Abnormal Platelets

Embolism

Epistaxis

Purpura

Thrombocytopenia

Psychiatric Disorders

Abnormal Dreaming

Aggressive Reaction

Agitation

Anorexia

Anxiety

Confusion

Delirium

Depression

Emotional Liability

Hallucination

Impaired Concentration

Impotence

Manic Reaction

Mental Deficiency

Nervousness

Paranoia

Sleep Disorders

Somnolence

Withdrawal Syndrome

Suicide

Red Blood Cell Disorders

Anemia

Reproductive Disorders

Ejaculation Failure

Resistance Mechanism Disorders

Fungal Infections

Genital Moniliasis

Respiratory System Disorders

ARDS

Asthma

Coughing

Dyspnea

Haemoptysis

Hypoxia

Pleural Effusion

Respiratory Insufficiency

Respiratory Failure

Skin and Appendages Disorders

Erythema Nodosum

Genital Pruritus

Increased Sweating

Skin Disorders

Skin Exfoliation

Skin Ulceration

Urticaria

Urinary System Disorders

Abnormal Renal Function

Acute Renal Failure

Face Edema

Crystalluria

Cylindruria

Hematuria

Vascular (Extracardiac) Disorders

Cerebrovascular Disorder

Phlebitis

Vision Disorders

Abnormal Vision

Conjunctivitis

Diplopia

Retina Damage

Cornea Damage

Ophthalmologic Abnormalities

Cataracts

Multiple Punctate Lenticular Opacities

White Cell and RES Disorders

Granulocytopenia

Leukocytosis

Leukopenia

Lymphadenopathy

WBC Abnormal Count

Allergic Pneumonitis

Anaphylactic Shock

Anaphylactoid Reaction

Dysphonia

Abnormal EEG

Encephalopathy

Eosinophilia

Erythema Multiforme

Hemolytic Anemia

Multi System Organ Failure (Death)

Increased International Normalized Ratio (INR) Prothrombin Time

Stevens-Johnson Syndrome

Tendon Rupture

Torsades de Pointes

Vasodilation

This is but a small sampling of various adverse reactions associated with such therapy.

This list goes on and on and on and on and on. The physician has no clue as to what these drugs can and will do to a patient. There is no known treatment for a majority of the severe reactions. Such reactions DO NOT abate once therapy is discontinued in a subset of those so treated and the current research indicates that such events are to be considered permanent in nature.

David T Fuller
Director
Fluoroquinolone Toxicity Research Foundation
davidtfull@aol.com
www.fqresearch.org

The following are the known, listed and published adverse drug events associated with fluoroquinolone therapy. Cipro is a chemotherapuetic antibiotic belonging to this class:

Adverse effects related to fluoroquinolones
Asthenia

Edema

Fever

Malaise

Rigors

Substernal Chest Pain

Syncope

Cardiovascular Disorders

Cardiac Failure

Circulatory Failure

Hypertension

Central and Peripheral Nervous System Disorders

Abnormal Coordination

Coma

Convulsions

Seizures

Hyperkinesia

Hypertonia

Hypoaesthesia

Involuntary Muscle Contractions

Paresthesia

Paralysis

Speech Disorders

Stupor

Tremor

Vertigo

Gastrointestinal System Disorders

Dry Mouth

Dysphagia

Gastroenteritis

G.I.Hemorrhage

Pancreatitis

Pseudomembranous Colitis

Tongue Edema

Hearing and Vestibular Disorders

Ear Disorders

Tinnitus

Heart Rate and Rhythm Disorders

Arrhythmia

Atrial Fibrillation

Bradycardia

Cardiac Arrest

Heart Block

Palpitation

Supraventricular Tachycardia

Tachycardia

Ventricular Fibrillation

Hematology

Decreased Lymphocytes

Liver and Biliary System Disorders

Abnormal Hepatic Function

Cholelithiasis

Hepatic Coma

Jaundice

Metabolic and Nutritional Disorders

Aggravated Diabetes

Mellitus

Decreased Glucose

Decreased Magnesium

Increased Calcium

Dehydration

Hyperglycemia

Hyperkalemia

Hypoglycemia

Hypokalemia

Increased LDH

Weight Loss

Musculo-Skeletal System Disorders

Arthralgia

Arthritis

Arthrosis

Muscle Weakness

Myalgia

Osteromyelitis

Rhabdomyolysis

Synovitis

Tendinitis

Myo, Endo, Pericardial and Valve Disorders

Angina

Pectoris

Coronary Thrombosis

Myocardial Infarction

Neoplasms

Carcinoma

Parosmia

Platelet, Bleeding and Clotting Disorders

Abnormal Platelets

Embolism

Epistaxis

Purpura

Thrombocytopenia

Psychiatric Disorders

Abnormal Dreaming

Aggressive Reaction

Agitation

Anorexia

Anxiety

Confusion

Delirium

Depression

Emotional Liability

Hallucination

Impaired Concentration

Impotence

Manic Reaction

Mental Deficiency

Nervousness

Paranoia

Sleep Disorders

Somnolence

Withdrawal Syndrome

Suicide

Red Blood Cell Disorders

Anemia

Reproductive Disorders

Ejaculation Failure

Resistance Mechanism Disorders

Fungal Infections

Genital Moniliasis

Respiratory System Disorders

ARDS

Asthma

Coughing

Dyspnea

Haemoptysis

Hypoxia

Pleural Effusion

Respiratory Insufficiency

Respiratory Failure

Skin and Appendages Disorders

Erythema Nodosum

Genital Pruritus

Increased Sweating

Skin Disorders

Skin Exfoliation

Skin Ulceration

Urticaria

Urinary System Disorders

Abnormal Renal Function

Acute Renal Failure

Face Edema

Crystalluria

Cylindruria

Hematuria

Vascular (Extracardiac) Disorders

Cerebrovascular Disorder

Phlebitis

Vision Disorders

Abnormal Vision

Conjunctivitis

Diplopia

Retina Damage

Cornea Damage

Ophthalmologic Abnormalities

Cataracts

Multiple Punctate Lenticular Opacities

White Cell and RES Disorders

Granulocytopenia

Leukocytosis

Leukopenia

Lymphadenopathy

WBC Abnormal Count

Allergic Pneumonitis

Anaphylactic Shock

Anaphylactoid Reaction

Dysphonia

Abnormal EEG

Encephalopathy

Eosinophilia

Erythema Multiforme

Hemolytic Anemia

Multi System Organ Failure (Death)

Increased International Normalized Ratio (INR) Prothrombin Time

Stevens-Johnson Syndrome

Tendon Rupture

Torsades de Pointes

Vasodilation

This is but a small sampling of various adverse reactions associated with such therapy.

This list goes on and on and on and on and on. The physician has no clue as to what these drugs can and will do to a patient. There is no known treatment for a majority of the severe reactions. Such reactions DO NOT abate once therapy is discontinued in a subset of those so treated and the current research indicates that such events are to be considered permanent in nature.

David T Fuller
Director
Fluoroquinolone Toxicity Research Foundation
davidtfull@aol.com
www.fqresearch.org

The following are the known, listed and published adverse drug events associated with fluoroquinolone therapy. Floxin is a chemotherapuetic antibiotic belonging to this class:

Adverse effects related to fluoroquinolones
Asthenia

Edema

Fever

Malaise

Rigors

Substernal Chest Pain

Syncope

Cardiovascular Disorders

Cardiac Failure

Circulatory Failure

Hypertension

Central and Peripheral Nervous System Disorders

Abnormal Coordination

Coma

Convulsions

Seizures

Hyperkinesia

Hypertonia

Hypoaesthesia

Involuntary Muscle Contractions

Paresthesia

Paralysis

Speech Disorders

Stupor

Tremor

Vertigo

Gastrointestinal System Disorders

Dry Mouth

Dysphagia

Gastroenteritis

G.I.Hemorrhage

Pancreatitis

Pseudomembranous Colitis

Tongue Edema

Hearing and Vestibular Disorders

Ear Disorders

Tinnitus

Heart Rate and Rhythm Disorders

Arrhythmia

Atrial Fibrillation

Bradycardia

Cardiac Arrest

Heart Block

Palpitation

Supraventricular Tachycardia

Tachycardia

Ventricular Fibrillation

Hematology

Decreased Lymphocytes

Liver and Biliary System Disorders

Abnormal Hepatic Function

Cholelithiasis

Hepatic Coma

Jaundice

Metabolic and Nutritional Disorders

Aggravated Diabetes

Mellitus

Decreased Glucose

Decreased Magnesium

Increased Calcium

Dehydration

Hyperglycemia

Hyperkalemia

Hypoglycemia

Hypokalemia

Increased LDH

Weight Loss

Musculo-Skeletal System Disorders

Arthralgia

Arthritis

Arthrosis

Muscle Weakness

Myalgia

Osteromyelitis

Rhabdomyolysis

Synovitis

Tendinitis

Myo, Endo, Pericardial and Valve Disorders

Angina

Pectoris

Coronary Thrombosis

Myocardial Infarction

Neoplasms

Carcinoma

Parosmia

Platelet, Bleeding and Clotting Disorders

Abnormal Platelets

Embolism

Epistaxis

Purpura

Thrombocytopenia

Psychiatric Disorders

Abnormal Dreaming

Aggressive Reaction

Agitation

Anorexia

Anxiety

Confusion

Delirium

Depression

Emotional Liability

Hallucination

Impaired Concentration

Impotence

Manic Reaction

Mental Deficiency

Nervousness

Paranoia

Sleep Disorders

Somnolence

Withdrawal Syndrome

Suicide

Red Blood Cell Disorders

Anemia

Reproductive Disorders

Ejaculation Failure

Resistance Mechanism Disorders

Fungal Infections

Genital Moniliasis

Respiratory System Disorders

ARDS

Asthma

Coughing

Dyspnea

Haemoptysis

Hypoxia

Pleural Effusion

Respiratory Insufficiency

Respiratory Failure

Skin and Appendages Disorders

Erythema Nodosum

Genital Pruritus

Increased Sweating

Skin Disorders

Skin Exfoliation

Skin Ulceration

Urticaria

Urinary System Disorders

Abnormal Renal Function

Acute Renal Failure

Face Edema

Crystalluria

Cylindruria

Hematuria

Vascular (Extracardiac) Disorders

Cerebrovascular Disorder

Phlebitis

Vision Disorders

Abnormal Vision

Conjunctivitis

Diplopia

Retina Damage

Cornea Damage

Ophthalmologic Abnormalities

Cataracts

Multiple Punctate Lenticular Opacities

White Cell and RES Disorders

Granulocytopenia

Leukocytosis

Leukopenia

Lymphadenopathy

WBC Abnormal Count

Allergic Pneumonitis

Anaphylactic Shock

Anaphylactoid Reaction

Dysphonia

Abnormal EEG

Encephalopathy

Eosinophilia

Erythema Multiforme

Hemolytic Anemia

Multi System Organ Failure (Death)

Increased International Normalized Ratio (INR) Prothrombin Time

Stevens-Johnson Syndrome

Tendon Rupture

Torsades de Pointes

Vasodilation

This is but a small sampling of various adverse reactions associated with such therapy.

This list goes on and on and on and on and on. The physician has no clue as to what these drugs can and will do to a patient. There is no known treatment for a majority of the severe reactions. Such reactions DO NOT abate once therapy is discontinued in a subset of those so treated and the current research indicates that such events are to be considered permanent in nature.

David T Fuller
Director
Fluoroquinolone Toxicity Research Foundation
davidtfull@aol.com
www.fqresearch.org

The following are the known, listed and published adverse drug events associated with fluoroquinolone therapy. Avelox is a chemotherapuetic antibiotic belonging to this class:

Adverse effects related to fluoroquinolones
Asthenia

Edema

Fever

Malaise

Rigors

Substernal Chest Pain

Syncope

Cardiovascular Disorders

Cardiac Failure

Circulatory Failure

Hypertension

Central and Peripheral Nervous System Disorders

Abnormal Coordination

Coma

Convulsions

Seizures

Hyperkinesia

Hypertonia

Hypoaesthesia

Involuntary Muscle Contractions

Paresthesia

Paralysis

Speech Disorders

Stupor

Tremor

Vertigo

Gastrointestinal System Disorders

Dry Mouth

Dysphagia

Gastroenteritis

G.I.Hemorrhage

Pancreatitis

Pseudomembranous Colitis

Tongue Edema

Hearing and Vestibular Disorders

Ear Disorders

Tinnitus

Heart Rate and Rhythm Disorders

Arrhythmia

Atrial Fibrillation

Bradycardia

Cardiac Arrest

Heart Block

Palpitation

Supraventricular Tachycardia

Tachycardia

Ventricular Fibrillation

Hematology

Decreased Lymphocytes

Liver and Biliary System Disorders

Abnormal Hepatic Function

Cholelithiasis

Hepatic Coma

Jaundice

Metabolic and Nutritional Disorders

Aggravated Diabetes

Mellitus

Decreased Glucose

Decreased Magnesium

Increased Calcium

Dehydration

Hyperglycemia

Hyperkalemia

Hypoglycemia

Hypokalemia

Increased LDH

Weight Loss

Musculo-Skeletal System Disorders

Arthralgia

Arthritis

Arthrosis

Muscle Weakness

Myalgia

Osteromyelitis

Rhabdomyolysis

Synovitis

Tendinitis

Myo, Endo, Pericardial and Valve Disorders

Angina

Pectoris

Coronary Thrombosis

Myocardial Infarction

Neoplasms

Carcinoma

Parosmia

Platelet, Bleeding and Clotting Disorders

Abnormal Platelets

Embolism

Epistaxis

Purpura

Thrombocytopenia

Psychiatric Disorders

Abnormal Dreaming

Aggressive Reaction

Agitation

Anorexia

Anxiety

Confusion

Delirium

Depression

Emotional Liability

Hallucination

Impaired Concentration

Impotence

Manic Reaction

Mental Deficiency

Nervousness

Paranoia

Sleep Disorders

Somnolence

Withdrawal Syndrome

Suicide

Red Blood Cell Disorders

Anemia

Reproductive Disorders

Ejaculation Failure

Resistance Mechanism Disorders

Fungal Infections

Genital Moniliasis

Respiratory System Disorders

ARDS

Asthma

Coughing

Dyspnea

Haemoptysis

Hypoxia

Pleural Effusion

Respiratory Insufficiency

Respiratory Failure

Skin and Appendages Disorders

Erythema Nodosum

Genital Pruritus

Increased Sweating

Skin Disorders

Skin Exfoliation

Skin Ulceration

Urticaria

Urinary System Disorders

Abnormal Renal Function

Acute Renal Failure

Face Edema

Crystalluria

Cylindruria

Hematuria

Vascular (Extracardiac) Disorders

Cerebrovascular Disorder

Phlebitis

Vision Disorders

Abnormal Vision

Conjunctivitis

Diplopia

Retina Damage

Cornea Damage

Ophthalmologic Abnormalities

Cataracts

Multiple Punctate Lenticular Opacities

White Cell and RES Disorders

Granulocytopenia

Leukocytosis

Leukopenia

Lymphadenopathy

WBC Abnormal Count

Allergic Pneumonitis

Anaphylactic Shock

Anaphylactoid Reaction

Dysphonia

Abnormal EEG

Encephalopathy

Eosinophilia

Erythema Multiforme

Hemolytic Anemia

Multi System Organ Failure (Death)

Increased International Normalized Ratio (INR) Prothrombin Time

Stevens-Johnson Syndrome

Tendon Rupture

Torsades de Pointes

Vasodilation

This is but a small sampling of various adverse reactions associated with such therapy.

This list goes on and on and on and on and on. The physician has no clue as to what these drugs can and will do to a patient. There is no known treatment for a majority of the severe reactions. Such reactions DO NOT abate once therapy is discontinued in a subset of those so treated and the current research indicates that such events are to be considered permanent in nature.

David T Fuller
Director
Fluoroquinolone Toxicity Research Foundation
davidtfull@aol.com
www.fqresearch.org