Asthma allergy symptoms and conditions

hi i came across this site through sheer desperation to find out if all the terrible symptoms my 13 yr old daughter was experiencing was through any of her asthma/allergy meds She has been on singulair since she was 5yrsold . But gradually over the past year her symptoms are that bad that she has weeks off school with dreadful headaches, stomach pains, mood swings which have been going on for last few years but put most of these down to puberty kicking in (but how i think i was so wrong). she has an allergy to peanuts which has been confirmed through tests but i was finding that lots of different foods were causing allergic reations which i could not understand(put it down to e numbers etc) she has been off this last week through yet again more headaches,chest infection, nausea but now the most terrible symptom is that of very painful ankles. knees, which are that sore she has been in tears.Since reading these post i am going to take her off the singulair but will do it at a gradual rate 1/2 tablet then 1/4 etc as she has been on this for a very long time and sudden withdrawal seems to be very risky. oh i also forget her rhinitis is also a major problem which causes her to be terribly bullied at school due to how noisy her breathing is and her snuffling being so often and seems to be getting worse. I am very grateful that i have come across this website.

I am 44 years old and have been taking singulair for about 4 years. 3 months ago I started experiencing crushing chest pain, tingling in my lower limbs, and felt very stressed out. I went to the ER last Thursday and was checked out for angina - the ER doctor told me I was suffering from chronic severe anxiety. I took Ativan for 4 days and felt better, but now the drigs are gone and I again having constant chest pain. In doing some research I found that anxiety can be caused by imbalance in adrenaline, and so started looking online to see if any of the allergy/asthma meds I am taking (adviar, singulair, allegra) can affect adrenaline. That';s when I found this website. Although i find the testimony compelling, I wish more folks would have poted about how their symptoms improved (or didn't) AFTER discontinuing singulair. Also I've noticed many of the stories are about children not adults; many people are taking more than one med for asthma, and most people's symptoms seem to come on right away whereas I have been taking sinulair for years and only recently have anxiety. I will stop singulair tonight and see what happens, but am wondering if anyone has come across further research that correlates singiulair with anxiety? My job life is really peaceful, I am otherwise happy, work can get hectic but that's true of any job, and I am out of ideas as to why suddenly at age 44, when I eat right and exercise - why get anxiety? Thanks for the posts, I'll try to remember to follow up after I am off Singulair for a few weeks.

My husband has been on Singulair for ten years now. It was a miracle drug for us as his asthma and allergies were ruining his quality of life. Little did I know that the Singulair would have such drastic effects as well. He is a police officer who has been through some traumatic events in his career. I attributed his irritability, depression, anger, severe nightmares, heartburn, weight gain, and puffy swollen eyes to post traumatic stress disorder. He stopped taking the medication about two weeks ago after his prescription ran out and he saw the FDA report. He is once again the man I fell in love with. Now I know what has been causing all of the changes in him, and we have decided he will never take Singulair again.

I am a part-time professional singer and attorney. I developed an odd cough-variant asthma this winter at age 42 -- it had scary breath shortness and wheezing plus lots of phlegm coughed up. I had never before had the shortness/wheezing/asthma, though I have always had allergies and occasional bronchitis following a cold. The asthma/allergy specialists put me on Advair 500 twice a day with each attack, plus an oral prednisone burst/short taper, nebulized (not just rescue inhaler) albuterol (beta 2 agonist), and antibiotics (a different one each time). I also take Claritin, Rhinocort and Astelin for my allergies. I had four attacks of asthma this winter that were treated this way; after the fourth, they put me on Advair 250 maintenance for a month. With each attack, I would get hoarse, have trouble sleeping, and get odd muscle cramps I never had had. The hoarseness was worse each time, but I was able to sing through it at my regular gigs. I attributed the side effects to the prednisone. With my fifth attack, they told me to ramp up the Advair to 500 and do all else the same, but as an experiment to see how this would alter those side effects, I decided to treat it with everything but the prednisone. The hoarseness, sleep trouble, and muscle cramps were all much worse. I found this site, noted the recommendation of several other singers to try Asmanex instead of Advair, and asked the docs about it. They agreed that all these symptoms could be related to the Advair and gave me Asmanex 250 twice/day instead instead of the Advair, plus all the other meds for the attack. The symptoms went away within a week, although it took a little longer for me to get over the asthma attack this time. I am extremely grateful to this site and all the users posting comments. I can sing again, sleep again, and exist without weird muscle cramps during treatment of my asthma. Thank you very much.

An allergist prescribed Singulair for my son when he was starting first grade for asthma/allergy prevention. The side affects were immediate. He became very explosive, angry, panicky and paranoid. Worst of all, he developed severe nightmares. We would be awakened at about 11:30 when he started yelling. He was terrified and could not fully awaken to come out of the nightmare. He dreamed he was being chased by meat-eating dinosaurs. It took a while for him to explain because his speech skills were delayed. About a week into this, I decided to take him off Singulair and was relieved to find the symptoms completely disappeared. I would not recommend this drug for children. Their brains are still developing. It would be like giving them meth!

I had been taking singulair for over two years. I am 70 yrs old and in good health except for light asthma, allergy problems. My doctor took me off it. It did some good in the beginning but the last four mts I was continuing to get wheezing and bronchitis infections. I also had a lot of leg pain and was tested for all kinds of blockage, etc. I experienced very painful leg cramping, toes twitching, etc. The only way I could stop it was to pull my toes forward as the worst happened at night and woke me up. I finally found Leg Cramps with Quinine an all natural homeopathic med. It worked like a charm. I didn't know that this was a side effect of Singulair. Since I am off singulair just two weeks. It was replaced with Flovent an inhaler ( 2 puffs 2 x a day to begin and then later it will be 1 puff as the inflammation gets better. It also comes in granules. I am feeling much better and now I am ready to stop Leg Cramps as I feel the singulair may have been causing the problem. While taking Singulair I also had stomach cramps with diarrhea. I will not go back on Singulair. If the cramping returns, I will definitely go back on Leg Cramps with Quinine (available in any pharmacy over the counter and very inexpensive.

So happy to find this site. I never noticed My son never had an eye tick until last month, ironically we started giving him Singular on a daily basis about the same time. My son just turned two and is has also been waking up screaming 3 times every night. Have others reported this same problem...also he is on Pulmicort too, have you read that it is linked to Glaucoma and Cataracts? Do you think that this could be causing the tick? Please HELP! I want a parent's opinion before bringing this up to the doctor...they are so quick to jump to more drugs it makes me sick! Thank you! Any other children with eye "ticks" like really quick consecutive blinks?

POLL: If you or your child have been adversely affected by Singulair could you please reply to this and let me know what ethnicity you are and skin tone. (fair, med., dark, etc.) I'm interested in the demographics of this drugs effects.
Thank you!

My daughter is 8 and was prescribed Singular AND Zyrtec for asthma/allergy maintenance. She's been on both meds for 7 months. I have seen a steady decline in her ability to learn. Prior to these meds, she knew her addition math facts. Now, she forgets simple equations (3 + 4). Her mind wanders, she is unable to focus, and homework that should take minutes takes hours.

In addition, her emotions are all over the place. My little girl who once loved nature and held wiggly earth worms in her hand now runs in terror from any bug. She is frightened of everything.A tiny scratch makes her emotionally distraught for hours. She obsesses over slights from friends and withdraws to her plush toys.

She's also created imaginary monster friends: werewolves, vampires, and other ghoulish creates. She tells me of the living dead who cut off part of your skull and eat your brain and so you become part of the living dead. This is from a child who has never seen, watched or been allowed to view a horror film of any kind, who still watches Noggin and PBS on TV, and who, 10 months ago, wanted to be a marine biologist when she grew up.

Like others, the first symptoms were nightmares and night terrors. She also experienced itching, which I thought was due to her ballet leotard and tights (why do we look at everything but the meds?--because we trust the doctors!!!). Then, toward the end of school, came the stomach and headaches, so frequent, in fact, her teacher emailed me that my daughter was going to the school nurse too much and wanted to know if something was wrong. Her teacher also said my daughter seemed very spacey in class. No behavior problems. Just drifting. Very inattentive.

Like others, my daughter had her tonsils removed prior to going on these meds. Like others, my daughter was seeing a specialist--a pediatric allergist--for treatment. I discussed adverse effects for all medications with the allergist.

Like others, Dr. Allergist said there were none for either Singulair OR Zyrtec. My daughter had been prescribed childrens' Claratin (Rx for liquid form) by a pediatrician when she was 5 and exhibited the same behavioral and learning problems she now has for Singulair and Zyrtec. Again, Dr. Allergist said there were no side effects, that Claratin had a different active ingredient (I don't recall the name, something like lurderine) and to keep away from online Web sites, as they will only scare me. Ha! She also said ignoring my daughter's asthma posed greater harm than treating it. This is for a child whose asthma was non-existant until she began Claratin.

From my research, I'm wondering if the meds used to treat allergies and asthma actually contribute to lung ailments. Since starting these "meds," my daughter has had pneumonia and bronchitis. She did not have any lung ailments prior to Claratin. In fact, she was perfectly healthy.

Has your child experienced the same? Have you?

As another alternative for action, I am contacting my PTA and am pushing from that direction. These meds affect our children's abilities to learn. Teachers care. I urge all parents to discuss your situation with your child's teacher and push an agenda with your PTA. Collectively, the PTA can be an influence (it already has a nationally recognized presence with solid reputation). Forget the medical community (for now--drug reps "buy" doctors). I am telling friends whose kids have asthma about Web sites. I am writing to my Senators and the FDA as well.

Thank you to everyone who has taken the time to post. We can collectively push forward to get action soon for our children. Please, do not just sit and read. Take action. Your kids need you to.

I am a 26 year old female and was prescribed Advair some years ago by my Asthma & Allergy doctor. I took it off and on for several years. Honestly I was scared to take it because of the side effects I thought it might have. About 16 months ago I went off birth control because my husband and I wanted to have a baby. I continued to take Advair 150/50 twice a day. I got pregnant in July and had a miscarriage Sep 1. Then while still taking Advair I got pregnant again shortly after that. After my first OB appointment it was established that the fetus/egg sack had no heartbeat. I had a D & C done in December to clear out the unsuccessful pregnancy. I decided after reading all these comments and thinking about my own side effects of taking Advair that my miscarriage were the cause of taking Advair. I believe Advair may have decreased my body's ability to clot blood properly and that is what has caused my babies not to thrive. I decided in January of 08 to stop taking Advair. I asked my doctor about the Advair and being put on another medicine in Jan and he seemed to think that there was nothing wrong with me taking Advair. I stopped taking it anyways. I decided since mostly all of my mild Asthma symptoms were caused by exercising that I would just use Proventil/Albuterol inhaler before exercise. It worked great and in Jan, Feb, March of 08 I trained for a 5k, and ran it in March under 26 minutes. I have been off Advair ever since Jan and have been fine. I used a peak flow meter to be sure my breathing was normal. I only use the Albuterol occasionally now. Furthermore I am now almost 20 weeks pregnant and doing fine. Besides the miscarriages I also blame Advair on other side effects I experienced when taking it including leg cramps, increase in heart rate, restlessness after taking in evening, night sweat, hoarseness, dry throat, headaches, and whenever I would get a cut or something it would take forever for me to stop bleeding.
now my blood clots quickly no problem. I was taking no other meds besides Advair when I experienced all this. DON'T TAKE ADVAIR...unless you feel the benefits of the drug outweigh all of the horrible side effects. Demand another med. with fewer side effects.

After an allergic episode about a year ago, I was diagnosed with asthma. The doc put me on advair (2 puffs - twice a day) . After 4 months, I started having an anxiety issues. I couldn't turn my mind off, felt restless and was stressed out and full of worry about dying from the asthma. At this time I got a job 80 miles from where I was living and had to move. My family and friends attributed my mental state to my life change. Up until now, I had never had any issues with anxiety or depression. Over the course of about another 4 months things got worse and I went to see a asthma/allergy specialist. He put me on Allegra for my allergies and prednisone for the asthma. Needless to say, things got exponentially worse. i could not sleep, was restless and found that I would just get up and run around my backyard. The anxiety had gotten so bad with the lack of sleep that I almost couldn't take life. The doc never let me know about the side effects of the prednizone. A month later (now almost nine months from my original diagnosis) I went back to the doc to see what was wrong because of the depression and anxiety. He sent me to the pysc unit to arrange counseling. That never happened due to the business of the clinic I was at. 2 weeks later I stopped taking the Allegra and Advair. Within a day to day and a half I felt like a huge weight had lifted and it took a couple months to get back to what I would call fairly normal life. I share this just in case someone else is having similar effects or life events. It has taken almost 6 months to shake the mental patterns from the few months of exposure that I experienced. Know your body, listen to it and don't blindly accept what a doctor tells you without research. Doctors are a great asset, but science only goes so far and then God.

I spent the weekend reading about the development of Singulair. The early studies recognized that the first phase of the acute asthma response bronco-constriction was probably not caused by leukotrienes. They identified histamines and prostaglandins as the probable sources. I don't think that changed because the Singulair literature states that it should not be considered as a treatment for that. Leukotrienes were a source of inflammation caused by eosinophils and mast cells present in greater numbers (than normal) in airway tissue. So, it was beneficial to find a way to decrease that.

The cysLT1 receptor was identified as source of the signals that tell the cells to produce leukotriene. The receptor, a gene, consist of 337 (they think) amino acids. They modified a compound that would bind to that receptor thus blocking the cells ability to produce leukotrienes. This compound is very specific. It was formulated to bind to the "model" receptor. This compound will not even bind to cysLT receptor sub-types. (That is the good thing.) There is an enormous amount of research that discusses the genetic variability of the chemical reactions that occur in the leukotriene (calling it this for simplicity) pathway. We are also seeing that a number of researchers would like to use gene profiles to predict whether patients will respond favorably to different asthma/allergy drugs. ALL PATIENTS HAVE A RIGHT TO KNOW IF IT IS INHERENT THAT SOME PEOPLE WILL NOT RESPOND TO SINGULAIR OR RESPOND ADVERSELY.

There are many studies from the 1998 era that conclude that montelukast is not effective for everyone. Those researchers stated that it can be predicted that those people who are going to respond favorably will do that within the first 14 days or so. That conclusion would be consistent with a genetic component for efficacy and safety of Singulair. Those doctors concluded that those who did not respond within that time frame should not take Singulair for fear of harming them. That makes good sense.

The Italian researchers wanted to know if there was more going on than blocking leukotrienes in the action of montelukast. They set up a "test tube" study regarding montelukast, the cysLT1 receptor, and some t-cells that they selected. Why? Researchers always have something on their minds. They observed the death of these particular t-cells.

Montelukast is a quinoline. We basically know of quinilines and quinolones as compounds that were invented as broad spectrum antibiotics. They work because they interference with bacterial DNA so they cannot replicate themselves. Montelukast is a quinoline modified to bind with the cysLT1 receptor (a gene) and prevent that gene from activating. That's consistent with what a quinoline/quinolone does.

So what does montelukast do in blood plasma if it does not bind to the receptor because of genetic mis-match? (If montelukast does bind, then a chemical reaction has occurred and the liver will break down the by-products. Montelukast metabolized in 10-12 hours.) What happens if it doesn't bind? How long before it breaks down? Does it produce toxic by-products?

I want to know what happens to lymphocytes such as t-cells just because montelukast is a quinoline. Maybe nothing but what's up with the Italians researchers? I want to know if montelukast has the capability to interfere with lymphocytes who can clone themselves. That could be a good thing under circumstances when these lymphocytes are causing inflammation. But it could be a bad thing in the case of normal individuals with no problems.

I want to know if the bad side effects are due to the fact that the body has to break down and metabolize a quinoline that did not bind to the receptor for which it was created. The side effects of Singulair are strangely similar to what is observed in the quinolones such as levaquin. I have not as yet been able to compare montelukast as a quinoline to levaquin as a quinolone. I am hoping to find something on these categories. There may be no reason to worry that they cause similar damage. But frankly, I think that there is. There is some terrible chit happening to some people. The scariest is the neurological damage.

All of these questions would be in the everybody pharma knows to ask category. I don't know where the answers are. I haven't found them as of yet. Maybe there are no answers. We have to remember that Singulair and Vioxx were released in the same year. They have continued to be drugs under the current executive management of Merck. If the Vioxx marketing promoters had their ghost writers, why not the Singulair marketing promoters. The genetic component appears to be widely accepted but we haven't heard one thing about even that.

I think that it is sad that maybe the marketing of Singulair as one stop shopping for asthma/allergies may have destroyed the original concept. I really think from reading the original work that they knew that they couldn't engineer a drug for one size fits all. Everybody gets harmed when information is withheld.

Shame on the allergist who yelled at the mother who wanted to discuss issues. Does he know exactly who is allergic to Singulair and who isn't? Get him a dunce hat. Just because Singulair is marketed for allergies does not mean that you cannot be allergic to it. See the power of Madison Avenue? The ad agencies focus group these drugs to death. The ad agencies cleverly craft the product information. A good piece of legislation would be to prohibit consumer drugs ads.

My 13 yr old daughter was put on Singulair along with Asmanex and Clarinex for her asthma about 6 weeks ago. Everything seemed to be going very well at first and her symptoms were starting to get controlled. I started noticing after about 3 to 4 weeks that her temper and attitude were getting much worse. Anyone with children this age knows what I mean but this was like a 180 degree turn for her. Her actions were becoming totally out of character. Before I knew it she would cry and get highly upset over the least little thing. Week 5 came around and things totally bottomed out. She came home from school and WAS NOT HERSELF. Made comments about how she hated her life and it was not worth living. Later that evening we had a big argument because I was telling her nothing was worth saying that. She went totally out of control and I had to physically restrain her to calm her down. It appeared everything was better so she went to her room. I went down to check on her and she calmly told me that she had taken advil and tylenol pm and things would be better for her forever now. We went to the ER where they made us wait for at least an hour, then finally took her back. She had to drink two cups of charcoal and was poked and prodded repeatedly. They did a catheter to get a urine sample. She was very cooperative but also was in a complete daze so who knows. The poor child couldn't even lift her head up when she started the vomiting to get rid of the drugs. It was very upsetting and sad. Her heart rate and blood pressure went very low and I really thought in the back of my mind that this was it. Finally, after several hours she started coming out of it and they sent us home. The next evening when she was starting to really come around she proceeded to tell me how she had been seeing a man walking around in her bedroom at night and she was afraid to go down there. Breaking down and crying telling me about all of the horrible nightmares she had been having recently and didn't know why. I thought what am I dealing with here? This just isn't her. Three days ago I heard about singulair in the news and looked it up on the internet. OH MY GOD THIS SOUNDED LIKE US!!!!! I immediately had her stop taking it and the next day phoned her asthma specialist who agreed she should stop now. We are going to watch her for two weeks and see if any symptoms return and then decide if she needs something else or will be fine on just the Asmanex. As a side note, she also mentioned being unable to concentrate in school (unable to do even the simplest math problems) and that her brain felt confused or like something was missing. She said this had been bothering her for several weeks. I know it was this drug. They really need to take this off the market NOW and stop flirting with disaster. The only reason I posted this was to let others know they are not alone.

Unfortunately my lawyer told me that they do not want to take our case because of the lack of evidence that Singulair has caused our daughters problems. :(

Does anyone out there have a pending class action lawsuit that We may be able to get in on? I have tons of proof that Singulair has caused our daughters problems and loss of almost 5 years of her elementary school career!

My phone number is *** and my email is ****** if You email me please put "Singulair" in Your subject line so I know it pertains to this posting.

Thank You in advance,
Chuck & Brenda
Jamestown New York

Effective after two weeks for some people - not effective for others. Side effects for some people - others do not report side effects. So why does Merck have to grow their market before they have any idea what's going on?

This isn't a big group of people in the study but it makes sense from what we are reading here. These researchers did examine the mast cells. We need to know about mast cells (while suppressed by montelukast) on a longer term basis.

J Asthma. 2008 Apr;45(3):243-50. Links
The efficacy of montelukast and airway mast cell profiles in patients with cough variant asthma.Kawai S, Baba K, Matsubara A, Shiono H, Okada T, Yamaguchi E.
Division of Respiratory Medicine and Allergology, Department of Internal Medicine, Aichi Medical University School of Medicine, Aichi, Japan.

Background. Cough variant asthma (CVA) is characterized by chronic cough without apparent wheezing; its pathophysiology is considered to be similar to that of classic asthma. Objective. The clinical effects of montelukast, a cysteinyl-leukotriene receptor antagonist, on cough variant asthma were assessed, and the activation profile of airway mast cells was examined. Methods. Montelukast (10 mg/day) was given orally to 36 CVA patients (25 women and 11 men; median age, 37.5 years). Before treatment, the patients' bronchial mucosa underwent a biopsy with a fiberoptic bronchoscope. The biopsy specimens were double stained with anti-CD63 antibody and anti-human tryptase antibody. Results. After 2 weeks of montelukast treatment, cough symptoms improved in 22 patients (the effective group) but did not improve in 14 patients (the ineffective group); in the ineffective group, the symptoms disappeared 2 weeks after they were switched to fluticasone propionate (400 mug/day) inhalation therapy. In the effective group, the time interval from the onset of symptoms to the initiation of treatment was significantly shorter than in the ineffective group. The bronchial mucosa biopsy specimens showed that the proportion of CD63-positive cells in tryptase-positive mast cells was significantly higher in the effective group than in the ineffective group; although the total numbers of mast cells were not different between the two groups. Conclusion. There is a subgroup of CVA patients in whom leukotrienes are closely involved in the pathogenesis of their chronic cough; activation of airway mast cells may be an essential feature in these patients.

PMID: 18415834

I just got a very condescending private message from a doctor on this site who said that while my articles from Europe are very helpful that I don't know what I am talking about and that I could mislead the public. Then I see how many parents and patients got a condescending attitude from their own doctors.

Well the public has been mislead but it is not my fault. I don't see any experts in this field stepping up to the plate to acknowledge that these side effects exist, have been reported by authorities in other countries, and that these experts are interested in learning why they are happening. This is an extremely widely prescribed medication that involves the lives of millions.

Merck's research director was quoted as saying that they know of no mechanisms by which these side effects could be related to psychiatric adverse drug reactions. That was a flat out LIE. So what if I quoted you a research article from China that was very complicated and yes, could possibly be misinterpreted by somebody? I just needed to give you an example. The only expert so far that had the guts to give you a truthful statement was Dr. J. Douglas Bremner. Thankfully, he corrected a misunderstanding about saying that it was "unclear."

I hope that we will all hang in there and something will be said by somebody, anybody on this site that will make the FDA listen and investigate Singulair (montelukast) all the way back to the very original studies done in test tubes not on people. And, then take a new look at it from the standpoint of what we now know about human genetics. I guess I will keep repeating myself about one size does not fit all.

I would also PRAY that all clinical studies on Singulair (montelukast) would be suspended until the FDA decides why these side effects occur. And that they would issue a statement to doctors to make conservative decisions regarding treatment with Singulair until the results of the investigation have been reported.

I hope that nobody thinks that I am trying to mislead anyone. The answers are either unknown or being hidden by Merck. How would I know the answers? I don't work for Merck. How many other people are out there trying to translate articles in foreign languages to see what's going on? American doctors are calling Merck and being assured that there is nothing to these claims.

I wonder how many experts there are that just don't want to be another Jeffrey Wigand or don't know what is wrong?

I know that I am ranting but somebody should do it.

My daughter, now 7 years old, took Singulair (4mg crystals) every evening from 12/29/2004-4/3/2008 (with 5 days off in 2/2008 ONLY). She developed significant mood disturbance/mood swings, sleep disturbance/frightening dreams and anxiety/unexplainable fears during this time, which we have now attributed to the drug, Singulair - the ONLY MEDICATION SHE WAS TAKING besides occasional antihistamines (which caused no problem). The drug Singulair clearly caused significant psychiatric symptoms in my daughter which are strikingly similar to symptoms now being attributed to the drug by MANY parents across the country. I suspected Singulair of negatively affecting my daughter and talked to her allergist about taking her off it in 2/2008 (before any news broke about links between Singulair and suicidal thoughts/behavior). The effects of Singulair on the brains of children are NOT UNDERSTOOD and/or NOT reported. I believe that this is a dangerous drug. It has been very difficult to connect the use of this asthma/allergy drug to behavior/mood issues in young children for two reasons. First, improperly trained physicians confuse drug "side effects" with normal child development (a "phase") or psychiatric illness. Second, Singulair has been heavily marketed as "SAFE" (to the medical community and directly to patients and their parents) and therefore has not been suspected when these serious psychiatric disturbances are reported to doctors. Pediatricians and allergists have said for years, "It couldn't be the Singulair" because that is the impression SOLD to them by Merck.

My 15 y.o. daughter has has first hand experience with weight gain on Advair. About 6 years ago at about 9 y.o., she gained 20 lbs in 6 months - and it started happening exactly when she started the drug. She was very active (swim team, gymnastics, etc) and did not overeat. It is very frustrating that both her pediatrician and her asthma/allergy specialist deny that her small dose of Advair is to blame.

For some reason, and I have talked to others that this has happened to, switching to Singulair did not help her with the weight problem. Seems the people who are hypersensitive to inhaled steroids are also sensitive to Singulair. Concerned about her rapid weight gain, and because she was always so thin, I took her to an endocrinologist to rule out any other problems. After a lot of bloodwork, he concluded that he could not rule out that it was a side effect of the Advair and/or Singulair, and that they may have elevated her blood sugar. I have read tons and tons of postings on the internet about children & adults rapidly gaining weight from inhaled corticosteroids (i.e. Flovent, Advair), along with the round face, bloated stomach, stretch marks, thin skin, easy bruising, etc. but nobody ever says what happens after stopping any of these drugs. Do people ever go back to normal? Do kids look like themselves again? Do any of the side effects disappear?

She is now 15 y.o. and cannot reverse her weight gain no matter what (30 lbs overweight). The last 2 years, she has only been on a small dose of Pulmicort (a different class of corticosteroid even safe to take when pregnant) since she has mild persistent asthma, and allergy shots have helped trememdously. My husband and I have been looking for 6 years now on how to avoid our daughter's weight gain with asthma drugs. If you run into any info., please let us know. Any experiences or info would be greatly appreciated. Thanks!

My 8 year old daughter has been taking Singulair for 4 years. She immediately began having sleeping problems. I never connected it to Singulair. When she was 5, she had a check-up with her Asthma/Allergy doctor. I received a new prescription and had it filled at Costco. She became more irritable and the sleeping problems persisted. After I had the second refill and had the information sheet Costco had given me, I decided to read the about side effects. That was when I realized she was taking the 10mg dose for ages 15 and up at 5 years old. I knew she was taking a different dose but it was new script because she had been at the doctors and I thought the doctor had just increased the dosage. I called Costco and had them check the original prescription and sure enough they had entered it wrong in their system and was given an OVERDOSE. They did pay for any tests for Physical damage (blood work and liver), and gave me free pills that were dispensed incorrectly. I assumed everything was ok now that she was back on the 5mg. dose again. She has still continued to have sleeping issues and her aggressive behavior has gotten worse. She has consistently had stomach problems, daily! A month ago I had an evaluation done for academic purposes, When the Psychologist was done he was saying she was a sweet girl. I proceeded to tell him about her violent outbursts. Just that morning her brother, 6yrs.old, was walking by her and out of the blue she took the pencil in her hand and slashed across his chest. I told him these were typical of the behavior at home and I had tried all type of discipline to no avail. HE WAS SHOCKED. He said that wasn't her personality at all. After talking to him a second time, He said it was probably a combination of her age, hormones starting to kick in and sibling rivalry! I knew it was more than that but still never connected it to Singulair! Well, as of today she is off the Singulair. I can't wait to see if her behavior changes. I see these posting go all the way back to 2003! If only I had thought to look online first!

I have a 9yr that was placed on Singulair about 3 or 4 years ago with Concerta for ADD. He was always coughing at night and the doctor said it was allergies and told me to give him 5mg every night before bed. And the school said he had ADD. Well needless to say, my son weights 48 lbs and has had headaches. But he also doesn't act like a normal 9 yr old should. He does things destructively (breaks toys and destroys things in the house) and states that he doesn't know why he does things. He doesn't want to clean his room, shower, brush his teeth like he used too, and he acts depressed all the time. I ask he whats wrong and he says he doesn't know. He doesn't want to play outside or do anything remotely fun. After reading all these post I'm wondering if I should take him off the medication he's on and see what happens but I'm afraid of more side effects. The doctor says he needs to be on this medication. He has problems going to sleep at night is this a side effect? Any advice would greatly be appreciated.

My 5 year old son was put on for very mild asthma before xmas. After he returned to school, the teacher noticed he was not listening, difficulty attending, talking nonstop ( normally quiet), and repeating the same questions. At home, we noticed complaints of tummy aches, after 2 weeks very loose stools, irritability, extreme difficulty attending to any task, disorientation, rolling around on the floor, tic disorder; he started flipping his head side to side as if he's checking for something, and poor sleep (3-4 times awakening) esp. w. vivid nightmares, eg. crying because his snowman was melting and dying and dry nasal passages w/ bleeding sometimes. I notified the asthma/allergy doc. that we were going to discontinue. It has been a week now and his stools have formed better, not complaining of tummy aches, but attention/concentration still an issue as are tic movements; also came down w/ sinus infection so perhaps being sick is attenuating these symptoms. I hope he can get back into his zone. We are worried.

My normally healthy 3 year old daughter came down with a cough that she couldn't shake. My husband and I have both had the same thing, but I still thought I'd better take her to her pediatrician. He said he did not think she had asthma, but he would give me a 30 day chewable sample of Singulair to get rid of the cough. My husband nor I could really understand why we were giving her an asthma/allergy medication for what we took to be a cold with a cough (again, we both have had the same thing ourselves), but we figured the doctor knows better than us.

Wish I had listened to my gut reaction. I only had her on Singulair 2 days before deciding I needed to find some more information about Singulair. In those 2 days, she immediately began complaining that her belly hurt. She wouldn't eat, had trouble sleeping, became even more temperamental and moody than she's ever been. She woke from a fitful sleep the second night and even though I was sitting right beside her, she cried that she couldn't see me. I have had her off Singulair for 4 days now and tonight was the first time she's had any appetite since she started the medication. I'm hoping she's on her way back to her normal self.

I am so glad I found this website before I gave her any more of what I consider to be a poison. It outrages me that I took her to the doctor for a cough and instead put her through this. It bothers me to no end that kids who don't even have asthma or allergies are being given Singulair. I've always trusted our pediatrician, but now I have serious issues with going back to him.

My son has been taking Singulair for the last three years. He was only 2 when his doctor said he needed it for asthma. I wondered why he never got out of his "terrible twos". He was so horrible to even live with I would be in tears by noon. Very rude , hurt people, And had atistic behavier to appeir