Cholestasis symptoms and conditions

Sever Urticaria on the 10th day of a 15 day course of Nitrofurantoin for chronic UTI. The urticaria has already lasted 2 weeks and has not subsided yet. Taking Antihistamines. This is the third such instance of urticaria after taking Nitrofurantoin in the last 7 years. In the previous 2 instances urticaria started weeks after finishing the antibiotics course hence could not associate it the drug. Doc feels it could be drug induced liver cholesterol which is causing the itching. I am a 34 yr old female

Took it a year and a half ago. Made me nauseous, weak, sleepy, tired, sad, no sex drive, and itchiness all over my body. I suffered from Cholestasis for 2 pregnancy and was experiencing the same symptoms. Also had the same effects from NuvaRing and Femcon Fe.

My significant other took Doxycylene, 100 mg, twice a day for two weeks to treat a swollen lymph node under his arm. During the treatment he experienced nausea, stomach pain, rash and cold sweats, nothing too bad. 3 days after the last dose everything got significantly worse. It started with sever chest pain, so bad we went to the emergency room thinking it was a heart attack or blood clot. They found nothing and discharged him. Over the next 3 weeks he started vomitting, diahrea and developed jaundice. Constant queeziness and chest pain. After numerous tests, ultra sounds, MRCP, the doctor has ruled out various hepatitas's and every other disease he could think of. He's also rulled out any kind of bile duct blockage after the MRCP. Its now been 7 weeks since all this started, my friend has dropped 40 lb's (190 down to 152) and still dropping. Our doctor (gastro interologist) has admitted he's stumped and is currently contacting a professor in Miami as a last hope. The only thing our doctor keeps comming back to is the Doxycyclene and that my friend may have had that one rare acute reaction. We're frazzled and don't know what to do next.