Clinical trial symptoms and conditions

On Vytorin for the first time 10/80 for 8 weeks -cholesterol numbers are fine now. My liver count was slightly high and my doctor said that was fine. I took myself off. This is the 3rd day without and I am less tired each day and I am feeling like myself again.

Welcome a board singulairsurvivor. I received back an email from the woman at the lung association,she was of course sorry for our experiancr,and went on to say the scientist that reviewed the data were some of the best,and the association has no ties to any product.then as i am watching the updates on the hurricanes,i am inendated with singulair commercials as once again it is allergy season,so what a windfall for Merck that this article came out this month and not next....Coincidense i think not shame shame shame on you.To all those unsuspecting people about to get their prescription .i am sorry

I was prescribed 750 mg. Levaquin, one a day for 14 days for a severe sinus infection. We left to visit my son and family in Texas two days after starting the medicine. The entire time we were there I could not sleep. The second day we were there I was walking down the stairs when a pain hit me in my left calf that was so bad I thought I had surely torn a muscle or something worse. It continued to be painful for several days. We returned in four days and I noticed that I was aching all over. I have arthritis and some other problems, so didn't think too much about it. However, it continued to get much worse. My feet hurt so badly that I could hardly bear to walk. My heels are especially painful. I cannot bend my toes without terrible pain and my feet have been swollen. I have sharp tingling pain in my toes as well. My hips and knees are very painful. I am shuffling around just trying to walk and get up and down. I started having a strange pain in my right shoulder area. Am still having insomnia. This is very scary and after reading all the posts it is even more frightening since you don't know what to expect even further down the road. I have an appointment in the morning with a neurologist. I don't know what they can do and I don't want to be put on a bunch of other drugs. I just hope he acknowledges that the Leviquan caused this and doesn't try to come up with some excuse. I have absolutely no doubt the Leviquan caused this as it was immediate and continued to get worse as I took it. I stopped after 11 days and only wish I had stopped sooner, but you just keep making excuses for the weird things that are happening until you finally realize there is something very wrong. I have experienced a lot of pain in my life, but nothing like this. My brother has acute leukemia and has horrible neuropathy in his hands/arms, feet/legs caused by a clinical trial with two chemotherapy drugs. Now I am afraid I may have it in my feet, or something as bad. If the doctor has anything worth reporting I will let you know. Good luck to everyone and thanks for listening.

I took Albuterol for my chest congestion. My daughter was given the prescription for pneumonia and slight asthmatic tendencies during colds.

OK, I thought if it was safe for a young child, it would be safe for me. After only one dosage (using a Nebulizer) I experienced tremors and heart palpitations. I had to stop because my heart was beating so fast! And it's 10 minutes later and I still have some tremors. According to the package, 20% of 135 patients in a clinical trial experienced tremors. That is a lot! Needless to say, I will not take it again. I question whether my daughter should, too.

Clinical trial of montelukast in the Netherlands.

I noticed two things:

1. The researcher states that sides effects are 10%.
2. The researcher will not allow patients to also take drugs which are metabolized by CYP2C8 because montelukast inhibits that as proved by in vitro (test tube) studies. American studies in vitro said yes montelukast is an inhibitor but in vivo (in people) that it didn't happen. I was always confused by that and would still like to know more
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Merck is experimenting on premature babies giving them montelukast as we speak. Does anyone believe that they care about these side effects that are posted here?

Here is the clinical trial. Write your congressman.

http://clinicaltrials.gov/ct2/show/NCT00492102?term=montelukast&rank=2

I am disheartened but not surprised that so many doctors are dismissing these reports of symptoms that patients have had after taking Singulair. The only reports that I have found to share with you are from Europe and Canada. All of these reports pre-date the recent news stories regarding Singulair and suicide.

In addition to those reports, the most important thing that I have posted is the reference to the fact that Merck itself recognizes that there are genetics differences among patients that are directly linked to the potential efficacy of Singulair (montelukast). I posted a British reports on that subject and a reference to Merck's clinical trial where they studied genetical differences and montelukast.

The best thing that we can do is to try to convince our doctors that this is not politics -- the major does not have to rule. Why do European countries publish frequent reports on all adverse drugs reactions not just those of the majority of the people? One size does not fit all.

The actual incident of headache in all users according to European reports is 18-19%. So when I read that headache, adverse drug reaction to a leukotriene receptor antagonist (Singulair) is then treated by ibuprofen (a Cox-2 inhibitor), which of course gets treated for stomach inflammation or GERD by Nexium or another drug-histamine receptor antagonist, then I wonder what the hell is left to inhibit? So if a patient does not fit the profile of the 80%, do we have to make that patient catatonic (meant figuratively)? I realize that this leaves out all of the receptors that aren't affected by any of these drugs but I am just trying to make a point.

So why does Merck list headache as just one of the side effects in a category of side effects just listed as greater than 1%? And why do so many people believe that there is no scientific proof of any of the complaints that we see here at this site?

If any one is following what research is being done, here is the description of the new study in children.

http://clinicaltrials.gov/ct2/show/NCT00540839?intr=%22Montelukast%22&rank=19

I love it. I've had it for a week now. Very little spotting, minimal cramps, and no discharge. I was told of the side effects, and knew all of this before I got it. Hormones act differently to some people. I did not react well with the patch or pill. So far, so good with Mirena. I don't think a lawsuit or complaint is exactly the way to go. You should start with talking to your doctor more and seeing if they give out pamphlets or just did not tell you everything you were supposed to know. I also believe not everyone's symptoms should be blamed on Mirean. People usually "feel" things they don't really have, esp. after coming on here and reading things. You can make your body feel that stuff. The insertion was not comfortable by any means, but it also wasn't a pain that I would ever cry or scream over. I'm 21, relatively healthy, and never had children. I work in healthcare and see people react like this all the time-no tolerance to pain, and just wanting an excuse as to where some of their "pains" come from.

I am 27 years old, male, and have had type 1 diabetes since I was 8.

My doctor prescribed Zocor repeatedly in 2007(for high blood pressure) and I was reluctant to taking it because I have no respect for any of the miracle drug companies and feel that they are only looking to make money, not help anyone with their health problems. I finally started taking Zocor (generic) in Nov 2007, then started getting some strange side effects that my doctor never mentioned when I asked him.

My side effects were, but not limited to, muscle pain in the legs and back. I noticed sharp pains in my knee like arthritis and Charlie horses in the calf during time at sleep. I noticed these after about 1 week of taking the drug and lasted through till the end. I stopped taking the drug in Dec 2007 and been off it since. I have yet to talk to my doctor about it, but I talked to his nurse and she recognized the symptoms. I reached my conclusion long before speaking to her however.

Now 2 months have passed since I stopped taking the drug and the pains in my back and legs have disappeared. The arthritis type feeling in the knee has gone away. I have more flexibility and none of the pain that I felt while taking the drug. I am astounded that the clinical trial for this drug doesn't note the muscle pain; at least the notes from trials I found on the internet didn't note it as a side effect.