Cold wash symptoms and conditions

I took z pack Monday morning and woke up Tuesday morning and found red spots all over my right ankle and lower leg anf its hard to walk when you first get up and its stiff.
They took me off it and put me on Prednizone and to put a cold wash cloth on it.And keep it elevated.

I took my first dose of Niaspan last night and it will be my last. A few hours after taking it I started to feel tingling and itching in my feet and legs. Suddenly I started having a nauseated pressure in my chest and then the firey itching started. My face and body felt like it was swelling so badly that it hurt move. I tried cold wash cloths but it didn't help. I had to sit up in bed to be able to breath right. I was in tears. I had a similar reaction when I took codiene and never took that again. I work in a emergency room and it is hard for me to get upset or scared about things, but this scared me. I finally was ablet o fall asleep a couple of hours later.

I have been on zoloft 50mg for about 8 weeks now. The first and very bothersome side affect is the problem sleeping. After getting to sleep, it is very hard to stay asleep. My nights are full of vivid dreams. I have read this is a normal side affect. The BIGGEST problem I've begun to have is that while sleeping...I guess I am dreaming that my skin is itching because I have woken up many times to the pain of me scratching my skin until I have left deep burning scratches. Last night I had to get up and get a cold wash cloth to put on the skin on the back of my neck from the harsh scratching. This has NEVER happened to me before the zoloft. It has made a world of difference in my depression, and do not want to have to go off of it. Has anyone ever heard of this? Please post if you have....need to know this is a side affect...not just me...