Compounds symptoms and conditions

Sorry to keeping annoying y'all with more posts from me, but I have another question. I noticed that my symptoms were worse with Yasmin's generic, Othello, than they were with Yasmin. I am not knowledgeable about generic drugs vs. brand-name drugs, but I wonder if there is something different about Othello that my body doesn't agree with. Just a thought... Any comments???? :)

I to experienced an allergic reaction but not to the sulfa-based compounds but to the filler used. Everyone, please review all seemingly allergic reactions when taking any drugs as the reaction may be from the filler ingredients.

Wow, who should I believe? Placebo controlled studies which suggest Avelox is a perfectly safe drug or a bunch of crazy people who like to TYPE every OTHER word IN all CAPS who are probably all middle aged women with psychological problems and/or fibromyalgia, irritable bowel syndrome, or other made up diagnoses.

Here's a hint morons: The reason why every drug in existence now lists every possible side effect is because of crazies like you. This way, the drug company can protect themselves from litigious idiots like the poster below who wants to join a class action lawsuit. This only compounds the problem, though, because then more crazies look at the side effect profile and when they see that "Oh my gosh, it says right here it causes x, y, and z" it just validates in there mind that this is somehow a dangerous drug.

I swear, if all of the pampered babies in this country were put to work in a rice field in Cambodia, there would be a lot less nonsense in the world. You would see what true pain and suffering is about.

I had to re-start Lisinopril recently (almost 3 months now) and did not realize until I saw my Dr. last week that it was quite possible that that was what was causing my nagging cough, liquid phlegm cough-ups, burping at night, dehydration overnight, scratchy throat off and on at all hours of the day, loud chest coughing occasionally, my eyelashes are more brittle now, some leg cramping, and toe cramps, and watery right eye, would tear up quite a bit during heavy bouts of coughing. :( He just changed me to HCTZ which now I'm wondering if that is the same thing as Lisinopril? It reads that at the top of this post--what if they both cause an allergic reaction like this I am ALLERGIC TO SULFA COMPOUNDS so upon reading that pharmacist note above, I'm going to speak to my Pharmacist, My Dr's and my chiropractor too. I'll tell everyone I know, I've already heard from 3 other people that say they had a nagging cough and it turned out to be their blood pressure medicine.

i had been on zoton for at least 7 years to treat a stomach erosion up until a year ago and my gp upped the dose last year but then i was having terrible wind and then developed i.b.s so they put me on 20 mg of omeprazole i was o/k for a few months and it started again so i recently visited my gp who increased the dosage and the wind and pain again with i.b.s was terrible so he added another tablet for the i.b.s which didn't do anything by now i got so fed up that i went off both tablets and put myself on zantac at the moment the pain and i.b.s symptoms are slowly going away i will in a weeks time be seeing my gp to report my findings as i am pretty sure that omeprazole and its similar compounds are to blame

Singulair, montelukast, contains a chloroquine in it's molecular structure. I am praying that the FDA takes this investigation seriously. Other countries are concerned about the neuro-psychiatric side effects of these categories of drugs for some very good reasons.

"In summary, we have used a combination of electrophysiology, ligand binding, homology modelling and simulated docking to define the mechanisms by which quinine, chloroquine and mefloquine inhibit the 5-HT3 receptor response. Our observations further extend the number of receptors known to be affected by these compounds and the growing diversity of targets may account for the broad spectrum of side effects that have been reported by patients receiving them (Luzzi and Peto, 1993; Palmer et al., 1993; Taylor and White, 2004). Inhibition of the 5-HT3-mediated current could have wide-ranging effects in the nervous system, as 5-HT3 receptors can modulate a variety of neurotransmitter responses such as those to GABA, dopamine and cholecystokinin (Thompson et al., 2006b)."

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I just saw this post and it makes me feel ashamed of our medical system which includes everybody.

about 12 hours ago on Apr 14, 2008 by jerseymomma, #7220
My boss has been in contact with all of the top law firms in the NJ & PA area. We want to make sure that we give you info thats actually going to help and not send you to some bloodsucker. When you file an injury suit, there is no money out of pocket. The lawyers only get paid if you win your trial or the case settles (so if you loose-- u dont loose anything either). And as a heads up, if this is something that can be proven to a jury, the suits take fooorrrrever. I think that is the worst part for the families that I personally have dealt with regarding liability suits-- u want closure and you want answers but it takes so long to get them!

Let talks about the "everybody knows category" of the pharmaceutical industry.

1. Everybody knows that: There are many compounds that never go to market for various reasons. Even back then, no pharmaceutical company wanted to spend money on a drug that was not as chemically "reliable" (I chose that word to encompass many things) as possible in all of the known interactions that could be expected in clinical use. The categories are also "everybody knows."
2. Everybody knows that: Merck did a lot of testing for "reliability" on Singulair. But Merck also did a lot of testing on Vioxx. No conclusions can be drawn from this per se.
3. Everybody knows that: Even back then, important decisions were being made as to whether to market a drug that related to how body enzymes metabolized that drug (meaning utilize the drug and then break it down so that the body could eliminate the waste products.) Genetics differences between different people were a factor that were also put into the decision making process.
4. Everybody knows that: clinical variations in efficacy and side effects can be a result of different factors. Some might include 1. genetic differences 2. drug-drug interactions 3. improper use 4. diet - take the grapefruit juice example. Those are just some.

What we don't seem to do in this country is adequately monitor post marketing complaints? Why did it take five years to find out about Vioxx? If we did monitor more carefully, could we identify some thing that was overlooked or the technology has changed so that it is easier to identify what is wrong?

When there is a problem, there is no way that we should go back to the same company for an explanation of the problem. Everybody knows that many companies work on the same category of drugs. Sometimes those companies encountered some road blocks and they abandoned the drug category. The FDA ought to require everything from everybody to get to the bottom of the problem. And also hire independent evaluators.

The next part of what I have to say is just a hypothetical - a FICTION like a WHAT IF. This is just to make a point. What if another group got different results for the metabolism studies? What if another group decided that the drug was not reliable because a hydrogen bond at a certain location could be influenced by too many different factors to be able to accurately predict what would happen?

So why do people have to hire lawyers, when the FDA should be doing it's job? There are many specialities of law just like the doctors. Does getting to the bottom of this problem require the lawyer-chemists? Why is it their job?

I think I maybe just figured out the answer to these symptoms you guys are describing, with mood changes and nightmares?

From Merck Frosst website:
The team finally chose quinolein as the basis for their compound, because it has affinities with the LTD4 (leukotriene) region.

Quinolein - elsewhere it has been listed as a seratonin inhibitor...

Also, is Quinolein related to Quinine (a malarial treatment that causes nightmares and psychotic symptoms?)

What do you all think?