Concerned citizen symptoms and conditions

Does anyone know if Singulair can cause heart valve problems? I just found out that I have Mitral Valve Prolapse, and have never had any problems until after taking Singulair. Any info would be greatly appreciated...especially from Concerned Citizen if he's out there...

Thanks,

K.

Concerned citizen!!!
Just had to share the news! 3 months after stopping singulair and taking omega 3 (for last 3 months) has resulted in my 6yrs olds cholesterol going down from 236 to 202! Absolutely no diet change, in fact he has been eating worse due to throat condition/tonsils. Makes me go HMMMMM!!!

I am posting my response to it's own thread.

Concerned citizen who worked for Upjohn has intestinal disorders worrying about all of these poor children and "slowly" Merck admits that Singulair got out of control.

I honestly believe that Singulair was invented for a very specific reason related to the fact that most people who suffer from asthma have a very similar profile. I believe the Merck originally wanted to identify that profile and solve some bad problems. Then, somebody in the "greed department" ruined everything by trying to market Singulair for everything. I hope we don't see Singulair for ingrown toe nail.

I looked at the research from the 80's and 90's. I don't believe that Merck Canada had gone evil and "desired" to invent a way to kill people. It does look like there is a profile regarding asthma and it was really of benefit to find a way to stop the damage that is done by the extreme over-reactive airway.

The problem is some kind of corporate/marketing strategy that dictates that every product be sold to the ULTIMATE regardless in order to maximize PROFITS.

hi, i posted a couple of days ago as i was not sure what to do because my daughter was prescribed this horrible poison. i went to another dr yesterday and has now given her something else and was disgusted that my dr gave it to her for 2 reasons, firstly the side effects and also my daughter suffers seasonal winter asthma.

THE DR I WENT TO YESTERDAY RECEIVED AN UPDATE LETTER FROM MERCK JUST YESTERDAY.

it said that the investigation will probably end around sept. and YES so far they have found about 3 % of users will SUFFER from side effects. my doctor said it doesn't sound full proof but slowly its seem that they are admitting there is problems. please ask your own doctors if they have received this letter as i don't recall everything in it.

My four old son has been on singulair for about two weeks. The change from wheezing/coughing attacks at night and terrible allergies during the day has been amazing. They are almost non-existent to this point a great plus. However, a i stress however his behavior and speech has been VERY INAPPROPRIATE and quite frankly it concerns me. He now states "im a bad boy" and "i dont listen" and his mornings are very testy to say the least. Granted these sound like normal 4 yr. old sayings that he would pick up from other children on the playground but how do you explain them happening almost simultaneously with his taking singulair. I find it very hard to believe that it is a coincidence and that these are normal things for a 4 yr old to say/do when all other things have remained the same. My advice is to diligently watch your child for these warning signs and find other remedies if you have reservations. Im not promoting natural cures but i am leaning toward a diet change for the whole family and consulting my doctor for food allergen testing. I hope this helps. Be Well.

OH and to those of you have taken the time to read these posts and have posted your own accounts and have not been offensive. Thank you! I appreciate you increasing awareness. Concerned citizen I am very thankful that you have done so much research. It has been very useful to me!

Does montelukast affect growth in children? Remember the report of identical twins, one took Singulair and one didn't. If I remember correctly, the one who took Singulair was at least two inches shorter in a short period of time.

If anyone would like a reason to look into that, then I refer you to this study. It could suggest that leukotrienes act on the pituitary to release pituitary hormones. We don't know what happens when the production of leukotrienes are blocked by montelukast.

"Finally, leukotrienes have also been found to act on the pituitary to modulate the release of the pituitary hormones."

"The distribution data of HPN321 suggests major role(s) for this receptor in endocrine and cardiovascular systems. CysLTs are well known for their modulatory effects in cardiovascular functions, where they reduce myocardial contractility and coronary blood flow (Letts and Piper, 1982) and have vasoactive effects (Drazen et al., 1980). They are thus considered to be important players in cardiovascular diseases (for review, see Folco et al., 2000). The strong expression of HPN321 in adrenal gland points at a new tissue where to study the influence of CysLTs on endocrine circuits. Finally, leukotrienes have also been found to act on the pituitary to modulate the release of the pituitary hormones (Hulting et al., 1984; Saadi et al., 1990). Our discovery of the existence of the HPN321 message in pituitary adds a molecular credence to this concept. The HPN321 receptor may thus modulate a variety of different physiological functions, which can now be tested using BAY u9773."

Vol. 58, Issue 6, 1601-1608, December 2000

ACCELERATED COMMUNICATION

Molecular Cloning and Characterization of a Second Human Cysteinyl Leukotriene Receptor: Discovery of a Subtype Selective Agonist
Hans-Peter Nothacker, Zhiwei Wang, Yuhong Zhu, Rainer K. Reinscheid, Steven H. S. Lin, and Olivier Civelli

Departments of Pharmacology (H.P.N., Z.W., Y.Z., R.K.R., S.H.S.L., O.C.) and Developmental and Cell Biology (O.C.), University of California at Irvine, Irvine, California; and NeoGene Technologies, Inc., Irvine, CA (H.P.N., Z.W., R.K.R., O.C.)

http://molpharm.aspetjournals.org/cgi/content/full/58/6/1601

Hi, I am a mother of 6. They are 11,9,7,4,and twins 2 1/2. So nothing surprises me as far as kids. I have been through it all. My 7 year old had been taking singulair for allergies and ear pain, for over a year. Did my doctor once ask me about any of the side effect, NO!! This is not ok. My son suffered, decrease appetite, weakness, fatigue, mood swings, irritability, fears of being alone, scary dreams, anger, bone and joint pains. Before he was a loving kid (who had his moments)!!! I had no idea the singulair was causing all these destructive side effects. I just thought this is a phase he is going through, he will soon get over it. Finally I took him to his ped. and we did blood work and x rays. I told her something was wrong with him, he has not been himself over the past 6-8 months. This is one reason why I never suspected his singulair, it did not show up immediately. All of his test came back fine. I just happened to look at the side effects of this medicine. I almost died!!! Every single thing that this poor child has suffered from was on this list. Then more, I found this page and other mothers have had the same experience. I was just amazed that this has happened to so many. I was relieved that my son was normal. He has been off singulair for 6 days now (he doesn't know why I took him off it) . But you would not believe the change. It is AMAZING!!! In only 3 days, I started to see change in his anger. You would not ever in a life time believe that a medication can do this. I have been poisoning my son for a year. I think that Merck should take some of that 4.3 BILLION dollars and do some better research!!!! Concerned citizen you are right on. I have read many pages of this forum and I think you are doing a good job researching this. Maybe Merck should hire you as one of there "experienced personal". It just makes me seriously sick to see that the medical field is not seeing this problem!!!

Concerned Citizen; I just went to Singulair.com and the website is quite good. Any practitioner would know to look at the product PI which is right there and the pharmacokinetics section tells you how it works. Put your glasses on.

Concerned Citizen Do you have a life? Quit scaring people and libeling a company. You don't know your science. Quit pretending you do.
Wait till you see the things that come out about the 15 year old in Upstate NY who committed suicide. You will wipe plenty of egg off of your face. Give it up.

I am starting a new post in the hopes that others will see what I am trying to say about the delayed reaction in those that took Singulair for allergies.

If it is consistent that Singulair does not stop allergy symptoms immediately, then the pathways that eventually stop allergy symptoms involve a change in the mast cell function, development and migration (or some combination).

I asked this question for a reason. Are allergy symptoms stopped immediatedly. My question below:

I have a question that will help me continuing looking for information. I can understand that in the case of asthma that Singulair would provide immediate relief. If it is used for seasonal allergies or other allergies without asthma, does it work right away or does it take a period of days or weeks to be effective? If it takes time, could you tell me how long it took in your situation?

My thinking was going in the right direction if the answer below is consistent of everyone or most.

about 2 hours ago on Apr 11, 2008 by catherineevans, #7045
My granddaughter was put on Singulair for allergy symptoms without asthma. Itching, red eyes, terrible congestion, etc. dark circles under her eyes all the time. When we first put her on this, we didn't see any consistent results for 2-3 weeks, then it seemed to 'kick in.' I don't know if this helps. By the way, she was 9, now she's almost 12 and was immediately taken off when this story came out 2 weeks ago.

Then after seeing one response, I gave my reason for asking.

I asked this question because I have a theory of how montelukast really works for allergies as compared to how it works for asthma.

Asthma is a hyper-sensitive state that gets going because the mast cell has a receptor (the leukotriene receptor that Singulair blocks) that sends a signal along a pathway that causes lung tissue to have that extreme response - the wheezing, the airway constriction.

On the mast cell is another receptor the histamine receptor that causes the secretions that make our noses runs and and stuff up. This is not the same immune response as the asthma response. When I saw a post that somebody's doctor said that Singulair is an anti-histamine, NO it is NOT.

So if Singulair does not block histamine immediately and your child's allergies did not go away immediately, then maybe Singulair is working through some other means such as changing normal mast cell homeostasis.
I know that this seems like "what does this mean?" I am really writing this hoping to God that there are people reading this site that know what I am talking about.

Thank you so much for responding. Your answer actually told me what I wanted to know and confirmed my hypothesis. More answers will help. I hope others respond.

PLEASE respond about the length of time that allergies disappeared if you took Singulair for allergies.

has anyone took their child off of singular for more than 2 weeks and has the child had any breathing issues since being off?

Just wanted to say thanks to "concerned citizen" for all the efforts you've put into finding us "real reports" on the "ADVERSE EFFECTS OF SINGULAIR ON OUR CHILDREN" that confirms what we all really knew in our gut! The sad thing is that if you've all noticed they are coming out of every country but the good USA!

A thanks also to Dr. Beemer for going on record in his latest post of today also confirming the dangers of this drug on our children.

I would everyone who's posted and keeps coming back (I can't stop myself) to encourage others to get their Dr.s to this site and to beg them to at least read the posts since April 1st! If they are at all human, they will be touched by these stories and think twice about prescribing this to children and spare the children and families all this pain!

I feel so happy when I see all the parents after reading our posts who have trusted us and at least tried to take their kids of of this to see if they see the change we know will take place! Let's keep on encouraging so we can continue to get the wonderful"UPDATES" that still make me tear up!

I take doxycycline as an anti-acne medication. I've been on it for two years now, with an increase in dosage from 50 mg 2 x a day to 100 mg 2 x a day.

If I take it without food, I feel incredibly nauseous, so I'm careful to take it always immediately after meals. My prescription says do not take within 2 hours of eating dairy products, but sometimes I can't avoid that, since I have to take it with meals... I am also a lot more prone to sunburn since I started taking this, including one really horrible sunburn I got in FEBRUARY last year! ugh!

Does anyone know if there is a limit on the number of years one should take this medication for? Having been taking it for two years now, I began wondering if there could be negative consequences to the drug being in my system for such a long time without break. I am going to ask my doctor the next time I go in for a visit, but wanted to try to find out on the 'net first.