Dr douglas symptoms and conditions

I just read the new article about Cody Miller and Dr. Douglas Briggs, who was taking Neurontin. That further confirms the work that I was doing to collect research regarding problems with GABA and suicide. How these drugs affect the brain chemicals is very complicated. I believe that the pharmaceutical companies do know that it is possible for a series of things to go wrong and create terrible adverse side effects in some people - not all.

I will be extremely disappointed if the FDA allows these companies to sweep this under the rug.

Suicide risks studied in drugs for physical ills
By RICARDO ALONSO-ZALDIVAR – 1 day ago
WASHINGTON (AP) — Cody Miller was a high school football player who was allergic to ragweed. Douglas Briggs was a doctor coping with pain from an old back injury.
Both are now dead, hanging victims driven to suicide, their families believe, when drugs prescribed to relieve physical symptoms upset their mental and emotional balance.

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This testimony should help strengthen our case for warnings for Singulair.
Neurologist Sought Warning for Pfizer Drug
By JEREMY SINGER-VINE
June 20, 2008; Page B10
A British neurologist who analyzed effects of the drug Neurontin told a court hearing Thursday that he advised its maker -- now a unit of Pfizer Inc. -- to include a warning on the drug's label for potential side effects of depression and aggression, but his advice wasn't followed.
The University of London neurologist, Michael R. Trimble, was testifying at a hearing to decide whether civil cases brought against Pfizer alleging suicides linked to Neurontin can proceed. The hearing was jointly held by judges for U.S. District Court in Boston and a New York state court who are hearing similar cases. In various lawsuits consolidated in the federal court, plaintiffs allege more than 100 suicides were connected to Neurontin usage.
Dr. Trimble described what he said was a "plausible biological pathway" that could lead from the compound gabapentin -- the chemical name for Neurontin -- to suicidal behavior, hostility, and aggression. Dr. Trimble said that in 1995 and 1996, he was hired to write two confidential reports for Parke-Davis -- now a unit of Pfizer -- because the company "was concerned about psychosis in relation to their drug." Dr. Trimble said he was unable to find a link to psychosis, but noted effects of depression and aggression.
Lawyers for Pfizer argued at the hearing that the evidence linking the drug to suicidal side effects wasn't scientifically sound. Under cross-examination, they challenged his description of a pathway as a patchwork of studies that didn't prove a biological connection. Neurontin and generic forms of gabapentin are approved for treating epileptic convulsions, but have also been prescribed widely "off label" for other conditions.
In five of nine patient cases he analyzed in 1996, Dr. Trimble said he saw depression and aggression in patients who had no previous symptoms of the side effects, so he said he recommended to the company that the drug "should carry some kind of warning" for susceptible patients.
Thursday's proceedings were the initial phase of a hearing requested by Pfizer to challenge the opinions of the plaintiffs' experts. Under cross-examination and a subsequent examination by the plaintiffs' attorney, Dr. Trimble said the biological pathway between Pfizer's Neurontin and suicidal events were plausible and supported by a series of peer-reviewed neurology research.

I read these posts and regarding my being quoted as saying that it is unclear whether there are leukotriene receptors in the brain, that isn't true, there are leukotriene receptors in the brain and the relationship between neural systems involved in inflammation and mood is well established. I don't think the misquote was deliberate, I wasnt that definitive when I commented to the reporter on the 'breaking' story (she called me because I had just blogged about it and I updated the blog after I got off the phone). There are a number of parallels with other drugs used to treat medical conditions that have been associated with psychiatric side effects, you can follow the links from the March 27 post "If they dont kill us they will drive us crazy" at
http://www.beforeyoutakethatpill.com/blog.html

Doug Bremner MD

I thought everybody would be interested to know about the researcher from Emory that commented on possible psychiatric side effects of Singulair if leukotriene receptors exist in the brain. Here is a description of his book. I hope that we will hear more from Dr. Bremner. And, no I am not here to promote his book. I just saw this today when I was searching for other information. I was thinking about his quote and wanted to know his background.

Merck’s Singulair likely to see prescription drop-off only in high-risk populations
By Beth Herskovits and Gayatri Iyer in New York
Published: March 28 2008 19:52 | Last updated: March 28 2008 19:52
This article is provided to FT.com readers by Pharmawire—a news service focused on providing insight into the most price sensitive issues in the global pharmaceutical market. www.pharmawire.com

"Dr Douglas Bremner, director of Emory’s Clinical Neuroscience Research Unit, noted that drugs can cause psychiatric effects when the targeted receptor also exists in the brain. But he added that it’s unclear whether the brain has leukotriene receptors.
He noted that despite the updated label, the side effects ”sort of flew below the radar.” However, he painted a grimmer picture of the effect on the market, saying this would affect Singular sales badly. People are likely to stop taking it, he added. "

Before You Take that Pill
Why the Drug Industry May Be Bad for Your Health
J. Douglas Bremner - Author Book: Paperback | 8.26 x 5.23in | 448 pages | ISBN 9781583332955 | 28 Feb 2008 | Avery | Adult
A medical expert reveals risks of the most commonly prescribed drugs-and why the drug industry doesn't want consumers to know about them.

Recent scandals involving diabetes drugs, Vioxx, and many other medications reveal the serious and undisclosed risks of some of the most commonly used prescription drugs in this country. In Before You Take That Pill, Dr. J. Douglas Bremner, a researcher and clinician at Emory University whose study on Accutane and depression made headlines, offers an inside look at the pharmaceutical industry, as well as a scientifically backed assessment of the risks of more than three hundred prescribed medications, vitamins, and supplements.

While many drugs are essential to the health of consumers, as Dr. Bremner explains, for many people, the benefits may not outweigh the potential side effects. This book contains warnings that are not on the drug labels. It also exposes tricks of the trade that demonstrate how the profit-making interests of "big pharma" may not always be in line with the safety of the public - from the corruption that exists in the drug approval process to the tactics drug companies use to encourage doctors to prescribe their products. Most important, Before You Take That Pill empowers readers by giving them sound information on specific medications so they can understand and weigh the potential risk themselves. Backed by the latest studies, as well as insight from a doctor who is in the trenches, this book should be on the shelf of every drug consumer.