Educated guess symptoms and conditions

I have had Mirena for about a year now. My periods never really went away. They did used to be very heavy before my Mirena was inserted but I seem to bleed or have bloodlike discharge more like three weeks out of four now. I too have experienced sore cyst like acne on my chin which I have never had in my life, and it comes and goes and seems to be in one area. I have not felt like myself at times, as if theres a cloudiness, which has often times made me wonder if I am coming down with a terminal illness. No doubt it is just the effects of the Mirena since I have always been healthy. I have lost complete interest in sex and that was NOT like me, I even need lotion and it takes a lot to get me interested, and I do it only to make him happy now. I feel like a completely different person right now. I have never had a problem maintaining my weight and knew how to take off an extra 5 lbs like no one else but seems like even if I starve myself I have the added puffiness around my abdomen even if I suck it in. I have always been 120 or 125 on a bad day, since I was a teen even after having three kids. If I work out or even if I don't, but now after a year I am 130 on a bad day and 125 on a good day and as I said I have to try extremely hard to have the good day. I have less energy in the gym and my heart rate goes through the roof, it seems much harder to catch my breath. I blame my IUD. I have for the past two days experienced lower pelvic pain, behind my vaginal wall. Im pretty sure it is the Mirena. Doctors seem to keep telling you guys what they think to be true when with all due respect they should be more concerned about what the patients who are actually on this method are experiencing and with that information they really should have more research done on this before making an non educated guess.

Hi to all,
I have read all comments in complete shock. I am a 53 year old female.
I was prescribed Simvastatin just over 6 months ago (40mg). I am hypothyrod and also have very high blood pressure. About 6 weeks ago I started to have severe (and I mean severe), night sweats. The sheets are absolutely wringing wet as if someone has thrown a bowl of water over me,
The headaches that start within about 30 minutes of getting up every morning radiate from the middle of my forehead right across my right eye and it throbs all day. My throat is sore, my skin very dry, my vision seems very blurred (especially first thing in the morning), and I don't seem to be able to focus very well. My appetite is almost non existent and my shoulder, legs & feet hurt dreadfully and although I hate to admit this I am quite depressed at how I feel.
Three nights ago I decided to stop taking Simvastin and guess what...hay-ho, no night sweats, no cramp and the headache today was much less severe.
I am glad I found this site and for sure I will be visiting my doctor next week to advise my findings.
I think I would rather live on a diet of bread & water rather than go through this again.
Good Luck to all fellow sufferers.

Why does Singulair cause these symptoms? I am going to give my explanation which is only a HYPOTHESIS. This should not be categorized as any thing but an educated guess. This is not backed by scientific research because nobody will do any research that would appear to anger
Merck even if people are suffering in the thousands.

1. The original research that preceded the development of Singulair (montelukast) seemed to focus on the theory that asthma was caused by an unusual immune response to certain pathological stimulus. There are many references to the observation that a high percentage of asthma sufferers are people whose asthma is caused by fungus. Many people suffer from asthma and are told that they are allergic to dust mites. Dust mites can live only because the fungus aspergillus pre-digests the
food source that dust mites can then absorb. Other sources of fungus occur in the home due to dampness or problems with wood rot.

2. The body's immune system fights certain categories of pathogens such as bacteria and fungus by creating nitric oxide which kills them at the site where they try to enter the body. The mast cell is the immune cell that is responsible for the production of nitric oxide. Mast cells are found in the skin, airways, intestines etc. The mast cell is capable of many different types of biochemical functions that are designed to signal other cells or other chemical responses. When the mast cell knows that pathogens
are present and nitric oxide is NOT produced, then it signals other immune cells to be sent to the site of the infection. Thus in the case of asthma, it is known that excessive numbers of eosinophils appear in the airways and these cells create inflammation.

3. Singulair was developed for asthma and later allowed to be prescribed for other reasons. I believe that montelukast probably creates a source of nitric oxide that prevents the mast cell from signalling for other immune cells to arrive at the source of infection. I arrived at that conclusion from studying the chemical structure of montelukast, the chemical structure of the gene cysLT1 receptor, and the chemical structure of the cell wall of fungus which would be what the mast cell uses to determine "what to do in order to kill the fungus."

The researchers who invented montelukast first had to clone the gene-cysLT1 receptor meaning that they had to be able to identify the gene and replicate it. Then by trial and error they had a find a "chemical"
that would bind (connect chemically) to the cysLT1 receptor. The theory would be that montelukast would take the place of the fungus or other pathogen and thus prevent the gene from reacting to produce the
responses that the sick patient with asthma produced. Merck says in the literature that montelukast binds with the cysLT1 receptor in order to prevent the mast cell from signalling the eosinophils to arrive in excessive
numbers that cause inflammation. I believe that montelukast is also causing the production of an amount of nitric oxide that is actually killing the pathogens that are present. For one thing, I would think that it
would be dangerous to incapacitate the immune system in that way without providing a way to kill the pathogens. I don't believe that the asthma response is just allergies to something like dust. Pollen from trees and flowers is loaded with fungus spores.

4. IF, IF, IF, montelukast does actually produce nitric oxide, then it does so by binding with the gene. Any place in the body where a molecule of montelukast encounters the cysLT1 receptor (a gene) then the corresponding molecules of nitric oxide are produced before the liver enzymes break the montelukast molecules up. Nitric oxide is TOXIC and
INFLAMMATORY. So let's look at the symptoms in regard to the location of the cysLT1 receptors. The location of these symptoms would not be places in the body where the mast cells normally encounter fungus or bacteria. The cysLT1 also has other functions in that it communicates with the cysLT2 receptors. Obviously, nitric oxide
should not be produced in these locations because of the signalling effect of nitric oxide on other physiological functions.

a. intestinal pain - the cysLT1 receptors are located in the small intestines
b. leg pain actually caused by vasculitis - cysLT1 receptors are found inside blood vessels- consistent with the fact that montelukast causes
Churg-Strauss
c. some people who didn't have asthma develop asthma - the cysLT1 receptors are in the airways
d. nightmares, depression, neurological damage - when montelukast penetrates the blood brain barrier probably due to unusual conditions of blood pH or electrolyte imbalance then nitric oxide in the brain causes neuron damage and excitoxicity

5. Why do some patients not experience side effects? Probably because genetically they are completely compatible with the model that researchers created when they cloned the cysLT1 receptor gene. I didn't not find any information about whether researchers knew that there are many different variations of this gene.

6. IF, my theory is even close to being correct, then why doesn't Merck do anything about researching these side effects. Maybe because nobody in the company knows how this drug works but the researchers who created it. All of the Merck literature is very vague about any biochemical information.

Again, this is just speculation and hypothesis. I have made an attempt to put this in simplistic language and therefore sacrifice scientific accuracy. But, I think that you will get the point.

SINGULAIR IS VERY DANGEROUS TO PATIENTS WHO EXPERIENCE NEGATIVE SIDE EFFECTS. DOCTORS SHOULD JUST REALIZE THAT
THOSE PATIENTS ARE NOT COMPATIBLE WITH THE MODEL FOR THE DRUG.

My son was born March 2007, when he was 8wks old, to much of my surprise I found out that I was pregnant again. Mirena sounded perfect!!!! I had it placed 7 weeks after my 2nd son was born in Jan 2008. I had what I still assume is normal with any type of birth control method, irregular bleeding,cramping,some slight mood swings. That all seems normal to me when you mess with you body like that. Aug 1, 2008 I woke up at4am with awful abdominal pain sooo bad that I turned to my husband and said that I think I have to go to the hospital. I decided that if I could fall back asleep then its probably nothing major. I fell back asleep (or passed out, I don't know) The next morning I was hurting so bad I couldn't lift anything, couldn't stand up straight, felt weak and felt as though I had rocks in my stomach but had an empty feeling at the same time. The pain was all over my abdomen, stabbing, shooting,pinching. I also had pain aroung my belly button and a noticeable discomfort about my pevic bone. Finally I called my husband to come home, went to the hospital, they took blood, cultures, did an exam and did a ctscan. All normal! WHAT!! Aug 11th still having pain and now having MAJOR HOT FLASHES. I find myself getting so hot and irritated that I cant be around the babies because I am afraid I will yell at them. If I get in a little disagreement with my husband it will most likely end with me saying I want a divorce (I noticed another lady with that same problem) Today I had a ultra sound done and it came back what my (new) doctor says is normal. The problem with that is that one of my ovaries is split and is NOW shaped like a horse-shoe. I was pregnant for almost 2yrs straight and had lots of ultrasounds NOT ONE TIME did anyone say anything about a odd ovary. I'm just going to make a educated guess that it wasn't deformed till after the Mirena. Now I am wanting to remove it but feel like I should get every test known to man first to rule out any other possibility. I really don't want to remove it. I am afraid of getting it removed and even more of getting pregnant when I already have two 10 months apart and still in diapers.
My biggest question is wanting to know if hot flashes are related or if I might be having something else going on. Am I the only one with he hot flashes? I have them all day long!!!!!!!!
Also I noticed after reading other post that some other things may be related like, piercing headaches, itchy flaky oily scalp, weight gain, ear drainage, lower back pain, oily skin, increased smoking, in-grown hairs in inner thigh area, joint pain, fatigue, decrease sex drive.

Hi,
I wanted to post this link just to give some small consolation to our concerns about the lack of awareness THAT DOCTORS HAVE ABOUT SINGULAIR.This is a voluntary online informational site,that doctor's can join. It provides updated information on serious label changes and safety concerns on drugs.Most doctors at this point still get snail mail updates,in the paper shuffle a lot of information gets misplaced.The AMA would like to have all information come in online,eventually.The link is ******
read it and tell me if you think more can be done By the way my pediatricians office does not have online communication.Our life is forever changed because of that ! Information is playing a vital role in this drugs destructive path ,or the lack there of information.Again this is voluntary for the Doctors to sign up .In this modern day of communication how does important information not get where it is the most useful, I ask you?When drugs are making multi billion dollar profits,that would be an educated guess.I am doing another interview with CBS affiliate out of Boston on the 23rd of June,they contacted me.I hope it will reach more people who are still unaware of this drugs serious potential side effects.If any of you parents have some connection to media ,please use it to your best advantage to get this very important information out to the publicAlso so many of you ask how to help.Contact your local Senators and keep bothering them to reach out to the FDA to expedite this investigation. Make a pain in the butt out of yourself and be persistent.I will try to make reference to this site so your stories are heard. Dave and I are coming up on a year since our son passed on to our lord .Still fighting Kate and Dave M.

Hi, I was on Prednisone for a little over a month for Crohn's disease. I had minor side effects while taking it: couldn't sleep, no patience, dehydrated, dry eyes. It is the side effects from AFTER stopping prednisone that concern me. I''ve been off Prednisone for 3 weeks and I think I am losing my hair and getting acne-that I didn't have before or during taking Prednisone. Anyone experience side effects that started after stopping the med?

After taking Razadyne ER for two days my mother became dizzy, fell, and had speech impairment that put her in the hospital for 5 days. All the tests done came back fine, but because she had a pace maker and was only one baby aspirin she was given coumain. She also had an unexplained fever. The doctors made an educated guess (quote) that she had had a TIA and did not think the drug caused these symptoms. She is not on the drug now, but is now on other drugs that are causing her more problems. The ER doctor felt that it was the drug, but the neurologist and cardiologist did not think so.