Enlarged thyroid symptoms and conditions

I have stated many times that I am not an expert. I just post what I find. This has been a mind boggling journey for me. This is way over my head but I struggle to read and understand. Finding answers to why children are suffering from neuro-psychiatric side effects is worth the effort.

I have made the following observations.

1. Some quinoline are known to be able to cross the blood brain barrier.
2. Molecules that ionize are known to be more likely to be able to cross cell membranes. So if montelukast ionizes as a result of change in blood pH to sufficient acid conditions that it ionizes, then it could be possible or maybe like that it does in fact cross the blood brain barrier.
3. We know that there are cysLT1 receptors in the brain.
4. We know that researchers believe that montelukast may bind at the arginine of the cysLT1 receptor.
5. We know that arginine contains four nitrogens. And montelukast contains one.
6. We don't know what happens to those nitrogens.
7. We do know what macrophages create nitric oxide as I posted.
8. We do know that if something cause excessive nitric oxide to build in the brain that there would be damage to the neurons.

Some people may remember when I got stuck at the astrocytes, the cysLT1 receptors and glutamate. I keep looking for research reports that may shed more light on this.

Titre du document / Document title
Nitric oxide causes glutamate release from brain synaptosomes
Auteur(s) / Author(s)
MCNAUGHT K. S. P. (1) ; BROWN G. C. (1) ;
Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
(1) Department of Biochemistry, University of Cambridge, Cambridge, ROYAUME-UNI
Résumé / Abstract
We determined the ability of pathological levels of nitric oxide (NO) to cause glutamate release from isolated rat brain nerve terminals using a fluorometric assay. It was found that NO (0.7 and 2 μM) produced (4 and 10 nmol/mg of synaptosomal protein) Ca2+-independent glutamate release from synaptosomes (after 1 min of exposure). Spermine/NO complex (spermine NONOate; a slow NO donor) and potassium cyanide (an inhibitor of cytochrome oxidase) also caused Ca2+-independent glutamate release. Preincubation of synaptosomes with 5 μM 1H- oxadiazole quinoxalin-1-one (an inhibitor of soluble guanylyl cyclase) had no effect on NO-induced Ca2+-independent glutamate release. Ca2+-independent glutamate release produced by NO was greater in a low-oxygen medium. NO, spermine NONOate, and potassium cyanide inhibited synaptosomal respiration with a similar order of potency with respect to their ability to cause glutamate release. Because NO has been shown previously to inhibit reversibly cytochrome oxidase in competition with oxygen, our findings in this study suggest that NO (and cyanide) causes glutamate release following inhibition of mitochondrial respiration at the level of cytochrome oxidase. Thus, elevated NO production leading to mitochondrial dysfunction, glutamate release, and excitotoxicty may contribute to neuronal death in neurological diseases.
Revue / Journal Title
Journal of neurochemistry ISSN 0022-3042 CODEN JONRA9
Source / Source
1998, vol. 70, no4, pp. 1541-1546 (29 ref.)

INIST-CNRS, Cote INIST : 4037, 35400007527188.0230

I'm glad I thought to check to see if Wellbutrin might be causing my hair loss. I had some natural thinning at my temples before and started using Rogaine for women with great success. Then after my mastectomy and breaking up with a guy I went on Wellbutrin. I am currently taking the 150mg three times a day. I am losing so much hair it's scaring me. It comes off my head all day long. Like others have said I also have a handful in the hour, another handful in my comb and then it just continues to jump ship all day long. I have lost at least half of my hair.

This was my first time taking birth control pills. In the beginning everything was fine. I have been on the pill for about 5mths now. Just recently I started bleeding for no reason at all. (not to mention it is 8 days before my wedding) I am nowhere near the time I am supposed to start. Plus I am gaining weight, I am bloated, and I am eating like a pig. I’ve had to have alterations 2x in the last 4 months. I have been emotional, sensitive, depressed, and impatient and everyone was saying it’s because of the wedding but I knew something was wrong when I started having trouble breathing. I didn’t know any better because this was my first time on birth control pills. I went to my long term doctor today and she suggested that I keep taking the pill even though I now have what appears to be a goiter. Hypothyroidism (An enlarged thyroid (goiter) I have an ultrasound scheduled but I’ve learned today that Estrogen increases the body's production of a blood protein that binds thyroid hormone to it, making it inactive. This may have lead to weight gain and my irregular cycle. I am stressed and I do not know what to do. The only good thing is that I do not bleed heavy but there is slot of cramping now and stomach pains like you wouldn’t believe. I now have high blood pressure, shortness of breath from my thyroid, back and stomach pains from the cramps, bloating, and I’ve been bleeding for 5days. It starts then stops, then starts, and then stops. Sadly my doctor will not give me any medicine and I don’t know when it’s going to end. Those little devil pills have really put me in a terrible situation for my wedding and honeymoon. I’m now seeking a new physician and I don’t know if I will ever take birth control pills again. For all of this, I could have just continue to purchase a few extra pads a month.:(

September 15, I first started taking Toprol XL 50 mg for an irregular heart
2007 beat. That was about 2.5 years ago. It didn't help me at
1:27 PM first so my Dr. upped it to 100mg. It helped for about a
year and a half before I began having diarrhea and loose bowels for over a year now. My doctor didn't seem too concerned about
that. At the same time I was taking 1500mg of Niacin a day. I thought
the loose bowels came from too much Niacin, so I asked the Dr. to take
me off that. That did not help me at all. I am seeiing my Dr. next week
I do hope I can get off of Toprol. I have other side effects as well, enlarged thyroid, dizziness, short term memory, depressed,sleepy. But I do mow the lawn without any fatigue. I am tired of the diarrhea every day 2 to 3 times a day. Thanks to everyone who has posted their side effects/ It helps to know others are having the same side effects I am with Toprol.

I was born without a thyroid gland so I can't compare the way I feel now to the way I would've felt with a thyroid. I've been on Synthroid my entire life (22 years), and I'm up to 112 mcg now. I am very skinny (5'5", 104 lbs) and feel constantly fatigued no matter how many hours I sleep, what I eat, and how much exercise I get. I periodically get pain in my hip joints, heart palpitations, and intense mood swings. My thoughts race but I have very little physical energy. I feel restless and gloomy almost all the time for absolutely no good reason. My doctor tells me I'm depressed but I honestly have no reason to be depressed and I wish she would see it as a symptom instead of a diagnosis. I graduated from a good college, I've got a job I like, I have friends, I enjoy life and my hobbies, yet I feel overwhelmingly sad. This does not seem like depression to me.

I find that after I do aerobics I get a tightness in my chest, which makes me worry about my heart, but again my doctor doesn't seem to think this is cause for concern. I have been irritable/fatigued for YEARS and I suspect I'll feel this way for the rest of my life. The worst of it started when I hit 16 years old and started the 112 mcg. My tests are always normal and it frustrates me that my doctor disregards my symptoms. I've tried other doctors, but they always send me away with my 'normal' test results. Can anybody help?

I love this site. I have been on Levoxyl for five years and it seems to be like a two edged sword. I had enlarged thyroid that now is practically gone, so are my heart flutterings which is a good thing....however, they have been replaced by joint pain, depression, huge appitite, and anxiety. I tried to switch to Synthriod but for me it had a Jeckle and Hyde effect and I was filled with a rage that would sweep over me. In fighting the rage I started having stomache cramps that seemed to be ulcer-like and I could find no food that didn't have me on the couch praying to God to just go ahead and take me..Switched back to Levoxyl simply because I had to have some quality of life and needed medical help...I have tried the health food route and my goiter returned. I appreciate everyone's stories because for the first time in years I see I am not alone,but I agree with those who say to keep trying and take responcibility for your own care, some doctors really do care and have every intent on our wellfare, however it has been my experience that most GP's lack the information on the diease to understand that this type of medication can do harm so they "ho, hum," us while they just keep writing out our prescriptions.

51 year old female. I have been diagnosed with Hashimoto's Thyroiditis.

I just started Levothyroxine 75 micrograms last thursday. Immediately my constipation issues improved, my libido increased and I was more alert after taking it on an empty stomach in the morning. I have not experienced any joint pain or depression yet. Previous to diagnosis I had difficulty losing weight, dry skin, cold-natured, lethargy, experienced three major depressive episodes, two which were almost suicidal. My thyroid hormone levels were within normal range even though I presented with these symptoms of low thyroid function. My pregnancies were difficult (3 births but pregnant six times), with the third and last pregnancy resulting in three false labor trips to the hospital and a post partum depression that would not go away for 13 years. Accupuncture took care of the depression since i tired of the many years of antidepressant side-effects.

I finally went to an endocronologist because of the growing goiter on my neck and all the symptoms of hypothyroidism.

I'll post any negative side effects as time goes on. For now, I am happy with Levothyroxine since I have begun to lose weight slowly and do not have the terrible constipation. Previous to starting this drug, no amount of Weight Watcher meetings or exercise regimens would allow consistant weight loss. Only in the years before my enlarged thyroid could I achieve my weight goal. In 2000 I lost a lot of weight by running 5 miles a day and attending Weight Watcher meetings, extreme measures by any standard. Even then, my weight loss was much slower than the other attending members.