Experience depression symptoms and conditions

I can't believe that I finally found the solution to my problem! I didn't know what was happening to me its like I am a whole different person.
My side effects:
mood swings
weight gain
decreased sex drive dramatically
depression
not caring about anyone
feeling like i am the biggest loser in the world
i cry at everything
I take the pill at night and it seems like night time is the worst time. I cry to my boyfriend about how I want more attention from him when he gives me the most attention ever lately. I cry about the stupidest things and he even said somethings wrong with you emotionally.
It's effecting our relationship because I been on Yaz for years and up until the last 2 months i been a complete nut case. I am a freaking psycho and hate everyone. I am so glad I found out what it was and I am stopping this and changing my birth control or just stopping it completely for a little while because I want my life back before I ruin it all.

I started reading articles about links between depression and ddp-4, Which Januvia is a ddp-4 inhibitor. after reading this forum and noticing that people experience depression on this drug.

I had depression as one of the side effects on this drug but what I noticed it was not easy to get off the drug. It took me a week of sleepless nights and anxiety and panic attacks which I never had until i took the drug. I am doing better but from what I read it takes a month for Januvia to leave your system.

So my question would be why would a doctor who knows of family background of depression in family history would prescribe this junk. I would think that if you have a predisposition to a disease that it would be taking into account. What this tells me is that our doctors are not doing their homework on the stuff they are giving us and we are having to do tha t for them. What am I paying for then?

What I got from my research was that lower levels of ddp-4 is seen in patients with depression. I found studies by searching on Dipeptidyl peptidase IV and depression.

Copyright © 1999 Elsevier Science Ltd. All rights reserved.
Dipeptidyl peptidase IV and adenosine deaminase activity: Decrease in depression

References and further reading may be available for this article. To view references and further reading you must purchase this article.

Serenay Elgün, , a, Aytaç Keskinegea and Hakan Kumbasarb

a Department of Biochemistry and Clinical Biochemistry, Faculty of Medicine, University of Ankara, 06100 Sihhiye, Ankara, Turkey

b Department of Psychiatry, Consultation–Liaison Unit, Faculty of Medicine, University of Ankara, Dikimevi, Ankara, Turkey

Received 22 December 1998; accepted 15 May 1999. Available online 17 September 1999.

Abstract
Dipeptidyl peptidase IV (DPPIV) and adenosine deaminase (ADA), two T cell associated enzymes, are known to have a possible interaction and play essential roles in immune system functioning. On the other hand, depression has been shown to be accompanied with some immune-inflammatory alterations. In this regard, in order to make a contribution to the understanding of the ongoing immune disturbances in depression, serum DPPIV and ADA activities were determined in minor and major depressives and compared with healthy controls. Both enzyme activities were found to be decreased in major depressives compared to controls while only DPPIV activity was significantly lower in major depressives than the minor depressives. There were significant inverse relationships between enzyme activities and the severity of depression. Moreover, a positive intracorrelation was found between decreased DPPIV and ADA levels. The correlated decrease in DPPIV and ADA, might be a further support for their possible association. Results also suggest that decreased enzyme activities might reflect the impaired immune state in depression while major depressed patients might have a greater tendency to immune dysfunction than the minor depressed ones.

I was using every excuse possible for what I have been experiencing. I started NR in May, now it's December, I was scheduled to take it out. Since I started I noticed acne, which I never had even in my teen years. I blamed it on the towels in the gym, stopped using those, then on the sweat from workout... kept trying new acne treatments, but acne magically disappears during the ring out days. I'm not sure if I can call depression, what I felt, it was like I'm never happy with anything and many days in a month my thoughts were very dark, unhappy. I noticed serious decrease in energy, blaming it on 2 children, but my son was a year old when I started NR and I had more energy before with newborn and a toddler daughter. Again I thought, he's so active... I have hard time getting out of bed, sometimes sleep is ok, sometimes no sleep for hours, but this happens to many people. night sweats I was blaming on the blanket, the thinnest one we have(my husband uses 2 at night), I was waking up many days in a month drenched in sweat. No discharge, yeast infection for me, lower sex drive. Even more interesting- I noticed the smell of my partner to be less attractive... Then I read in a magazine that BC messes up with the smell as well. I had horrible headaches, feeling I'm going to pass out< dizzy< especially if I was trying to rush(blamed it on rushing too much). I was growling(like my daughter said) at the kids with the smallest mischief, it's like a little bomb heating up and bursting in my head, I felt rage, not anger, total rage.Life has lost any appeal for me, this is not living, just suffering, I thought all the time. But here I am at home with two little children, hardly ever see friends, always doing work around the house, laundry. Hot flashes during the day are frequent and I feel like I want to tear my clothes off. Recently I started to have a lot of pressure in my chest, like it's hard to breathe. Just last week I almost went to the ER, because I was laying on the couch unable to speak out loud, just whispering, could not move. Then couple of days ago my heart started to ache, it aches now, so last night I looked up the side effects of NR, because I didn't even know where to start with this condition, that has all these symptoms I have been listing. I was planning to go to the doc for all the test. My stomach has been hurting slightly in the last 3-4 weeks(I thought it was food, but no one in our family had any problems). I am 28year old in great shape(I cut back on my food intake to keep th weight the same), I work out 2 times a week and have a very active lifestyle. My relationship with my husband is great, my children are well behaved for their age, So I'm stopping NR before I get divorced like some other women did. If you want to try NR go ahead, it's really convenient, but be aware of all these side effects, so you know, it's not something else, before it's too late.

Hi there - I made a post around 6 weeks ago concerning my brother's symptoms on Doxy and the fact he ended up killing himself. In short, if you experience depression, anxiety or panic attacks on this drug you must inform whatever government body in your country regulates these type of drugs. If your in the US that will be the FDA. If you don't tell them, they don't know there is a problem. For the sake of others, please do this as posting your problems on this site will not make them look into the drug.

I am 49 yr old male and was diagnosed with a severe upper respiratory infection. Was put on Prednisone for 20 days. I never did experience depression, but I did experience the hyper state and was full of energy big time. It was actually nice ...had felt better than I had in a long time. Two of the side effects that I have been experiencing is sweating a lot more than normal ... I mean just the littlest of exercise and my shirt is soaked. Also my back and the back of my neck has broken out with acne ... that really hurts. I am using Desoximetasone which is a prescription cream and it has almost cleared all my acne up. I was about 250lbs and lost to 235lbs in the twenty days I was on it. I never changed my eating habits ...weight just fell off ...... man I wish they could put that it another pill without all the side effects. Now that I have been off for a couple of weeks ...I have gained some of the weight back ... but I'm really trying to change my eating habits and get back to 235 and go lower.
I wonder if everyone posting would also put their blood type on their comments. There are so many different opinions of Prednisone ...there has to be a reason why you have so many effects for some and very little for others. I did research this drug while I ws taking it and read that if you take it for longer than 30 days that your body will stop making the natural prednisone that it makes. Thats why you hear when people take it for long periods of time ...you are destined to take for the rest of your life.
As far as lung condition, I can breathe again and I think I'm totally cured ... I have a follow up with my lung doctor next week.
My prayers are with you guys .... I agree .. I don't think I want to take Prednisone ever again. My blood type is AB+

I feel compelled to post to this site because it's a big part of why I chose to have my Mirena removed. I had it in for two weeks before having it removed because of ever-increasing depression that started after one week. I also was passing large clots and I think my hair was starting to fall out in greater amounts. After two weeks I found myself standing at the kitchen counter making breakfast and balling my eyes out for "no reason." I had had a pretty bad bout of post-partum depression two years ago, and this felt like being right back there. But why? Then it hit me, I wonder if it could be Mirena. Long story short, I found this site and many others like it (do read the article for doctors that reports 5% or more women experience depression), called and got it removed that afternoon, and the clouds parted that night and the sun came out the next day. It was a 180 degree turn around for me within 48 hours. I feel completely back to normal, thank goodness! There is no doubt it was the Mirena. Also, it had come out of place and was sitting in my cervix, which my doctor said probably caused the clotting. I'm so glad it's out. No more artificial hormones for me. I think I'm one of those women who just can't handle them. I hope this helps someone else, as this site helped me so much. Good luck everyone!

Jill in Little Rock, Ark.

I've never responded to a site like this, but now feel compelled to. I had my Mirena fitted 13months ago, after a friend recommended it on the strength of her excellent experience with it. I was on anti-depressants already, so haven't felt an overwhelming sense of depression, but have been thinking for the past 10 months or so, that I get way more tired, have an overall achy body often, painful joints and swollen ankles. All stuff I never experienced before. But the thing that really did it for me was the weight gain. I was only slightly over normal weight at the time of insertion but have been gaining weight steadily. Initially I thought it was just a bit over over-indulgence, but after weighing myself last week, I've made the horrifying discovery that I've gained 13kg in 13 months!!!!!!!! I've never fluctuated more than about 4 kg in my whole life, eat healthily and am normally active. Nothing has changed to what I was eating/doing before. I specifically searched the internet today to see if weight-gain is a problem. It's not listed as a major side-effect on the 'official' sites, yet I see it on many of the postings on this one.
And for those of you who are into alternative therapies, I had myself checked with a kinesiologist for dietary intolerances/allergies that could have caused this weight issue, and what came up is that the problem is progesterone. When she checked if my Mirena was a problem for me, it came up VERY positive. When checked if I should have it removed, the response was equally positive.
It's a pity, as I had none of the other problems mentioned and it's such a convenient method of bc. But in my case it's coming out, before I have to come out as a seriously obese 41 yr old!!!!!

This is a weight of my shoulders.
I have been experiencing many of the symptoms that have been posted here and cannot begin to tell you what a relief it is that I'm not alone. I have been using the Nuvaring for 6 months. Some of the pros were convenience, larger breasts ( I went from a full C to a DD), and more lubrication. My side affects were extreme leg pain, excessive weight gain (about 30 pounds), increased appetite, fatigue, head aches, irritability, heart rate increase, dizziness, gas, bloating need I say more? Last night I took it out immediately because I finally put all the pieces together. It's amazing to know that I'm not alone in all of this. The weight gain was so fast that I have stretch marks that are extremely deep and I have belly fat for the first time in my life it has sprung right on my stomach. I'm only 19 so this is quit concerning for me... I went from 165 to 195. I have stayed around 165 for 5 years and the fact that I put on this thirty pounds was extremely concerning. I am grateful I know what's the issue, and hopefully with more energy and a decrease in appetite, I will be well on my way to my old self.

I first used the nuva ring in the summer of 2005. I was in a terrible relationship with an alcoholic and not living a very healthy lifestyle. I had good reasons to be depressed and did not link my emotional intensity to my new birth control. I remember, shortly after starting the nuva ring, my depression and helplessness intensified to the point of becoming suicidal. I did not even want to get out of bed and sometimes did not. Then, by some miracle or grace of God, I had a great job offer that took me to a new city. I finally broke from my relationship and bad habits and felt positive I was out of the funk I had been in. However, I often speculated that the nuva ring had something to do with my intense sadness.

In my new life I started dating a wonderful guy and have a great new career. About September 2006 I came off the nuva ring and have been using the rhythm method. We are getting married in May 2008 and my doctor recently put me back on bc so I won't end up huge and pregnant at my wedding. It has been 2 weeks back on the nuva ring, after one year of being off, and I am extremely depressed, full of anger, rapid mood swings (within the hour), crying uncontrollably, deep sadness and loneliness, and feelings of suicide. All in two weeks. Does that sound like a woman who is getting married and has a good career? NO!!!! I just canceled appointments at work and am jeopardizing my job because I feel so out of control. I don't want clients to vibe off of my freak-out, psycho mode. And, although my fiance and I are experiencing typical stress, none of my feelings are being taken serious by him because my behavior is so awful.

Two weeks ago everything in my life was wonderful. Now, it is un-threading. The power of these hormones is too much to handle. When I experience depression with out the nuva ring, I do a great job of countering out my depression with my cognitive behavioral skills. But, on the nuva ring, I feel powerless to control my depression. I am going right now to take out this ring. I do feel like I pushed through the depression the first time. But I had all of these positive things thrown my way. I don't have time for this damaging interference in my life. I'd rather have a baby! So, if you are prone to depression, or depression runs in your family, I would stay far away from the nuva ring. The company who manufactures the nuva ring should conduct more studies about the affects in patients prone to depression. My thoughts of suicide are so casual and vivid I am scared. I am scared a sweet young woman is going to kill herself if they are not educated that the severity of their depression is due to their birth control!

I took this pill for 2 years. Soon after starting I became severely depressed. I was hospitalized for depression twice while on this drug, and began self mutilating. My mom heard from a coworker that Yasmin causes depression, and she took me off the drug. Within two weeks I felt better. And I'm trying to get my life back on track. I am happier now than I can ever remember being. Now, even at my lowest points, I am still happier than I was for the two years I was taking Yasmin. I went from being an honor roll student, and now I am barely graduating. Please, if you are experiencing depression after taking this pill, take yourself off of it. Nothing is worth feeling like that.

Hi, Im not much of a computer person. I from old school. Anyway, Im in my 40s and have been on the levox for about a year. I thought night sweats, head aches ,bone aches,and muscle aches were part of my aging factor. My blood levels are good as per my endocrinologist. but I too experience depression at times, constipation, irritability and fatigue as well as mental dullness. Im a very educated women and must admit , I sometimes feel like a total mental moron. Mary