Flap symptoms and conditions

I have been on Toprol XL for 8 years. I began taking it when I was 19 after a "attack" where my heart rate was close to 200 bpm for a couple of hours. I was put on Toprol 50 mg for my SVT. This appeared to help but in the beginning I definitely had a slight difficulty with breathing which was exacerbated by stress. It took me a couple of months to get use to the drug especially since my heart rate didn't necessary adapt to the drug right away. I have been trying for a while to get off the medication without the ablation surgery. My cardiologist(s) never thought I should have the procedure since I was so young. It has been a challenge to get off the medication because my heart rate is so high. I was told that my body is so use to the medication that I need to ween myself off. I went down to 25mg for the last year and just in the last week went off of it completely. While I can feel my heart rate (very rarely) every once and a while, it's not enough to get me to go back on the meds. The one side effect that I have had that my doctors have told me about is stomach trouble. Toprol can weaken the muscles in the esophagus (the flap) and cause pain/burning/nausea. My doctors are not 100% certain that this is what is causing my stomach issues but they feel that my prolonged use of the drug has lead to a weakening of my muscle.

More evidence of what I have been saying about genetics and the leukotriene pathway that Singulair blocks. FLAP's as mentioned below are actually the same era as Singulair (late 90's)--many scientists were looking at this pathway.

The genetic component is so "in your face" every where that I am quite appalled that Merck has not at least addressed that issue by now.

Monday, June 02, 2008
Amira Pharmaceuticals Achieves Milestones in FLAP Inhibitor Program With GlaxoSmithKline
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SEND ComtexDigg It StumbleUpon Newsvine Reddit SAN DIEGO, Jun 02, 2008 (PR Newswire Europe via COMTEX) ----GSK exercises option for AM803, a FLAP inhibitor which recently completed phase I studies

Amira Pharmaceuticals today announced that under the terms of a worldwide exclusive agreement entered into in Feb 2008, GlaxoSmithKline (GSK: 43.65, -0.88, -1.97%) will exercise its right to a second FLAP compound, AM803. Under the original agreement, GSK has rights to develop, manufacture and commercialize FLAP (5-Lipoxygenase Activating Protein) inhibitors for the treatment of respiratory and cardiovascular disease. The decision to develop AM803 follows the successful completion of a phase I study by Amira, which demonstrated its potential as a once-daily FLAP inhibitor.

"Exercise of this option by GSK caps a productive first few months during which Amira has hit a number of near term milestones. Hitting these milestones early has not only further strengthened our relations with GSK, but has resulted in meaningful economic benefit to Amira," said Hari Kumar, Chief Business Officer, Amira. "The project has started extremely well and we are very pleased at the commitment of GSK and the progression of development."

About FLAP Inhibitors

FLAP (5-Lipoxygenase Activating Protein) is a key component early in the leukotriene pathway, a complex signaling process that exerts control over biological processes, such as inflammation and immunity. Excessive production of leukotrienes exacerbates inflammatory diseases, such as asthma; the FLAP gene has also been linked to a significant increase in the risk of myocardial infarction and stroke. AM103 and AM803 bind to FLAP, inhibiting the synthesis of leukotrienes that cause inflammation.

About Amira

Founded in 2005 and headquartered in San Diego, Amira Pharmaceuticals is a small molecule pharmaceutical company focused on the discovery and early development of compounds to treat inflammatory disease linked to the eicosanoid pathway.

The company combines the rigor of a big pharmaceutical company with the ingenuity and energy of a small company, creating an environment for efficient and effective pre-clinical and clinical program decisions. Its scientific founders have successfully worked together for more than a decade and were pivotal in the discovery of a number of inflammatory drugs, including Singulair(R: 73.05, -0.38, -0.51%). The drug hunters at Amira are now actively leveraging their history of success to create high-value compounds for the future. For more information, visit http://www.amirapharm.com.

Web site: http://www.amirapharm.com

I started taking Chantix in August right after I had my teeth cleaned by a periodontal office which I was doing every three months. Three months later my periodontal disease which had been controlled for four years came back full force. I had just had an implant placed in July and now am in fear of losing it along with some other teeth. I have had to have new bone graphs and gigival flap cleanings trying to stop the problem. I have now been off the drug four months and things seem to be going better. PLEASE CHECK WITH YOUR PERIODONTIST IF YOU HAVE EVER HAD PERIODONTAL DISEASE BEFORE TAKING THIS DRUG.

Have been on Doxycycline Hyclate on and off for the last 6 months for acne treatment. I hadn't been enjoying the way the pills made me feel so I had neglected to use my last bottle of sixty (100mg 2Xdaily) until my acne flared up this past holiday season. On Friday the 18th of January I went to workout, came home and cooked myself a big breakfast, and then decided to lie down for a nap an hour later. The bottle was next to my bed and I hadn't taken my dose for the day, but I had just eaten a big meal so I wasn't too worried. I took the pill w/o water and lied down. BIG MISTAKE. I woke from my nap about 90 minutes later with the most intense burning sensation I've ever felt. It was just below my rip cage in the center of my body (I think it's the flap between the esophagus and the stomach) and now it's Tue. the 22nd of January and it still hurts every time I swallow and especially when I eat food. It sounds like I'm not alone with this problem and I would love to hear from somebody if this is temporary or what their Doctor told them to do. Thanks for your help.

I know everything al of you say is true its just so difficult going thru this Dejay told me her doctor said that the chemicals in the brain get altered by the pill and that scares me so much. I dont want to go on a anti depressant I just want to get back on my own but Iam a mess.

Reading this forum everyday is the only thing keeping me going.

I went back to the ER last night because that thing on the roof of my mouth is so weird its like a flap of skin but its thick I was so afraid it was cancer it seems whenever I get something it is magnified 100x I just have all these things happening and I dont know what they are. I was perfectly healthy happy take charge on the go woman.

Now I cant do anythign its so scary.

The ER said they think its a benigh growth perhaps a ulcer or a canker but its attached to the roof of my mouth and its not a piece of skin its pretty thick like a nickel so scary.

Iam at 6 weeks now and you guys all say 2-3 months I hope thats true.

Sad Kim