Freakin symptoms and conditions

One of the most important questions we should be asking as parents is:

How does Singulair - a leukotriene receptor antagonist (blocks the receptors) affect the normal function of the mast cell?

The mast cell is the FRONT LINE DEFENSE against invading micro-organisms. When Singulair was invented, there was limited knowledge regarding the mechanisms by which the mast cell performed it's function. In my opinion, the focus was very narrow - those interested zeroed in on how the leukotriene receptor performed a role in the cause of asthma attacks and how ashma attacks could be prevented. Well, that's good preventing asthma attacks. But what happens to the mast cell if that receptor is blocked on a long term basis. I am not suggesting that blocking the receptor is bad but what if the long term effect is different than what we are are lead to believe-which is this is a safe medication with no known long term effects. What if the leukotriene receptor was just blocked short term a week or two to allow the body to clean up the mess from the last attack?

I seriously question what is going on with all of these infections. Are they related to crippling the mast cell? Parents should be allowed to question. If Merck doesn't want to answer questions regarding what happens to the mast cell (including are the numbers of mast cell decreased on Singulair), then something really BIG is missing. If by any chance (unknown at the moment) that the mast cell is significantly changed and therapy by montelukast is proper on a short but not long term basis, so freakin' what if Singulair is not a huge money maker any more.

Parents deserve every answer possible when decisions regarding their child's growth and development is on the line. I hope that we get some answers.

Of course, what was there in 2002 were new questions-not necessarily answers about the mast cell. Did anybody apply this to Singulair studies?
May 2002

From Journal of Clinical Investigation

Pattern recognition receptors on mast cells
The Toll-like receptors (TLRs) fit the definition of pattern-recognition molecules, which were originally postulated to allow the innate immune system to detect the 'molecular signatures' of various infectious agents. Although the innate immune system has no memory, it shows a degree of specificity, in part because the various TLRs recognize different sets of pathogen-associated molecules. Dermal mast cells are usually associated, not with the innate immune system, but with atopic dermatitis, but Supajatura et al. have found that these cells also express TLRs. They report here that TLR4, which binds the gram-negative product lipopolysaccharide (LPS), and TLR2, which binds peptidoglycan (PGN) from gram-positive organisms like Staphylococcus aureus, induce distinct mast cell responses. Staphylococcus is known to exacerbate allergic dermatitis, but it has generally been thought to act by inducing antibacterial IgE's, which trigger mast cell degranulation by stimulating the IgE receptor. Interestingly, the authors show that the interaction between PGN and TLR2 can provoke mast cell degranulation directly, sidestepping the need for IgE receptor engagement.

I have had the Mirena in for about 8 mos.I love having no periods.But that is the only good thing I have found!I am 5.7" and weigh 186.I was 145 before I had my son.After I had him I was going to the gym every day and even had a personal trainer.It seems No matter what I eat good or bad I cannot lose the weight.I thought maybe it was just because I had a child, but Ive found other woman are having the same problem.Just cannot lose a pound.Until they get it removed.Before I got the Mirena I was already pretty emotional but now its ten times worse!And the acne, OMG!!! I have it so bad I am using face stuff everyday nothing is working.I have it on my face,arms,back and butt.Absolutely hideous.I feel like crap.I cant even walk in front of my husband without thinking he is thinking something bad about how I look.This has upped the depression,I am feeling like everything is screwed up in my life (but its not) its just my perception right now.I have found that the doctors look at me like I am lying to them, like its all in my head.I should print everyones blogs and show them to my doctor! It makes me mad that the medical industry will present something so perfect and screw how it effects peoples lives.I had to pay cash for the freaking thing too!That makes me even more pissed off.I want this thing out so bad.Now my husband and I are talking about vasectomy because its much easier then a tubal.Its sucks that we had to come to that.

I really, really regret ever having started Lamictal to begin with. Even though lamictal has greatly helped me with my social anxiety/ocd/gad/whatever it is I have (lol), it has caused too many damn side effects.

I started taking it sometime July and now it's September 21st, so it's been in my system for a couple of months now. When I first started on the starter pack, the 25 mg didn't have any effect on me- and then it started making me really, really anxious. I'd have super big physiological reactions to stress, but then I was advised to take it at night. Of course that started insomnia, and when I increased it to 50 mg I was really sensitive to light. It also caused my eyes to twitch and not stay closed when I tried to sleep- which was really, really annoying.

When I was first doing the 100 mg, at one point I became manic (I couldn't stop talking, I had racing thoughts, energetic- felt like I was on top of the world) and then I crashed. It was really hard going from being manic to really depressed, but that's the shit that happens on lamictal lol.(for me at least)

Anyways, so finally the 100 mg started to level me out- but I still have the rapid mood swings. I also feel incredibly spacey all the time and have trouble focusing/concentrating. Oh yeah, and my short term memory is shot. And my libido- which is really important to me. I hate having freakin' vaginal dryness and not really wanting sex- so irksome.

My advice to anyone reading this: don't ever try lamictal- it's not worth it.

I was perscribed Sulfamethoxazole for MRSA. This is my list of complications so far:

CANNOT FREAKIN SLEEP!
itchiness
confusion
some memory loss
moodiness
loss of appetite
jitteriness

yeah..some of them are listed as side effects...but most of them are not,but I found from websites like this, that several people experience side effects not listed.

I'm not worried. I'm just glad my infection is going away. I just don't like not feeling myself. It's sort of like Lex Luther...when he "goes crazy" for a few months on Smallville.

it stopped the cramps and breast tenderness, but i get my period about a week early every freakin month! and then just spot a bit when i am supposed to have it. its relaly getting annoying! i think i need to switch. i also get awful headaches whihc i usually attribute to allergies but i see that headaches and trouble wearing contacts is a listd side effect so now im wondering about that too.

Hi I was a nuvaring user. I am 18 and my gyno told me that nuvaring would be better than any other birth control on the market. I really wanted to start on the patch but my gyno insisted on nuvaring.....yea that was the biggest mistake ever!! I had it for only 15 days because a 15 day period wasnt exactly what I wanted... I had no smile on my face for 13 days and I hated it! My back felt like I was constantly carrying boulders on it and I felt tired all the time. My coworkers had to constantly crack my back for me because I was almost in tears from the pain. I stopped using it and within a few days I was fine. I felt better, my freakin back felt better, and I finally felt clean for sex! But now im experiencing a problem that I hope someone out there can help me with... I stopped nuvaring about 3 weeks ago and ever since I have had gross brown discharge come out of me... Yea lost alot of nice underwear due to that. and now I have my period but its like alot!! minimal cramps but the blood sucks but im assuming that its normal? but does anyone have any advice??? maybe been through it???

Okay I am 22, and I was on yasmin for well over 3 years. I need some help though. I suffer from depression ect... too even with out it.. But yes yasmin did make my problems worse... it got bad... But I took myself off of the pill over a months ago... And I have yet to have my period. Should I go and see a Dr. I took a test to see if I had an oops... but it came out neg.. But I need some help.. Why havent I had my period.... Im freakin out about it so please help me

Hi everyone,
I'm really worried that I haven't gotten my period yet. I am officially 9 days late. Someone please tell me if this is normal. I was on Yasmin for over 3 yrs. and have been off of it for 4 months. I got what I thought was my real period exactly on time for 3 months. I got it on the thurs. and it lasted until the sun. Now I didn't get it. It feels like I should get it at any time now. I have sore breasts, and I am breaking out like a teenager. However they aren't really zits, kinda more like bumps with clear liquid in them.

I'm wondering if I should take a pregnancy test or if this is normal. I have heard of people taking tests and having it read positive due to messed up hormones as well which would really scare me more. I'm kinda freakin out. My boyfriend and I have been using condoms and there weren't any accidents, but I can't figure out why it hasn't come yet. Was the past 3 months just my fake period or what?

Thanks,
Hill

My Daughter has been taking Singulair for 4 weeks and has demonstrated many of the sideffects listed in these here pages.
Before Treatment she was a well adjusted little girl who cared and loved her younger sister of about 1 year 8 months and was very easy to care for now she actsa like she is possesed by some freakin monster she is calm one second and just explodes in a fury of rage kicking screaming .
She also has night mares shuddering boddy itchy skin and has scratched it that bad it bleeds extreme irritibility fatigue tantrums that last an hour or so i stoped treatment today all of the information i have read on www with google searches have all but 3 percent reported good treatment with no apparent unwanted effects.

I agree with previous posts that we need to remember that this IS supposed to make your body feel pregnant and most of the mentioned symptoms are like that when you're pregnant. I've never really been on much birth control. I took Depo about four years ago and had a VERY bad reaction to it. Then I took Lunelle about two years ago and Looooved it but they took it off the market. Now, I've been on Nuvaring for three weeks. I initially had the headaches and minor nausea for the first week and then it went away but the MAJOR and I mean major side effect I've had is depression. I have never had a problem with depression and I've been through a LOT of crap in my life and dealt with it just fine. But I am depressed to the point that my body and limbs feel heavy. I can not get myself to get out of bed and I have two baby girls that I adore. I cry about any and everything and I feel so freakin hopeless about everything. I talked about it with my fiancee and he asked "well what are you depressed about?" and I have NO reason. I'm doing great in school, I'm in a wonderful relationship, my girls are great...so that's how I know it's this ring. I'm taking it out this weekend and we're gonna go back to condoms for now. This is just so bad and I know other friends and classmates who are on this and have even had suicidal thoughts until they took it out. I'm sorry...it may be the hormones but it isn't worth all of the emotional ups and downs.

I am becoming so *itchy! The mood swings are horrendous! I suffer from Crohns and have to take large doses of Prednisone. Right now I'm on 40 mg daily for 7 day, then 30 mg's for 7 days, then 20 mg's then 10 mg's! I'm still in the 30 mg's and feel like I'm going to have a freakin' heart attack because my nerves are so rattled. I am ready to cry one minute and ready to fight the next. My poor husband and son are trying to be supportive but I don't blame them for getting tired of it, I'm tired of it. Has this been the case for any of you? Also, I am up a good 5-6 times nightly to pee! And I mean, can't hold it any longer, gotta go right now kind of pee! Is this supposed to be a side effect? Does it signal something bad? Any advice from any of you would be very helpful. I haven't gained any weight from taking the meds yet but I'm fearful of it and fearful of what I've heard is called "moon faced" ???? When the information says "prolonged" - how long is considered prolonged use? A month, a year, longer? Any advice is appreciated! Angel

hello, i was on prednisone for 3 weeks to treat shingles. my face is so bloated like chipmunk cheeks! is this normal and will it go away??? how long will it take? i feel like i don't even look like myself anymore. also i sweat a lot at night and have a hard time sleeping soundly. when my dose started tapering off, i was so freakin' irritable and suffered from low self-esteem. i felt like a monster inside and out. kind of still do but i am realizing that it is drug-induced and not necessarily me. thanks to all of you for sharing your experiences.

I've been on Yasmin for probably over 2 years now. I was taking it continuously for endometriosis but if I forgot one pill or took it later than usual I would start BLEEDING, not spotting, and a lot of bloating and cramping. I also had a lot of stomach problems when I bled and I just got so very frustrated with the bleeding, stomach pain & bloating as well as the severe cramping that comes with endometriosis. Well I stopped the darn pills for about 2 weeks but I was worried about getting pregnant so I decided to get back on them. First off, I have noticed in the past week since I re-started the pills that I am getting cystic acne which is very distressing to me because I am 29 years old and I suffered from cystic acne for a long time before I got it under control with Accutane but not before the scar damage was done. I never even thought that the Yasmin could be causing it since I didn't have this problem prior to stopping it. I happened to stumble upon this website looking for help with pregnancy issues related to Yasmin users. I was just on Yasmin's website which said that recent studies indicate that women are the most fertile the first two weeks after stopping Yasmin. So I'm freakin' out a bit here because I was off exactly two weeks and my husband and I were quite "frisky" these past two weeks. Is there anyone out there that may have experienced an unexpected "quick" pregnancy right after stopping Yasmin? I already see that many people have suffered from the acne, I'm just not sure why it didn't affect my skin before.

I've been on Levothyroxine for years, and recently my fingers on my left hand tingle,are numb, I can't FEEL with them. So after complaining to my doctor, he shoots some cortisone in my wrist telling me it's carpal tunnel. Carpal tunnel, my butt!! I don't know what made me do it, but somehow I got to this site. I've been on antideppressants for years cause I'm tired, fatigued, then on valium so I can sleep,
I can't concentrate at all, my memory is GONE....
I called him this afternoon and said I wanted to go on Armour
Thyroid. His nurse tells me that he says " We'll address that when he sees me in April". %#@* that, I'll be 400 lbs by April!! My sex drive is nonexistant, and I'm a freakin' couch potato when I used to go to the gym, go out with friends, DO THINGS!! Now I'm lucky if I make it through work. ENOUGH DRUGS... I'm goin' off everything and starting over. I'll get up the money and see an endocrinologist. I'm through being a drug reps dream....

Ok! I've been on this pill for 4 days now and I feel like I"m breathing fire. I finally got some rest after an entire day of migraine severe bitchiness, and now am happy I finally get to toss this freakin pack. (The fire breathing feeling comes from feeling HEAT all day, especially the throat area). For all you ladies that this pill worked wonders for, I'm glad it's all working out for you. I just happen to not be one of them.

The worst is trying to explain to your boyfriend, "i'm so lethargic, I feel down, I got enough sleep and I still can't seem to get out of bed, I think it may be the pills I'm taking" and being made to feel like it was all in your mind. Thanks to all the women on this board who posted, otherwise I wouldnt' have known. Thank you!!

Another symptom I experienced after 4 short days was blurry vision, and dizziness. And a whole heck of a lot of gas, which was kinda enjoyable. but the others are not acceptable.

the point of this is, the last few days were mental hell. I'm gonna take care of my body & make him wear condoms if he has to.