May 18th
2007
7:52 AM
May 24th
2006
9:33 PM
I had started taking Lamasil for toe nail fungus infection for about 20 days. I came down with fevers, chills and sweats about 20 days into 30 day doseage. My doctor prescribed Levaquinn for the fevers. I had a blood test and found my liver was very effected by the Lamasil. I was to take about 8 day of Levaquinn which I did. After 4 days of the Levaquinn my fever was gone but muscle pain developed for which I took Ibuprofen even after the levaquinn ran out. The pain became excrutiating. My calves felt as if they had been kicked and charle horsed. My shoulders felt as if they had drills drilling into the scapulas, My blood vessles felt as if they had gasoline running through them. My right hip started to get a deadened spot on top of the front of my hip joint, Pain flashed at various spots as if stuck with a knife. about two days fter stopping the Levaquinn, I had a period of three nights I could not sleep or lay down the pain was so great. Three weeks after stopping Levaquinn I am still in pain. My hip joint feels like it is being stabed by 40 Ice pics at time, it is sensitive to pressure and quick movement, my calves are still sore and make it hard to walk at times. Over the period I was tested for hepatitus A, B, C, HIV Lyme disease, Shingles Herpes, had Cat scans of my head and Abdomen, I developed Bells Palsy on my left face. After 7 weeks of pure hell and none of my local doctors culd think of any more test to give me, I went to a Nurologist on my own at the Lahey Clinic who identified the culprit the Levequinn. He tells me the pain will eventually go away in 1 to 3 months it has gotten more bearable after the many weeks but I still take Celebrex to sleep. No one thought to read the contra indications including me, least of all my doctors-except the last one at Lahey Clinic. Two medications suposed to cure damn near did me in!
Stay far away from this stuff unless you are dying- or want to.
May 6th
2008
6:52 PM
We have all been saying that our issues regard not being informed about all of the possible side effects. And, we know that Singulair works well for some people. Nobody wants to take a good drug away from those for which it probably performs miracles. People who have toxic side effects have a right to know up front.
My observations about montelukast's chemical structure are either general or not quite 100% correct or could be quite vague - so forgive me. I do not claim to be good at organic chemistry. But from doing a little work, I have come up with some observations.
1. It would seem to me that montelukast might work quite well for people who have developed mold category related asthma. I observed that chloroquinolin, a component of montelukast, is a good fungicide effective against Aspergillus, Alternaria, Cladosporium, Penicillium and Candida. Dust mites can only digest if helped by aspergillus so they go into the mold category. Molds produce millions of spores so anyone who lives in contact with mold would be chronically sick from their presence. Then people get hypersensitized to that.
I am probably wrong but I could imagine that montelukast is: 1) a ligand that binds to an empty cysLT1 receptor for a period of time 2) 7-chloroquinolin-2-yl which either acts intact or breaks down into a quinoline fungicide so that it kills the chronic mold/fungus infection and 3) a sulphur/methyl anti-inflammatory component that tells the t-cells that they are not needed so they will die. Wow, that would be great for mold asthma if it was completely non-toxic. It would be also great under controlled circumstances for many people who are mold-miserable. If I am wrong, I better go out into my garage and start inventing such a drug.
This is my visualization to try to explain the side effects of neurotoxicity. So adverse reactions could be to the quinoline component as an allergic reaction or dose related so that it just built up to a toxic level over time. There are many signs that t-cell populations are significantly reduced by montelukast. The fact that the Italians can do it in the test tube might be that it's a chemical component of montelukast designed to cause the t-cells to die.
Montelukast is a large molecule so Artie says it cannot penetrate the blood brain barrier. That would be an argument if nobody was complaining about neuro-psychiatric side effects. The neuro-psychiatric side effects are identical to quinoline and quinolones. When I read about Lariam, it just sounds like a more extreme version of Singulair side effects. Chloroquinolins were used before they invented Lariam, which is stronger. The malaria Plasmodiums became immune. Hallucinations, anxiety, depression, suicidal thoughts are completely consistent in all of the quinoline/quinolones. If montelukast breaks into sub-molecules then quinolines easily penetrate the blood brain barrier.
I find clinical evidence that montelukast may act as more than more molecule. And, that there is a rational for the existence of the chloroquinolin and evidence that it may be the source of toxicity.
I am glad to risk being called crazy. That is what the internet is for. We can present our ideas and discuss. So, just take this with a grain of salt. If I am close to the truth, this post will find it's proper home.
-- By concernedcitizen | Reply | (12) replies | Private Message me