Gabapentin symptoms and conditions

Worst night of my life--woke up feeling filled with anxiety, insomnia, had to get up repeatedly to urinate, felt very agitated, though I felt very peaceful & relaxed at bedtime, feet were swollen so badly I couldn't put on my shoes. I took 10 mg of Benadryl, which did not change how I felt. My internist took me off the Singulair immediately, when I contacted him the next morning.

Despite being on an antidepressant which was recently increased, very recently I felt sad, anxious, and was crying all the time, felt irritable, and was chronically tired. I took 400mg of gabapentin (Neurontin), prescribed for nerve pain, numbness, tingling in both hands & feet at 9 p.m. Just before bedtime at 10:00 I'd take 10 mg Singulair. 1-2 hours later I was wide awake, sometimes not sleeping for hours or at all, even after taking 1-2 Benadryl, without the dyes.

Over the past two years I've had eczema, for which I saw 2 different dermatologists and an infectious disease specialist. Eczema was so bad, I couldn't sleep at night. I consulted with every imaginable doctor, including the allergist who prescribed Singulair & was told it couldn't be the Singulair because Singluair was FOR ALLERGIES. Was diagnosed with fibromyalgia by a neurologist, recently had a repeat of an MRI because I couldn't walk the pain was so bad. My neurologist was unable to find any reason I had pain & difficulty walking, after reviewing the results of the MRI.

I've seen my internist for heart palpitations. When I reported urinary frequency, he had me get a cystocopy (negative) because I had hematuria, blood in my urine, and I had weight loss.

I still have many of the side effects, like the numbness & tingling in my feet and hands, however, I am able to sleep through the night and did so immediately after going off the Singulair. A lot of the fibromyalgia pain I was having has subsided, depression, anxiety has subsided as well.

I was first prescribed Neurontin in November of 2008 for cervical disc bulge touching my spinal cord causing severe nerve pain in my left extremities. I was prescribed narcotics and eventually prescribed Neurontin. The side effects from Neurontin, at that time, were seemingly intolerable, but as the narcotics were decreased several months later, I found the Neurontin was actually effective and did its purpose. The side effects from the Neurontin were not that great to outway the pain factor I had. I believe this drug does its job!!!!

I've been on Wafarin since September of 2008 because of a massive DVT stretching from my jugular vein to my right arm. Since the initial injection of Heparin and oral consumption of Wafarin I have experienced daily migraines. They seem almost like 'pressure-headaches' pushing on the sides of my head, temples, forehead and the bridge of my nose. My thrombosis doctors have sent me for Ophthalmology tests, MRIs, and plan to send me for Neurology tests as well to discover the cause of my headaches. They've put me on codeine, Tylenol 3's, Gabapentin, Naproxen, and Co Sumatriptan because of the fact that I'm so immune to painkillers in general (For the blood clot pains themselves, I was on Hydromorphone, Morphine and Codeine). Although the Co Sumatriptan along with the Tylenol 3's give me some relief, I can't help but wonder if the cause of my daily migraines are from the Warfarin itself.
My doctors are reluctant to agree with me, saying that they plan to take me of Warfarin within the next few months, but aren't certain of exactly when.

49 year old male started 4 years ago at 20mg and 10mg HCTZ. some results in lowering BP. 2 years ago MD upped it to 40mg because BP inching up. quit smoking 3 years ago, not one puff since. After MD upped mg the side affects have really kicked in. I experience all the side effects listed on this site with the exception of the cough which I started with but went away after a couple months. I have had stress tests, Holter monitor for heart arrhythmias, mri, blood work, stool samples, colonoscopy, and all sorts of other tests all coming saying I'm ok, yet I don't feel ok, I get progressively worse. After 4 weeks of 5 day a week exercising with weights and aerobics to get in shape to return to racquetball I have had it. I couldn't last 45 minutes my second day out. I felt like I was hit by a truck and it took a couple days to recover.
My MD attributes the issues to aging. I going for a second opinion and third if necessary. I am told by my MD that there are no studies showing these side affects for this medications. However I look at this web site and find it hard to believe that these doctors just haven't seen any evidence of what we are all suffering from. Why don't doctors really listen to patients. We are asked to listen to our own bodies and told we know our bodies better than anyone, yet when we bring up these issues we are treated like children.
No real answers, just questions

I have been taking gabapentin for a couple of years now for neuropathy and I have the most stupid dreams that just don't make sense, and some feel like it really happened. Does anybody else have weird dreams while on this medicine? I feel like I'm the only one.

I have been on gabapentin for almost two weeks now. It seems to have helped with my sleep problems and also has helped minimally with my pain. Unfortunately, I have also experienced severe headaches, rapid heart beat and the inability to climax, along with feeling very "spacey" mentally. As I type this, I am waiting for a call back from my doctor's office. I don't think I am going to be able to continue taking gabapentin.

October 22, 1998 I had resp. failure (with intubation). My new pulmonary doctor put me on Singulair 10 mg once a day, a few weeks after. Within time, I started to have numbing and tingling in my face, arms, and legs. March of 1999 the symptoms worsened and started causing pressure in my face, arms, and legs, and anxiety started to kick in. I was told I had neuropathy and to take mobic. Symptoms getting worse, and went to a rheumatologist in June 1999, and he was suspect of singulair. The doctor thought that what I was experiencing was due to the singulair. He (the rheumatologist) discussed this with the pulmonary doctor and the pulmonary doctor did not believe this to be the case. Not forgetting, in March of 1999, I had a ct of the sinus area, and low and behold 1/3 of the cavity was and probably still is full of polyps.

As time went on, symptoms getting worse, and not one bloody doctor could figure out why I was feeling this way. In addition, at times, I was put on steroids for my asthma (not including my inhalers).

Two years ago, my body went into shock, leaving my left side very different than my right side. Affecting: my head, my face, my eye, my ear, my esophogus, my lungs, my arm, my leg.

I have been depressed and anxious not knowing what the heck was going on with me.

Recently ruled out thyroid, and lupus, and possibly ms.

Last weekend, I reviewed the letter from the rheumatologist (dated 1999) and the ct report from March 1999 (regarding the sinus/ polyps) and made copies to present to a pulmonary doctor that I have recently been seeing.

This past Monday the 10th, I had my appt with him. He knew of my situation from the last few visits (in addition, I had met him this past March for a pulmonary rehab program, and thought he seemed to be knowledgeable and compassionate). While waiting for him to enter the exam room, he had read those reports before entering.

The doctor looked at my hands (red as a beet and swollen) and said "You have Churg-Strauss Syndrome, and get off the singulair."

I had done my homework from a few weeks ago, where I looked up untreated polyps.
Untreated polyps, can turn into vasculitis. There are many types of vasculitis, to include Churg-Strauss Syndrome.

I then cross ref CSS and singulair, and low and behold, BINGO!

I have been suffering for ten years, physically and emotionally because of this drug!

There is also recent updates from the fda (fda.gov) regarding singulair, of which most recently includes anxiety and depression.

I suggest before taking singulair, be aware of the side effects. As soon as a side effect comes up, contact your doctor. Also, be aware of existing conditions (like me, sinus problems and asthma) for this could lead to churg-strauss syndrome.

This info is indicated on the actual disclosure (the paper insert that indicates studies, side effects, etc...) not the handout that is given with the drug.

By the way, I am now working with a new rheumatologist in Los Angeles (Cedar-Sinai affiliated) and a new neurologist.

mdklezmer

I have two experiences with Prednisone to share: I am a 52 year old woman, married, no kids. One year ago I came down with a serious case of shingles on the top and inside of my left eyelid. What started out as a bump that looked like a pimple or a bite on a Friday afternoon (and I don't have acne), spread across and under my eyelid by Mon, morning, up into my eyebrow and down the side of my nose. My eye felt like there was glass in it every time I blinked. I got to the doctor on Mon, the dermatologist on Tues and the opthamologist on Wed. All confirmed shingles. I have never felt anything to excruciating in my life! The dermatologist prescribed a 3-week descending dose of Pred starting with 6 pills a day. I was also given Gabapentin (a nerve blocked), Acyclovir, a muscle relaxant, pain medication and two separate eye drops, one of which was also low-dose Pred. After the 3 week course of treatment was done, I had to continue for another week, but with lower doses.
Side effects: I did not notice any side effects except that my appetite was seriously jacked up! I ate anything and everything -- and then some! Food was my best friend and I hogged everything in site! In hindsight, when I try to assess myself and any changed, I guess I do have some attitude issues in that I am quicker to anger, quicker to react and respond and seem to "snap" a lot quicker.... Oh yeah I am also on antidepressants.... I now have one droopy eyelid due to the nerve damage from the Shingles and permanent damage to the cornea and tear ducts.... However I am not really sure how much of that is due to the Shingles and how much is due to the Prednisone.

My 89-year old mother was hospitalized in August for emphysema and chronic lung disease, she was down to 81 lbs. They treated & released her and she was on a descending dose of Prednisone for a week. She needed to gain some weight & gained 3 lbs! This was very good.... She is still smoking and her doctor will NOT insist she quit (I think they have given up). They put her back on a 2-week course of Pred again last week. Her appetite is back up Yeah! but she has some serious attitude and anger issues. We are only 1 week into the 2 weeks and I don't know how our family is going to stand taking care of this evil old woman during this Prednisone treatment, and afterwards. I'm sorry I ever let the doctor put her back on it--- however she is gaining weight and getting (falsely) stronger, which she needed.

I am my husbands caregiver. He is on many medications the last 26 years due to chemical poisoning thanks to our government not protecting their civilian painters at the Army Depot where he worked.
He has permanent brain damage, CRS damage, memory loss and short term memory, CHF and Bollis Emphysema. Now he also has Type II diabetes a severe case as he was not diagnosed for 7+ years of testing.
To make this short. He has been on many drugs for pain, diabetes, blood pressure, the brain damage, ( he is a recovering, not drinking alcoholic)
Recently the doctor took him off the Codeine # 3 that he had been taking for almost 15 years, 8 per day. and gave him time release Morphine Sulfate.15 MG. They also gave him Gabapentin for the neuropathy which is severe in his feet and starting to go up his legs. He is over weight, above the waist, and has not had a problem with High Blood Pressure, for many years since taking 60 mg daily of Inderal. His Blood Sugars have been between 98-140 without medication. When he was first diagnosed he was put on glyberide and it worked so good he was off it in 6 months and totally diet controlled since then but about every 3 years he would go on it for about 6 months and then he was ok again.
He has not needed it for the last 7 years. Since starting the gabapentin he went from 300 to 600 to 900 and slowly increased the dose to 1600 mg. The 300's are caps, the 600's are tablets.
All the sudden he has pounding headaches, I took his BP which we had not been watching and it was 198/115 with a 98 pulse. The only change was the gabapentin and Morphine. The morphine does not seem to be causing any side effects, once he was used to getting sleepy.. but once the gabapentin was added, all he does is sleep. The blood sugars also went up with the blood pressure. His were 358 higher than they have ever been except when he was first diagnosed. I was able to get the glyberide and that is bring down the sugar levels only taking 1/4 tab 2 x a day, and the blood pressure is also coming down, it was 139/85 with a pluse of 76 which is still too fast. I talked to some pharmancy friends and they said " Its the gabapentin " so I told the doc I wanted to stop it and he said to start leveling off, one 300 mg cap every 4 days. We were down to 2 a day till Friday and saw the doctor. Due to his taking Cymbalta they did not want to give him any of the other anti depressants so they want him to back on the gabapentin up to 1200 a day instead of the 1600 a day.
Taking into consideration his medical issues and meds, I don't believe this is a safe or sound decision, but I know how much pain he was in before the gabapentin.
I wish they would be more forthright about the side effects of this medication. They said it only causes blood sugar issues in 1 % and they did not even address the high blood pressure etc.
His pupils are also different, he has the kidney pain, but his biggest problem is sleepy.. hopefully it's not his kidneys or his heart. They did blood tests on Friday and I am asking for a EKG.. in the mean time we are monitoring both blood pressure and blood sugar 6 or more times a day. Thank you so much for sharing. It really helps to know we are not alone.

This testimony should help strengthen our case for warnings for Singulair.

Neurologist Sought Warning for Pfizer Drug
By JEREMY SINGER-VINE
June 20, 2008; Page B10

A British neurologist who analyzed effects of the drug Neurontin told a court hearing Thursday that he advised its maker -- now a unit of Pfizer Inc. -- to include a warning on the drug's label for potential side effects of depression and aggression, but his advice wasn't followed.

The University of London neurologist, Michael R. Trimble, was testifying at a hearing to decide whether civil cases brought against Pfizer alleging suicides linked to Neurontin can proceed. The hearing was jointly held by judges for U.S. District Court in Boston and a New York state court who are hearing similar cases. In various lawsuits consolidated in the federal court, plaintiffs allege more than 100 suicides were connected to Neurontin usage.

Dr. Trimble described what he said was a "plausible biological pathway" that could lead from the compound gabapentin -- the chemical name for Neurontin -- to suicidal behavior, hostility, and aggression. Dr. Trimble said that in 1995 and 1996, he was hired to write two confidential reports for Parke-Davis -- now a unit of Pfizer -- because the company "was concerned about psychosis in relation to their drug." Dr. Trimble said he was unable to find a link to psychosis, but noted effects of depression and aggression.

Lawyers for Pfizer argued at the hearing that the evidence linking the drug to suicidal side effects wasn't scientifically sound. Under cross-examination, they challenged his description of a pathway as a patchwork of studies that didn't prove a biological connection. Neurontin and generic forms of gabapentin are approved for treating epileptic convulsions, but have also been prescribed widely "off label" for other conditions.

In five of nine patient cases he analyzed in 1996, Dr. Trimble said he saw depression and aggression in patients who had no previous symptoms of the side effects, so he said he recommended to the company that the drug "should carry some kind of warning" for susceptible patients.

Thursday's proceedings were the initial phase of a hearing requested by Pfizer to challenge the opinions of the plaintiffs' experts. Under cross-examination and a subsequent examination by the plaintiffs' attorney, Dr. Trimble said the biological pathway between Pfizer's Neurontin and suicidal events were plausible and supported by a series of peer-reviewed neurology research.

I was put on Singulair about 2 years ago because of my COPD. No allergies were ever mentioned by my Doctor. This site has been a god send for me.
Since starting Singulair I have been put on Digoxin for an irregular heart beat that I never had before. I have been put on Gabapentin for leg pain and cramping in my feet whenever I put my feet up or laid down to TRY and get to sleep. I have been put on so many pain killers for back pain, leg pain, neck pain I can't even count them all. I won't take them, they make me so sick. Now I find that I wake up with a headache every morning, feeling sick..oh yes, I was given medication for nausea also. And I don't want to forget the six months of experiencing never ending dizzy spells. That was another medication to ad to the list of ALL THE MEDICATIONS I HAVE TAKEN OVER THE PAST 2 YEARS for the side effects of Singulair. I stopped taking it a couple of days ago and I woke up this morning feeling so good. Oh, lets not forget the Xanax, Prozac and Cymbalta for depression.......OMG! I'm looking forward to see how many of these medications I can toss now that I've stopped taking Singulair. I just wish I had found this site two years ago, oh yeah, I am on Advair also. I've been, lets say "in a chronic bad mood" too. Some would say a "B". I've already noticed a difference there too.

Lipitor reduced my Cholesterol from 280 to 140. But... after only 4 months on the drug I developed pain in my legs. After several visits to the doctor I was told to get off the drug. One month later my health had deteriorated to the point that I could hardly walk. After another doctors visit and many tests I was diagnosed with peripheral neuropathy with the symptoms of leg pain, muscle loss and nerve damage in both legs, feet and hands. Also numbness in both hands and feet. Inability to move any of my toes. Liver damage. Of course with the problems with my feet I have poor balance. Additionally I have memory loss. Because of the neuropathy I can not get health insurance without paying a much higher preminum than normal. I am taking Gabapentin 1200 ml 3x day.

My condition has improved gradually but I still have the P. Neuropathy and there is no cure for it. My balance remains poor and the numbness, pain, nerve and muscle damage remain.

This diagnois is from a family doctor as well as a neourologist.

My recommendation is stay away from the statins.

Starting ever 3-4 months, then every 1 to 6 weeks with no known trigger I get a burning skin sensation that comes on suddenly and within 10 minutes or so I feel blow torch heat staring with neck and face then limbs and trunk that actually looks exactly like a sunburn, but feels about 10x worse and no peel afterwards. And my face muscles weaken, face droops, and I look 10 years older at it's peak. These "attacks" usually only last 30 to 45 minutes and driving with AC on full blast or taking a cold shower is the only relief during. All I know for sure is this never happened in my 44 years until prescribed gabapentin.(Nuerontin). I have GAD and my doctor suggested a 400 mg pill along with at Xanax 4x a day. I have tapered down to 1 gabapentin in the mornining and intend to quit in 10 days. Bad news is I've been at the low dose for the last 6 months out of the 18 months on it and the attacks haven't changed as hoped, in fact I'm writing because I just had one last Thursday and again today (Monday, only 4 days later)... a new record for shortest span between attacks. Could recognize no benefit or difference with regards to it's effectiveness treating my Generalized Anxiety Disorder. The Xanax as needed appears to be all I need alone. Only exception being that early on if I took my 100 mg Xanax w/out a gabapentin you could get drowsy while driving.... I break them in 1/2 doses or drink coffee, does the trick. I'm on only these two drugs and don't see the same side affects posted about Xanax so I deduced it's the gabapentin and am stopping it. Yes I too noticed occasional blurred vision, confusion, and munchies, reduced libido, more difficult or no orgasm as well on gabapentin. Too bad.

i have been given gabapentin 300 mg twice a day
I have taken it only for 3 days but with the very first dose I felt funny...dizzy, sleepy...but I still drive my car...will I get used to these effects or will i have to discontinue??
I take it for cervical spondylosis.

I took Lipitor 40 mg q.d. for a few years. Then I started having unbearable leg cramps upon awakening in the mornings. They were practically debilitating! I also started having another kind of leg pain, the kind which is very hard to describe. My leg or legs would feel kind of dead, not crampy, but pain inside the leg near the bone you might say. That was worse than the leg cramps, because I could usually get up and walk around and eventually the leg cramps would go away for the rest of the day. This dead but extremely painful feeling in my legs would go all the way up into the thigh area and I would just have to lie there until it went away. Thank God it did always eventually go away, but not before my vowing to have my legs amputated if the pain continued. My doctor had no idea what could be causing this, and I got the impression that he thought the symptoms were psychosomatic. As a last resort, I stopped taking Lipitor and within 24 hours the leg pain (both kinds) stopped. After one year of blessed relief and no Lipitor the doctor tested my cholesterol and it was very high again. So I tried going back on Lipitor, only I cut the dose in half. The doctor also gave me 300 mg of gabapentin and 325 mg of quinine to take at night about three hours before bedtime. To date, my cholesterol is down to below normal levels and I have not had any more of either kind of leg pain. But if I forget the quinine or gabapentin even one night, the pain comes back. I hope this helps someone else who is suffering as I did.

I've been taking Neurontin for about 2 months (300mg 3x/day) to lessen the pain of occipital neuralgia.....the pain is still present, but not disabling. This is the only medication I am taking.

Side effects I've experienced are extreme fatigue the first couple weeks....then, tired often if I don't get enough sleep. Another thing I've experienced is weight gain and increased appetite - Big time!! All I want to do is eat.

I'm forgetful and miss doses often. If I skip two doses, the pain comes back full force and I'm in bed for a day.

wish you all the best.

Someone here mentioned one pupil was "unequal", which I found interesting: I had an eye exam a couple weeks ago for eye pain; it was noted that my left pupil was more dialated....this is a first for me. However, overall, my eyes are good...

I,ve had a stroke, I,ve been on Gabapentin (neuronton) for 3 years. I take 600mg 3 times a day. I have memory problems; I feel weak most of the time. My daughter says I stare out into space lots. Ihave alot of headaches. I don't go a day without getting sick!!!

My Father took Gabapentin for less than 2 weeks as a pain med for nerve pain caused by cancer along with Morphine and within 1 day of starting Gabapentin he could hardly move and rapidly became debilitated to the point of paraylsis. We took him off the Gabapentin ourselves. He has been paraylized since October 28th, from the waist down. Any other readers affected in this way???

After taking 200 mg a day for 5 months I developed hives on my stomach and love handles. The itching is driving me nuts. Anyone else have this and could it be kidney damage at this low dose?

I have been seriously ill for 8 months now after taking 3 500 mg. doses of Levaquin for a simple uncomplicated UTI. My doctor assured me that the antibiotic was perfectly safe. I trusted him, to my regret. I have been plagued with Severe Central Nervous System neurotoxicity. I also have severe tenonitis in both wrists and both ankles. My veins bulge. I have blurred vision, visual distortions, headache, muscle spasms through my whole body, abdominal pain with indigestion,,nausea, acid reflux, memory loss, confusion, agitation, abnormal dreams, tingling in my feet, toes, legs, arms, head and back. Severe back pain. Lumpy large muscule tissue in lower back. Pain upon walking. Difficulty concentrating, sensitivity to light and sound. Ringing in ears. Neuromuscular pain in chest, underarms,legs, arms, shoulders, all over body. This nightmare is ongoing and getting worse. I hope that I can help others with these problems. I flew to Indianapolis, Indiana to see Dr. David A. Flockhart, Chief of Clinical Pharmacology at IU School of Medicine. He was the only person that I read about that had background and experience in fluoroquinolone antibiotic adverse drug reations. He told me that this class of drugs, when not eliminated from the body, binds to the nerve endings/gaba receeptors in the brain. He stated that the drug does not metabolize much and sits in the brain and causes events to happen. He also stated that the drug binds to the nerve endings throughout the body including the stomach and also binds to the ends of the bone. He stated that it would take time for me to get better. He stated it would take three years if everything went ok. He prescribed Valium in as low a dose as possible to control tremors,seizures, and muscle spasms. If that did not work he recommended the gabapentin/Neurontin that my current neurologist had me on. The valium does help with the muscle spasms and nausea. The Neurontin helps me to sleep better and helps with the nerve pain. I still need further testing to determine the possibility of front temporal lobe partial epilepsy. I have already experienced two episodes of full body convulsions. Don't let your doctors tell you that its all in your head or dismiss your syptoms. If you have tendon problems, refrain from strenous exercise and lifting heavy objects as you are at risk for tendon rupture. I take low dose valium and 1 Neurontin at bedtime to help with nerve pain. The set back to these types of drugs are that your body builds up a tolerance and you eventually need to increase dosage. They are hard to come off of and can cause increased seizures if withdrawn too quickly. Dr. Flockhart told me that I would need to check in to a drug rehab center to come off of valium after prolonged use. I think that all victims of fluoroquinolone antibiotics should come together and work to get these drugs removed from the market. That's what it will take. The FDA cannot ignore publicity in numbers. Thanks to all for listening. Jessica/adrvictim