June 10th
2008
2:05 PM
The example that I am posting below is not the only patent for an aminoquinoline derivative that is proposed for the treatment of neuro-psychiatric disorders. Even though we are not comparing exact chemical structures, it is certainly worth considering how the quinolines relate to this receptor.
It is also worth considering why montelukast, a quinoline, seems to be causing some of the problems that this owners of this particular patent think that they can treat.
As I mentioned before, I have no answers. Regardless of how small Merck believes the population of Singulair patients who suffer neuro-psychiatric disorders is, I do not believe that any patient should be ignored. It also seems that many companies have studied this area in depth and more than one company knows a lot more than we know about why it is possible for these side effects to happen.
" The compounds of formula I have a good activity on the 5-HT.sub.5A receptor. Therefore, the invention further provides methods for the treatment of depression (which term includes bipolar depression, unipolar depression, single or recurrent major depressive episodes with or without psychotic features, catatonic features, melancholic features, atypical features or postpartum onset, seasonal affective disorders and dysthymia, depressive disorders resulting from a general medical condition including, but not limited to, myocardial infarction, diabetes, miscarriage or abortion), anxiety disorders, (which includes generalized anxiety and social anxiety disorder, panic disorders, agoraphobia, social phobia, obsessive compulsive disorders, post-traumatic stress disorders, psychotic disorders (which includes schizophrenia, schizoaffective disorders, bipolar disease, mania, psychotic depression, and other psychoses involving paranoia and delusions), pain (particularly neuropathic pain), memory disorders (including dementia, amnesic disorders and age-associated memory impairment), disorders of eating behaviors (including nervosa and bulimia nervosa), sexual dysfunction, sleep disorders (including disturbances of circadian rhythm, dyssomnia, insomnia, sleep apnea and narcolepsy), withdrawal from abuse of drugs (such as of cocaine, ethanol, nicotine, benzodiazepines, alcohol, caffeine, phencyclidine and phencyclidine-like compounds, opiates such as cannabis, heroin, morphine, sedative hypnotic, amphetamine or amphetamine-related drugs), motor disorders such as Parkinson's disease, dementia in Parkinson's disease, neuroleptic-induced Parkinsonism and tardive dyskinesias, as well as other psychiatric disorders and gastrointestinal disorders such as irritable bowel syndrome (WO 2004/096771). "
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-- By concernedcitizen | Reply | Private Message me
April 23th
2008
5:24 PM
Hi all,
My first time on this site, it's quite interesting to see how people have very similar side effects. My case is I fought with a Poison Ivy and lost, my left arm shows the battle scars. Before going to the doctor, I tried Calamine, Caladryl, Cort Aide, Ivarest, Aveeno Oat Meal Baths & Tee Tree Oil. All failed to help, so off to my doc I went. After what I told him I tried using, he told me to stop. He noted those things do nothing to help Poison Ivy rashes to go away, he prescribed for me to take 20mg of Prednisone 3x a day for 4 days, then knock it down to 2x for 4 days and then 1x for 4 days. He also prescribed Cortisone Cream and to buy OTC Doneboro to soak my arm, it smells just like vinegar..I wonder! I have been taking Prednisone since Monday, so far the only side effects that have shown up is Insomnia and coughing. I do have A LOT more energy than I used to have, my job is enjoying my spitfire mode. The question is, what will happen once I am off this stuff? I've read and heard a lot of nasty things about this drug and I guess I will find out in another 9 more days, I've never been on Prednisone before, I do watch for changes in my body. Making sure I am not growing a beard or mustache, that my boobs don't expand (even though it would make my husband VERY happy). I am sorry to see many on here are having a bad time with this, maybe some of you should get a second opinion. Some doctors today are babied by pharmaceutical companies to push drugs, with some issues some of you have you may want to research your health problems more. Never take the word of your doctor as concrete, they are human too and make mistakes. I believed one fertility doctor until I researched my condition to find out I would never be able to have children, they milked my health plan until I faced them with my findings of medical research sites and online articles by universities. Never again! Fool me once, shame on you, fool me twice, shame on me. Don't be fooled, research for yourself. I will keep you posted as to my next 9 day countdown.
Alison
-- By alison1960 | Reply | (1) replies | Private Message me
September 28th
2007
8:59 AM
I was prescribed Lisinopril for pre-hypertension at 10 mg a day. I've only taken it for 2 days and have felt so sluggish and tired but revved up on the inside at the same time. Had a headache too last night and blurry vision. It does work in lowering the BP though. Last night I felt as if I couldn't take deep breaths to relax myself and then I started having shaking chills and tingling in the hands and feet. Thought I was having a panic attack so I took my clonazepam. Then I felt like I'd have to throw up or go to the bathroom to get relief. The clonazepam kicked in after about an hour and knocked me out, but I still woke up a few hours later still feeling extremely anxious even though the clonazepam was still in my system (I take it twice a day for panic attacks) along with Lexapro for depression/generalized anxiety. I'm refusing to take any more of this drug. I will lose weight and exercise and eat healthy just to avoid this drug.
-- By gunnrwife | Reply | (2) replies | Private Message me
July 31th
2007
2:56 PM
I'm so glad I googled side effects of Yasmin and found this site. All of the sudden my mood swings for the past almost YEAR make sense. I started out fine. The pill was great, and I haven't had to worry about acne at all. Of course I gained a few pounds, but not too much. However, I'm a pre medical student trying to study for the MCAT this summer. I've been SO tired and drained and majorly depressed that I just can't seem to concentrate. I feel like I'm always crying over the stupidest stuff (AKA: no reason at ALL), and my grades are starting to suffer. Hopefully now that I've read this, I can stop taking this pill and see an improvement. It's just not worth the depression. I'm 22 right now, and until recently had never had a suicidal thought. I was starting to panic, because I couldn't identify the cause of my depression. I'm a good student, have lots of friends, and have the most amazing boyfriend and family. Life is good, I shouldn't feel this bad. Now that I have a clue as to what this may be, I can fix it.
-- By garnetpirate | Reply | (41) replies | Private Message me
July 19th
2007
6:49 PM
Took mostly for seizures, but have been informally diagnosed with Bipolar II.
Had tremors at night, almost immediately, marked anxiety, weight loss, strange heat flashes, severe headaches (already have a migraine problem), complete w olfactory hallucinations (could have been breakthrough simple seizures, or headache auras).
Felt detached from myself and others. But the most disturbing symptom of all was auditory hallucinations. I have no history of psychosis and this only happened after starting Lamictal. Basically I could hear a constant chirping sound, subtle, but loud enough at night to keep me from sleeping unless my radio was playing to distract me from the sound. Could it have been a new form of seizure? Maybe, but regardless, the sounds started at the time I started this drug. Plus, according to a psychiatrist, I had no signs of psychosis, just the unexplained phantom sounds. One last possibility: Maybe an inner ear problem. Still would like to look into that.
People are right when they say this is still an experimental drug. If I had known what I was getting myself into, I never would have tried this drug to begin with. If any of you have had auditory hallucinations on this drug, without a history of any sort of hallucination or psychosis, PLEASE respond here and let me know about your experience. Thanks!
-- By drugsensible | Reply | (5) replies | Private Message me
March 16th
2006
7:14 AM
After I began taking the 12 day regimine for stubborn tendonitis, I noticed emotional side effects such as generalized anxiety and depression=like symptoms. I took the last dose a week ago, however, now I am experiencing numbness on the right side of my face. My tendonitis is still there and now I'm a basket case. I have an appointment w/my dr. this afternoon..When should I see some relief from all this goofiness? Soon, I hope. Thanks, CA
-- By clewis | Reply | Private Message me
July 8th
2005
12:38 PM
Hi ladies,
Well it has been 4.5 months since I took my last Yasmin pill and I am finally starting to notice a real difference in my anxiety level. Within a month of starting Yasmin, I developed panic attacks, generalized anxiety, depression, severe mood swings, and an array of physical symptoms such as nausea, vomiting, diarrhea, weight gain, joint aches and pains, headaches, and blurred vision. After stopping Yasmin, I noticed the physical symptoms disappeared within a month, but I was left with the emotional symptoms, particularly anxiety. I would cry at the drop of a hat and I became hypersensitive to everything. I became very insecure, started taking everything personally, and the anxiety and panic attacks created a lot of self doubt which I am still dealing with. Only now, 4.5 months later, am I starting to have more normal days similar to the old me, but the anxiety is still there (at a much lower level though) and I do deal with irrational thoughts at different points in my cycle. All I can say is this is probably the worst thing I have ever put in my body and it is pure poison. If it weren't for this website and having friends that I e-mail who are going through the same thing, I probably would have lost everything and been in some mental institution. These have been some of the worst months of my life when they could have been the best because I have so much to be thankful for and I really have a great life. Yasmin has made me question everything about myself and every aspect of my life including personal relationships and my job. Somewhere along the way, I kind of forgot who I was because of the constant anxiety and living in fear. Now that I am finally starting to feel better, I am trying to re-claim what was lost and build things back up, but it is a slow and emotionally difficult process because I am having a hard time trusting myself and others. To all of you who are still on Yasmin, I strongly advise you to quit if you are developing symptoms such as mine. I wouldn't wish this experience on my worst enemy. Good luck to all of you in Yasmin recovery--it does get better, but it takes time and patience.
Yasmin (2) PredniSONE (2) Zoloft (2) Lisinopril (1) Lamictal (1) Singulair (1) Coreg CR (1)
October 7th
2009
9:12 AM
I'm glad I found this website this morning. I have been taking the generic of Zoloft (Sertraline 50mg) for 4 months now. Every night this week I have been having nightmares. I'm happy to have found a medication that works with my Generalized Anxiety/Depression--but I have started experiencing anxiety in the evenings and have insomnia also. I take it as soon as I wake up in the morning but with a new job, new hours, I have skipped on occasion this last week. I don't know if it's a side effect I should mention to my doctor?
-- By nikkifernandez | Reply | Private Message me