Genetics symptoms and conditions

cannot believe how many stories I have read about mirena and hair loss etc..etc.. etc.. I have experienced many of the side effects that everyone is mentioning.. I actually feel I could live with most of them if it weren't for the hair loss. I have had ( copying from other post.. ridiculous right?)Tired all the time ~ Depression ~ Hungry all the time ~ leg cramps ~ HAIR LOSS TO THE POINT OF BALDING IN SEVERAL AREAS ~ oily skin and bad breakouts ~ Mood swings (huge...yelling fits at my husband and the kids) ~ fluttering in uterus~Sore breasts.. I have medium thick hair that is about 10 inches. I noticed a bald spot in June and now have discovered 4-5 others starting. I just had the iud removed today and my OB pretty much tried to convince me that there is no way that the IUD is causing my issues. I have never had any of these issues before. I got the Mirena on 4/30 of 08 and noticed slowly but surely all of the side effects mentioned. My OB told me that the progesterone could not be causing my issues because it is such a small dosage that it would be comparable to spitting in the ocean as far as the amount that is in my blood stream. She said because I am black and 35 that I may have an autoimmune disorder and that I should stop reading blogs. I told her that all of my research wasn't from a blog and that ALOPECIA is a side effect just not mentioned in my pamphlet that I can find. I understand what she is saying and that she is the one that is the dr. but nobody knows my body better than I do.. I am in it!! I have !never had any problems and have been healthy my entire life. There is no history of autoimmune disease in my family. I am going to my primary care doctor.. to have some blood tests done. I think that the mirena has caused an autoimmune response in my body.. it may not necessarily be the progesterone..although I don't rule it out no matter what she says . the progesterone is synthetic and has an androgynous like activity that is similar to testosterone the main thing that causes male pattern baldness. also Mirena is made out of Silicone.. perhaps those of us that are having hair loss are having it due to our body trying to fight off the foreign invader of the IUD itself. I was going to go and have the Paragard inserted.. because i was thinking it may just be the progesterone.. nope... I read that many women are complaining of ACNE and HAIRLOSS even with that because its made out of copper. So with that being said.. not sure what to do.. may have to go back on Yasmin.. didn't seem to have any problems with that.. I really just don't want to risk putting another hormone in my body.. We all need to get together and look into a class action suit because I am tired of being made to feel crazy by doctors.. sometimes what seems to not be possible is .. especially when there are so many women having the same problem. Feel free to e-mail me re: a class action suit.. if they took depo off Mirena needs to come of too. It seems like it has really screwed a lot of peoples system up.. Hopefully I won't find out I know have a thyroid problem etc.. etc..

I am a 39 year old mother of two teenager daughters. I had my original Mirena inserted in July, 2002 due to extreme bleeding for many months. I would bleed for about 24 days out of every month and felt horrible. As I was only 32 years old at the time, my GYN did not want to perform a hysterectomy and suggested the Mirena. I bled for a couple of months after insertion, but shortly thereafter I had no bleeding and have had no period ever since. This is the side effect that is fantastic!

Shortly after having the Mirena inserted, my marriage fell apart and I was feeling very depressed, EXTREMELY EXHAUSTED and overall "crappy". I assumed that this was all due to my life circumstances. I gained significant weight in my mid-section, I had (and still have) constant headaches, I am always still very very tired, am dizzy, fuzzy-minded, blurred vision, achey, etc. etc. etc. I never once thought about the Mirena being the cause of any of these symptoms.

My doctor has checked my bloodwork numerous time to ensure my iron levels, etc. were okay as well as my thyroid - every time the results were normal so I thought it must all be in my head and all be due to me being somewhat depressed, etc. due to my marital breakdown.

I had my 2nd Mirena put in in December, 2009 as the first one was in for the full 5 years. It was a little painful getting it taken out and the new one put in, but for me the pain was worth it to continue to be period-free for another 5 years!

Recently I have been experiencing hot flashes and night sweats so I asked my doctor if I could be going through menopause. She ordered bloodwork to check my hormones and informed me last week that yes, in fact I am quite far into menopause!!! (remember, age 39)! Because I have not had a period in almost 6 years, I did have the early warning signs of menopause such as missed or irregular periods.

I wondered why I would be going through it so early so googled "Mirena and early menopause" which brought me to this site. When I started reading all the side effects, I wondered if it was maybe the Mirena that cause a lot my problems over the years and it wasn't in fact the dissolving of my marriage and change in life circumstances.

I now have to decide what to do. My doctor stated that I should (because of my young age) go on Hormone Replacement for quality of life. (I am close to my decision and believe that HRT is beneficial for me) - hopefully this will help with the terrible symptoms of menopause I have been having.

I am wondering if having the Mirena inserted had any part in accelerating my body into menopause. I am thinking of having it removed before starting HRT because even though the doctor told me that there is a very low hormone dosage in the Mirena, I don't want to over-do it with hormones as that could cause me even more problems. It would be amazing if I had it removed that I would feel the way I used to feel back 6 years ago (minus the husband)

FYI, before I had the Mirena inserted the first time I read and re-read the pamphlet which contained all the possible side effects, etc. But, as I stated above, my life changed dramatically very shortly after insertion so it never occurred to me that some of my problems may be related to the Mirena.

If this device does accelerate a woman's body into menopause, this should be well publicized as it would be tragic for young women who use this as a form of contraception early in their life to only find out later that they are no longer able to conceive due to their body going though "the change".

I have a history of sinus infections. After two rounds of Augmentin did not clear up my latest one, my doctor finally gave me the steroid pack and Avelox. He had tried to avoid the steroids. I have had them so many times. I finished my steroids 5 days ago and my Avelox yesterday. I read the side effects and did as it suggested. Since it mentions low potassium would not be good I ate a banana every day and had some orange juice to keep my potassium levels up. The drug warms against taking any pain killers such as Aleve, Advil, etc. One earlier reviewer admitted taking Aleve and had a bad reaction... well.... bad move.... I have had no real side effects that I can say for sure are Avelox related. I did feel a little less focused at times, but was not obviously groggy or woosey. I did have a little abdominal discomfort that I usually do not have with drugs, but it was short-lived and only occurred 3 of the 10 days. Many people have bad effects because they do not follow the warnings against anti-acids, pain killers, low potassium, etc. Some people are more likely to react to any medicine, while others like me rarely have a side effect. My tendons did not hurt... nothing.... People who are out of shape, have a poor physical life style, etc. sometimes help contribute to the drugs reactions by being in basically poor physical health to begin with. America is one of the fattest, out of shape nations out there due to our abundance of everything. The majority of persons can take Avelox with no real issues. I will take it again. I truly feel concern for those who had problems, but sometimes we are partly guilty by how we don't take care of ourselves when we are well...... As with any drug, some persons will react no matter what... It's often just a matter of inherited genetics...... Be safe everyone, and take time to evaluate how you take care of your body and really decide to do better. For the record I am almost 58, 5-9 158 pounds and work out semi-regularly.... Take care of that temple God gave you. Its the only one we get on this Earth,,,,,,

It has been almost two years since I took one tablet of 500 mg levaquin for a throat infection. I immediately felt lightheaded, then came the hot prickly skin, rapid heartbeat, insomnia and just a feeling of doom. I did not take another pill. Right after this my ankles started to hurt and podiatrist said had a torn posterier tibial tendon. To this day, I cannot walk without a limp, and can only wear athletic shoes with orthotics. If I stand for or walk for a small period of time I am in a lot of pain and have to sit. I was diagnosed with rheumatoid arthritis from the inflammatory markers in blood tests and rf factor, even though mri of my hands and wrists are normal. My right shoulder and arm hurt, my wrists and fingers hurt, my knees, neck. It is better, but I will never be the same as I was - no more running, walking my dog, going camping with my daughters girl scout troop - can't go hiking. I am 50 and I feel like I am 90. Would like to sue someone.

There may be no way to get Levaquin out of one's body except time. But I wanted to at least try to speed it up. I don't know if it will work for me or others, only time will tell. There is genetics involved since each of us has a unique tolerance for Levaquin. But here is what I am doing:

1. 8 glasses of water daily with fresh-squeezed lemon juice.
2. Lots of fiber - a tblsp of wheat bran 3 times a day with more water.
3. Plain yogurt with live active cultures 5 times a day.
4. A hot bath with epsom salts once a day.
5. Magnesium, Calcium and Iron, a couple of times a day.
6. Vitamins B and C a few times a day.
7. Body Cleanse and Liver Cleanse from the drug store, as directed.

I took 7 Levaquin pills and stopped 10 days ago. Some symptoms have improved. Notably, my appetite is better, the bloated stomach is gone and food moves through normally, anxiety spells are gone, the brain fog is still there but maybe a slightly better each day.

I will be watching my body for any signs of tendon pain in the 12 - 18 months ahead. No pain so far, but Levaquin is capable of doing damage with the pain not felt until later. I will ease back into exercising very slowly over the coming months.

I will be posting updates periodically over the next couple of years. I am a 50 year-old man.

Good luck to all and God bless.

I have been on the nuvaring since May of 08 to relieve my endometriosis. At first I loved it; less cramping, lighter periods, but then around November I started feeling stressed. Lots of anxiety during the first few days of every cycle to the point it was like I was paranoid. I'm not one to worry about what to do if my husband dies but with the Ring I was getting these feelings. I thought it was stress of work messing with me, maybe some winter blues. When I finally got around to seeing my Dr. he said it could be the ring and I needed to get off of it. He's putting me on the pill and I look forward to seeing if things change.

I am 34 years old. I am a pharmacy tech. I have asthma and allergies. I have taken singulair pretty much every day since it came out on the market. I've had asthma since i was about 10 years old. I took theophylline as a kid. Steriods on and off especially during times when my allergies are bad. I still use Advair during the fall and spring. Every drug has a side effect. However breathing is pretty good damn thing. Do I have days when I feel low? Yeah. Do I sometimes have nightmares? Yup. Are "natural" products the answer. Not always. The fish oil that some of the posters are touting can also cause GI problems. Some of the natural products contain herbs and other plant derivatives that can be harmful for a child that suffers from allergies. Not proactively treating asthma can be deadly. Some of the parents are suggesting steriods as the answer - those can cause weight gain, growth suppression and can lead to a worsening of asthma.

Singulair has never made me feel like I've wanted to kill myself. I was more depressed and angry as kid when my asthma did not allow me to partipate in normal childhood things. I was sad and hated life when I couldn't keep up with friends at recces because I was having trouble breathing. You have to outweigh the costs with the benefits. I am more irritable when I have asthma flareup then I am on a normal day. For me, I choose to breathe. And singulair has been helping me for almost a decade.

I'm not saying the medication isn't causing these symptoms but maybe there is an underlying cause to your child's depression.

Any drug has a side effect. But without medical research and the medications that come with them - people would still be dying of simple diseases and we wouldn't have vaccinations. As a society, as a whole, we are a culture that looks to someone else to fix things and then blames the people who try to fix it. We need to stop being the "hot McDonald's coffee'" society.

i personally have had the best experience with my Yasmin birth control. I have been on it for 5 years now. Before Yasmin I was a wreck.Before i ever took any birth control i had my period twice a month, super heavy bleeding,10 days,and cramps so bad I would pass out. I even bled for 5 months straight on the Depoprovera shot. I found all of the tricyclic pills make me crazy and over emotional. I have tried so many different kinds of pills and birth control all with the result of bleeding for months on end and finally my doctor recommended Yasmin and I have been completely happy with it. I have not gained weight, I do not get migraines (and i did with other birth control pills), I am much more emotionally stable (although I will never be a hundred percent sane, but I blame genetics for that one) I have never gotten pregnant, I have not suffered any gastrointestinal side effects, I finally have regular 7 day periods and my cramps are less horrible, my skin has cleared up, i have a perfectly healthy if not over active sex drive, my breast are not particularly tender ever, I don't get any more yeast infections than before, basically it is my saving grace in my opinion. I must also add to this that I did stop taking Yasmin once for 5 months in these 5 years just to see how I am without BC and nothing crazy happened. My periods were heavier, i had worse cramps, my skin broke out. I expected all of that to happen. A month after getting back on Yasmin I was back to my happy ol self again. One last thing is that I did try the Ocello generic version of Yasmin and it was all bad for me. I once again bled for 2 months even though I only took it for two weeks, and i went completely nutso overemotional chick. Long story short, everyone is built differently, not every BC will be the right one for you. Try some different ones out. If you are on a pill and it is not doing the right things for you then switch it instead of taking it for 2 years and then blogging about how miserable it makes you. I will leave you with a wonderful quote from I don't know who but I live for this saying "More orgasms, fewer kids, copulate, don't populate!" HOORAY

Went off simvastatin in March, all pain went away within a couple of months, but muscle weakness in legs remained. In October, found out my cholesterol is sky high, over 325. So Dr. wanted to try Crestor 5 mg. Within 1 week, I had overwhelming fatigue, could hardly stay awake during the day and the weakness in my legs was getting worse. So I just went off Crestor. Frustrating!!

Leukotriene receptor cysLT1 in intestinal epithelial cells and variation in montelukast blood levels between individuals.

We know many things about this topic:

1. Montelukast enters the blood stream through the intestines
2. the cysLT1 (receptor that Singulair blocks) exists in intestinal epithelial cells
3. montelukast will bind with high affinity to the ideal gene type cysLT1 receptor
4. after montelukast enters into the blood stream is it 99% bound to plasma proteins (that point is hypothesized to be the reason that montelukast does not inhibit CYP2C8 in vivo but it does in vitro if it is true that in vivo it does not inhibit CYP2C8)
5. there is variation between individuals on how much montelukast makes it into the blood stream

Well, did anybody out there in science land think of trying to find out how much montelukast binds to the cysLT1 receptors in intestinal epithelial cells? They got all interested in transport proteins but where are the studies about the cysLT1 receptors in intestinal epithelial. And, what is the effect of montelukast if it binds to intestinal cysLT1receptors?

Now, concernedcitizen believes that if montelukast binds to intestinal epithelial cysLT1receptors that could be a BIG problem because those receptors have a different function than in respiratory tissue. In the one place, we gotta' breathe. In the other place, we gotta' digest food properly.

We have all of these children who have stomach pain. Does anybody want to find out why?

This drug belongs in the science HALL OF SHAME. Somebody please call Arnold Diaz. I am quite discussed today.

Oncogene. 2006 Oct 26;25(50):6660-5. Epub 2006 May 22. Links
Endogenous production of leukotriene D4 mediates autocrine survival and proliferation via CysLT1 receptor signalling in intestinal epithelial cells.Paruchuri S, Mezhybovska M, Juhas M, Sjölander A.
Cell and Experimental Pathology, Department of Laboratory Medicine, Lund University, Malmö University Hospital, Malmö, Sweden.

The cysteinyl leukotriene1 (CysLT1) receptor (CysLT1R) enhances survival and proliferation of intestinal cells via distinct pathways. Here, we have demonstrated that there is significant endogenous production of CysLTs from both non-tumour- and tumour-derived intestinal epithelial cells. Treatment of two non-tumour cell lines, Int 407 and IEC-6, with CysLT1R antagonists led to shrinkage and detachment of cells, confirmed as apoptotic cell death, and a dose-dependent reduction in proliferation. However, in the tumour intestinal cell lines Caco-2, SW480, HCT-116 and HT-29, treatment with CysLT1R antagonists significantly reduced proliferation, but had no effect on apoptosis. A unique characteristic of intestinal cancer cells is the presence of nuclear CysLT1Rs, which are inaccessible to receptor antagonists. In these cells, inhibition of the endogenous production of CysLTs indirectly, by 5-lipoxygenase inhibition, impaired CysLT1R signalling throughout the cell, and resulted in apoptosis of the tumour cells. These data reveal the existence of constitutive CysLT1R signalling that mediates both survival and proliferation in intestinal cells. Importantly, we propose that tumour-derived intestinal cells are resistant to CysLT1R antagonist-induced apoptosis, a phenomena that could be explained by nuclear CysLT1R signalling.

PMID: 16715140

CLINICAL TRIAL - transport proteins and montelukast

http://clinicaltrials.gov/ct2/show/record/NCT00513760

More evidence of what I have been saying about genetics and the leukotriene pathway that Singulair blocks. FLAP's as mentioned below are actually the same era as Singulair (late 90's)--many scientists were looking at this pathway.

The genetic component is so "in your face" every where that I am quite appalled that Merck has not at least addressed that issue by now.

Monday, June 02, 2008
Amira Pharmaceuticals Achieves Milestones in FLAP Inhibitor Program With GlaxoSmithKline
Rated Not yet rated
Rate This Recommend Email this Story | Respond to Editor | Print

SEND ComtexDigg It StumbleUpon Newsvine Reddit SAN DIEGO, Jun 02, 2008 (PR Newswire Europe via COMTEX) ----GSK exercises option for AM803, a FLAP inhibitor which recently completed phase I studies

Amira Pharmaceuticals today announced that under the terms of a worldwide exclusive agreement entered into in Feb 2008, GlaxoSmithKline (GSK: 43.65, -0.88, -1.97%) will exercise its right to a second FLAP compound, AM803. Under the original agreement, GSK has rights to develop, manufacture and commercialize FLAP (5-Lipoxygenase Activating Protein) inhibitors for the treatment of respiratory and cardiovascular disease. The decision to develop AM803 follows the successful completion of a phase I study by Amira, which demonstrated its potential as a once-daily FLAP inhibitor.

"Exercise of this option by GSK caps a productive first few months during which Amira has hit a number of near term milestones. Hitting these milestones early has not only further strengthened our relations with GSK, but has resulted in meaningful economic benefit to Amira," said Hari Kumar, Chief Business Officer, Amira. "The project has started extremely well and we are very pleased at the commitment of GSK and the progression of development."

About FLAP Inhibitors

FLAP (5-Lipoxygenase Activating Protein) is a key component early in the leukotriene pathway, a complex signaling process that exerts control over biological processes, such as inflammation and immunity. Excessive production of leukotrienes exacerbates inflammatory diseases, such as asthma; the FLAP gene has also been linked to a significant increase in the risk of myocardial infarction and stroke. AM103 and AM803 bind to FLAP, inhibiting the synthesis of leukotrienes that cause inflammation.

About Amira

Founded in 2005 and headquartered in San Diego, Amira Pharmaceuticals is a small molecule pharmaceutical company focused on the discovery and early development of compounds to treat inflammatory disease linked to the eicosanoid pathway.

The company combines the rigor of a big pharmaceutical company with the ingenuity and energy of a small company, creating an environment for efficient and effective pre-clinical and clinical program decisions. Its scientific founders have successfully worked together for more than a decade and were pivotal in the discovery of a number of inflammatory drugs, including Singulair(R: 73.05, -0.38, -0.51%). The drug hunters at Amira are now actively leveraging their history of success to create high-value compounds for the future. For more information, visit http://www.amirapharm.com.

Web site: http://www.amirapharm.com

Clinical trial of montelukast in the Netherlands.

I noticed two things:

1. The researcher states that sides effects are 10%.
2. The researcher will not allow patients to also take drugs which are metabolized by CYP2C8 because montelukast inhibits that as proved by in vitro (test tube) studies. American studies in vitro said yes montelukast is an inhibitor but in vivo (in people) that it didn't happen. I was always confused by that and would still like to know more
.
******

Hopefully this will prove to the doubters that there are genetic reasons for the variation of efficacy and adverse side effective when taking Montelukast.

I have several areas of concern (concerned citizen is concerned). One of the main areas is the reliability of Montelukast due to differences in genetics among populations. The cysLT1 (Singulair) receptor is a GENE. As I said before, it would be possible to predict those patients for which Montelukast would and would not be effective and those patients whose gene expression profile would cause them to have unwanted side effectives.

I have been looking for a way to give reasonable proof of that which could be used to convince your doctors that Montelukast is not for everybody. I happened to locate a researcher who had invented and patented methods for predicting drug sensitivity and efficacy in inflammatory disease. I have quoted below from his patent application. He intended to provide a method for determining efficacy and drug sensitivity for pharmaceuticals which include leukotriene antagonists - Montelukast.

Quoted from:

Methods for predicting drug sensitivity in patients afflicted with an inflammatory disease
US Patent Issued on December 12, 2006

Methods are disclosed for predicting the efficacy of a drug for treating an inflammatory disease in a human patient, including: obtaining a sample of cells from the patient; obtaining a gene expression profile of the sample in the absence and presence of in vitro modulation of the cells with specific cytokines and/or mediators; and comparing the gene expression profile of the sample with a reference gene expression profile, wherein similarities between the sample expression profile and the reference expression profile predicts the efficacy of the drug for treating the inflammatory disease in the patient.

-----------------------------------------------------------
The field of pharmacogenomics measures differences in the effect of medications that are caused by genetic variations. Such differences are manifested by differences in the therapeutic effects or adverse events of drugs. For most drugs, the genetic variations that potentially characterize drug-responsive patients from non-responders remain unknown.
---------------------------------------------------------

In another embodiment, the invention is directed to a method for predicting the efficacy in a human asthma patient of leukotriene antagonists including, but not limited to, montelukast (a.k.a., SINGULAIR™; Merck, Whitehouse Station, N.J.), zafirlukast (a.k.a., ACCOLATE™, AstraZeneca, Wilmington, Del.), and zileuton (a.k.a., ZYFLO™; Abbott Laboratories, Chicago, Ill.), comprising: obtaining a sample of cells from the patient; obtaining a gene expression profile from the sample in the absence and presence of in vitro modulation of the cells with specific mediators; and comparing the gene expression profile of the sample with a reference gene expression profile, wherein similarity in expression profiles between the sample and reference profiles predicts the efficacy in the human asthmatic patient of leukotriene antagonists.

Many of the cells involved in causing airway inflammation are known to produce signaling molecules within the body called "leukotrienes." Leukotrienes are responsible for causing the contraction of the airway smooth muscle, increasing leakage of fluid from blood vessels in the lung, and further promoting inflammation by attracting other inflammatory cells into the airways. Oral anti-leukotriene medications have been introduced to fight the inflammatory response typical of allergic disease. These drugs are used in the treatment of chronic asthma. Recent data demonstrates that prescribed anti-leukotriene medications can be beneficial for many patients with asthma, however, a significant number of patients do not respond to anti-leukotriene drugs.

--------------------------------------------------

The genes selected are those that have been determined to be differentially expressed in either a disease, drug-responsiveness, or drug-sensitive cell relative to a normal cell and confer power to predict the response to the drug. By comparing tissue samples from patients with these reference expression profiles, the patient's susceptibility to a particular disease, drug-responsiveness, or drug-resistance can be determined.

http://www.patentstorm.us/patents/7148008-description.html

The inventor's website: Hakon Hakonarson M.D. The Children's Hospital of Philadelphia

http://stokes.chop.edu/research/profiles/?ID=251

I just saw this post and it makes me feel ashamed of our medical system which includes everybody.

about 12 hours ago on Apr 14, 2008 by jerseymomma, #7220
My boss has been in contact with all of the top law firms in the NJ & PA area. We want to make sure that we give you info thats actually going to help and not send you to some bloodsucker. When you file an injury suit, there is no money out of pocket. The lawyers only get paid if you win your trial or the case settles (so if you loose-- u dont loose anything either). And as a heads up, if this is something that can be proven to a jury, the suits take fooorrrrever. I think that is the worst part for the families that I personally have dealt with regarding liability suits-- u want closure and you want answers but it takes so long to get them!

Let talks about the "everybody knows category" of the pharmaceutical industry.

1. Everybody knows that: There are many compounds that never go to market for various reasons. Even back then, no pharmaceutical company wanted to spend money on a drug that was not as chemically "reliable" (I chose that word to encompass many things) as possible in all of the known interactions that could be expected in clinical use. The categories are also "everybody knows."
2. Everybody knows that: Merck did a lot of testing for "reliability" on Singulair. But Merck also did a lot of testing on Vioxx. No conclusions can be drawn from this per se.
3. Everybody knows that: Even back then, important decisions were being made as to whether to market a drug that related to how body enzymes metabolized that drug (meaning utilize the drug and then break it down so that the body could eliminate the waste products.) Genetics differences between different people were a factor that were also put into the decision making process.
4. Everybody knows that: clinical variations in efficacy and side effects can be a result of different factors. Some might include 1. genetic differences 2. drug-drug interactions 3. improper use 4. diet - take the grapefruit juice example. Those are just some.

What we don't seem to do in this country is adequately monitor post marketing complaints? Why did it take five years to find out about Vioxx? If we did monitor more carefully, could we identify some thing that was overlooked or the technology has changed so that it is easier to identify what is wrong?

When there is a problem, there is no way that we should go back to the same company for an explanation of the problem. Everybody knows that many companies work on the same category of drugs. Sometimes those companies encountered some road blocks and they abandoned the drug category. The FDA ought to require everything from everybody to get to the bottom of the problem. And also hire independent evaluators.

The next part of what I have to say is just a hypothetical - a FICTION like a WHAT IF. This is just to make a point. What if another group got different results for the metabolism studies? What if another group decided that the drug was not reliable because a hydrogen bond at a certain location could be influenced by too many different factors to be able to accurately predict what would happen?

So why do people have to hire lawyers, when the FDA should be doing it's job? There are many specialities of law just like the doctors. Does getting to the bottom of this problem require the lawyer-chemists? Why is it their job?

Have any of you seen this site: http://www.askapatient.com/viewrating.asp?drug=20829&name=SINGULAIR - the side effects we all recently began discussing is documented from users and parents of users as far back as seven years ago!
Why is it that the FDA just became concerned and Merck had no clue of these reports?? Interesting and distressing wouldn't you say?

I am disheartened but not surprised that so many doctors are dismissing these reports of symptoms that patients have had after taking Singulair. The only reports that I have found to share with you are from Europe and Canada. All of these reports pre-date the recent news stories regarding Singulair and suicide.

In addition to those reports, the most important thing that I have posted is the reference to the fact that Merck itself recognizes that there are genetics differences among patients that are directly linked to the potential efficacy of Singulair (montelukast). I posted a British reports on that subject and a reference to Merck's clinical trial where they studied genetical differences and montelukast.

The best thing that we can do is to try to convince our doctors that this is not politics -- the major does not have to rule. Why do European countries publish frequent reports on all adverse drugs reactions not just those of the majority of the people? One size does not fit all.

The actual incident of headache in all users according to European reports is 18-19%. So when I read that headache, adverse drug reaction to a leukotriene receptor antagonist (Singulair) is then treated by ibuprofen (a Cox-2 inhibitor), which of course gets treated for stomach inflammation or GERD by Nexium or another drug-histamine receptor antagonist, then I wonder what the hell is left to inhibit? So if a patient does not fit the profile of the 80%, do we have to make that patient catatonic (meant figuratively)? I realize that this leaves out all of the receptors that aren't affected by any of these drugs but I am just trying to make a point.

So why does Merck list headache as just one of the side effects in a category of side effects just listed as greater than 1%? And why do so many people believe that there is no scientific proof of any of the complaints that we see here at this site?

I have been on topamax for almost a year now. I had been having a nearly constant migraine cycle for three months which had to be broken with migranol nasal spray. I then started on escalating dosages of topamax. By 100mg I realized that life was wonderful but that I couldn't retain much information which was a problem as I had just gone back to school for an advanced degree. Upon consultation with my doctor, we reduced my dosage to 50mg and things improved dramatically.

I have experienced some fingertip and toe tingling which have been completely tolerable. I take the medication right before bed so that I don't have problems with fatigue during the day. I do get out of breath easily when I exert myself and carbonated beverages taste horrible. But my migraines are under control.

I have a Ph.D. in molecular biology and a few years of neuroscience research under my belt. I would like to say that it is EXTREMELY important for people to understand that no medication is going to work identically for any two people. What works for one person, may not work for everyone. I know people who swear by imitrex but this medication does absolutely nothing for me. You have to be your own advocate when it comes to medications and treatments. Your genetics will also determine how well, if at all, you respond to any medication. For some topamax is a life saver, for others it will be the bane of their existence. This will always be the case for any medication. Be tolerant of others' experiences and understanding of each others' pain and progress will be made.

Has anyone ever had tons of weight gain while taking Singulair? I have been on this drug for about four years now and my weight has increased to more than 50 pounds of weight gain! I have a lot of aches and pains, leg cramps at night, insomnia, but the asthma has improved. I still get my once a year very bad attack with bronchitis, etc, but the improvement was great.

I have had everything else checked out for my weird continued weight gain and everything is normal. So I am checking out this drug and one other I am on for thyroid. (No, it's not my thyroid, my thyroid tests are normal now). It doesn't matter what I do I gain weight. Just wondering if this drug is causing it. My doc told me it was the cause of my insomnia and suggested moving it to the A.M..

I am tired of this weight gain, and it is starting more physical problems, like my bad knees. I ahve always been active and my eating habits haven't changed. Dieting is not working either. Any suggestions? Anyone else gaining unexplained weight?

Thanks!

I saw one woman say that she noticed hair loss. I also have noticed hair loss. I am 21 years old and I had such a full head of hair right before i started taking this xl and now my hair is much thinner all within a year. It may be just be genetics, but I found it interesting that somebody else had the same problem.