Glaxo symptoms and conditions

I am 57 years old, male, and active, and have been on Warfarin since 1987 post Aortic Valve Replacement. I was quite happy with the dosage up till 2001, when I had an episode of TIA due to a malfunctioning thyroid and when my heart rate went down to 30 bpm. Since then, I have also been on a daily dosage of thyroxine, just enough to get my TSH up to normal levels.

Since then, I have a creeping condition of body aches and back pain, which has now, after 7 years, become chronic. This does not seem to alleviate with change from the Eltroxin from Glaxo, to Thyronorm from Ranbaxy. I have now accepted to live with this sometimes-chronic pain.

I tried some experiments with my dosages of the medications, and so I reduced my Warfarin to 5mg from 8mg. Within a week I was plagued with cramps and aches, and I got scared and went back to my old dosage.

Has my body, my heart, my arteries, adjusted to the thin blood over this time since 1987? Due to this thinning of the blood, will the detection of constriction of arteries and veins be more difficult? And consequently the detection of angina pectoris and atherosclerosis? Or can it be just old age catching up?

If any of you are on a similar combination of these two drugs and with similar symptoms, I would appreciate a line.

I must admit I am very surprised by all of the side effects of Advair. I have been taking Advair 250 for years and have NEVER had any problems. I'm 28, healthy, thin, and happy. I exercise several times a week. ALL drugs have side effects. I don't think it's fair for anyone to say "don't take Advair, it's a horrible drug" because it works for some of us. I was taking Flovent before but it didn't work for me. I needed a rescue inhaler several times a week. Since I've been taking Advair I don't even fill my prescription for my rescue inhaler! All drugs have side effects, but they don't effect all people!

I was taking Wellbutrin for about 2weeks (i had taken for about 7yrs previously) from Effexor because of sexual side effects. The Welbutrin worked to get rid of that problem and my Dr in the hospital warned me about generic Budeprion, but my regular PA-C said that the 150's were different and made by Glaxo. Huh???? Like an idiot i got the generics and 5 days later I feel like i have no anti-depressant in me. Im having panic like "emotional attacks" where i just cry if I hear or see something that triggers an emotion, sleeplessness (i don't need any more of that), weight loss (what's food and why is my stomach gurgling) and over all lethargy. I hate this drug, its useless beyond belief, I really wonder who got paid at the FDA to pass this one through.

It is day 4 off my advair and WOW what a difference! I feel great, clearer,lighter, its hard to explain. No withdrawls YET, I am sure the biggest asthma attack ever is impending, but things are really good right now. My mood and personality are even better, I guess when you feel like your dying all the time you can get a little moody. I also enjoyed reading yesterday about Advair and tooth decay (4 fillings and root canal this year) and chicken pox (got them AGAIN last year). Don't worry glaxo, my rotten teeth and life threating bout of pox and spasms of my HEART, which I hear is an important organ, is all a trade off to be able to breathe a little better. Sure. I plan on sending my unused (and will remain) Advair to GSK with a bill for my teeth. We will see what happens.

I was on Singulair for a few years. I started seasonally and eventually stayed on it all year. It kept my mild asthma and seasonal allergies completely in control to the point where I no longer felt like I had those problems. Even after cold viruses, my peak flows never dropped as far and it didn't take as many weeks to recover peak flow. As a singer, that was very important to me.
Then I spent a year barely able to walk from the severe leg cramps and pain and swelling. My GP was stumped and I had several diagnostic and blood tests that ruled out all the possibilities she could think of. Then I called up Glaxo and asked if it could be the Singulair? Yes, in rare cases it causes edema and/or muscle cramps. My doc took me off and the problems faded away and I'm back to walking. But now my asthma is not doing as well back on the older drugs. Sigh.

I have had severe chronic asthma for over 20 years. Started Advair 500/50 4 years ago and my asthma is completely under control--almost never need to use my abuterol. But I have gained 50lbs, and I exercise 5x a week and eat a 1200 calorie diet, and I still gain 1-2 pounds a month. I have several cushing's like symptoms. Excessive weight gain in abdomen and breasts while my arms/legs are thin. Hair loss. Severe stretch marks on abdomen and thighs. Blurry vision, headaches, severe cramping in my calves and strange rash-like bumps on the backs of my arms. Not to mention chronic tachycardia and constant thrush in my mouth. Also my thyroid quit working a year ago and I am on synthroid now. Now it appears I may have an adrenal gland problem. I never had these problems before the Advair. When I mentioned my concerns to my pulmonologist he actually laughed at me. I wonder if Glaxo gives kickbacks to Dr.'s who prescribe their drug.

I took one dose of advair because my doctor recommended it and my heart began pounding like a Jack Hammer within 2 hours of using it. I have a pulmonologist who prescribed it for me again and he thinks I should try it and get over the side-effects within 2 days.

After reading this website I think I'm just going to chuck the stuff. Don't you think that those of us who have used this stuff and had adverse reactions get together and file a class action law suit or at least try to warn the public in a major way about the dangers of this drug?

What are the statistics? I also would like to know if Glaxo has handled this drug like some other drug companies have handled anti-depressant drug reactions (ghost written the studies and pushed it through anyway). I don't trust the big drug companies.

I have been on Advair for severe COPD for 2 yrs now. In the beginning I was feeling great. I am off prednisone and hardly using my inhaler. After about 2 months I started having severe pain in my bones and muscles. Went to several rhuematologists for diagnosis. Rhuematoid arthiritis,
fibromylgia, Osteopenia and whatever else!I now have depression, memory problems, and a horrible cough, and having a lot of difficulty functioniong.At that time I contacted Glaxo and was told that they had no side effects. Now I am hearing all these side effects that people are having I think this does have to be reported.