Going in the right direction symptoms and conditions

I am starting a new post in the hopes that others will see what I am trying to say about the delayed reaction in those that took Singulair for allergies.

If it is consistent that Singulair does not stop allergy symptoms immediately, then the pathways that eventually stop allergy symptoms involve a change in the mast cell function, development and migration (or some combination).

I asked this question for a reason. Are allergy symptoms stopped immediatedly. My question below:

I have a question that will help me continuing looking for information. I can understand that in the case of asthma that Singulair would provide immediate relief. If it is used for seasonal allergies or other allergies without asthma, does it work right away or does it take a period of days or weeks to be effective? If it takes time, could you tell me how long it took in your situation?

My thinking was going in the right direction if the answer below is consistent of everyone or most.

about 2 hours ago on Apr 11, 2008 by catherineevans, #7045
My granddaughter was put on Singulair for allergy symptoms without asthma. Itching, red eyes, terrible congestion, etc. dark circles under her eyes all the time. When we first put her on this, we didn't see any consistent results for 2-3 weeks, then it seemed to 'kick in.' I don't know if this helps. By the way, she was 9, now she's almost 12 and was immediately taken off when this story came out 2 weeks ago.

Then after seeing one response, I gave my reason for asking.

I asked this question because I have a theory of how montelukast really works for allergies as compared to how it works for asthma.

Asthma is a hyper-sensitive state that gets going because the mast cell has a receptor (the leukotriene receptor that Singulair blocks) that sends a signal along a pathway that causes lung tissue to have that extreme response - the wheezing, the airway constriction.

On the mast cell is another receptor the histamine receptor that causes the secretions that make our noses runs and and stuff up. This is not the same immune response as the asthma response. When I saw a post that somebody's doctor said that Singulair is an anti-histamine, NO it is NOT.

So if Singulair does not block histamine immediately and your child's allergies did not go away immediately, then maybe Singulair is working through some other means such as changing normal mast cell homeostasis.
I know that this seems like "what does this mean?" I am really writing this hoping to God that there are people reading this site that know what I am talking about.

Thank you so much for responding. Your answer actually told me what I wanted to know and confirmed my hypothesis. More answers will help. I hope others respond.

PLEASE respond about the length of time that allergies disappeared if you took Singulair for allergies.

J. Douglas Bremner, M.D., I hope that you google your name and will give us your opinion. We are going in the right direction. We need expert help.

My daughter's last dose was Wed 3/26/08. Today she woke up in a great mood - very happy! My husband and I noticed how "euphoric" she was. We could tell she had not felt this good in a long time. She was happy, laughing, and skipping when we went out today. She even spilled a soda in the car and that would have normally started a MAJOR scene (crying, blaming others, extreme anger) and instead she was very calm about it and helped clean it up. What a surprise that was! She has not been like this for years! She actually had an appetite today and asked for food! It tears me up to think she lost almost 4 years of precious childhood to this medicine! She used to be so depressed before that my husband had suggested to her that she see a psychiatrist. We asked her about those times this morning. She said she was so depressed because of the bad dreams she had before. We never mentioned these side effects to her so it was surprising to hear her say that! I'll post again later to see if the changes continue.

I've been skimming through all of these blogs and I feel like I must be one of the lucky few that didn't get an side effects from the Mirena. I had it implanted on Sept. 21st 2007 ( 6 weeks after I had my baby) and since then I really haven't had any problems with it. I didn't feel a thing when it was implanted and after wards... just a little bleeding but no more then a panty liner. I stopped having my period with in the first 3 months. Sure the occasional spotting here and there, but nothing to get stressed over. My hair was falling out more the usual in the shower, but my doctor assured me that it usually happenes after women have babies and will go over after the first few months. So to all the women who've had problems, I'm sorry to hear it, maybe the Mirena just wasn't right for you all. But it sure was right for me. ;)