Gsk symptoms and conditions

PLEASE STAY AWAY FROM THIS DRUG! IT"S LETHAL> I was on Advair 500/50 for 2years to control my severe asthma, which it did and for about 6months I felt great, but at what a price?....Chronic Bronchitis, Pneumonia, Teeth Breaking, Bone Density Issues, severe hair loss, most awful leg cramps, dizziness, shortness of breath, night sweats, anxiety and chest pains. I suspected that Advair was too blame, came across this site and it all just clicked!. I immediately quit Advair cold turkey in March this year. In May during my annual physical I had an abnormal EKG and a murmur was noticed (for the 1st time in 20years). My primary care physician of 25years was as baffled as I was,.I had a perfect EKG the year before. She referred me to a cardiologist and he did a battery of tests (EKG, echocardiogram and stress test with contrast).The echocardiogram came back as abnormal with mitral valve regurgitation and tricuspid valve regurgitation. Is it coincidental that some of the side effects triggered by Advair such as Chest Pain, dizziness, heart palpitations is also the common symptoms of heart valve issues? I don't know. I'm not a doctor, but my common sense tells me that this drug is the culprit.
Before taking this drug, I was a very healthy 40 year old. I could run 10miles a day, work 10hours a day and take care of 4year old. 3months ago before quitting Advair, I felt like a 83year old with advance heart failure. I'm finding my way back to almost feeling and looking my old self again minus less hair, broken teeth and a not so perfect ticker, courtesy of GSK and Advair.

More evidence of what I have been saying about genetics and the leukotriene pathway that Singulair blocks. FLAP's as mentioned below are actually the same era as Singulair (late 90's)--many scientists were looking at this pathway.

The genetic component is so "in your face" every where that I am quite appalled that Merck has not at least addressed that issue by now.

Monday, June 02, 2008
Amira Pharmaceuticals Achieves Milestones in FLAP Inhibitor Program With GlaxoSmithKline
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SEND ComtexDigg It StumbleUpon Newsvine Reddit SAN DIEGO, Jun 02, 2008 (PR Newswire Europe via COMTEX) ----GSK exercises option for AM803, a FLAP inhibitor which recently completed phase I studies

Amira Pharmaceuticals today announced that under the terms of a worldwide exclusive agreement entered into in Feb 2008, GlaxoSmithKline (GSK: 43.65, -0.88, -1.97%) will exercise its right to a second FLAP compound, AM803. Under the original agreement, GSK has rights to develop, manufacture and commercialize FLAP (5-Lipoxygenase Activating Protein) inhibitors for the treatment of respiratory and cardiovascular disease. The decision to develop AM803 follows the successful completion of a phase I study by Amira, which demonstrated its potential as a once-daily FLAP inhibitor.

"Exercise of this option by GSK caps a productive first few months during which Amira has hit a number of near term milestones. Hitting these milestones early has not only further strengthened our relations with GSK, but has resulted in meaningful economic benefit to Amira," said Hari Kumar, Chief Business Officer, Amira. "The project has started extremely well and we are very pleased at the commitment of GSK and the progression of development."

About FLAP Inhibitors

FLAP (5-Lipoxygenase Activating Protein) is a key component early in the leukotriene pathway, a complex signaling process that exerts control over biological processes, such as inflammation and immunity. Excessive production of leukotrienes exacerbates inflammatory diseases, such as asthma; the FLAP gene has also been linked to a significant increase in the risk of myocardial infarction and stroke. AM103 and AM803 bind to FLAP, inhibiting the synthesis of leukotrienes that cause inflammation.

About Amira

Founded in 2005 and headquartered in San Diego, Amira Pharmaceuticals is a small molecule pharmaceutical company focused on the discovery and early development of compounds to treat inflammatory disease linked to the eicosanoid pathway.

The company combines the rigor of a big pharmaceutical company with the ingenuity and energy of a small company, creating an environment for efficient and effective pre-clinical and clinical program decisions. Its scientific founders have successfully worked together for more than a decade and were pivotal in the discovery of a number of inflammatory drugs, including Singulair(R: 73.05, -0.38, -0.51%). The drug hunters at Amira are now actively leveraging their history of success to create high-value compounds for the future. For more information, visit http://www.amirapharm.com.

Web site: http://www.amirapharm.com

I am very skeptical of all of the claims I have read here. I am no advocate of GSK or any other drug company for that matter, but I think people are getting carried away with attributing their symptoms to Advair. The known side-effects are readily available, anything else is purely based on assumption. I agree that Advair may in fact have many more possible adverse effects than they let the public know, but let us be careful about making ourselves little scientific researchers and concluding a causal relationship based upon a single case study (and an informal one at that). Talk to your doctor about trying something with less risk, such as Singulair, Azmacort, Intall, Fluticasone Propionate, etc. Please though, be careful not to be so quick to claim generalizable findings based on your specific case. I myself am going to work with my physician to attempt a gluten-free diet and a less invasive medication therapy. Advair is not habit-forming or addictive, so withdrawals are doubtful at best. Read up on the pharmacology of Advair (salmeterol in particular), and you can come to your own conclusions. Best wishes to all of you fellow asthmatics!

Its me again, the next statistic for GSK, I just also wanted to say if anyone feels like joining me on my takedown of the purple beast please feel free to contact me via e-mail. I Also, I read alot about nebulizers (sp?) and am not familar. Can anyone please explain? Can it help me not die from not taking my meds? That would be helpful. Thanks in advance!

I've been on Advair for 4 or 5 years and can never find a doctor who will even entertain the notion of taking me off of it. Although I have many symptoms that have been documented by GSK they consider it "very unlikely" that Advair is causing my joint pain, bloating, headaches, mouth sores etc. Last year I had pneumonia (also a reported adverse reaction) and THIS year I was diagnose with osteoporosis (yet another risk). I think these doctors are afraid that if they agree to wean me off & I die they'll get sued. Sorry to be so blunt but the problem is that the last doctor who tried to wean me off (now retired) even contacted the manufacturer & was told there is "currently no protocol" recommended for the cessation of Advair. My asthma got so bad when I tapered off, even with oral steroids he eventually just put me back on, hoping to hear of a protocol later. I'm very frustrated to say the least. Doctors seem to think "well it seems to be working since your still alive". Of course I can't to a certainty attribute all my symptoms to Advair it seems very unlikely that NONE of them are. Can't say if the Advair is directly causing depression but the Advair SITUATION is depressing!

My husband was given a sample of this for a month-long bout of bronchitis and we are now thinking it has done permanent damage to his vocal chords. He only used it 5 times, got thrush (yeast infection) in his throat and is still hoarse after a week of being off of it. Does anyone know the history of this drug and has the word "class action lawsuit" crossed anyone's mind besides mine? I am amazed at the way pharmaceutical companies run the healthcare business in this country!

I don't want to go off on a rant here, but are people aware that a large portion of the FDA's operating budget is provided by pharmaceutical manufacturers? This isn't our first experience with this type of thing and I'm about to launch a grassroots campaign to educate the public. Maybe they'll stop believing all the marketing hype.

I'm thinking that the pharmaceutical companies ought to heed the Hippocratic oath - FIRST, DO NO HARM. Wouldn't it be a remarkably different world if they would take all the money they're spending on marketing and use it to lower the price of orphan and AIDS drugs? They keep saying that research is expensive - and advertising on every possible television show, radio and magazines is cheap? Hello? Are we going to be sheep or are we going to be citizens and hold these companies responsible for what they're doing. Thanks for letting me vent. Please contact me if you want to do something about this. And no, I'm not an attorney, but I'm a writer and I think I just found out what my first book is going to be about...